Metastin (KiSS-1) Mimetics Identified from Peptide Structure−Activity Relationship-Derived Pharmacophores and Directed Small Molecule Database Screening

Journal of Medicinal Chemistry - Tập 50 Số 3 - Trang 462-471 - 2007
Michael J. Orsini1, Mark Klein1, Mary Pat Beavers1, Peter J. Connolly1, Steven A. Middleton1, Kevin H. Mayo1
1Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Health Science Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, Minnesota 55455, Johnson & Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, New Jersey 08869, and Division of Hematology, Oncology, and Transplantation, University of Minnesota, 14-142 PWB, 516 Delaware St. SE, Minneapolis, Minnesota 55455

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Tài liệu tham khảo

Lee J. H., 1996, J. Natl. Cancer Inst., 88, 1737

Lee J. H., 1997, Int. J. Cancer, 71, 1044

Lee J. H., 1997, Cancer Res., 57, 2387

West A., 1998, Genomics, 54, 148, 10.1006/geno.1998.5566

Ohtaki T., 2001, Nature, 411, 617, 10.1038/35079135

Muir A. I., 2001, J. Biol. Chem., 276, 28975

Kotani M., 2001, J. Biol. Chem., 276, 34636, 10.1074/jbc.M104847200

Horikoshi Y., 2003, J. Clin. Endocrinol. Metab., 88, 919, 10.1210/jc.2002-021235

Ikeguchi M., 2004, Clin. Cancer Res., 10, 1383, 10.1158/1078-0432.CCR-1519-02

Sanchez-Carbayo M., 2003, Am. J. Pathol., 162, 617, 10.1016/S0002-9440(10)63854-0

Dhar D. K., 2004, Int. J. Cancer, 111, 872

Ringel M. D., 2002, J. Clin. Endocrinol. Metab., 87, 2399, 10.1210/jcem.87.5.8626

Takino T., 2003, Oncogene, 22, 4626, 10.1038/sj.onc.1206542

Yan C., 2001, J. Biol. Chem., 276, 1172

Becker J. A., 2005, Biochem. Biophys. Res. Commun., 326, 686, 10.1016/j.bbrc.2004.11.094

Seminara S. B., 2003, N. Engl. J. Med., 349, 1627, 10.1056/NEJMoa035322

Colledge W. H., 2004, Trends Endocrinol. Metab., 15, 453, 10.1016/j.tem.2004.09.008

Steeg P. S., 2003, Clin. Breast Cancer, 4, 62, 10.3816/CBC.2003.n.012

Steeg P. S, 2003, Nat. Rev. Cancer, 3, 63, 10.1038/nrc967

Orsini M. J., 2005, J. Biol. Chem., 280, 8142, 10.1074/jbc.M406405200

Bax N., 1985, J. Magn. Reson., 65, 360

Wider G., 1984, J. Magn. Reson., 56, 234

States D. J., 1982, J. Magn. Reson., 48, 292

Bodenhausen G., 1980, J. Magn. Reson., 37, 106

Delaglio F., 1995, J. Biomol. NMR, 6, 293, 10.1007/BF00197809

Baxter N. J., 1997, J. Biomol. NMR, 9, 369, 10.1023/A:1018334207887

Brunger A. T., 1992, A system for X-ray crystallography and NMR

Koradi R., 1996, J. Mol. Graphics, 14, 55, 10.1016/0263-7855(96)00009-4

Wuthrich K., 1986, NMR of Proteins and Nucleic Acids, 10.1051/epn/19861701011

Arfmann H. A., 1977, Biopolymers, 16, 1826, 10.1002/bip.1977.360160815

Zhang H.-C., 2002, WO, 046183, 2002

Mazarguil H., 2001, Peptides, 22, 1478, 10.1016/S0196-9781(01)00468-5

Gicquel S., 1994, J. Med. Chem., 37, 3481, 10.1021/jm00047a005

Clements M. K., 2001, Biochem. Biophys. Res. Commun., 284, 1193, 10.1006/bbrc.2001.5098

Lange A. B., 1995, Proc. Natl. Acad. Sci. U.S.A., 92, 9253, 10.1073/pnas.92.20.9250

Mollereau C., 2001, Br. J. Pharmacol., 133, 4, 10.1038/sj.bjp.0704049

Mollereau C., 2002, Eur. J. Pharmacol., 451, 256, 10.1016/S0014-2999(02)02224-0

Engstrom M., 2003, J. Pharmacol. Exp. Ther., 305, 832, 10.1124/jpet.102.047118

Niida A., 2006, Bioorg. Med. Chem. Lett., 16, 137, 10.1016/j.bmcl.2005.09.054