Metabolic fates of 2′-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma

Kiichi Ishiwata1, Kiyotaka Sato2, Motonobu Kameyama2, Takashi Yoshimoto2, Tatsuo Ido1
1Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, 980, Japan
2Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Seiryo-cho 2-1, Aoba-ku, Sendai 980, Japan

Tài liệu tham khảo

Abe, 1983, Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals, Eur. J. Nucl. Med., 8, 258, 10.1007/BF00522517 Abe, 1985, Cancer detection with 18F-5-fluorodeoxyuridine—a new cancer diagnostic agent reflecting the nucleic acid metabolism, Jpn. J. Nucl. Med., 22, 583 Chadwick, 1972, The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia, Cancer Res., 32, 1045 Chaudhuri N. K., Mukherjee K. L. and Heidelberger C. Studies on fluorinated pyrimidines. VII—The degradative pathway. Biochem. Pharmacol.1, 328–341. Evelhoch, 1989, In vivo19F nuclear magnetic resonance spectroscopy: a potential monitor of 5-fluorouracil pharmacokinetics and metabolism, Invest. New Drugs, 7, 5, 10.1007/BF00178187 Griffiith, 1986, β-Amino acids: mammalian metabolism and utility as α-amino acid analogues, Ann. Rev. Biochem., 55, 855, 10.1146/annurev.bi.55.070186.004231 Heidelberger, 1983, Fluorinated pyramidines and their nucleosides, Adv. Enzymol., 54, 57 Hull, 1988, Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment, Cancer Res., 48, 1680 Ido, 1982, Biochemical applications of radioactive fluorine, 142 Ishiwata, 1988, Comparison of l-[I-11C]methionine and l-methyl-[11C]methionine for measuring in vivo protein synthesis rates with PET, J. Nucl. Med., 29, 1419 Ishiwata, 1988, Metabolic studies with l-[I-11C]tyrosine for the investigation of a kinetic model to measure protein synthesis rates with PET, J. Nucl. Med., 29, 524 Ishiwata, 1987, Automated synthesis of 5-[18F]fluoro-2′-deoxyuridine, Appl. Radiat. Isot., 38, 467, 10.1016/0883-2889(87)90101-8 Ishiwata, 1985, Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice, Eur. J. Nucl. Med., 10, 39, 10.1007/BF00261761 Ishiwata, 1984, Studies on 18F-labeled pyrimidines II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2′-deoxyuridine and 18F-5-fluorouridine in rats, Eur. J. Nucl. Med., 9, 185 Kameyama, 1991, Clinical application of 18FUdR in glioma patients—PET study of nucleic acid metabolism, J. Neurol. Neurosurg. Psychiat. Kameyama, 1989, Nucleic acid metabolism in gliomas studied with 18FdUrd and PET, J. Cereb. Bld Flow Metab., 9, S221 Keniry, 1986, Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells, Cancer Res., 46, 1754 Kiyosawa, 1986, Orbital tumor diagnosis by positron emission tomography using 18F-fluorodeoxyuridine, Ophthal. Res., 18, 292, 10.1159/000265451 Malet-Martino, 1986, Evidence for the importance of 5′-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry, Cancer Res., 46, 2105 Martino, 1985, Release of fluoride ion from 5′-deoxy-5-fluorouridine, an antineoplastic fluoropyrimidine, in humans, Drug Metab. Dispos., 13, 116 McSheehy, 1989, Prediction of 5-fluorouracil cytotoxity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo, Br. J. Cancer, 60, 303, 10.1038/bjc.1989.275 Mukherjee, 1963, Studies on fluorinated pyrimidines xvii. Tissue distribution of 5-fluorouracil-2-C14 and 5-fluoro-2′-deoxyuridine in cancer patients, Cancer Res., 23, 67 Oldendorf, 1971, Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection, Am. J. Physiol., 221, 1629, 10.1152/ajplegacy.1971.221.6.1629 Sommadossi, 1982, Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography, J. Biol. Chem., 257, 8171, 10.1016/S0021-9258(18)34313-8 Stevens, 1984, 5-Fluorouracil metabolism monitored in vivo by 19F NMR, Br. J. Cancer, 113, 10.1038/bjc.1984.146 Tsurumi, 1990, 18F-fluoro-2′-deoxyuridine as a tracer of nucleic acid metabolism in brain tumors, J. Neurosurg., 72, 110, 10.3171/jns.1990.72.1.0110 Washtien, 1979, Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil, Cancer Res., 39, 3397 Winnick, 1963, Some metabolic and enzymic experiments with α-fluoro-β-alanine, Biochim. Biophys. Acta, 69, 48, 10.1016/0006-3002(63)91224-1 Wolf, 1987, Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy, Magn. Reson. Imaging, 5, 165, 10.1016/0730-725X(87)90016-6 Young, 1982, Metabolic and distribution studies with radiolabeled 5-fluorouracil, Nucl. Med., 21, 1