Metabolic acidosis in patients receiving anticonvulsants

Zeitschrift für Kinderheilkunde - Tập 132 - Trang 161-168 - 1979
Bunsaku Nagai1,2,3, Ichiro Matsuda1,2,3, Takahito Kondo1,2,3, Naoyuki Taniguchi1,2,3, Shinichiro Arashima1,2,3, Takashi Mitsuyama1,2,3, Yogo Oka1,2,3, Masakatsu Honma1,2,3
1Department of Pediatrics and Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan
2Department of Environmental Medicine, Hokkaido University, Graduated School of Environmental Science, Hokkaido, Japan
3Department of Pediatrics, Kumamoto University Medical School, Kumamoto, Japan

Tóm tắt

Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.

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Zeitschrift für Kinderheilkunde

Tập 132

161-168

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