Methotrexate mechanism in treatment of rheumatoid arthritis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Weinblatt, 1985, Efficacy of low-dose methotrexate in rheumatoid arthritis, N Engl J Med, 312, 818, 10.1056/NEJM198503283121303
Visser, 2009, Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature, Ann Rheum Dis, 68, 1094, 10.1136/ard.2008.092668
Whittle, 2004, Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review, Rheumatology (Oxford), 43, 267, 10.1093/rheumatology/keh088
Pichlmeier, 2014, Subcutaneous administration of methotrexate with a prefilled autoinjector pen results in a higher relative bioavailability compared with oral administration of methotrexate, Clin Exp Rheumatol, 32, 563
Desmoulin, 2012, The human proton-coupled folate transporter: Biology and therapeutic applications to cancer, Cancer Biol Ther, 13, 1355, 10.4161/cbt.22020
Seideman, 1993, The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis, Br J Clin Pharmacol, 35, 409, 10.1111/j.1365-2125.1993.tb04158.x
Nuernberg, 1990, Biliary elimination of low-dose methotrexate in humans, Arthritis Rheum, 33, 898, 10.1002/art.1780330620
Godfrey, 1998, The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis, Br J Clin Pharmacol, 46, 369, 10.1046/j.1365-2125.1998.t01-1-00790.x
Angelis-Stoforidis, 1999, Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis, Clin Exp Rheumatol, 17, 313
Brown, 2016, Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers, Nat Rev Rheumatol, 731, 10.1038/nrrheum.2016.175
Budzik, 2000, Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line, Life Sci, 66, 2297, 10.1016/S0024-3205(00)00559-2
Fairbanks, 1999, Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?, Biochem J, 342, 143, 10.1042/bj3420143
Cronstein, 2017, Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases, Nat Rev Rheumatol, 13, 41, 10.1038/nrrheum.2016.178
Baggott, 1986, Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5’-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide, Biochem J, 236, 193, 10.1042/bj2360193
Hasko, 2008, Adenosine receptors: therapeutic aspects for inflammatory and immune diseases, Nat Rev Drug Discov, 7, 759, 10.1038/nrd2638
Varani, 2011, A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release, Arthritis Res Ther, 13, R197, 10.1186/ar3527
Varani, 2009, Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate, Arthritis Rheum, 60, 2880, 10.1002/art.24794
Nguyen, 2003, The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis, J Immunol, 170, 3337, 10.4049/jimmunol.170.6.3337
Cronstein, 1991, Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells, Proc Natl Acad Sci U S A, 88, 2441, 10.1073/pnas.88.6.2441
Cronstein, 1993, The anti-inflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation, J Clin Invest, 92, 2675, 10.1172/JCI116884
Montesinos, 2006, Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis, Arthritis Res Ther, 8, R53, 10.1186/ar1914
Montesinos, 2007, The anti-inflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5’-nucleotidase: findings in a study of ecto-5’-nucleotidase gene-deficient mice, Arthritis Rheum, 56, 1440, 10.1002/art.22643
Morabito, 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5’-nucleotidase-mediated conversion of adenine nucleotides, J Clin Invest, 101, 295, 10.1172/JCI1554
Huang, 1997, Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T cell activation and expansion, Blood, 90, 1600, 10.1182/blood.V90.4.1600
Koshiba, 1997, Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells, J Biol Chem, 272, 25881, 10.1074/jbc.272.41.25881
Peres, 2016, Dispersal limitation induces long-term biomass collapse in overhunted Amazonian forests, Proc Natl Acad Sci U S A, 113, 892, 10.1073/pnas.1516525113
Feoktistov, 2009, Adenosine receptors in wound healing, fibrosis and angiogenesis, Handb Exp Pharmaco, 193, 383, 10.1007/978-3-540-89615-9_13
Teramachi, 2011, Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis, Lab Invest, 91, 719, 10.1038/labinvest.2011.9
Phillips, 2003, The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species, Br J Pharmacol, 138, 501, 10.1038/sj.bjp.0705054
Spurlock, 2011, Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK, Arthritis Rheum, 63, 2606, 10.1002/art.30457
Dolhain, 1998, Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis, Br J Rheumatol, 37, 502, 10.1093/rheumatology/37.5.502
Johnston, 2005, The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules, Clin Immunol, 114, 154, 10.1016/j.clim.2004.09.001
Klimiuk, 2007, Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis, Scand J Rheumatol, 36, 345, 10.1080/03009740701406460
Sands, 2004, Specific inhibition of nuclear factor-kappaB-dependent inflammatory responses by cell type-specific mechanisms upon A2A adenosine receptor gene transfer, Mol Pharmacol, 66, 1147, 10.1124/mol.104.001107
Gerards, 2003, Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis, Rheumatology (Oxford), 42, 1189, 10.1093/rheumatology/keg323
Rudwaleit, 2000, Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4, Ann Rheum Dis, 59, 311, 10.1136/ard.59.4.311
Miranda-Carus, 2004, L-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate, J Immunol, 173, 1463, 10.4049/jimmunol.173.2.1463
Chan, 2010, Methotrexate – how does it really work?, Nat Rev Rheumatol, 6, 175, 10.1038/nrrheum.2010.5
Nesher, 1991, In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine, Ann Rheum Dis, 50, 637, 10.1136/ard.50.9.637
Kremer, 1986, Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates, Arthritis Rheum, 29, 832, 10.1002/art.1780290703
Puig, 1984, Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate, J Clin Invest, 74, 936, 10.1172/JCI111512
Chan, 2006, Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis, Br J Pharmacol, 148, 1144, 10.1038/sj.bjp.0706812
Montesinos, 2002, Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors, Am J Pathol, 160, 2009, 10.1016/S0002-9440(10)61151-0
Merrill, 1997, Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis, Arthritis Rheum, 40, 1308
Shea, 2013, Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis, Cochrane Database Syst Rev, CD000951
Morgan, 1994, Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial, Ann Intern Med, 121, 833, 10.7326/0003-4819-121-11-199412010-00002
Kurzawski, 2016, ATIC missense variant affects response to methotrexate treatment in rheumatoid arthritis patients, Pharmacogenomics, 17, 1971, 10.2217/pgs-2016-0125
Lee, 2016, Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis, Rheumatol Int, 36, 1591, 10.1007/s00296-016-3523-2
Li, 2016, The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis, Int Immunopharmacol, 38, 8, 10.1016/j.intimp.2016.05.012
Lima, 2016, Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therapeutic outcome, Pharmacogenomics, 17, 1649, 10.2217/pgs-2016-0067
Hider, 2008, Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX, Rheumatology (Oxford), 47, 1156, 10.1093/rheumatology/ken182
Bartelds, 2011, Development of anti-drug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up, JAMA, 305, 1460, 10.1001/jama.2011.406
Pascual-Salcedo, 2011, Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis, Rheumatology (Oxford), 50, 1445, 10.1093/rheumatology/ker124
Bartelds, 2007, Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis, Ann Rheum Dis, 66, 921, 10.1136/ard.2006.065615
Bartelds, 2010, Anti-infliximab and anti-adalimumab antibodies in relation to response to adalimumab in infliximab switchers and anti-tumour necrosis factor naive patients: a cohort study, Ann Rheum Dis, 69, 817, 10.1136/ard.2009.112847
Maini, 1998, Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis, Arthritis Rheum, 41, 1552, 10.1002/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W
Bendtzen, 2006, Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab, Arthritis Rheum, 54, 3782, 10.1002/art.22214
Krieckaert, 2010, The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review, Arthritis Res Ther, 12, 217, 10.1186/ar3147