Metabolic changes by acute insulin deficiency in rabbits injected with anti-insulin serum
Tóm tắt
Acute insulin deficiency was produced in rabbits treated with anti-insulin guinea pig serum. The changes in the levels of blood sugar, free fatty acids, aceto-acetate, SGOT, SGPT, liver glutamicoxaloacetic and glutamic-pyruvic transaminases, and liver lactate dehydrogenase were examined. A significant increase of the blood glucose level and the free fatty acids as well as glycosuria was observed. The other examined parameters remained unchanged. The results confirm the statement that acute insulin deficiency causes a prompt impairment of glucose and fat metabolism.
Tài liệu tham khảo
Armin G., Grant R. T., Wright P. H.: Acute Insulin Deficiency Produced by Separate Injections of Anti-Insulin Serum - J. Physiol. (Lond.)153 131, 1960.
Dole V. P.: A Relation between non-Esterified Fatty Acids in Plasma and the Metabolism of Glucose - J. clin. Invest.35 150, 1956.
Dolkart R. E., Torok E. E., Wright P. H.: Hepatic Enzyme Activities in Rats Made Diabetic with Alloxan and with Guinea Pig Anti-Insulin Serum - Diabetes13 78, 1964.
Gregor W. H., Martin J. M., Williamson J. R., Lacy P. E., Kipnis D. M.: A Study of the Diabetic Syndrome Produced in Rats by anti-Insulin Serum - Diabetes12 73, 1963.
Hugget A., Nixon D.: Enzymic Determination of Blood Glucose -Biochem. J.66 12, 1957.
Mahler R. F.: Some Effects of Anti-Insulin Serum on Glucose Metabolism - 4e Congr. Feder. Intern. Diabète - Medic. et Hyg., Genève, 1961, pag. 627.
Moloney P. J.: Insulin Resistance and Diabetic Syndrome Produced by Antibodies to Insulin - Proc. Sec. Intern. Congr. Endocr., Excerpta med. Found., Amsterdam, 1964, pag. 888.
Moloney P. J., Coval M.: Antigenicity of Insulin: Diabetes Induced by Specific Antibodies - Biochem. J.59 179, 1955.
Schmidt E., Schmidt F.: Untersuchungen über optimale Reaktions-Bedingungen für Enzym-Aktivitätsbestimmungen in Leberextrakten, in Extrakten anderer Organe und im Serum -Enzymol. biol. clin.2 201, 1962.
Sweeney M. J., Ashmore J.: Effects of Acute Insulin Insufficiency in Liver and Adipose Tissue Fatty Acid Synthesis - Metabolism14 516–521, 1965.
Walker P. G.: A Colorimetric Method for the Estimation of Aceto-Acetate - Biochem. J.58 699, 1954.
Wright P. H.: The Production of Experimental Diabetes by Means of Insulin Antibodies -Amer. J. Med.31 892, 1961.
Wright P. H.: Experimental Diabetes Induced by Insulin Antibodies. On Nature and Treatment of Diabetes - Excerpta med. Found. pag. 354, Amsterdam 1964.