Metals in Alzheimer's and Parkinson's Diseases

Current Opinion in Chemical Biology - Tập 12 Số 2 - Trang 222-228 - 2008
Kevin J. Barnham1,2, Ashley I. Bush1,2
1Bio21 Molecular Science & Biotechnology Institute, Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
2The Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia

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Bush, 2000, Metals and neuroscience, Curr Opin Chem Biol, 4, 184, 10.1016/S1367-5931(99)00073-3

Frederickson, 2005, The neurobiology of zinc in health and disease, Nat Rev Neurosci, 6, 449, 10.1038/nrn1671

Rogers, 2002, An iron-responsive element type II in the 5’ untranslated region of the Alzheimer's amyloid precursor protein transcript, J Biol Chem, 277, 45518, 10.1074/jbc.M207435200

Son, 2007, Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology, Proc Natl Acad Sci U S A, 104, 6072, 10.1073/pnas.0610923104

Frederickson, 2006, Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration, J Neurosci Methods, 154, 19, 10.1016/j.jneumeth.2005.11.014

Danscher, 2005, Zinc-specific autometallographic in vivo selenium methods: tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells, J Histochem Cytochem, 53, 141, 10.1369/jhc.4R6460.2005

Schlief, 2005, NMDA receptor activation mediates copper homeostasis in hippocampal neurons, J Neurosci, 25, 239, 10.1523/JNEUROSCI.3699-04.2005

Schlief, 2006, Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity, Proc Natl Acad Sci U S A, 103, 14919, 10.1073/pnas.0605390103

El Meskini, 2007, ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis, Mol Cell Neurosci, 34, 409, 10.1016/j.mcn.2006.11.018

Niciu, 2007, Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease, Neurobiol Dis, 27, 278, 10.1016/j.nbd.2007.05.004

Uchida, 2002, Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging, J Biol Chem, 277, 32353, 10.1074/jbc.M111263200

Adlard, 2006, Metals and Alzheimer's disease, J Alzheimer's Dis, 10, 145, 10.3233/JAD-2006-102-303

Religa, 2006, Elevated cortical zinc in Alzheimer disease, Neurology, 67, 69, 10.1212/01.wnl.0000223644.08653.b5

Hardy, 2005, Correlation of R2 with total iron concentration in the brains of rhesus monkeys, J Magn Reson Imaging, 21, 118, 10.1002/jmri.20244

Suh, 2005, Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex, Redox Rep, 10, 52, 10.1179/135100005X21624

Chinnery, 2007, Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation, Brain, 130, 110, 10.1093/brain/awl319

Mantovan, 2006, Exploring mental status in Friedreich's ataxia: a combined neuropsychological, behavioral and neuroimaging study, Eur J Neurol, 13, 827, 10.1111/j.1468-1331.2006.01363.x

Zecca, 2004, Iron, brain ageing and neurodegenerative disorders, Nat Rev Neurosci, 5, 863, 10.1038/nrn1537

Kong, 2007, Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions, J Mol Biol, 367, 148, 10.1016/j.jmb.2006.12.041

Falangola, 2005, Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice, Neurochem Res, 30, 201, 10.1007/s11064-004-2442-x

Jack, 2005, In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice, J Neurosci, 25, 10041, 10.1523/JNEUROSCI.2588-05.2005

El Tannir El Tayara, 2006, Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease, Neurobiol Dis, 22, 199, 10.1016/j.nbd.2005.10.013

Dong, 2003, Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence, Biochemistry, 42, 2768, 10.1021/bi0272151

Opazo, 2002, Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol and biological reducing agents to neurotoxic H2O2, J Biol Chem, 277, 40302, 10.1074/jbc.M206428200

Stoltenberg, 2005, Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques, Histochem Cell Biol, 123, 605, 10.1007/s00418-005-0787-0

Miller, 2006, Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease, J Struct Biol, 155, 30, 10.1016/j.jsb.2005.09.004

Grundke-Iqbal, 1990, Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia, Acta Neuropathol (Berl), 81, 105, 10.1007/BF00334497

Quintana, 2006, Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level, J Struct Biol, 153, 42, 10.1016/j.jsb.2005.11.001

Bartzokis, 2000, MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease, Cell Mol Biol (Noisy-le-grand), 46, 821

Butterfield, 2006, Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics, Eur J Pharmacol, 545, 39, 10.1016/j.ejphar.2006.06.026

Cappai, 2007, Molecular determinants of Alzheimer's disease Abeta peptide neurotoxicity, Future Neurol, 2, 397, 10.2217/14796708.2.4.397

Squitti, 2005, Excess of serum copper not related to ceruloplasmin in Alzheimer disease, Neurology, 64, 1040, 10.1212/01.WNL.0000154531.79362.23

Lee, 2002, Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice, Proc Natl Acad Sci U S A, 99, 7705, 10.1073/pnas.092034699

Friedlich, 2004, Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease, J Neurosci, 24, 3453, 10.1523/JNEUROSCI.0297-04.2004

Lee, 2004, Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain, J Biol Chem, 279, 8602, 10.1074/jbc.M309730200

Puglielli, 2005, Cholesterol oxidase mimetic activity of Alzheimer's disease β-amyloid, J Clin Invest, 115, 2556, 10.1172/JCI23610

Ali, 2005, Methionine regulates copper/hydrogen peroxide oxidation products of Abeta, J Pept Sci, 11, 353, 10.1002/psc.626

Chen, 2007, Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease, J Neural Transm, 114, 835, 10.1007/s00702-007-0697-5

Ali, 2006, Dimerisation of N-acetyl-l-tyrosine ethyl ester and Abeta peptides via formation of dityrosine, Free Radic Res, 40, 1, 10.1080/10715760500329721

Metodiewa, 1998, Molecular mechanisms of cellular injury produced by neurotoxic amino acids that generate reactive oxygen species, Amino Acids, 14, 181, 10.1007/BF01345260

Maeda, 2007, Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography, J Neurosci, 27, 10957, 10.1523/JNEUROSCI.0673-07.2007

Atwood, 2004, Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta, Biochemistry, 43, 560, 10.1021/bi0358824

Barnham, 2004, Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid, FASEB J, 18, 1427, 10.1096/fj.04-1890fje

Lesne, 2006, A specific amyloid-beta protein assembly in the brain impairs memory, Nature, 440, 352, 10.1038/nature04533

Bush, 1994, Modulation of Aß adhesiveness and secretase site cleavage by zinc, J Biol Chem, 269, 12152, 10.1016/S0021-9258(17)32694-7

Garai, 2006, Selective destabilization of soluble amyloid beta oligomers by divalent metal ions, Biochem Biophys Res Commun, 345, 210, 10.1016/j.bbrc.2006.04.056

Dong, 2007, Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity, Proc Natl Acad Sci U S A, 104, 13313, 10.1073/pnas.0702669104

Melov, 2007, Mitochondrial oxidative stress causes hyperphosphorylation of tau, PLoS One, 2, e536, 10.1371/journal.pone.0000536

Li, 2004, Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice, J Neurochem, 89, 1308, 10.1111/j.1471-4159.2004.02455.x

Esposito, 2006, Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice, J Neurosci, 26, 5167, 10.1523/JNEUROSCI.0482-06.2006

Bayer, 2003, Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A{beta} production in APP23 transgenic mice, Proc Natl Acad Sci U S A, 100, 14187, 10.1073/pnas.2332818100

Phinney, 2003, In vivo reduction of amyloid-{beta} by a mutant copper transporter, Proc Natl Acad Sci U S A, 100, 14193, 10.1073/pnas.2332851100

Morris, 2006, Dietary copper and high saturated and trans fat intakes associated with cognitive decline, Arch Neurol, 63, 1085, 10.1001/archneur.63.8.1085

Sparks, 2003, Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease, Proc Natl Acad Sci U S A, 100, 11065, 10.1073/pnas.1832769100

Sparks, 2006, Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology, J Nutr Health Aging, 10, 247

Stoltenberg, 2007, Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency, Neuroscience, 150, 357, 10.1016/j.neuroscience.2007.09.025

Bellingham, 2004, Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts, J Neurochem, 91, 423, 10.1111/j.1471-4159.2004.02731.x

Armendariz, 2004, Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App, Physiol Genomics, 20, 45, 10.1152/physiolgenomics.00196.2003

Bellingham, 2004, Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene, J Biol Chem, 279, 20378, 10.1074/jbc.M400805200

Angeletti, 2005, BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper, J Biol Chem, 280, 17930, 10.1074/jbc.M412034200

Hoke, 2005, In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc, FEBS J, 272, 5544, 10.1111/j.1742-4658.2005.04950.x

Strozyk D, Launer LJ, Adlard PA, Cherny RA, Tsatsanis A, Volitakis I, Blennow K, Petrovitch H, White LR, Bush AI: Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid. Neurobiol Aging, in press.

Kaur, 2003, Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease, Neuron, 37, 923, 10.1016/S0896-6273(03)00126-0

Youdim, 2004, Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases, J Neural Transm, 111, 1455, 10.1007/s00702-004-0143-x

Youdim, 2005, Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases, Mech Ageing Dev, 126, 317, 10.1016/j.mad.2004.08.023

Gal, 2006, M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease, J Neural Transm Suppl, 70, 447, 10.1007/978-3-211-45295-0_68

Zhu, 2007, Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators, FASEB J, 21, 3835, 10.1096/fj.07-8386com

Cole, 2005, Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments, J Biol Chem, 280, 9678, 10.1074/jbc.M409946200

Yamin, 2003, Certain metals trigger fibrillation of methionine-oxidized alpha-synuclein, J Biol Chem, 278, 27630, 10.1074/jbc.M303302200

Larsen, 2006, Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis, J Neurosci, 26, 11915, 10.1523/JNEUROSCI.3821-06.2006

Berg, 2006, Disturbance of iron metabolism in Parkinson's disease — ultrasonography as a biomarker, Neurotox Res, 9, 1, 10.1007/BF03033302

Hochstrasser, 2004, Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease, Neurology, 63, 1912, 10.1212/01.WNL.0000144276.29988.C3

Hochstrasser, 2005, Functional relevance of ceruloplasmin mutations in Parkinson's disease, FASEB J, 19, 1851, 10.1096/fj.04-3486fje

Shang, 2006, Novel mutation in the ceruloplasmin gene causing a cognitive and movement disorder with diabetes mellitus, Mov Disord, 21, 2217, 10.1002/mds.21121