Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes

Katsuya Yamada1, Takayoshi Suzuki2, Atsushi Hakura3, Takaharu Mizutani1, Ken-ichi Saeki1
1Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan
2Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
3Drug Safety Research Laboratories, Eisai Co. Ltd., 1 Takehaya-machi, Kawashima-cho, Hashima-gun, Gifu 501-6195, Japan

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