Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress

Ilhan Onaran1, Gulgun S. Guven1, Sule Beyhan Ozdaş2, Gonul Kanigur1, Suphi Vehid3
1Department of Medical Biology Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
2Department of Chemical and Biological Engineering, Koc University, İstanbul, Turkey
3Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

Tài liệu tham khảo

Sohal, 1993, The free radical hypothesis of aging: an appraisal of the current status, Aging (Milano), 5, 3 Mercuri, 2000, Oxidative stress evaluation in diabetes, Diabet. Technol. Ther., 2, 589, 10.1089/15209150050502014 Ceriello, 2000, Oxidative stress and glycaemic regulation, Metabolism, 49, 27, 10.1016/S0026-0495(00)80082-7 Nuttall, 1999, Age-independent oxidative stress in elderly patients with non-insulin-dependent diabetes mellitus, Quart. J. Med., 92, 33, 10.1093/qjmed/92.1.33 Dincer, 2002, Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes, Mutat. Res., 29, 75, 10.1016/S0027-5107(02)00143-4 Pitozzi, 2003, Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes, Mutat. Res., 529, 129, 10.1016/S0027-5107(03)00114-3 Ames, 1992, Oxidants are a major contributor to aging, Ann. N.Y. Acad. Sci., 663, 85, 10.1111/j.1749-6632.1992.tb38652.x Ceriello, 2003, New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy, Diabet. Care, 26, 1589, 10.2337/diacare.26.5.1589 Wiernsperger, 2000, Metformin: intrinsic vasculoprotective properties, Diabet. Technol. Ther., 2, 259, 10.1089/15209150050025230 Faure, 1999, An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats, Diabetes, 48, 353, 10.2337/diabetes.48.2.353 Kanigur-Sultuybek, 1995, The effect of metformin on insulin receptors and lipid peroxidation in alloxan and streptozotocin induced diabetes, J. Basic Clin. Physiol. Pharmacol., 6, 271, 10.1515/JBCPP.1995.6.3-4.271 Tessier, 1999, Effects of gliclazide versus metformin on the clinical profile and lipid peroxidation markers in type 2 diabetes, Metabolism, 48, 897, 10.1016/S0026-0495(99)90226-3 Srividhya, 2002, Metformin improves liver antioxidant potential in rats fed a high-fructose diet, Asia Pac. J. Clin. Nutr., 11, 319, 10.1046/j.1440-6047.2002.00306.x Bonnefont-Rousselot, 2003, An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress, Metabolism, 52, 586, 10.1053/meta.2003.50093 Rattan, 1989, DNA damage and repair during cellular aging, Int. Rev. Cytol., 116, 47, 10.1016/S0074-7696(08)60638-5 Hannon-Fletcher, 2000, Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects, Mutat. Res., 460, 53, 10.1016/S0921-8777(00)00013-6 Chicca, 1996, Correlation between age and DNA damage detected by FADU in human peripheral blood lymphocytes, Mutat. Res., 316, 201, 10.1016/S0921-8734(96)90004-1 Tice, 1985, DNA repair and replication in aging organisms and cells, 25 Anisimov, 2005, Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice, Exp. Gerontol., 40, 685, 10.1016/j.exger.2005.07.007 Nagata, 2006, Prevention of the manifestation of diabetes in the elderly in the presymptomatic stage, Nippon Ronen Igakkai Zasshi, 43, 84, 10.3143/geriatrics.43.84 Yuen, 1998, Simple high-performance liquid chromatographic method for the determination of metformin in human plasma, J. Chromatogr, 12, 243, 10.1016/S0378-4347(98)00117-0 Fenech, 1993, The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations, Mutat. Res., 285, 35, 10.1016/0027-5107(93)90049-L Fenech, 2000, The in vitro micronucleus technique, Mutat. Res., 455, 81, 10.1016/S0027-5107(00)00065-8 Singh, 1988, A simple technique for quantitation of low levels of DNA damage in individual cells, Exp. Cell Res., 175, 184, 10.1016/0014-4827(88)90265-0 Tice, 2000, Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing, Environ. Mol. Mutagen., 35, 206, 10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J Anderson, 1994, The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutat. Res., 307, 261, 10.1016/0027-5107(94)90300-X Diem, 2002, Basal levels of DNA strand breaks in human leukocytes determined by comet assay, J. Toxicol. Environ. Health, 65, 641, 10.1080/15287390252900331 Taffe, 1987, Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. Formation of alkyl and alkoxyl radicals from tert-butyl hydroperoxide and cumene hydroperoxide, J. Biol. Chem., 262, 12143, 10.1016/S0021-9258(18)45328-8 Gaikwad, 2001, Formation of DNA adducts by microsomal and peroxidase activation of p-cresol: role of quinone methide in DNA adduct formation, Chem. Biol. Interact., 38, 217, 10.1016/S0009-2797(01)00274-5 Park, 2002, Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells, Biochimie, 84, 1199, 10.1016/S0300-9084(02)00039-1 Reliene, 2004, Effect of N-acetylcysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice, Cancer Res., 64, 5148, 10.1158/0008-5472.CAN-04-0442 Mayer, 2000, Lipid peroxidation status, somatic mutations and micronuclei in peripheral lymphocytes: a case observation on a possible interrelationship, Cancer Lett., 152, 169, 10.1016/S0304-3835(00)00332-3 Vineis, 1997, Molecular epidemiology: low dose carcinogens and genetic susceptibility, Int. J. Cancer, 7, 1, 10.1002/(SICI)1097-0215(19970328)71:1<1::AID-IJC1>3.0.CO;2-Y Buttke, 1994, Oxidative stress as a mediator of apoptosis, Immunol. Today, 15, 7, 10.1016/0167-5699(94)90018-3 Beyersmann, 1997, Cadmium, gene regulation, and cellular signalling in mammalian cells, Toxicol. Appl. Pharmacol., 144, 247, 10.1006/taap.1997.8125 Park, 1998, Thermotolerance inhibits various stress-induced apoptosis in NIH3T3 cells, Arch. Pharm. Res., 21, 46, 10.1007/BF03216752 Atkins, 2000, N-Acetylcysteine and endothelial cell injury by sulfur mustard, J. Appl. Toxicol., S125 Lee, 2005, Role of ERK in hydrogen peroxide-induced cell death of human glioma cells, Neurochem. Res., 30, 263, 10.1007/s11064-005-2449-y Manov, 2002, Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells, Exp. Toxicol. Pathol., 53, 489, 10.1078/0940-2993-00215 Khouri, 2004, Radical-induced oxidation of metformin, Eur. J. Biochem., 271, 4745, 10.1111/j.1432-1033.2004.04438.x Shi, 1993, Generation of free radicals in reactions of Ni(II)–thiol complexes with molecular oxygen and model lipid hydroperoxides, J. Inorg. Biochem., 50, 211, 10.1016/0162-0134(93)80026-6 Aruoma, 1989, The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radic. Biol. Med., 6, 593, 10.1016/0891-5849(89)90066-X Glei, 2002, Beta-carotene reduces bleomycin-induced genetic damage in human lymphocytes, Toxicol. Appl. Pharmacol., 179, 65, 10.1006/taap.2001.9329 Detaille, 1999, Cellular and molecular mechanisms involved in insulin's potentiation of glycogen synthase activity by metformin, Biochem. Pharmacol., 58, 1475, 10.1016/S0006-2952(99)00222-1 Detaille, 2002, Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function, Biochem. Pharmacol., 63, 1259, 10.1016/S0006-2952(02)00858-4