Metallo-β-Lactamases: the Quiet before the Storm?

Clinical Microbiology Reviews - Tập 18 Số 2 - Trang 306-325 - 2005
Timothy R. Walsh1,2, Antoine Andremont1,2, Laurent Poirel1,2, Patrice Nordmann1,2
1Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom
2Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France

Tóm tắt

SUMMARYThe ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistantPseudomonas aeruginosastrains possess a metallo-β-lactamase. Acquisition of a metallo-β-lactamase gene will invariably mediate broad-spectrum β-lactam resistance inP. aeruginosa, but the level of in vitro resistance inAcinetobacterspp. and Enterobacteriaceae is less dependable. Their clinical significance is further embellished by their ability to hydrolyze all β-lactams and by the fact that there is currently no clinical inhibitor, nor is there likely to be for the foreseeable future. The genes encoding metallo-β-lactamases are often procured by class 1 (sometimes class 3) integrons, which, in turn, are embedded in transposons, resulting in a highly transmissible genetic apparatus. Moreover, other gene cassettes within the integrons often confer resistance to aminoglycosides, precluding their use as an alternative treatment. Thus far, the metallo-β-lactamases encoded on transferable genes include IMP, VIM, SPM, and GIM and have been reported from 28 countries. Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-β-lactamase inhibitor studies securing the longevity of important anti-infectives.

Từ khóa


Tài liệu tham khảo

10.1128/AAC.45.2.583-588.2001

10.1098/rstb.1980.0049

10.1093/jac/dkg270

10.1128/AAC.48.5.1876-1878.2004

10.1128/AAC.39.7.1612

10.1128/JCM.38.1.40-43.2000

10.1128/AAC.45.2.413-419.2001

10.1093/jac/dkh321

10.1038/nature02241

Bellais, S., S. Leotard, L. Poirel, T. Naas, and P. Nordmann. 1999. Molecular characterization of a carbapenem-hydrolyzing β-lactamase from Chryseobacterium (Flavobacterium) indologenes.FEMS Microbiol. Lett.171:127-132.

10.1128/AAC.46.6.2032-2034.2002

10.1128/AAC.46.9.2791-2796.2002

10.1128/AAC.44.11.3028-3034.2000

Bennett, P. M. 1999. Integrons and gene cassettes: a genetic construction kit for bacteria. J. Antimicrob. Chemother.43:1-4.

10.1128/AAC.44.6.1538-1543.2000

10.1128/AAC.44.6.1556-1561.2000

10.1016/S0968-0896(00)00257-1

10.1042/bj3310703

10.1128/CMR.14.4.933-951.2001

Bush, K. 1999. β-Lactamases of increasing clinical importance. Curr. Pharm. Des.5:839-845.

10.1128/AAC.33.3.271

10.1086/514922

10.1086/319610

10.1128/AAC.39.6.1211

10.1016/j.bmcl.2003.12.037

10.1089/107662902760190635

10.1107/S0907444997010627

Carfi, A., E. Duee, R. Paul-Soto, M. Galleni, J. M. Frere, and O. Dideberg. 1998. X-ray structure of the ZnII β-lactamase from Bacteroides fragilis in an orthorhombic crystal form. Acta Crystallogr. D Biol. Crystallogr.54:45-57.

10.1128/AAC.48.12.4654-4661.2004

10.1128/JB.185.3.823-830.2003

10.1128/AAC.45.3.710-714.2001

10.1046/j.1365-2958.2002.03260.x

10.1021/bi992569m

10.1016/S0969-2126(96)00089-5

10.1128/AAC.47.7.2313-2315.2003

10.1016/S0140-6736(98)05954-6

10.1021/bi960976h

10.1016/S0014-5793(01)02686-2

Da Silva, G. J., M. Correia, C. Vital, G. Ribeiro, J. C. Sousa, R. Leitao, L. Peixe, and A. Duarte. 2002. Molecular characterization of blaIMP-5, a new integron-borne metallo-β-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal. FEMS Microbiol. Lett.215:33-39.

10.1128/JCM.37.6.2109-2110.1999

10.1093/jac/dkg067

10.1128/AAC.46.6.1823-1830.2002

10.1128/AAC.47.5.1522-1528.2003

10.1021/bi9730339

10.1111/j.1365-2958.1995.tb02404.x

10.1093/jac/dkg416

10.1016/S0732-8893(02)00500-X

10.1128/AAC.45.3.660-663.2001

10.1016/j.jmb.2004.10.070

10.1128/AAC.48.7.2347-2349.2004

10.1074/jbc.M301062200

10.1016/S0022-2836(02)01271-8

10.1128/JCM.41.8.3893-3896.2003

10.1128/AAC.46.1.255-258.2002

10.1128/AAC.47.9.3034-3035.2003

10.1248/bpb.20.1136

10.1016/S0960-894X(99)00425-4

Hammond, G. G., J. L. Huber, M. L. Greenlee, J. B. Laub, K. Young, L. L. Silver, J. M. Balkovec, K. D. Pryor, J. K. Wu, B. Leiting, D. L. Pompliano, and J. H. Toney. 1999. Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives. FEMS Microbiol. Lett.179:289-296.

Hanson N. D. A. Hossain L. L. Buck E. S. Moland and K. S. Thomson. 2004. Program and abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy Washington D.C. abstr. C1-291 2004.

Hawkey, P. M., J. Xiong, H. Ye, H. Li, and F. H. M′Zali. 2001. Occurrence of a new metallo-β-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China. FEMS Microbiol. Lett.194:53-57.

10.1128/AAC.47.1.268-273.2003

10.1128/AAC.42.8.2006

10.1128/AAC.46.10.3286-3287.2002

10.1128/AAC.47.4.1382-1390.2003

10.1128/jb.164.1.223-229.1985

10.1128/AAC.39.4.824

10.1128/AAC.48.7.2364-2369.2004

10.1128/AAC.44.8.2023-2027.2000

10.1128/AAC.46.6.2014-2016.2002

10.1093/jac/dkg047

10.1248/bpb.27.851

10.1016/j.diagmicrobio.2004.03.016

10.1086/380461

10.1128/AAC.45.6.1939-1940.2001

10.1128/AAC.48.6.2334-2336.2004

10.1039/B209086D

10.3201/eid1003.020799

10.1128/AAC.43.4.902

10.1128/AAC.43.7.1584

10.3201/eid0907.030012

10.1128/AAC.46.4.1053-1058.2002

10.1128/AAC.48.9.3576-3578.2004

10.1128/jb.170.6.2873-2878.1988

10.1086/379611

Livermore, D. M. 2002. The impact of carbapenemases on antimicrobial development and therapy. Curr. Opin. Investig. Drugs3:218-224.

10.1016/S1369-5274(00)00128-4

10.1128/JCM.40.11.4051-4055.2002

10.1128/AAC.48.2.648-650.2004

10.1128/AAC.46.11.3561-3567.2002

10.1046/j.1469-0691.2003.00558.x

Markou, N., H. Apostolakos, C. Koumoudiou, M. Athanasiou, A. Koutsoukou, I. Alamanos, and L. Gregorakos. 2003. Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patients. Crit. Care7:R78-R83.

10.1128/jb.173.15.4611-4617.1991

10.1093/jac/46.6.1041

10.1021/bi9826512

10.1016/S0968-0004(98)01264-X

10.1128/AAC.48.4.1433-1434.2004

10.1128/AAC.48.12.4654-4661.2004

Migliavacca R. C. Colinon J. D. Docquier M. Spalla E. Nucleo M. Li Bergoli M. Labonia G. M. Rossolini and L. Pagani. 2004. Abstr. 14th European Congress on Clinical Microbiology and Infectious Diseases abstr. P1876 2004.

10.1128/JCM.40.11.4388-4390.2002

10.1016/S1471-4892(01)00079-0

10.1074/jbc.M107054200

10.1128/AAC.47.2.582-587.2003

10.1093/jac/dkg069

10.1093/jac/45.3.271

10.1128/AAC.43.10.2497

10.1001/jama.289.7.885

10.1128/AAC.37.5.939

10.1046/j.1469-0691.2002.00401.x

10.1016/S0167-7012(03)00090-3

10.1128/AAC.38.1.71

Page, M. I. 1999. The reactivity of β-lactams, the mechanism of catalysis and the inhibition of β-lactamases. Curr. Pharm. Des.5:895-913.

Page, M. I. 2002. Understanding metallo-β-lactamases. ASM News68:217-221.

Pagniez G. M. Radice A. Amoroso A. Famiglietti and G. Gutkind. 2004. Abstr. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy abstr. C1-293 Washington D.C.

Pallecchi, L., M. L. Riccio, J. D. Docquier, R. Fontana, and G. M. Rossolini. 2001. Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-β-lactamase. FEMS Microbiol. Lett.195:145-150.

10.1128/JB.185.21.6371-6384.2003

10.1093/jac/dkh095

10.1099/00222615-39-2-93

10.1016/S0378-1097(97)00472-2

10.1128/AAC.41.1.135

10.1128/AAC.38.5.991

10.1517/13543784.9.2.247

10.1128/AAC.46.6.1880-1886.2002

10.1093/jac/dkh398

10.1074/jbc.M312080200

10.1128/jb.177.18.5270-5275.1995

10.1111/j.1365-2958.1994.tb00999.x

Poirel, L., L. Collet, and P. Nordmann. 2000. Carbapenem-hydrolyzing metallo-β-lactamase from a nosocomial isolate of Pseudomonas aeruginosa in France. Emerg. Infect. Dis.6:84-85.

10.1128/AAC.48.1.348-351.2004

10.1128/AAC.45.2.546-552.2001

10.1128/AAC.48.4.1406-1409.2004

10.1128/AAC.44.4.891-897.2000

Poirel, L., J. N. Pham, L. Cabanne, B. J. Gatus, S. M. Bell, and P. Nordmann. 2004. Carbapenem-hydrolysing metallo-β-lactamases from Klebsiella pneumoniae and Escherichia coli isolated in Australia. Pathology (Philadelphia)36:366-367.

10.1128/AAC.45.9.2598-2603.2001

Poole, K. 2003. Overcoming multidrug resistance in gram-negative bacteria. Curr. Opin. Investig. Drugs4:128-139.

10.1093/jac/dkg239

10.1128/AAC.46.12.4026-4028.2002

10.1128/AAC.46.3.932-933.2002

10.1016/j.mib.2003.08.003

10.1128/AAC.44.11.3035-3039.2000

10.1159/000007275

10.1128/AAC.41.2.223

10.1128/AAC.40.9.2080

10.1016/0147-619X(91)90027-T

10.1128/AAC.44.5.1229-1235.2000

10.1128/AAC.45.4.1249-1253.2001

10.1128/AAC.45.3.837-844.2001

10.1128/AAC.43.9.2193

10.1042/bj3320145

10.1128/AAC.47.7.2330-2333.2003

Sahud A. K. Lolans A. M. Queenan and J. P. Quinn. 2004. Presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy Washington D.C.

10.1128/AAC.42.5.1245

10.3201/eid0908.020373

10.1021/bi034672o

10.1016/j.diagmicrobio.2003.09.012

10.1021/bi990986t

10.1128/jcm.34.12.2909-2913.1996

10.1128/AAC.40.2.349

10.1128/JCM.41.12.5407-5413.2003

10.1021/bi027072i

10.1128/AAC.46.8.2450-2457.2002

10.1016/S0014-5793(01)03152-0

10.1074/jbc.M105550200

Spencer J. A. M. Simm A. R. Clarke R. B. Sessions and T. R. Walsh. 2003. Abstr. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago Ill. abstr. C1-568.

10.1128/jb.172.5.2584-2593.1990

10.1093/jac/dkg410

10.1128/AAC.48.1.329-332.2004

10.1093/jac/dkf210

Toney, J. H. 2003. Metallo-β-lactamase inhibitors: could they give old antibacterials new life? Curr. Opin. Investig. Drugs4:115-116.

10.1016/S0960-894X(99)00458-8

10.1016/S1074-5521(98)90632-9

10.1074/jbc.M104742200

10.1093/jac/dkg012

10.1016/j.bmcl.2004.01.047

10.1093/jac/49.1.217

10.1006/jmbi.1998.2148

10.1086/374847

10.1128/JCM.40.8.2755-2759.2002

10.1016/0167-4781(94)90011-6

10.1128/AAC.41.7.1460

10.1128/AAC.42.2.436

10.1093/jac/dkg299

10.1016/0960-894X(96)00453-2

10.1074/jbc.273.35.22402

10.1021/ja982621m

10.1021/bi990356r

10.1016/S1367-5931(99)00017-4

10.1128/AAC.35.1.147

10.1128/AAC.44.6.1448-1452.2000

10.1006/jmbi.2000.5161

10.1093/jac/dkg103

10.1128/AAC.43.11.2808

10.1128/AAC.45.8.2224-2228.2001

10.1093/jac/dkf170

10.1128/JCM.39.12.4433-4439.2001

10.1016/j.diagmicrobio.2004.01.002

Yang, Y., and K. Bush. 1996. Biochemical characterization of the carbapenem-hydrolyzing β-lactamase AsbM1 from Aeromonas sobria AER 14M: a member of a novel subgroup of metallo-β-lactamases. FEMS Microbiol. Lett.137:193-200.

10.1128/AAC.34.5.755

10.1128/AAC.45.5.1343-1348.2001

10.1128/AAC.48.2.626-628.2004

10.1128/AAC.45.4.1151-1161.2001

10.1128/JCM.41.9.4246-4251.2003

10.1128/JCM.40.10.3798-3801.2002

10.1016/S0732-8893(01)00352-2

Thông tin
Thông tin xuất bản

Clinical Microbiology Reviews

Tập 18 Số 2

306-325

Thông tin tác giả