Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner

Nanomedicine: Nanotechnology, Biology and Medicine - Tập 14 - Trang 883-896 - 2018
Shakti Ranjan Satapathy1, Anmada Nayak1, Sumit Siddharth1, Sarita Das1, Deepika Nayak1, Chanakya Nath Kundu1
1Cancer Biology Division, KIIT School of Biotechnology, KIIT University, Bhubaneswar, Orissa, India

Tài liệu tham khảo

Risau, 1997, Mechanisms of angiogenesis, Nature, 386, 671, 10.1038/386671a0 Papetti, 2002, Mechanisms of normal and tumor-derived angiogenesis, Am J Physiol Cell Physiol, 282, C947, 10.1152/ajpcell.00389.2001 Folkman, 1971, Tumor angiogenesis: therapeutic implications, N Engl J Med, 285, 1182, 10.1056/NEJM197111182852108 Weidner, 1991, Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma, N Engl J Med, 324, 1, 10.1056/NEJM199101033240101 Weidner, 1992, Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma 1, J Natl Cancer Inst, 84, 1875, 10.1093/jnci/84.24.1875 Riabov, 2014, Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis, Front Physiol, 5, 75, 10.3389/fphys.2014.00075 Korkaya, 2011, Breast cancer stem cells, cytokine networks, and the tumor microenvironment, J Clin Invest, 121, 3804, 10.1172/JCI57099 Wang, 2012, Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells, Stem Cell Res Ther, 3, 5, 10.1186/scrt96 D'Anello, 2010, Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells, Mol Cancer, 9, 300, 10.1186/1476-4598-9-300 Bharti, 2016, Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: a snapshot of IL-6 mediated involvement, Cancer Lett, 375, 51, 10.1016/j.canlet.2016.02.048 Ndlovu, 2009, Hyperactivated NF-kappa B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells, Mol Cell Biol, 29, 5488, 10.1128/MCB.01657-08 Nagasaki, 2014, Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction, Br J Cancer, 110, 469, 10.1038/bjc.2013.748 Li, 2003, IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis, J Immunol, 170, 3369, 10.4049/jimmunol.170.6.3369 Fràter-Schröder, 1987, Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo, Proc Natl Acad Sci U S A, 84, 5277, 10.1073/pnas.84.15.5277 Folkman, 2003, Fundamental concepts of the angiogenic process, Curr Mol Med, 3, 643, 10.2174/1566524033479465 Segal, 2009, Design and development of polymer conjugates as anti-angiogenic agents, Adv Drug Deliv Rev, 61, 1159, 10.1016/j.addr.2009.06.005 Davis, 2008, Nanoparticle therapeutics: an emerging treatment modality for cancer, Nat Rev Drug Discov, 7, 771, 10.1038/nrd2614 Satapathy, 2015, Enhancement of cytotoxicity and inhibition of angiogenesis in oral cancer stem cells by a hybrid nanoparticle of bioactive quinacrine and silver: implication of base excision repair cascade, Mol Pharm, 12, 4011, 10.1021/acs.molpharmaceut.5b00461 Mukherjee, 2005, Antiangiogenic properties of gold nanoparticles, Clin Cancer Res, 11, 3530, 10.1158/1078-0432.CCR-04-2482 Panyam, 2003, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv Drug Deliv Rev, 55, 329, 10.1016/S0169-409X(02)00228-4 Preet, 2012, Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity, Int J Cancer, 130, 1660, 10.1002/ijc.26158 Mohapatra, 2012, Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism, Oncol Res, 20, 81, 10.3727/096504012X13473664562628 Das, 2017, Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade, Oncotarget, 8, 248, 10.18632/oncotarget.11335 Guo, 2009, 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways, Oncogene, 28, 1151, 10.1038/onc.2008.460 Liang, 2008, Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine, Fundam Clin Pharmacol, 22, 429, 10.1111/j.1472-8206.2008.00613.x Edwards, 2007, Gold in a metallic divided state-from Faraday to present-day nanoscience, Angew Chem Int Ed Engl, 46, 5480, 10.1002/anie.200700428 Visvader, 2012, Cancer stem cells: current status and evolving complexities, Cell Stem Cell, 10, 717, 10.1016/j.stem.2012.05.007 Calabrese, 2007, A perivascular niche for brain tumor stem cells, Cancer Cell, 11, 69, 10.1016/j.ccr.2006.11.020 Sun, 2014, Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds, Biomaterials, 35, 836, 10.1016/j.biomaterials.2013.10.011 Wang, 2011, Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells, ACS Nano, 5, 3679, 10.1021/nn200007z Wang, 2013, Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles, Biomaterials, 34, 4667, 10.1016/j.biomaterials.2013.03.008 Nayak, 2016, Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1, Sci Rep, 6, 20600, 10.1038/srep20600 Preet, 2014, Synthesis and biological evaluation of andrographolide analogues as anti-cancer agents, Eur J Med Chem, 85, 95, 10.1016/j.ejmech.2014.07.088 Chakraborty, 2014, Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis, PLoS One, 9, e99743, 10.1371/journal.pone.0099743 Satapathy, 2015, The apoptotic effect of plant based nanosilver in colon cancer cells is a p53 dependent process involving ROS and JNK cascade, Pathol Oncol Res, 21, 405, 10.1007/s12253-014-9835-1 Chazotte, 2011, Labeling mitochondria with MitoTracker dyes, Cold Spring Harb Protoc, 2011, 990 Toth, 2012, Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography, Methods Mol Biol, 878, 121, 10.1007/978-1-61779-854-2_8 Mohapatra, 2014, The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K-AKT-NFκB cascade, Toxicol Appl Pharmacol, 274, 168, 10.1016/j.taap.2013.09.028 Das, 2017, Etoposide and doxorubicin enhance the sensitivity of triple negative breast cancers through modulation of TRAIL-DR5 axis, Apoptosis, 22, 1205, 10.1007/s10495-017-1400-4 Shin, 2015, Role of physicochemical properties in nanoparticle toxicity, Nanomaterials, 5, 1351, 10.3390/nano5031351 Korkaya, 2011, Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots, Clin Cancer Res, 17, 6125, 10.1158/1078-0432.CCR-10-2743 Naldini, 2005, Role of inflammatory mediators in angiogenesis, Curr Drug Targets Inflamm Allergy, 4, 3, 10.2174/1568010053622830 Reuter, 2010, Oxidative stress, inflammation, and cancer: how are they linked?, Free Radic Biol Med, 49, 1603, 10.1016/j.freeradbiomed.2010.09.006 Voronov, 2003, IL-1 is required for tumor invasiveness and angiogenesis, Proc Natl Acad Sci U S A, 100, 2645, 10.1073/pnas.0437939100 Yao, 2007, Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells, Int J Cancer, 121, 1949, 10.1002/ijc.22930 Fisman, 2010, The ubiquitous interleukin-6: a time for reappraisal, Cardiovasc Diabetol, 9, 62, 10.1186/1475-2840-9-62 Han, 2008, Auranofin inhibits overproduction of pro-inflammatory cytokines, cyclooxygenase expression and PGE2 production in macrophages, Arch Pharm Res, 31, 67, 10.1007/s12272-008-1122-9 Thakor, 2011, Gold nanoparticles: a revival in precious metal administration to patients, Nano Lett, 11, 4029, 10.1021/nl202559p Sumbayev, 2013, Gold nanoparticles downregulate interleukin-1β-induced pro-inflammatory responses, Small, 9, 472, 10.1002/smll.201201528 Sullivan, 2009, Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells, Oncogene, 28, 2940, 10.1038/onc.2009.180 Gonzalez-Moreno, 2010, VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop, Exp Cell Res, 316, 554, 10.1016/j.yexcr.2009.11.020 Zhang, 2000, Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1, Proc Natl Acad Sci U S A, 97, 6427, 10.1073/pnas.97.12.6427 Yeh, 2000, The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest, Proc Natl Acad Sci U S A, 97, 12782, 10.1073/pnas.97.23.12782 Pan, 2014, Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway, Biomed Res Int, 2014, 418624, 10.1155/2014/418624 Roma-Rodrigues, 2016, Peptide-caoted gold nanoparticles for modulation of angiogenesis in vivo, Int J Nanomedicine, 11, 2633 Bharti, 2017, Somatostatin receptor targeted liposomes with diacerein inhibit IL-6 for breast cancer therapy, Cancer Lett, 388, 292, 10.1016/j.canlet.2016.12.021 Asharani, 2010, DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles, Nanomedicine (London), 5, 51, 10.2217/nnm.09.85 Mkandawire, 2015, Induction of apoptosis in human cancer cells by targeting mitochondria with gold nanoparticles, Nanoscale, 7, 10634, 10.1039/C5NR01483B Deniaud, 2008, Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis, Oncogene, 27, 285, 10.1038/sj.onc.1210638 Butterworth, 2010, Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy, Nanotechnology, 21, 295101, 10.1088/0957-4484/21/29/295101