Methicillin-resistant Staphylococcus aureus: a new zoonotic agent?

Burkhard Springer1, Ulrike Orendi1, Peter Much1, Gerda Höger1, Werner Ruppitsch1, K. Krziwanek2, Sigrid Metz-Gercek2, H. Mittermayer2
1Austrian Agency for Health and Food Safety, Institute of Medical Microbiology and Hygiene, National Reference Laboratory for Antimicrobial Resistance and National Reference Laboratory for Coagulase-Positive Staphylococci including Staphylococcus aureus, Graz, Austria
2Department of Hygiene, Microbiology and Tropical Medicine, National Reference Center for Nosocomial Infections and Antibiotic Resistance, Elisabethinen Hospital Linz, Linz, Austria

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Kluytmans J, van Belkum A, Verbrugh H (1997) Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10: 505–520

von Eiff C, Becker K, Machka K, Stammer H, Peters G (2001) Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 344: 11–16

Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y (2003) Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 36: 53–59

Kollef MH (2007) Limitations of vancomycin in the management of resistant staphylococcal infections. Clin Infect Dis 45: S191–195

Voss A, Loeffen F, Bakker J, Klaassen C, Wulf M (2005) Methicillin-resistant Staphylococcus aureus in pig farming. Emerg Infect Dis 11: 1965–1966

Boucher HW, Corey GR (2008) Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 46: S344–349

Vandenesch F, Naimi T, Enright MC, Lina G, Nimmo GR, Heffernan H, et al (2003) Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 9: 978–984

Tristan A, Bes M, Meugnier H, Lina G, Bozdogan B, Courvalin P, et al (2007) Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg Infect Dis 13: 594–600

David MZ, Glikman D, Crawford SE, Peng J, King KJ, Hostetler MA, et al (2008) What is community-associated methicillin-resistant Staphylococcus aureus? J Infect Dis 197: 1235–1243

Deurenberg RH, Vink C, Kalenic S, Friedrich AW, Bruggeman CA, Stobberingh EE (2007) The molecular evolution of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 13: 222–235

Okuma K, Iwakawa K, Turnidge JD, Grubb WB, Bell JM, O'Brien FG, et al (2002) Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 40: 4289–4294

Ender M, McCallum N, Adhikari R, Berger-Bächi B (2004) Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus. Antimicrob Agents Chemother 48: 2295–2297

Lee SM, Ender M, Adhikari R, Smith JM, Berger-Bächi B, Cook GM (2007) Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture. Antimicrob Agents Chemother 51: 1497–1499

Jansen WT, Beitsma MM, Koeman CJ, van Wamel WJ, Verhoef J, Fluit AC (2006) Novel mobile variants of staphylococcal cassette chromosome mec in Staphylococcus aureus. Antimicrob Agents Chemother 50: 2072–2078

Kenner J, O'Connor T, Piantanida N, Fishbain J, Eberly B, Viscount H, et al (2003) Rates of carriage of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in an outpatient population. Infect Control Hosp Epidemiol 24: 439–444

Salgado CD, Farr BM, Calfee DP (2003) Community-acquired methicillin resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis 36: 131–139

Wertheim HF, Vos MC, Boelens HA, Voss A, Vandenbroucke-Grauls CM, Meester MH, et al (2004) Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use. J Hosp Infect 56: 321–325

Scott GM, Thomson R, Malone-Lee J, Ridgway GL (1988) Cross-infection between animals and man: possible feline transmission of Staphylococcus aureus infection in humans? J Hosp Infect 12: 29–34

van Duijkeren E, Wolfhagen MJ, Heck ME, Wannet WJ (2005) Transmission of a Panton-Valentine leucocidin-positive, methicillin-resistant Staphylococcus aureus strain between humans and a dog. J Clin Microbiol 43: 6209–6211

Weese JS, Archambault M, Willey BM, Hearn P, Kreiswirth BN, Said-Salim B, et al (2005) Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000–2002. Emerg Infect Dis 11: 430–435

Huijsdens XW, van Dijke BJ, Spalburg E, van Santen-Verheuvel MG, Heck ME, Pluister GN, et al (2006) Community-acquired MRSA and pig-farming. Ann Clin Microbiol Antimicrob 5: 26

de Neeling AJ, van den Broek MJ, Spalburg EC, van Santen-Verheuvel MG, Dam-Deisz WD, Boshuizen HC, et al (2007) High prevalence of methicillin resistant Staphylococcus aureus in pigs. Vet Microbiol 122: 366–372

Witte W, Strommenger B, Stanek C, Cuny C (2007) Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerg Infect Dis 13: 255–258

Wulf MW, Sørum M, van Nes A, Skov R, Melchers WJ, Klaassen CH, et al (2008) Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study. Clin Microbiol Infect 14: 29–34

Bens CC, Voss A, Klaassen CH (2006) Presence of a novel DNA methylation enzyme in methicillin-resistant Staphylococcus aureus isolates associated with pig farming leads to uninterpretable results in standard pulsed-field gel electrophoresis analysis. J Clin Microbiol 44: 1875–1876

Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38: 1008–1015

Harmsen D, Claus H, Witte W, Rothganger J, Turnwald D, Vogel U (2003) Typing of methicillin resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 41: 5442–5448

Nemati M, Hermans K, Lipinska U, Denis O, Deplano A, Struelens M, et al (2008) Antimicrobial resistance of old and recent Staphylococcus aureus isolates from poultry: first detection of livestock-associated methicillin-resistant strain ST398. Antimicrob Agents Chemother 52: 3817–3819

van den Eede A, Martens A, Lipinska U, Struelens M, Deplano A, Denis O, et al (2009) High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples. Vet Microbiol 133: 138–144

Reischl U, Linde HJ, Metz M, Leppmeier B, Lehn N (2000) Rapid identification of methicillin-resistant Staphylococcus aureus and simultaneous species confirmation using real-time fluorescence PCR. J Clin Microbiol 38: 2429–2433

Clinical and Laboratory Standards Institute (2008) Performance Standards for Antimicrobial Susceptibility Testing: Eighteenth Informational Supplement M100-S18 Wayne, PA, USA

Ruppitsch W, Stöger A, Braun O, Strommenger B, Nübel U, Wewalka G, et al (2007) Methicillin-resistant Staphylococcus aureus: occurrence of a new spa type in two acute care hospitals in Austria. J Hosp Infect 67: 316–322

van Loo IH, Diederen BM, Savelkoul PH, Woudenberg JH, Roosendaal R, van Belkum A, et al (2007) Methicillin-resistant Staphylococcus aureus in meat products, the Netherlands. Emerg Infect Dis 13:1753–1755

van Loo I, Huijsdens X, Tiemersma E, de Neeling A, van de Sande-Bruinsma N, Beaujean D, et al (2007) Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg Infect Dis 13: 1834–1839

Guardabassi L, Stegger M, Skov R (2007) Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs. Vet Microbiol 122: 384–386

Khanna T, Friendship R, Dewey C, Weese JS (2008) Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers. Vet Microbiol 128: 298–303

Yu F, Chen Z, Liu C, Zhang X, Lin X, Chi S, et al (2008) Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin Microbiol Infect 14: 381–384

Gibbs SG, Green CF, Tarwater PM, Scarpino PV (2004) Airborne antibiotic resistant and non-resistant bacteria and fungi recovered from two swine herd confined animal feeding operations. J Occup Environ Hyg 1: 699–706

Gibbs SG, Green CF, Tarwater PM, Mota LC, Mena KD, Scarpino PV (2006) Isolation of antibiotic-resistant bacteria from the air plume downwind of a swine confined or concentrated animal feeding operation. Environ Health Perspect 114: 1032–1037

Wagenvoort JH, De Brauwer EI, Sijstermans ML, Toenbreker HM (2005) Risk of re-introduction of methicillin-resistant Staphylococcus aureus into the hospital by intrafamilial spread from and to healthcare workers. J Hosp Infect 59: 67–68

Cespedes C, Said-Salim B, Miller M, Lo SH, Kreiswirth BN, Gordon RJ, et al (2005) The clonality of Staphylococcus aureus nasal carriage. J Infect Dis 191: 444–452

Welinder-Olsson C, Florén-Johansson K, Larsson L, Oberg S, Karlsson L, Ahrén C (2008) Infection with Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus t034. Emerg Infect Dis 14: 1271–1272

Melles DC, Gorkink RF, Boelens HA, Snijders SV, Peeters JK, Moorhouse MJ, et al (2004) Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus. J Clin Invest 114: 1732–1740

van Rijen MM, Van Keulen PH, Kluytmans JA (2008) Increase in a Dutch hospital of methicillin-resistant Staphylococcus aureus related to animal farming. Clin Infect Dis 46: 261–263

Annigeri R, Conly J, Vas S, Dedier H, Prakashan KP, Bargman JM, et al (2001) Emergence of mupirocin-resistant Staphylococcus aureus in chronic peritoneal dialysis patients using mupirocin prophylaxis to prevent exit-site infection. Perit Dial Int 21: 554–559

Allerberger F, Mittermayer H (2008) Antimicrobial Stewardship. Clin Microbiol Infect 14: 197–199

WHO (2007) Critically important antimicrobials for human medicine. Report of the second WHO-Expert meeting. Copenhagen, 29–31 May 2007