Metal wear particles: What we know, what we do not know, and why

Jacobs, 2008, How has the biologic reaction to wear particles changed with newer bearing surfaces?, J Am Acad Orthop Surg, 16, S49, 10.5435/00124635-200800001-00011 Carr, 2008, Osteolysis in patients with a metal-on-metal hip arthroplasty, ANZ J Surg, 78, 144, 10.1111/j.1445-2197.2007.04390.x Goodman, 2007, Wear particles, periprosthetic osteolysis and the immune system, Biomaterials, 28, 5044, 10.1016/j.biomaterials.2007.06.035 Groot, 2006, Wear-induced osteolysis and synovial swelling in a patient with a metal-polyethylene wrist prosthesis, J Hand Surg Am, 31, 1615, 10.1016/j.jhsa.2006.09.009 Ingham, 2005, The role of macrophages in osteolysis of total joint replacement, Biomaterials, 26, 1271, 10.1016/j.biomaterials.2004.04.035 MacQuarrie, 2004, Wear-particle-induced osteoclast osteolysis: the role of particulates and mechanical strain, J Biomed Mater Res B Appl Biomater, 69, 104, 10.1002/jbm.b.20031 Hallab, 2003, Spinal implant debris-induced osteolysis, Spine, 28, S125, 10.1097/00007632-200310151-00006 Doorn, 1998, Metal wear particle characterization from metal on metal total hip replacements: transmission electron microscopy study of periprosthetic tissues and isolated particles, J Biomed Mater Res, 42, 103, 10.1002/(SICI)1097-4636(199810)42:1<103::AID-JBM13>3.0.CO;2-M Tipper, 1999, Quantitative analysis of the wear and wear debris from low and high carbon content cobalt chrome alloys used in metal on metal total hip replacements, J Mater Sci Mater Med, 10, 353, 10.1023/A:1026473723777 Firkins, 2001, Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested in a physiological hip joint simulator, Biomed Mater Eng, 11, 143 Williams, 2004, The role of wear debris and biological response in the assessment of total joint performance, J Bone Joint Surg Br, 86-B, 437 Lewis, 2007, The role of the surface chemistry of CoCr alloy particles in the phagocytosis and DNA damage of fibroblast cells, J Biomed Mater Res A, 82, 363, 10.1002/jbm.a.31064 Cobb, 2006, The clinical significance of metal ion release from cobalt-chromium metal-on-metal hip joint arthroplasty, Proc Inst Mech Eng [H], 220, 385, 10.1243/09544119JEIM78 Brown, 2006, Biological effects of clinically relevant wear particles from metal-on-metal hip prostheses, Proc Inst Mech Eng [H], 220, 355, 10.1243/095441105X63291 Rakshit, 2006, Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma, J Bone Joint Surg Am, 88, 788, 10.2106/JBJS.E.00711 Willert, 2005, Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints, J Bone Joint Surg Am, 87, 28, 10.2106/JBJS.A.02039pp Ren, 2003, Distinct gene expression of receptor activator of nuclear factor-[kappa]B and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles, Biomaterials, 24, 4819, 10.1016/S0142-9612(03)00384-3 Ingham, 2005, The role of macrophages in osteolysis of total joint replacement, Biomaterials, 26, 1271, 10.1016/j.biomaterials.2004.04.035 Shanbhag, 1994, Macrophage/particle interactions: effect of size, composition and surface area, J Biomed Mater Res, 28, 81, 10.1002/jbm.820280111 Campbell P, McKellop H, Alim R, et al. Metal-on-metal hip replacements: Wear performance and cellular response to wear particles. In: JA D, RL K, RM P (eds). Cobalt base alloys for biomedical applications. ASTM: 1999. Volume STP 1365, p. 193–209. Chang, 2004, Evaluation of the biological response of wear debris, Spine J, 4, 239S, 10.1016/j.spinee.2004.07.014 Endo, 2002, Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses, Proc Inst Mech Eng [H], 216, 111, 10.1243/0954411021536333 Ingham, 2000, Biological reactions to wear debris in total joint replacement, Proc Inst Mech Eng [H], 214, 21, 10.1243/0954411001535219 Sommer, 2005, Wear particles and surface topographies are modulators of osteoclastogenesis in vitro, J Biomed Mater Res A, 72, 67, 10.1002/jbm.a.30202 Buscher, 2005, Subsurface microstructure of metal-on-metal hip joints and its relationship to wear particle generation, J Biomed Mater Res B Appl Biomater, 72, 206, 10.1002/jbm.b.30132 2008, Guidance for industry and FDA staff: Preparation and review of investigational device exemption applications (IDEs) for total artificial discs ISO_17853-2003. Wear of implant materials - Polymer and metal wear particles - Isolation, characterization and quantification. ASTM_F1877-98. Standard practice for characterization of particles. Schmalzried, 1994, Polyethylene wear debris and tissue reactions in knee as compared to hip replacement prostheses, J Appl Biomater, 5, 185, 10.1002/jab.770050302 Campbell, 1995, Isolation of predominantly submicron-sized UHMWPE wear particles from periprosthetic tissues, J Biomed Mater Res, 29, 127, 10.1002/jbm.820290118 Maloney, 1995, Isolation and characterization of wear particles generated in patients who have had failure of a hip arthroplasty without cement, J Bone Joint Surg Am, 77, 1301, 10.2106/00004623-199509000-00002 McKellop, 1995, The origin of submicron polyethylene wear debris in total hip arthroplasty, Clin Orthop Relat Res, 311, 3 Doorn, 1996, Metal versus polyethylene wear particles in total hip replacements, Clin Orthop Relat Res, 329, S206, 10.1097/00003086-199608001-00018 Hirakawa, 1996, Characterization and comparison of wear debris from failed total hip implants of different types, J Bone Joint Surg Am, 78, 1235, 10.2106/00004623-199608000-00014 Schmalzried, 1997, Shapes and dimensional characteristics of polyethylene wear particles generated in vivo by total knee replacements compared to total hip replacements, J Biomed Mater Res, 38, 203, 10.1002/(SICI)1097-4636(199723)38:3<203::AID-JBM4>3.0.CO;2-T Wirth, 1999, Isolation and characterization of polyethylene wear debris associated with osteolysis following total shoulder arthroplasty, J Bone Joint Surg Am, 81, 29, 10.2106/00004623-199901000-00005 Catelas, 2001, Effects of digestion protocols on the isolation and characterization of metal-metal wear particles. I. Analysis of particle size and shape, J Biomed Mater Res, 55, 320, 10.1002/1097-4636(20010605)55:3<320::AID-JBM1020>3.0.CO;2-3 Visentin, 2005, Isolation and characterization of wear debris generated in patients wearing polyethylene Hylamer inserts, gamma irradiated in air, J Biomater Appl, 20, 103, 10.1177/0885328205049407 Tipper, 2006, Isolation and characterization of UHMWPE wear particles down to ten nanometers in size from in vitro hip and knee joint simulators, J Biomed Mater Res A, 78, 473, 10.1002/jbm.a.30824 Wagner, 1976, Preparation and characterization of wear debris of orthopedic materials for biocompatibility studies, J Biomed Mater Res, 10, 653, 10.1002/jbm.820100503 Blumenthal, 1994, A new technique for quantitation of metal particulates and metal reaction products in tissues near implants, J Appl Biomater, 5, 191, 10.1002/jab.770050303 Jacobs, 1994, Wear debris in total joint replacements, J Am Acad Orthop Surg, 2, 212, 10.5435/00124635-199407000-00004 Margevicius, 1994, Isolation and characterization of debris in membranes around total joint prostheses, J Bone Joint Surg Am, 76, 1664, 10.2106/00004623-199411000-00010 Salvati, 1994, Particulate debris in cemented total hip replacement, Instr Course Lect, 43, 277 Savio, 1994, Size and shape of biomaterial wear debris, Clin Mater, 15, 101, 10.1016/0267-6605(94)90076-0 Schmiedberg, 1994, Isolation and characterization of metallic wear debris from a dynamic intervertebral disc prosthesis, J Biomed Mater Res, 28, 1277, 10.1002/jbm.820281105 Brown, 2007, Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation, J Mater Sci Mater Med, 18, 819, 10.1007/s10856-006-0015-z Catelas, 2001, Effects of digestion protocols on the isolation and characterization of metal-metal wear particles, J Biomed Mater Res, 55, 330, 10.1002/1097-4636(20010605)55:3<330::AID-JBM1021>3.0.CO;2-Y Catelas, 2003, Size, shape, and composition of wear particles from metal-metal hip simulator testing: effects of alloy and number of loading cycles, J Biomed Mater Res A, 67, 312, 10.1002/jbm.a.10088