Metabolic Stress Triggers Immune Escape by Tumors

Trends in Cancer - Tập 5 - Trang 656-658 - 2019
Joana B. Nunes1, Bart Everts2
1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
2Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

Tài liệu tham khảo

Ho, 2015, Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses, Cell, 162, 1217, 10.1016/j.cell.2015.08.012 Chang, 2015, Metabolic Competition in the tumor microenvironment is a driver of cancer progression, Cell, 162, 1229, 10.1016/j.cell.2015.08.016 Marijt, 2019, Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling, J. Immunother. Cancer, 7, 152, 10.1186/s40425-019-0627-8 Chouaib, 2016, Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer, Oncogene, 36, 439, 10.1038/onc.2016.225 Zhang, 2017, Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy, Cancer Cell, 32, 377, 10.1016/j.ccell.2017.08.004 Laderoute, 2006, 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments, Mol. Cell Biol., 26, 5336, 10.1128/MCB.00166-06 Reits, 2006, Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy, J. Exp. Med., 203, 1259, 10.1084/jem.20052494 Verbrugge, 2014, The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling, Radiat. Res., 182, 219, 10.1667/RR13511.1 Paddock, 2019, Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance, J. Lipid Res., 60, 747, 10.1194/jlr.S092130 Catalán, 2015, MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells, Oncoimmunology, 4, 10.4161/2162402X.2014.985924