Metabolic flux analysis in eukaryotes
Tài liệu tham khảo
Niittylae, 2009, Comparison of quantitative metabolite imaging tools and carbon-13 techniques for fluxomics, Methods Mol Biol, 553, 355, 10.1007/978-1-60327-563-7_19
Varma, 1994, Metabolic flux balancing: basic concepts, scientific and practical use, Biotechnol, 12, 994, 10.1038/nbt1094-994
Wiechert, 2001, 13C metabolic flux analysis, Metab Eng, 3, 195, 10.1006/mben.2001.0187
Wiechert, 1999, Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems, Biotechnol Bioeng, 66, 69, 10.1002/(SICI)1097-0290(1999)66:2<69::AID-BIT1>3.0.CO;2-6
Antoniewicz, 2007, Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions, Metab Eng, 9, 68, 10.1016/j.ymben.2006.09.001
Dunn, 2000
Stephanopoulos, 1998
Deshpande, 2009, Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling, Biotechnol J, 4, 247, 10.1002/biot.200800143
Noh, 2006, Computational tools for isotopically instationary (13)C labeling experiments under metabolic steady state conditions, Metab Eng, 8, 554, 10.1016/j.ymben.2006.05.006
Noh, 2006, Experimental design principles for isotopically instationary 13C labeling experiments, Biotechnol Bioeng, 94, 234, 10.1002/bit.20803
Hofmann, 2008, Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations, Biotechnol Bioeng, 100, 344, 10.1002/bit.21747
Maier, 2008, Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation, Biotechnol Bioeng, 100, 355, 10.1002/bit.21746
Bolten, 2007, Sampling for metabolome analysis of microorganisms, Anal Chem, 79, 3843, 10.1021/ac0623888
Zelle, 2008, Malic acid production by Saccharomyces cerevisiae: engineering of pyruvate carboxylation, oxaloacetate reduction, and malate export, Appl Environ Microbiol, 74, 2766, 10.1128/AEM.02591-07
Kleijn, 2007, Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC–MS, LC–MS and NMR-derived C-labelling data, FEMS Yeast Res, 7, 216, 10.1111/j.1567-1364.2006.00180.x
Frick, 2005, Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis, Microb Cell Fact, 4, 30, 10.1186/1475-2859-4-30
Velagapudi, 2007, Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function, J Biotechnol, 132, 395, 10.1016/j.jbiotec.2007.08.043
Costenoble, 2007, 13C-Labeled metabolic flux analysis of a fed-batch culture of elutriated Saccharomyces cerevisiae, FEMS Yeast Res, 7, 511, 10.1111/j.1567-1364.2006.00199.x
Sola, 2007, Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates, Microbiology, 153, 281, 10.1099/mic.0.29263-0
Celik, 2010, Metabolic flux analysis for recombinant protein production by Pichia pastoris using dual carbon sources: effects of methanol feeding rate, Biotechnol Bioeng, 105, 317, 10.1002/bit.22543
Gheshlaghi, 2007, Metabolic flux analysis for optimizing the specific growth rate of recombinant Aspergillus niger, Bioproc Biosyst Eng, 30, 397, 10.1007/s00449-007-0136-x
Meijer, 2009, Overexpression of isocitrate lyase-glyoxylate bypass influence on metabolism in Aspergillus niger, Metab Eng, 11, 107, 10.1016/j.ymben.2008.12.002
Melzer, 2007, Metabolic flux analysis using stoichiometric models for Aspergillus niger: comparison under glucoamylase-producing and non-producing conditions, J Biotechnol, 132, 405, 10.1016/j.jbiotec.2007.08.034
Kleijn, 2007, Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum, Metab Eng, 9, 112, 10.1016/j.ymben.2006.08.004
Zhao, 2008, Isotopic non-stationary 13C gluconate tracer method for accurate determination of the pentose phosphate pathway split-ratio in Penicillium chrysogenum, Metab Eng, 10, 178, 10.1016/j.ymben.2008.04.003
Niklas, 2009, Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2, Toxicol Appl Pharmacol, 240, 327, 10.1016/j.taap.2009.07.005
Sidorenko, 2008, Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media, Biotechnol Prog, 24, 311, 10.1021/bp0702673
Llaneras, 2007, A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient, BMC Bioinform, 8, 421, 10.1186/1471-2105-8-421
Niklas J, Schräder E, Noll T, Sandig V, Heinzle E: Time resolved 13C supported metabolic flux analysis characterizes growth phases of the new human cell line Age1.hn, 2009, submitted for publication.
Metallo, 2009, Evaluation of (13)C isotopic tracers for metabolic flux analysis in mammalian cells, J Biotechnol, 10.1016/j.jbiotec.2009.07.010
Bonarius, 2001, Metabolic-flux analysis of continuously cultured hybridoma cells using (13)CO(2) mass spectrometry in combination with (13)C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing, Biotechnol Bioeng, 74, 528, 10.1002/bit.1145
Quek, 2009, Metabolic flux analysis in mammalian cell culture, Metab Eng
Wahl, 2008, Metabolic flux model for an anchorage-dependent MDCK cell line: characteristic growth phases and minimum substrate consumption flux distribution, Biotechnol Bioeng, 101, 135, 10.1002/bit.21873
Santos, 2007, Stirred vessel cultures of rat brain cells aggregates: characterization of major metabolic pathways and cell population dynamics, J Neurosci Res, 85, 3386, 10.1002/jnr.21409
Maier, 2009, Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis, Metab Eng, 11, 292, 10.1016/j.ymben.2009.06.001
Balcarcel, 2003, Metabolic screening of mammalian cell cultures using well-plates, Biotechnol Prog, 19, 98, 10.1021/bp025617u
Ratcliffe, 2006, Measuring multiple fluxes through plant metabolic networks, Plant J, 45, 490, 10.1111/j.1365-313X.2005.02649.x
Allen, 2009, Metabolic flux analysis in plants: coping with complexity, Plant Cell Environ, 32, 1241, 10.1111/j.1365-3040.2009.01992.x
Kruger, 2007, Network flux analysis: Impact of C-13-substrates on metabolism in Arabidopsis thaliana cell suspension cultures, Phytochemistry, 68, 2176, 10.1016/j.phytochem.2007.03.033
Graham, 2007, Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling, Plant Cell, 19, 3723, 10.1105/tpc.107.053371
Heinzle, 2007, Estimation of metabolic fluxes, expression levels and metabolite dynamics of a secondary metabolic pathway in potato using label pulse-feeding experiments combined with kinetic network modelling and simulation, Plant J, 50, 176, 10.1111/j.1365-313X.2007.03037.x
Matsuda, 2005, Metabolic flux analysis of the phenylpropanoid pathway in elicitor-treated potato tuber tissue, Plant Cell Physiol, 46, 454, 10.1093/pcp/pci042
Baxter, 2007, Determination of metabolic fluxes in a non-steady-state system, Phytochemistry, 68, 2313, 10.1016/j.phytochem.2007.04.026
Williams, 2008, Metabolic network fluxes in heterotrophic Arabidopsis cells: stability of the flux distribution under different oxygenation conditions, Plant Physiol, 148, 704, 10.1104/pp.108.125195
Allen, 2007, Compartment-specific labeling information in 13C metabolic flux analysis of plants, Phytochemistry, 68, 2197, 10.1016/j.phytochem.2007.04.010
Lehmeier, 2008, Root and shoot respiration of perennial ryegrass are supplied by the same substrate pools: assessment by dynamic 13C labeling and compartmental analysis of tracer kinetics, Plant Physiol, 148, 1148, 10.1104/pp.108.127324
Troufflard, 2007, In vivo 13C NMR determines metabolic fluxes and steady state in linseed embryos, Phytochemistry, 68, 2341, 10.1016/j.phytochem.2007.04.018