Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols

British Journal of Nutrition - Tập 101 Số 8 - Trang 1178-1184
Rodrigo Ferreira de Moura1, Carla Ribeiro1, Juliana Aparecida de Oliveira2, Eliane Stevanato2, María Alice Rostom de Mello1
1Physical Education Department, São Paulo State University (UNESP), Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil
2Physical Education Department, University of Taubaté (UNITAU), Rua Terras de Cambra 27, 04383-145 São Paulo, SP, Brazil

Tóm tắt

In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1;n6) received regular rodent chow (Labina, Purina) and a fructose group (F1;n6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2;n6) was fed on a balanced diet (AIN-93G) and a fructose group (F2;n6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3;n6) was fed on the AIN-93G diet and a fructose group (F3;n6) was fed on a 60 % fructose diet. After 4–8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0·05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water.

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British Journal of Nutrition

Tập 101 Số 8

1178-1184

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