Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms
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Steinbüchel, 2001, Perspectives for biotechnological production and utilization of biopolymers: metabolic engineering of polyhydroxyalkanoate biosynthesis pathways as a successful example, Macromol. Biosci., 1, 1, 10.1002/1616-5195(200101)1:1<1::AID-MABI1>3.0.CO;2-B
Anderson, 1990, Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates, Microbiol. Rev., 54, 450, 10.1128/MMBR.54.4.450-472.1990
Y. Doi, Microbial Polyesters, first ed., VCH Publishers, New York, 1990.
J. Hocking, R.H. Marchessault, Biopolyesters, in: G.F.L. Griffin (Ed.), Chemistry and Technology of Biodegradable Polymers, Chapman and Hall, London, 1994, pp. 48–96.
R.N. Reusch, Non-storage poly(R)-3-hydroxyalkanoates (complexed PHAs) in prokaryotes and eukaryotes, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 123–171.
Steinbüchel, 1995, Diversity of bacterial polyhydroxyalkanoic acids, FEMS Microbiol. Lett., 128, 219, 10.1016/0378-1097(95)00125-O
Lütke-Eversloh, 2001, Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages, Microbiol. UK, 147, 11, 10.1099/00221287-147-1-11
Lütke-Eversloh, 2001, Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB), Biomacromolecules, 2, 1061, 10.1021/bm015564p
Lütke-Eversloh, 2002, Characterization of microbial polythioesters: physical properties of novel copolymers synthesized by Ralstonia eutropha, Biomacromolecules, 3, 159, 10.1021/bm015603x
Müller, 1993, Poly(hydroxyfettsäureester), eine fünfte Klasse von physiologisch bedeutsamen organischen biopolymeren?, Angew. Chem., 105, 483, 10.1002/ange.19931050404
Jendrossek, 1996, Biodegradation of polyhydroxyalkanoic acids, Appl. Microbiol. Biotechnol., 46, 451, 10.1007/s002530050844
S.Y. Lee, S.J. Park, Fermentative production of SCL-PHAs, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 263–290.
R.A. Weusthuis, B. Kessler, M.P.M. Dielissen, B. Witholt, G. Eggink, Fermentative production of medium-chain-length poly(3-hydroxyalkanoate), in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 291–316.
J. Asrar, K.J. Gruys, Biodegradable polymer (Biopol®), in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 53–90.
Byrom, 1992, Production of poly-β-hydroxybutyrate: poly-β-hydroxyvalerate copolymers, FEMS Microbiol. Lett., 103, 247
S.F. Williams, D.P. Martin, Applications of PHAs in medicine and pharmacy, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 91–127.
A. Steinbüchel, New degradable resins, in: H.J. Rehm, G. Reed, A. Pühler, P. Stadler (Eds.), Biotechnology, second ed., Wiley/VCH, Weinheim, 2001, pp. 423–438.
Haywood, 1989, The importance of PHB-synthase substrate specificity in polyhydroxyalkanoate synthesis in Alcaligenes eutrophus, FEMS Microbiol. Lett., 57, 1, 10.1111/j.1574-6968.1989.tb03210.x
Pieper-Fürst, 1994, Purification and characterization of a 14-kilodalton protein that is bound to the surface of polyhydroxyalkanoic acid granules in Rhodococcus ruber, J. Bacteriol., 176, 4328, 10.1128/jb.176.14.4328-4337.1994
Steinbüchel, 1995, Considerations of the structure and biochemistry of bacterial polyhydroxyalkanoic acid inclusions, Can. J. Microbiol., 41, 94, 10.1139/m95-175
Maehara, 2001, PhaR: a protein of unknown function conserved among short-chain-length polyhydroxyalkanoic acids producing bacteria, is a DNA-binding protein and represses Paracoccus denitrificans phaP expression in vitro, FEMS Microbiol. Lett., 200, 9, 10.1111/j.1574-6968.2001.tb10685.x
York, 2002, The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production, J. Bacteriol., 184, 59, 10.1128/JB.184.1.59-66.2002
Pötter, 2002, Regulation of phasin expression and polyhydroxyalkanoate (PHA) granule formation in Ralstonia eutropha H16, Microbiol. UK, 148, 2405, 10.1099/00221287-148-8-2413
Rehm, 1999, Biochemical and genetic analysis of PHA synthases and other proteins required for PHA synthesis, Int. J. Biol. Macromol., 25, 3, 10.1016/S0141-8130(99)00010-0
A. Steinbüchel, S. Hein, Biochemical and molecular basis of polyhydroxyalkanoic acids in microorganisms, in: A. Steinbüchel, W. Babel (Eds.), Biopolyesters, Adv. Biochem. Eng. Biotechnol. 71 (2001) 81–123.
B.H.A. Rehm, A. Steinbüchel, PHA synthases: the key enzymes of PHA synthesis, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 173–215.
McCool, 2001, PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium, J. Bacteriol., 183, 4235, 10.1128/JB.183.14.4235-4243.2001
Kalousek, 1992, Genetic engineering of PHB synthase from Alcaligenes eutrophus H16, FEMS Microbiol. Rev., 103, 426
Gerngross, 1994, Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required post-translational modification for catalytic activity, Biochemistry, 33, 9311, 10.1021/bi00197a035
Hoppensack, 1999, Analysis of 4-phosphopantetheinylation of polyhydroxybutyrate synthase from Ralstonia eutropha: generation of β-alanine auxotrophic Tn5 mutants and cloning of the panD gene region, J. Bacteriol., 181, 1429, 10.1128/JB.181.5.1429-1435.1999
Müh, 1999, PHA synthase from Chromatium vinosum: cysteine 149 is involved in covalent catalysis, Biochemistry, 38, 826, 10.1021/bi9818319
Taguchi, 2001, Analysis of mutational effects of a polyhydroxybutyrate (PHB) polymerase on bacterial PHB accumulation using an in vivo assay system, FEMS Microbiol. Lett., 198, 65, 10.1111/j.1574-6968.2001.tb10620.x
Jia, 2001, Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: classes I and III synthases share a similar catalytic mechanism, Biochemistry, 40, 1011, 10.1021/bi002219w
Jia, 2000, Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase, Biochemistry, 39, 3927, 10.1021/bi9928086
Amara, 2002, In vivo evolution of the Aeromonas punctata polyhydroxyalkanoate (PHA) synthase: isolation and characterization of modified PHA synthase with enhanced activity, Appl. Microbiol. Biotechnol., 59, 477, 10.1007/s00253-002-1035-3
Kichise, 2002, Enhanced accumulation and changed monomer composition in polyhydroxyalkanoate (PHA) copolyester by in vitro evolution of Aeromonas caviae PHA synthase, Appl. Environ. Microbiol., 68, 2411, 10.1128/AEM.68.5.2411-2419.2002
Solaiman, 2002, Synthesis of poly(hydroxyalkanoates) by Escherichia coli expressing mutated and chimeric PHA synthase genes, Biotechnol. Lett., 24, 1011, 10.1023/A:1015685229489
K. Taguchi, S. Taguchi, K. Sudesh, A. Maehara, T. Tsuge, Y. Doi, Metabolic pathways and engineering of PHA biosynthesis, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 217–247.
Ishizaki, 1991, Microbial production of poly-d-3-hydroxybutyrate from CO2, Appl. Microbiol. Biotechnol., 57, 6
Miyake, 2000, Polyhydroxybutyrate production from carbon dioxide by cyanobacteria, Appl. Biochem. Biotechnol., 84, 991, 10.1385/ABAB:84-86:1-9:991
Poirier, 1992, Polyhydroxybutyrate: biodegradable thermoplastic, produced in transgenic plants, Science, 256, 520, 10.1126/science.256.5056.520
Poirier, Y., Gruys, K.J., Production of polyhydroxyalkanoates in transgenic plants, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 401–435.
Snell, 2002, Polyhydroxyalkanoate polymers and their production in transgenic plants, Metabol. Eng., 4, 29, 10.1006/mben.2001.0214
Rohlin, 2001, Microbial pathway engineering for industrial processes: evolution, combinatorial biosynthesis and rational design, Curr. Opin. Microbiol., 4, 330, 10.1016/S1369-5274(00)00213-7
York, 2001, Accumulation of the PhaP phasin of Ralstonia eutropha is dependent on production of polyhydroxybutyrate in cells, J. Bacteriol., 183, 4217, 10.1128/JB.183.14.4217-4226.2001
Steinbüchel, 1998, Bacterial and other biological systems for polyester production, Trends Biotechnol., 16, 419, 10.1016/S0167-7799(98)01194-9
S.Y. Lee, S.H. Hong, S.J. Park, R. van Wegen, A.P.J. Middelberg, Metabolic flux analysis of the production of poly(3-hydroxybutyrate), in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 249–261.
Carlson, 2002, Metabolic pathway analysis of a recombinant yeast for rational strain development, Biotechnol. Bioeng., 79, 121, 10.1002/bit.10305
S. Kobayashi, H. Uyama, Enzymatic polymerization to polyesters, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 373–400.
S. Zhang, R.W. Lenz, S. Goodwin, In vitro biosynthesis of polyhydroxyalkanoates, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 353–372.
Jossek, 1998, In vitro synthesis of poly(3-hydroxybutyric acid) by using an enzymatic coenzyme A recycling system, FEMS Microbiol. Lett., 168, 319, 10.1111/j.1574-6968.1998.tb13290.x
Liu, 2000, A novel genetically engineered pathway for synthesis of poly(hydroxyalkanoic acids) in Escherichia coli, Appl. Environ. Microbiol., 66, 739, 10.1128/AEM.66.2.739-743.2000
Slater, 1998, Multiple β-ketothiolaes mediate poly(β-hydroxyalkanoate) copolymer synthesis in Ralstonia eutropha, J. Bacteriol., 180, 1979, 10.1128/JB.180.8.1979-1987.1998
P.A. Holmes, L.F. Wright, S.H. Collins, Eur. Pat. Appl. EP 052.459 (1981).
Textor, 1997, Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria, Arch. Microbiol., 168, 428, 10.1007/s002030050518
Noanto, 2001, Integrated production of biodegradable plastic, sugar and ethanol, Appl. Microbiol. Biotechnol., 57, 1, 10.1007/s002530100732
Brämer, 2002, Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content, Appl. Environ. Microbiol., 68, 271, 10.1128/AEM.68.1.271-279.2002
Valentin, 2000, Application of a propionyl coenzyme A synthetase for poly(3-hydroxypropionate-co-3-hydroxybutyrate) accumulation in recombinant Escherichia coli, Appl. Environ. Microbiol., 66, 5253, 10.1128/AEM.66.12.5253-5258.2000
Priefert, 1992, Identification and molecular characterization of the acetyl-coenzyme A synthetase gene (acoE) of Alcaligenes eutrophus, J. Bacteriol., 174, 6590, 10.1128/jb.174.20.6590-6599.1992
Schweiger, 1984, On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum, FEBS Lett., 171, 79, 10.1016/0014-5793(84)80463-9
Valentin, 1994, Application of enzymatically synthesized short-chain-length hydroxy fatty acid coenzyme A thioesters for assay of polyhydroxyalkanoic acid synthases, Appl. Microbiol. Biotechnol., 40, 699, 10.1007/BF00173332
Slater, 1992, Production of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) in a recombinant Escherichia coli strain, Appl. Environ. Microbiol., 58, 1089, 10.1128/AEM.58.4.1089-1094.1992
Rhie, 1995, Role of fadR and atoC (Con) mutations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli, Appl. Environ. Microbiol., 61, 2487, 10.1128/AEM.61.7.2487-2492.1995
Valentin, 1995, Accumulation of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid-co-4-hydroxyvaleric acid) by mutants and recombinant strains of Alcaligenes eutrophus, J. Environ. Polym. Degrad., 3, 169, 10.1007/BF02068468
Bozell, 2000, Production of levulinic acid and use as a platform chemical for derived products, Res. Conserv. Recycl., 28, 227, 10.1016/S0921-3449(99)00047-6
Gorenflo, 2001, Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties, Biomacromolecules, 2, 45, 10.1021/bm0000992
Brämer, 2001, The methylcitric acid pathway in Ralstonia eutropha: new genes identified in propionate metabolism, Microbiol. UK, 147, 2203, 10.1099/00221287-147-8-2203
Yamane, 1996, Growth-associated production of poly(3-hydroxyvalerate) from n-pentanol by a methylotrophic bacterium, Paracoccus denitrificans, Appl. Environ. Microbiol., 62, 380, 10.1128/AEM.62.2.380-384.1996
Steinbüchel, 1992, Production of a copolyester of 3-hydroxybutyric acid and 3-hydroxyvaleric acid from single unrelated carbon sources by a mutant of Alcaligenes eutrophus, Appl. Microbiol. Biotechnol., 37, 1, 10.1007/BF00174193
Slater, 1999, Metabolic engineering of Arabidopsis and Brassica for poly(3-hydroxybutyrate-co-3-hydroxyvalterate) copolymer production, Nat. Biotechnol., 17, 1011, 10.1038/13711
Haywood, 1991, Accumulation of a poly(hydroxyalkanoate) copolymer containing primarily 3-hydroxyvalerate from simple carbohydrate substrates by Rhodococcus sp. NCIMB 40126, Int. J. Biol. Macromol., 13, 83, 10.1016/0141-8130(91)90053-W
Anderson, 1995, Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Rhodococcus ruber, Can. J. Microbiol., 41, 4, 10.1139/m95-162
Alvarez, 1997, Accumulation of storage lipids in species of Rhodococcus and Nocardia and effect of inhibitors and polyethylene glycol, Fett-Lipid, 99, 239, 10.1002/lipi.19970990704
Williams, 1994, Production of a co-polyester of 3-hydroxybutyric acid and 3-hydroxyvaleric acid from succinic acid by Rhodococcus rubber—biosynthetic considerations, Appl. Microbiol. Biotechnol., 40, 717, 10.1007/BF00173334
Valentin, 1996, Metabolic pathway for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) formation in Nocardia corallina: inactivation of mutB by chromosomal integration of a kanamycin resistance gene, Appl. Environ. Microbiol., 62, 372, 10.1128/AEM.62.2.372-379.1996
Aldor, 2002, Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar Typhimurium, Appl. Environ. Microbiol., 68, 3848, 10.1128/AEM.68.8.3848-3854.2002
De Smet, 1983, Characterization of intracellular inclusions formed by Pseudomonas oleovorans during growth on octane, J. Bacteriol., 154, 870, 10.1128/JB.154.2.870-878.1983
Haywood, 1990, Accumulation of a polyhydroxyalkanoate containing primarily 3-hydroxydecanoate from simple carbohydrate substrates by Pseudomonas sp. strain NCIMB 40135, Appl. Environ. Microbiol., 56, 3354, 10.1128/AEM.56.11.3354-3359.1990
Timm, 1990, Formation of polyesters consisting of medium-chain-length 3-hydroxyalkanoic acids from gluconate by Pseudomonas aeruginosa and other fluorescent pseudomonads, Appl. Environ. Microbiol., 56, 3360, 10.1128/AEM.56.11.3360-3367.1990
Eggink, 1987, Controlled and functional expression of the Pseudomonas oleovorans alkane utilizing system in Pseudomonas putida and Escherichia coli, J. Biol. Chem., 262, 17712, 10.1016/S0021-9258(18)45437-3
Favre-Bulle, 1991, Bioconversion of N-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor, BioTechnology, 9, 367, 10.1038/nbt0491-367
Huisman, 1991, Metabolism of poly(3-hydroxyalkanoates) (PHAs) by Pseudomonas oleovorans, J. Biol. Chem., 266, 2191, 10.1016/S0021-9258(18)52227-4
Gross, 1989, Biosynthesis and characterization of poly(β-hydroxyalkanoates) produced by Pseudomonas oleovorans, Macromolecules, 22, 1106, 10.1021/ma00193a018
Ashby, 1998, Poly(hydroxyalkanoate) biosynthesis from triglyceride substrates, Appl. Microbiol. Biotechnol., 49, 431, 10.1007/s002530051194
Langenbach, 1997, Functional expression of the PHA synthase gene PhaC1 from Pseudomonas aeruginosa in Escherichia coli results in poly(3-hydroxyalkanoate) synthesis, FEMS Microbiol. Lett., 150, 303, 10.1016/S0378-1097(97)00142-0
Qi, 1997, Synthesis of poly(3-hydroxyalkanoates) in Escherichia coli expressing the PHA synthase gene phaC2 from Pseudomonas aeruginosa; comparison of PhaC1 and PhaC2, FEMS Microbiol. Lett., 157, 155, 10.1111/j.1574-6968.1997.tb12767.x
Qi, 1998, Metabolic routing towards polyhydroxyalkanoic acid synthesis in recombinant Escherichia coli (fadR): inhibition of fatty acid beta-oxidation by acrylic acid, FEMS Microbiol. Lett., 167, 89
Prieto, 1999, Engineering of stable recombinant bacteria for production of chiral medium-chain-length poly-3-hydroxyalkanoates, Appl. Environ. Microbiol., 65, 3265, 10.1128/AEM.65.8.3265-3271.1999
Fukui, 1997, Cloning and analysis of the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) biosynthesis genes of Aeromonas caviae, J. Bacteriol., 179, 4821, 10.1128/jb.179.15.4821-4830.1997
Tsuge, 2000, Molecular cloning of two (R)-specific enoyl-CoA hydratase genes from Pseudomonas aeruginosa and their use for polyhydroxyalkanoate synthesis, FEMS Microbiol. Lett., 184, 193, 10.1111/j.1574-6968.2000.tb09013.x
Taguchi, 1999, Co-expression of 3-ketoacyl-ACP reductase and polyhydroxyalkanoate synthase genes induces PHA produces in Escherichia coli HB101 strain, FEMS Microbiol. Lett., 176, 183, 10.1111/j.1574-6968.1999.tb13660.x
Ren, 2000, FabG, an NADPH-dependent 3-ketoacyl reductase of Pseudomonas aeruginosa, provides precursors for medium-chain-length poly-3-hydroxyalkanoate biosynthesis in Escherichia coli, J. Bacteriol., 182, 2978, 10.1128/JB.182.10.2978-2981.2000
Ren, 2000, Properties of engineered poly-3-hydroxyalkanoates produced in recombinant Escherichia coli strains, Appl. Environ. Microbiol., 66, 1311, 10.1128/AEM.66.4.1311-1320.2000
Huijberts, 1992, Pseudomonas putida KT2442 cultivated on glucose accumulates poly(3-hydroxyalkanoates) consisting of saturated and unsaturated monomers, Appl. Environ. Microbiol., 58, 536, 10.1128/AEM.58.2.536-544.1992
Huijberts, 1994, 13C nuclear magnetic resonance studies of Pseudomonas putida fatty acid metabolic routes involved in poly(3-hydroxyalkanoate) synthesis, J. Bacteriol., 176, 1661, 10.1128/jb.176.6.1661-1666.1994
Rehm, 1998, A new metabolic link between fatty acid de novo synthesis and polyhydroxyalkanoic acid synthesis—the phaG gene from Pseudomonas putida KT2440 encodes a 3-hydroxyacyl-acyl carrier protein coenzyme A transferase, J. Biol. Chem., 273, 24044, 10.1074/jbc.273.37.24044
Hoffmann, 2000, The Pseudomonas aeruginosa phaG gene product is involved in the synthesis of polyhydroxyalkanoic acids consisting of medium-chain-length constituents from non-related carbon sources, FEMS Microbiol. Lett., 184, 253, 10.1111/j.1574-6968.2000.tb09023.x
Matsumoto, 2001, Cloning and characterization of the Pseudomonas sp. 61-3 phaG gene involved in polyhydroxyalkanoate biosynthesis, Biomacromolecules, 2, 142, 10.1021/bm005604+
Hoffmann, 2000, Homologous functional expression of cryptic phaG from Pseudomonas oleovorans establishes the transacylase-mediated polyhydroxyalkanoate biosynthetic pathway, Appl. Microbiol. Biotechnol., 54, 665, 10.1007/s002530000441
Klinke, 2000, Inactivation of isocitrate lyase leads to increased production of medium-chain-length poly(3-hydroxyalkanoates) in Pseudomonas putida, Appl. Environ. Microbiol., 66, 909, 10.1128/AEM.66.3.909-913.2000
Fiedler, 2000, PhaG-mediated synthesis of poly(3-hydroxyalkanoates) consisting of medium-chain-length constituents form non-related carbon sources in recombinant Pseudomonas fragi, Appl. Environ. Microbiol., 66, 2117, 10.1128/AEM.66.5.2117-2124.2000
Rehm, 2001, Heterologous expression of the acyl–acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli, Appl. Microbiol. Biotechnol., 55, 205, 10.1007/s002530000541
Klinke, 1999, Production of medium-chain-length poly(3-hydroxyalkanoates) from gluconate by recombinant Escherichia coli, Appl. Environ. Microbiol., 65, 540, 10.1128/AEM.65.2.540-548.1999
Mittendorf, 1998, Synthesis of medium-chain-length polyhydroxyalkanoates in Arabidopsis thaliana using intermediates of peroxisomal fatty acid beta-oxidation, Proc. Natl. Acad. Sci. U.S.A., 95, 13397, 10.1073/pnas.95.23.13397
Poirier, 2001, Synthesis of polyhydroxyalkanoate in the peroxisome of Saccharomyces cerevisiae by using intermediates of fatty acid beta-oxidation, Appl. Environ. Microbiol., 67, 5254, 10.1128/AEM.67.11.5254-5260.2001
Poirier, 2002, Synthesis of polyhydroxyalkanoate in the peroxisome of Pichia pastoris, FEMS Microbiol. Lett., 207, 97, 10.1111/j.1574-6968.2002.tb11035.x
Saito, 1994, Microbial synthesis and properties of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in Comamonas acidovorans, Int. J. Biol. Macromol., 16, 99, 10.1016/0141-8130(94)90022-1
Mukai, 1993, Substrate specificities in hydrolysis of polyhydroxyalkanoates by microbial esterases, Biotechnol. Lett., 15, 601, 10.1007/BF00138548
Jaeger, 1995, Substrate specificities of bacterial polyhydroxyalkanoate depolymerases and lipases: bacterial lipases hydrolyse poly(ω-hydroxyalkanoates), Appl. Environ. Microbiol., 61, 3113, 10.1128/AEM.61.8.3113-3118.1995
Kunioka, 1988, New bacterial copolyesters produced in Alcaligenes eutrophus from organic acids, Polym. Commun., 29, 174
Doi, 1990, Biosynthesis and characterization of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in A. eutrophus, Int. J. Biol. Macromol., 12, 1012, 10.1016/0141-8130(90)90061-E
Sudesh, 1999, Improved production of poly(4-hydroxybutyrate) by Comamonas acidovorans and its freeze-fracture morphology, Int. J. Biol. Macromol., 25, 79, 10.1016/S0141-8130(99)00018-5
Choi, 1999, Production of poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) and poly(4-hydroxybutyric acid) with subsequent degradation by Hydrogenophaga pseudoflava, Appl. Environ. Microbiol., 65, 1570, 10.1128/AEM.65.4.1570-1577.1999
Song, 2000, Cloning, nucleotide sequence and primary biochemical characterization of esterase EstA from Ralstonia eutropha CH34, Biotechnol. Lett., 22, 443, 10.1023/A:1005686914133
Valentin, 1995, Metabolic pathway for biosynthesis of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from 4-hydroxybutyrate by Alcaligenes eutrophus, Eur. J. Biochem., 227, 43, 10.1111/j.1432-1033.1995.tb20358.x
Lütke-Eversloh, 1999, Biochemical and molecular characterization of a succinate semialdehyde dehydrogenase involved in the catabolism of 4-hydroxybutyric acid in Ralstonia eutropha, FEMS Microbiol. Lett., 181, 63, 10.1016/S0378-1097(99)00515-7
Hein, 1997, Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains of Escherichia coli, FEMS Microbiol. Lett., 153, 411, 10.1016/S0378-1097(97)00282-6
Song, 1999, Production of poly(4-hydroxybutyric acid) by fed-batch cultures of recombinant strains of Escherichia coli, Biotechnol. Lett., 21, 193, 10.1023/A:1005451810844
Y. Doi, A. Segawa, S. Nakamura, M. Kunioka, 1990. Production of biodegradable copolyesters by Alcaligenes eutrophus, in: E.A. Dawes (Ed.), Novel Biodegradable Microbial Polymers, Kluwer Academic Press, Dordrecht, pp. 37–48.
Fetzner, 1998, Bacterial dehalogenation, Appl. Microbiol. Biotechnol., 50, 633, 10.1007/s002530051346
Valentin, 1997, Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in recombinant Escherichia coli grown on glucose, J. Biotechnol., 58, 33, 10.1016/S0168-1656(97)00127-2
Valentin, 2000, Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) formation from gamma-aminobutyrate and glutamate, Biotechnol. Bioeng., 67, 291, 10.1002/(SICI)1097-0290(20000205)67:3<291::AID-BIT5>3.0.CO;2-J
Buckel, 2001, Unusual enzymes involved in five pathways of glutamate fermentation, Appl. Microbiol. Biotechnol., 57, 263, 10.1007/s002530100773
Gerhardt, 2000, Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA, Arch. Microbiol., 174, 189, 10.1007/s002030000195
Timm, 1990, Formation of blends of various poly(3-hydroxyalkanoic acids) by a recombinant strain of Pseudomonas oleovorans, Appl. Microbiol. Biotechnol., 33, 296, 10.1007/BF00164525
Preusting, 1983, Formation of polyester blends by a recombinant strain of Pseudomonas oleovorans: different poly(3-hydroxyalkanoates) are stored in separate granules, J. Environ. Polym. Degrad., 1, 45
Liebergesell, 1993, Analysis of polyhydroxyalkanoic acid biosynthesis genes of anoxygenic phototrophic bacteria reveals synthesis of a polyester exhibiting an unusual composition, Appl. Microbiol. Biotechnol., 40, 292, 10.1007/BF00170383
Fukui, 1997, Cloning and analysis of the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) biosynthesis genes of Aeromonas caviae, J. Bacteriol., 179, 4821, 10.1128/jb.179.15.4821-4830.1997
Lee, 2000, Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high-cell-density cultivation of Aeromonas hydrophila, Biotechnol. Bioeng., 67, 240, 10.1002/(SICI)1097-0290(20000120)67:2<240::AID-BIT14>3.0.CO;2-F
Kato, 1996, Production of a novel copolyester of 3-hydroxybutyric acid and medium-chain-length 3-hydroxyalkanoic acids by Pseudomonas sp. 61-3 from sugars, Appl. Microbiol. Biotechnol., 45, 363, 10.1007/s002530050697
Green, 2002, Formation of short chain length/medium-chain-length polyhydroxyalkanoate copolymers by fatty acid β-oxidation inhibited Ralstonia eutropha, BioMacromolecules, 3, 208, 10.1021/bm015620m
Dennis, 1998, Formation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by PHA synthase from Ralstonia eutropha, J. Biotechnol., 64, 177, 10.1016/S0168-1656(98)00110-2
Antonio, 2000, Analysis of in vitro substrate specificity of the PHA synthase from Ralstonia eutropha: formation of novel copolyesters in recombinant Escherichia coli, FEMS Microbiol. Lett., 182, 111, 10.1111/j.1574-6968.2000.tb08883.x
Chen, 2001, Industrial scale production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate), Appl. Microbiol. Biotechnol., 57, 50, 10.1007/s002530100755
S.Y. Lee, S.J. Park, Biosynthesis and fermentative production of SCL-MCL-PHAs, in: Y. Doi, A. Steinbüchel (Eds.), Biopolymers, vol. 3a, Wiley/VCH, Weinheim, 2002, pp. 317–336.
Dürre, 1998, New insights and novel developments in clostridial acetone/butanol/isopropanol fermentation, Appl. Microbiol. Biotechnol., 49, 639, 10.1007/s002530051226
Liu, 2000, Exploitation of butyrate kinase and phosphotransbutyrylase from Clostridium acetobutylicum for the in vitro biosynthesis of poly(hydroxyalkanoic acid), Appl. Microbiol. Biotechnol., 53, 545, 10.1007/s002530051655
Gao, 2002, Enhanced production of d-(−)-3-hydroxybutyric acid by recombinant Escherichia coli, FEMS Microbiol. Lett., 213, 59