Metabolomic analysis of animal models of depression

Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G (2010) Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry 15(5):501–511 Berman R, Narasimhan M, Miller H, Anand A, Cappiello A, Oren D (1999) Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker? Arch Gen Psychiatry 56(5):395–403 Bhagya V, Srikumar BN, Raju TR et al (2011) Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression. Psychopharmacology 214(2):477–494 Bielski RJ, Ventura D, Chang CC (2004) A double-blind comparison of escitalopram with venlafaxine XR in the treatment of major depressive disorder. J Clin Psychiatry 65:1190–1196 Blardi P, De Lalla A, Urso R et al (2005) Activity of Citalopram on Adenosine and Serotonin Circulating Levels in Depressed Patients. J Clin Psychopharmacol 25(3):262–266 Boorman E, Zajkowska Z, Ahmed R, Pariante CM, Zunszain PA (2015) Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression? Psychopharmacology 233:1591–1604 Chandrasekhar BVS, Elango P, Maheswari SU, Rajukumar D (2017) A focus on the effect of L-theanine on improving depression and cognition in C57BL/J male mice subjected for chronic stress induced neuroinflammation. Biomed Pharma J 10(2):1015–1027 Chen G, Yang D, Yang Y et al (2015) Amino acid Metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression. Behav Brain Res 278:286–292 Chong J, Jasmine C, Othman S, Carin L, Iurie C, Shuzhao L, Guillaume B (2018) MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. Nucleic Acids Res 46(W1):W486–W494 Chong J, Wishart DS, Xia J (2019) Using metaboanalyst 4.0 for comprehensive and integrative metabolomics data analysis. Curr Protoc Bioinforma 68:e86 Clark SM, Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, Mcmahon RP (2016) Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals. J Psychiatry Neurosci 41:150226 Cui W, Ning Y, Hong W, Wang J, Liu Z, Li M (2018) Crosstalk between inflammation and glutamate system in depression: signaling pathway and molecular biomarkers for ketamine’s antidepressant effect. Mol Neurobiol 56(5):3484–3500 Dailly E, Chenu F, Renard CE, Bourin M (2004) Dopamine, depression and antidepressants. Fundam Clin Pharmacol 18(6):601–607 Dale E, Andersen BB, Connie S (2015) Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs. Biochem Pharmacol 95(2):81–97 Deutsch S, Long K, Rosse R, Mastropaolo J, Eller J (2005) Hypothesized deficiency of guanine-based purines may contribute to abnormalities of neurodevelopment, neuromodulation, and neurotransmission in Lesch-Nyhan syndrome. Clin Neuropharmacol 28:28–37 Elabd S (2014) Use of prescription opioids may contribute to increased risk of depression. Top Pain Manag 29:9–10 González-Sepúlveda M, Pozo OJ, Marcos J, Valverde O (2016) Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice. J Psychopharmacol 30(2):188–203 Green P, Anyakoha N, Yadid G, Gispan-Herman I, Nicolaou A (2009) Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology. Prostaglandins Leukot Essent Fat Acids 80(4):213–220 Hayes A, Beevers C, Feldman G, Laurenceau J, Perlman C (2005) Avoidance and processing as predictors of symptom change and positive growth in an integrative therapy for depression International. Int J Behav Med 12(2):111–122 Hill M, Carrier E, Mclaughlin R, Morrish A, Meier S, Hillard C, Gorzalka B (2008) Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. J Neurochem 106:2322–2336 Homan P, Neumeister A, Nugent AC, Charney DS, Drevets WC, Hasler G (2015) Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression. Transl Psychiatry 5:e532 Hu Y, Xin J, Hu Y, Zhang L, Wang J (2017) Analyzing the genes related to Alzheimer’s disease via a network and pathway-based approach. Alzheimers Res Ther 9:29 Hu Y, Fang Z, Yang Y, Fan T, Wang J (2018) Analyzing the pathways enriched in genes associated with nicotine dependence in the context of human protein-protein interaction network. J Biomol Struct Dyn 1–26 Jakubovski E, Varigonda AL, Freemantle N, Taylor MJ, Bloch MH (2016) Systematic review and meta-analysis: dose-response relationship of selective serotonin reuptake inhibitors in major depressive disorder. Am J Psychiatry 173(2) Jakubowski (2011) Quality control in tRNA charging-editing of homocysteine. Acta Biochim Pol 58(2):149–163 Jia P, Kao CF, Kuo PH, Zhao Z (2011) A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol 5:1–13 Jin M, Lu J, Chen Z, Nguyen S, Mao L, Li J, Yuan Z, Guo J (2018) Antidepressant fluoxetine induces multiple antibiotics resistance in Escherichia coli via ROS-mediated mutagenesis. Environ Int 120:421–430 Karolewicz B, Maciag DDG, Stockmeier CA, Feyissa AM, Rajkowska G (2010) Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacol 13:411–420 Khairova R, Machado-Vieira R, Du J, Manji HK (2009) A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 12:561 Kim S, Lee D, Kim H, Bang E, Chae J, Choe B (2014) Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T. Neurosci Lett 572:32–37 Krämer A, Green J, Pollard J Jr, Tugendreich S (2013) Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30:523–530 Kupfer DJ, Ellen F, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045–1055 Kvetnansky R, Sabban EL, Palkovits M (2009) Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev 89:535–606 Li C, Wang Y, Gao H, Pan W, Xiang Y, Huang M, Lei H (2008a) Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. Neurochem Res 33(11):2342–2349 Li C, Wang Y, Pan W, Xiang Y, Lei H (2008) Cerebral metabolic changes in prefrontal cortex of depression-like rat model with long-term chronic forced swimming studied by ex vivo high resolution 1H NMR. J Wuhan Univ 54(4):451–456 (Article in Chinese) Li B, Guo K, Zeng L et al (2018) Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers. Transl Psychiatry 8(1):34 Liu Z, Wang Y, Zhang X, Chen L (2010) Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer’s disease brains. BMC Syst Biol 4(Suppl 2):S11 Liu L, Zhou X, Zhang Y et al (2016) The identification of Metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression. Behav Brain Res 305:148–156 Liu YY, Zhou X, Yang L et al (2017) Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats. PLoS One 12(4):e0176725 Liu Y, Fan P, Zhang S, Wang Y, Liu D (2019) Prioritization and comprehensive analysis of genes related to major depressive disorder. Mol Genet Genomic Med 7(6):e659 Luo X, Yuan S, Wang F, Yamamoto R, Kato N (2017) Impaired retention of depression-like behavior in a mouse model of Alzheimer’s disease. IBRO Rep 2:81–86 Maes M (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog Neuro-Psychopharmacol Biol Psychiatry 19(1):11–38 Mineur YS, Picciotto MR, Sanacora G (2007) Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice. Biol Psychiatry 61:250–252 Nurnberger JI Jr, Koller DL, Jung J et al (2014) Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry 71:657–664 Ossowska G, Nowak G, Kata R, Majewska BK, Danilczuk Z, Łupina IZ (2001) Brain monoamine receptors in a chronic unpredictable stress model in rats. J Neural Transm (Vienna) 108(3):311–319 Park DI, Dournes C, Sillaber I et al (2016) Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans. Sci Rep 6:35317 Pu J, Yu Y, Liu Y et al (2019) MENDA: a comprehensive curated resource of metabolic characterization in depression. Brief Bioinform. https://doi.org/10.1093/bib/bbz055 Pu J, Liu Y, Zhang H et al (2020) An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Mol Psychiatry. https://doi.org/10.1038/s41380-020-0645-4 Qian Z, Wang S, Tao W, Long H, Wang J (2016) Effects of Jiaotaiwan on depressive-like behavior in mice after lipopolysaccharide administration. Metab Brain Dis 32(2):415–426 Reiter RJ, Tan DX (2011) Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response. Neuropharmacology 60:1243–1253 Sartorius A, Mahlstedt MM, Vollmayr B, Henn FA, Ende G (2007) Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. Neuroreport 18(14):1469–1473 Scherrer JF, Svrakic DM, Freedland KE et al (2014) Prescription opioid analgesics increase the risk of depression. J Gen Intern Med 29(3):491–499 Schmidt K, Nolte-Zenker B, Patzer J, Bauer M, Schmidt LG, Heinz A (2001) Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence. Pharmacopsychiatry 34:66–72 Smaga I, Jastrzębska J, Zaniewska M et al (2017) Changes in the brain endocannabinoid system in rat models of depression. Neurotox Res 31(3):421–435 Spasojevic N, Gavrilovic L, Dronjak S (2010) Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats. Auton Autacoid Pharmacol 30(4):213–217 Sun S, Yang S, Mao Y, Jia X, Zhang Z (2015) Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-ht1a receptor. Lipids Health Dis 14:22 Szewczyk B, Albert PR, Rogaeva A (2010) Decreased expression of Freud – 1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression [J]. Int J Neuropsy Chopharmacol 13(8):1089–1101 Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A, Patel AB (2014) Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. Biol Psychiatry 76(3):231–238 Vinod KY, Hungund BL (2006) Role of the endocannabinoid system in depression and suicide. Trends Pharmacol Sci 27(10):539–545 Wang W, Guo H, Zhang S et al (2016) Targeted Metabolomic Pathway Analysis and Validation Revealed Glutamatergic Disorder in the Prefrontal cortex among the Chronic Social Defeat Stress Mice Model of Depression. J Proteome Res 15(10):3784–3792 Wang Q, Shao F, Wang W (2018) Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plast 2018:9870985 Wang HK, Huang B, Wang W et al (2019) High urea induces depression and ltp impairment through mtor signalling suppression caused by carbamylation. EBioMedicine 48:478–490 Webhofer C, Gormanns P, Tolstikov V, Zieglgã NW, Sillaber I, Holsboer F, Turck CW (2011) Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Transl Psychiatry 1:e58 Wu Y, Fu Y, Rao C et al (2016) Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression. Behav Brain Res 308:115–127 Xia J, Wishart DS (2011) Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nat Protoc 6:743–760 Xu H, Zhang H, Zhang J, Huang Q, Shen Z, Wu R (2016) Evaluation of Neuron-glia Integrity by in vivo Proton Magnetic Resonance Spectroscopy: Implications for Psychiatric Disorders. Neurosci Biobehav Rev 71:563–577 Yong L, Agarwal P, Rajagopalan D (2008) A global pathway crosstalk network. Bioinformatics 24(12):1442–1447 Yoshimi N, Futamura T, Kakumoto K et al (2016) Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder. BBA Clin 5:151–158 Yu X, Qiao S, Wang D et al (2016) A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model. RSC Adv 6:25751–25765 Yuan CW, Kriz J (2007) Differential neuroprotective effects of a minocycline-based drug cocktail in transient and permanent focal cerebral ischemia. Exp Neurol 204(1):433–442 Zhang J, Abdallah C, Chen Y et al (2013) Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress. Neurosci Lett 545:132–137 Zhao N, Li J, Li L et al (2015) Molecular network-based analysis of Guizhi- Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy. Acta Pharmacol Sin 36(6):716–723 Zhong H, Haddjeri N, Sánchez C (2012) Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action. Psychopharmacology 219(1):1–13 Zhou X, Liu L, Zhang Y et al (2017) Metabolomics identifies perturbations in amino acid metabolism in the prefrontal cortex of the learned helplessness rat model of depression. Neuroscience 343:1