Metastases to the Parotid Gland: Study from a Tertiary Care Centre
Tóm tắt
Metastases account for 6–25% of parotid tumors, often presenting dilemmas in their diagnosis. Parotid metastases diagnosed on histology/cytology were retrieved. MUC2, MUC5AC, androgen receptor immunohistochemistry was performed in select cases. Fifty-one samples were identified from 42 patients, including 14 aspirates, 7 biopsies and 30 parotidectomies. Previous history was available in 17 cases, 13 parotidectomies accompanied excision of the primary, and relevant clinical data was unavailable for 12 patients. Majority (81%) had head and neck primaries; eye and ocular adnexa were the commonest subsite (52.4%), and sebaceous carcinoma the commonest histology (33%). When history was unavailable, most metastases were initially diagnosed as poorly differentiated carcinoma/malignant tumor, or mucoepidermoid carcinoma on cytology. Intraparotid metastases encompass a wide spectrum, often mimicking primary salivary gland neoplasms, particularly on limited samples. Metastases should be considered when histological/cytological features are unusual; detailed clinical information and ancillary techniques aid in arriving at an accurate diagnosis.
Tài liệu tham khảo
Kessler AT, Bhatt AA. Review of the major and minor salivary glands, Part 2: Neoplasms and tumor-like lesions. J Clin Imaging Sci. 2018;8:48.
Bou-Assaly W. The forgotten lymph nodes: review of the superficial head and neck lymphatic system. J Radiol Imaging. 2016;1:9–13.
Pastore A, Ciorba A, Soliani M, et al. Secondary malignant tumors of the parotid gland: not a secondary problem! J BUON. 2017;22:513–8.
Franzen A, Buchali A, Lieder A. The rising incidence of parotid metastases: our experience from four decades of parotid gland surgery. Acta Otorhinolaryngol Ital. 2017;37:264–9.
Taxy JB. Squamous carcinoma in a major salivary gland: a review of the diagnostic considerations. Arch Pathol Lab Med. 2001;125:740–5.
Emanuelli E, Ciorba A, Borsetto D, et al. Metastasis to parotid gland from non head and neck tumors. J BUON. 2018;23:163–6.
Franzen AM, Günzel T, Lieder A. Parotid gland metastases of distant primary tumours: a diagnostic challenge. Auris Nasus Larynx. 2016;43:187–91.
Bron LP, Traynor SJ, McNeil EB, O’Brien CJ. Primary and metastatic cancer of the parotid: comparison of clinical behavior in 232 cases. Laryngoscope. 2003;113:1070–5.
Seifert G, Hennings K, Caselitz J. Metastatic tumors to the parotid and submandibular glands: analysis and differential diagnosis of 108 cases. Pathol Res Pract. 1986;181:684–92.
Nuyens M, Schüpbach J, Stauffer E, Zbären P. Metastatic disease to the parotid gland. Otolaryngol Head Neck Surg. 2006;135:844–8.
Malata CM, Camilleri IG, McLean NR, Piggoat TA, Soames JV. Metastatic tumours of the parotid gland. Br J Oral Maxillofac Surg. 1998;36:190–5.
Sarangi J, Kakkar A, Roy D, Thakur R, Singh CA, Sharma MC. Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Eur J Ophthalmol. 2021;31:126–30.
Sarangi J, Konkimalla A, Kaur K, Sikka K, Sen S, Kakkar A. Endocrine mucin producing sweat gland carcinoma with metastasis to parotid gland: not as indolent as perceived? Head Neck Pathol. 2021. https://doi.org/10.1007/s12105-021-01353-1.
Kakkar A, Biswas A, Goyal N, et al. The expression of cyclin D1, VEGF, EZH2 and H3K27me3 in atypical teratoid/rhabdoid tumors of CNS: possible role in targeted therapy. Appl Immunohistochem Mol Morphol. 2016;24:729–37.
Shashinder S, Tang IP, Velayutham P, et al. A review of parotid tumours and their management: a ten-year-experience. Med J Malaysia. 2009;64:31–3.
Kashiwagi N, Murakami T, Toguchi M, et al. Metastases to the parotid nodes: CT and MR imaging findings. Dentomaxillofac Radiol. 2016;45:20160201.
Mayer M, Thoelken R, Jering M, Märkl B, Zenk J. Metastases of cutaneous squamous cell carcinoma seem to be the most frequent malignancies in the parotid gland: a hospital-based study from a salivary gland center. Head Neck Pathol. 2021;15:843–51.
Khullar G, Saikia UN, De D, Radotra BD. Nonmelanoma skin cancers: an Indian perspective. Indian J Dermatopathol Diagn Dermatol. 2014;1:55–62.
Hussaini AS, Dombrowski JJ, Bolesta ES, Walker RJ, Varvares MA. Esthesioneuroblastoma with bilateral metastases to the parotid glands. Head Neck. 2016;38:E2457-2460.
Purkayastha A, Sharma N, Pathak A, Kapur BN, Dutta V. An extremely rare case of metastatic retinoblastoma of parotids presenting as a massive swelling in a child. Transl Pediatr. 2016;5:90–4.
Wang P, Li YJ, Zhang SB, Cheng QL, Zhang Q, He LS. Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report. BMC Ophthalmol. 2017;17:229.
Mazzini C, Pieretti G, Vicini G, et al. Adenocarcinoma arising in the conjunctiva with periparotid lymph node metastases. Cornea. 2020;39:519–22.
Alhoulaiby S, Abdulrahman A, Alouni G, Mahfoud M, Shihabi Z. Extra-CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: a case report. Clin Case Rep. 2020;8:1672–7.
Swinnen J, Gelin G, Fransis S, Vandevenne J, Van Cauter S. Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report. Radiol Case Rep. 2019;14:1334–47.
Romero-Rojas AE, Diaz-Perez JA, Amaro D, Lozano-Castillo A, Chinchilla-Olaya SI. Glioblastoma metastasis to parotid gland and neck lymph nodes: fine-needle aspiration cytology with histopathologic correlation. Head Neck Pathol. 2013;7:409–15.
Kolokythas A, Weiskopf S, Singh M, Cabay RJ. Renal cell carcinoma: delayed metachronous metastases to parotid and cerebellum. J Oral Maxillofac Surg. 2015;73:1296–303.
Mueller SA, Gauthier ME, Ashford B, et al. Mutational patterns in metastatic cutaneous squamous cell carcinoma. J Invest Dermatol. 2019;139:1449–58.
Shi S, Fang QG, Liu FY, Sun CF. Parotid gland metastasis of lung cancer: a case report. World J Surg Oncol. 2014;12:119.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP. Expression of mucins in salivary gland mucoepidermoid carcinoma. Head Neck Pathol. 2021;15:491–502.
Handra-Luca A, Lamas G, Bertrand JC, Fouret P. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol. 2005;29:881–9.