Metformin influences on respiratory system in obese mice induced by postnatal overnutrition

Bender, 2007, Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts, Diabetes Obes. Metab., 9, 688, 10.1111/j.1463-1326.2006.00650.x Bernardis, 1968, Correlation between ‘Lee index' and carcass fat content in weanling and adult female rats with hypothalamic lesions, J. Endocrinol., 40, 527, 10.1677/joe.0.0400527 Calixto, 2013, Metformin attenuates the exacerbation ofthe allergic eosinophilic inflammation in high fat-diet induced obesity in mice, PLoS One, 8, e76786, 10.1371/journal.pone.0076786 DePalo, 2005, Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus, Geriatrics, 36, 39 Eom, 2015, Foam cells and the pathogenesis of kidney disease, Curr. Opin. Nephrol. Hypertens, 24, 245 Ermert, 2002, Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs, Lab. Invest., 82, 425, 10.1038/labinvest.3780436 Eskens, 2013, Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice, Cardiovasc. Diabetol., 12, 175, 10.1186/1475-2840-12-175 Evans, 2005, Metformin and reduced risk of cancer in diabetic patients, BMJ, 330, 1304, 10.1136/bmj.38415.708634.F7 Fukumura, 2001, Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability, Proc. Natl. Acad. Sci., 98, 2604, 10.1073/pnas.041359198 Gomes, 2000, Comparative respiratory system mechanics in rodents, J. Appl. Physiol., 89, 908, 10.1152/jappl.2000.89.3.908 Green, 1982, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem., 126, 131, 10.1016/0003-2697(82)90118-X Gruber, 2008, Obesity reduces the bioavailability of nitric oxide in juveniles, Int. J. Obes. (Lond.), 32, 826, 10.1038/sj.ijo.0803795 Hantos, 1992, Input impedance and peripheral inhomogeneity of dog lungs, J. Appl. Physiol., 72, 168, 10.1152/jappl.1992.72.1.168 Ismaiel, 2016, Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system, Toxicol. Appl. Pharmacol., 298, 19, 10.1016/j.taap.2016.03.004 Kim, 2014, Association of insulin resistance with bronchial hyperreactivity, Asia Pac. Allergy, 4, 99, 10.5415/apallergy.2014.4.2.99 Kristensen, 2013, Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice, PLoS One, 8, e53533, 10.1371/journal.pone.0053533 Lee, 2004, Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung, Nat. Med., 10, 1095, 10.1038/nm1105 Lee, 2011, Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease, Proc. Am. Thorac. Soc., 8, 512, 10.1513/pats.201102-018MW Leiria, 2015, Increased airway reactivity and hyperinsulinemia in obese mice are linked by ERK signaling in brain stem cholinergic neurons, Cell. Rep., 11, 934, 10.1016/j.celrep.2015.04.012 Lewis, 2014, Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug development, J. Appl. Toxicol., 34, 319, 10.1002/jat.2950 Liu, 2016, Activation of AMPK α2 inhibits airway smooth muscle cells proliferation, Eur. J. Pharmacol., 791, 235, 10.1016/j.ejphar.2016.09.003 Lundberg, 2008, The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics, Nat. Rev. Drug Discov., 7, 156, 10.1038/nrd2466 Namgaladze, 2016, Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation, Biochim. Biophys. Acta, 1861, 1796, 10.1016/j.bbalip.2016.09.002 Nath, 2009, Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis, J. Immunol., 182, 8005, 10.4049/jimmunol.0803563 Novelli, 2007, Anthropometrical parameters and markers of obesity in rats, Lab. Anim., 41, 111, 10.1258/002367707779399518 Olefsky, 2010, Macrophages, inflammation, and insulin resistance, Annu. Rev. Physiol., 72, 219, 10.1146/annurev-physiol-021909-135846 Park, 2012, AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma, Inflamm. Res., 61, 1069, 10.1007/s00011-012-0499-6 Park, 2012, Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase, Biochem. Pharmacol., 84, 1660, 10.1016/j.bcp.2012.09.025 Peták, 1997, Methacholine-induced bronchoconstriction in rats: effects of intravenous vs aerosol delivery, J. Appl. Physiol., 82, 1479, 10.1152/jappl.1997.82.5.1479 Saisho, 2015, Metformin and inflammation: its potential beyond glucose-lowering effect, Endocr. Metab. Immune Disord. Drug Targets, 15, 196, 10.2174/1871530315666150316124019 Sansbury, 2014, Regulation of obesity and insulin resistance by nitric oxide, Free Radic. Biol. Med., 73, 383, 10.1016/j.freeradbiomed.2014.05.016 Scalia, 2007, Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of μ-calpain, Diabetes, 56, 1842, 10.2337/db06-1198 Shore, 2008, No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice, J. Appl. Physiol., 105, 1127, 10.1152/japplphysiol.00117.2008 Singh, 2013, 2013: Insulin and the lung: connecting asthma and metabolic syndrome, J. Allergy (Cairo), 62738, 4 Singh, 2015, Metabolic syndrome is associated with increased oxo-nitrative stress and asthma like changes in lungs, PLoS One, 10, e0129850, 10.1371/journal.pone.0129850 Teixeira, 2016, Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol, J. Physiol. Sci., 66, 221, 10.1007/s12576-015-0417-0 Triggle, 2017, Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium, Acta Physiol., 219, 138, 10.1111/apha.12644 Voelkel, 2006, Vascular endothelial growth factor in the lung, Am. J. Physiol.-Lung Cell. Mol. Physiol., 290, L209, 10.1152/ajplung.00185.2005 Wallace, 2004, Use and abuse of HOMA modelling, Diabetes Care, 27, 1487, 10.2337/diacare.27.6.1487 Wiernsperger, 2000, Metformin: intrinsic vasculoprotective properties, Diabetes Technol. Ther., 2, 259, 10.1089/15209150050025230 Yang, 2016, Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells, Biochim. Biophys. Acta, 30243 Yang, 2017, Macrophage-derived foam cells impair endothelial barrier function by inducing endothelial-mesenchymal transition via CCL-4, Int. J. Mol. Med., 40, 558, 10.3892/ijmm.2017.3034 Ye, 2012, Obesity induced by neonatal overfeeding worsens airway hyperresponsiveness and inflammation, PLoS One, 7, e47013, 10.1371/journal.pone.0047013 Zou, 2004, Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species, J. Biol. Chem., 279, 43940, 10.1074/jbc.M404421200