Metacognitive training for psychosis (MCT): past, present, and future

Springer Science and Business Media LLC - Tập 273 Số 4 - Trang 811-817 - 2023
Steffen Moritz1, Mahesh Menon2, Ryan Balzan3, Todd S. Woodward4
1Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
3College of Education, Psychology and Social Work, Flinders University, Bedford Park, SA, Australia
4Mental Health and Addictions Research Institute, Vancouver, BC, Canada

Tóm tắt

Abstract

This article provides an overview and retrospective on metacognitive training for psychosis (MCT), which first appeared approximately 2 decades ago. We recount how our empirical understanding of psychosis at that time led to the first preliminary version of the program. We describe setbacks and challenges that led to major changes, including revisions to existing modules (e.g., more focus on metacognitive variables, particularly on decision confidence as one of the primary targets of treatment) and the creation of new modules addressing mood, as well as attempts to improve sustainability of effects via homework exercises and a smartphone app (www.uke.de/mct_app). We have also enhanced dissemination efforts by creating new culturally sensitive language versions and facilitating low-threshold training through e-learning courses (www.uke.de/e-mct). Finally, we discuss several meta-analyses on the efficacy of MCT that have been published over the last decade. While reviews were initially inconsistent, possibly reflecting the insufficient statistical power and lower design quality of the first MCT studies, more recent meta-analyses have confirmed the efficacy of MCT on positive symptoms, insight, and cognitive biases, which has led to the inclusion of MCT in some national treatment guidelines for schizophrenia.

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Tài liệu tham khảo

Liddle PF (1987) Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med 17:49–57. https://doi.org/10.1017/S0033291700012976

Abramovitch A, Short T, Schweiger A (2021) The C factor: cognitive dysfunction as a transdiagnostic dimension in psychopathology. Clin Psychol Rev 86:102007. https://doi.org/10.1016/j.cpr.2021.102007

Garety PA, Freeman D (1999) Cognitive approaches to delusions: a critical review of theories and evidence. Br J Clin Psychol 38:113–154. https://doi.org/10.1348/014466599162700

Pohl RF (2004) Cognitive illusions. A handbook on fallacies and biases in thinking, judgement and memory. Psychology Press, Hove

Sharot T (2011) The optimism bias. Curr Biol 21:941–945

Kahneman D, Tversky A (1996) On the reality of cognitive illusions. Psychol Rev 103:582–591. https://doi.org/10.1037/0033-295X.103.3.582

Huq SF, Garety PA, Hemsley DR (1988) Probabilistic judgements in deluded and non-deluded subjects. Q J Exp Psychol A 40:801–812. https://doi.org/10.1080/14640748808402300

Woodward TS, Moritz S, Cuttler CC, Whitman JC (2004) A generalized cognitive deficit in integrating disconfirmatory evidence underlies delusion maintenance in schizophrenia. Schizophr Res 67:79

Moritz S, Woodward TS (2004) Plausibility judgement in schizophrenic patients: evidence for a liberal acceptance bias. Ger J Psychiatry 7:66–74

Moritz S, Woodward TS (2002) Memory confidence and false memories in schizophrenia. J Nerv Ment Dis 190:641–643. https://doi.org/10.1097/00005053-200209000-00012

Kinderman P, Bentall RP (1996) A new measure of causal locus: the internal, personal and situational attributions questionnaire. Personal Individ Differ 20:261–264. https://doi.org/10.1016/0191-8869(95)00186-7

Moritz S, Woodward TS (2006) A generalized bias against disconfirmatory evidence in schizophrenia. Psychiatry Res 142:157–165. https://doi.org/10.1016/j.psychres.2005.08.016

Woodward TS, Moritz S, Cuttler C, Whitman JC (2006) The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions in schizophrenia. J Clin Exp Neuropsychol 28:605–617. https://doi.org/10.1080/13803390590949511

Garety PA, Freeman D (2013) The past and future of delusions research: from the inexplicable to the treatable. Br J Psychiatry 203:327–333. https://doi.org/10.1192/bjp.bp.113.126953

Freeman D, Garety P, Kuipers E et al (2006) Delusions and decision-making style: use of the need for closure scale. Behav Res Ther 44:1147–1158. https://doi.org/10.1016/j.brat.2005.09.002

Moritz S, Balzan RP, Bohn F et al (2016) Subjective versus objective cognition: evidence for poor metacognitive monitoring in schizophrenia. Schizophr Res 178:74–79. https://doi.org/10.1016/j.schres.2016.08.021

Balzan RP, Neaves A, Denson LA et al (2014) Cognitive deficit awareness in schizophrenia: absent, intact, or somewhere in-between? Cogn Neuropsychiatry 19:471–484. https://doi.org/10.1080/13546805.2014.909311

Koriat A (2002) Metacognition research: an interim report. In: Perfect TJ, Schwartz BL (eds) Applied metacognition. Cambridge University Press, Cambridge, pp 261–286

Capobianco L, Wells A (2018) Letter to the editor: Metacognitive therapy or metacognitive training: What’s in a name? J Behav Ther Exp Psychiatry 59:161. https://doi.org/10.1016/j.jbtep.2017.12.003

Moritz S, Lysaker PH (2018) Metacognition: what did James H. Flavell really say and the implications for the conceptualization and design of metacognitive interventions. Schizophr Res 201:20–26. https://doi.org/10.1016/j.schres.2018.06.001

Moritz S, Klein JP, Lysaker PH, Mehl S (2019) Metacognitive and cognitive-behavioral interventions for psychosis: new developments. Dialogues Clin Neurosci 21:309–317. https://doi.org/10.31887/DCNS.2019.21.3/smoritz

Mendelson D, Thibaudeau É, Sauvé G et al (2021) Remote group therapies for cognitive health in schizophrenia-spectrum disorders: feasible, acceptable, engaging. Schizophr Res Cognit. https://doi.org/10.1016/J.SCOG.2021.100230

Lüdtke T, Pult LK, Schröder J et al (2018) A randomized controlled trial on a smartphone self-help application (Be Good to Yourself) to reduce depressive symptoms. Psychiatry Res 269:753–762. https://doi.org/10.1016/j.psychres.2018.08.113

Bruhns A, Lüdtke T, Moritz S, Bücker L (2021) The self-esteem booster: a randomized controlled trial investigating a mobile-based intervention in students with depressive symptoms. JMIR mHealth uHealth (in press)

Taleb NN (2010) The black swan: the impact of the highly improbable, 2nd edn. Penguin, London

Kahneman D (2011) Thinking, fast and slow. Farrar, Straus and Giroux, New York

Balzan RP, Delfabbro PH, Galletly CA, Woodward TS (2014) Metacognitive training for patients with schizophrenia: preliminary evidence for a targeted, single-module programme. Aust N Z J Psychiatry 48:1126–1136. https://doi.org/10.1177/0004867413508451

Jiang J, Zhang L, Zhu Z et al (2015) Metacognitive training for schizophrenia: a systematic review. Shanghai Arch Psychiatry 27:149–157

Oosterhout B, Smit F, Krabbendam L et al (2016) Letter to the editor: should we focus on quality or quantity in meta-analyses? Psychol Med 46:2003–2005. https://doi.org/10.1017/S003329171600009X

van Oosterhout B, Krabbendam L, de Boer K et al (2014) Metacognitive group training for schizophrenia spectrum patients with delusions: a randomized controlled trial. Psychol Med 44:3025–3035. https://doi.org/10.1017/S0033291714000555

Moritz S, Veckenstedt R, Randjbar S et al (2011) Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms. Psychol Med 41:1823–1832. https://doi.org/10.1017/S0033291710002618

Balzan R, Mattiske J, Delfabbro P et al (2019) Individualised metacognitive training (MCT+) reduces delusional symptoms in psychosis: a randomized clinical trial. Schizophr Bull. https://doi.org/10.1093/schbul/sby152

Köther U, Vettorazzi E, Veckenstedt R et al (2017) Bayesian analyses of the effect of Metacognitive Training on social cognition deficits and overconfidence in errors. J Exp Psychopathol 8:158–174. https://doi.org/10.5127/jep.054516

Andreou C, Moritz S, Veith K et al (2013) Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study. Schizophr Bull 40:558–565. https://doi.org/10.1093/schbul/sbt064

Philipp R, Kriston L, Lanio J et al (2019) Effectiveness of metacognitive interventions for mental disorders in adults: a systematic review and meta-analysis (METACOG). Clin Psychol Psychother 26:227–240. https://doi.org/10.1002/cpp.2345

Eichner C, Berna F (2016) Acceptance and efficacy of metacognitive training (MCT) on positive symptoms and delusions in patients with schizophrenia: a meta-analysis taking into account important moderators. Schizophr Bull 42:952–962. https://doi.org/10.1093/schbul/sbv225

Liu Y-C, Tang C-C, Hung T-T et al (2018) The efficacy of metacognitive training for delusions in patients with schizophrenia: a meta-analysis of randomized controlled trials informs evidence-based practice. Worldviews Evidence-Based Nurs 15:130–139. https://doi.org/10.1111/wvn.12282

Sauvé G, Lavigne KM, Pochiet G et al (2020) Efficacy of psychological interventions targeting cognitive biases in schizophrenia: a systematic review and meta-analysis. Clin Psychol Rev 78:101854. https://doi.org/10.1016/j.cpr.2020.101854

Lopez-Morinigo J-D, Ajnakina O, Martínez AS-E et al (2020) Can metacognitive interventions improve insight in schizophrenia spectrum disorders? A systematic review and meta-analysis. Psychol Med 50:2289–2301. https://doi.org/10.1017/S0033291720003384

Penney D, Sauvé G, Mendelson D et al (2022) Effectiveness, durability, and moderators of metacognitive training for psychosis (MCT): a systematic review and meta-analysis. JAMA Psychiatry (in press)

Byrne R, Davies L, Morrison AP (2010) Priorities and preferences for the outcomes of treatment of psychosis: a service user perspective. Psychosis 2:210–217. https://doi.org/10.1080/17522430903456913

Moritz S, Berna F, Jaeger S et al (2017) The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis. Eur Arch Psychiatry Clin Neurosci 267:335–339. https://doi.org/10.1007/s00406-016-0694-5

Kuhnigk O, Slawik L, Meyer J et al (2012) Valuation and attainment of treatment goals in schizophrenia: perspectives of patients, relatives, physicians, and payers. J Psychiatric Pract 18:321–328. https://doi.org/10.1097/01.pra.0000419816.75752.65

Moritz S, Göritz AS, McLean B et al (2017) Do depressive symptoms predict paranoia or vice versa? J Behav Ther Exp Psychiatry 56:113–121. https://doi.org/10.1016/j.jbtep.2016.10.002

Moritz S, Rietschel L, Veckenstedt R et al (2015) The other side of “madness”: frequencies of positive and ambivalent attitudes towards prominent positive symptoms in psychosis. Psychosis 7:14–24. https://doi.org/10.1080/17522439.2013.865137

Ishikawa R, Ishigaki T, Shimada T et al (2019) The efficacy of extended metacognitive training for psychosis: a randomized controlled trial. Schizophr Res. https://doi.org/10.1016/j.schres.2019.08.006

Chen Q, Sang Y, Ren L et al (2021) Metacognitive training: a useful complement to community-based rehabilitation for schizophrenia patients in China. BMC Psychiatry 21:38. https://doi.org/10.1186/s12888-021-03039-y

Acuña V, Otto A, Cavieres A, Villalobos H (2021) Eficacia del entrenamiento metacognitivo en una muestra chilena de personas con esquizofrenia (efficacy of Metacognitive Training in a Chilean sample of people with schizophrenia). Rev Colomb Psiquiatr. https://doi.org/10.1016/j.rcp.2020.12.006

Mehl S, Werner D, Lincoln TM (2015) Does cognitive behavior therapy for psychosis (CBTp) show a sustainable effect on delusions? A meta-analysis. Front Psychol 6:1450. https://doi.org/10.3389/fpsyg.2015.01450