Metabolic Engineering through Cofactor Manipulation and Its Effects on Metabolic Flux Redistribution in Escherichia coli

Metabolic Engineering - Tập 4 Số 2 - Trang 182-192 - 2002
Ka‐Yiu San1,2, George N. Bennett3, Susana J. Berrı́os-Rivera2, Ravi V. Vadali1, Yea‐Tyng Yang3, Emily Horton3, Frederick B. Rudolph3, Berna Sarıyar1, Kimathi Blackwood3
1Department of Bioengineering, Rice University, Houston, Texas 77005
2Department of Chemical Engineering, Rice University, Houston, Texas, 77005
3Department of Biochemistry and Cell Biology, Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, 77005

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Tài liệu tham khảo

Alam, 1989, Anaerobic fermentation balance of Escherichia coli as observed by in vivo nuclear magnetic resonance spectroscopy, J. Bacteriol., 171, 6213, 10.1128/jb.171.11.6213-6217.1989

Aristidou, 1999, Metabolic flux analysis of Escherichia coli expressing the Bacillus subtilis acetolactate synthase in batch and continuous cultures, Biotechnol. Bioeng., 63, 737, 10.1002/(SICI)1097-0290(19990620)63:6<737::AID-BIT12>3.0.CO;2-9

Bailey, 1991, Toward a science of metabolic engineering, Science, 252, 1668, 10.1126/science.2047876

Bernofsky, 1973, An improved cycling assay for nicotinamide adenine dinucleotide, Anal. Biochem., 53, 452, 10.1016/0003-2697(73)90094-8

Berrı́os-Rivera, S. J, Lu, B, Yang, Y.-T, San, K.-Y, and, Bennett, G. N. 1999, The effect of NADH recycling on the NADH/NAD+ ratio and metabolic flux redistribution in Escherichia coli. 1999 AIChE Annual Meeting, Dallas, TX.

Berrı́os-Rivera, S. J, San, K.-Y, and, Bennett, G. N. 2001, The effect of NAPRTase overexpression on the total levels of NAD, the NADH/NAD+ ratio, and the distribution of metabolites in Escherichia coli. Submitted for publication.

Berrı́os-Rivera, 2000, Effect of glucose analog supplementation on metabolic flux distribution in anaerobic chemostat cultures of Escherichia coli, Metab. Eng., 2, 149, 10.1006/mben.1999.0141

Cameron, 1997, Development in metabolic engineering, Curr. Opin. Biotechnol., 8, 175, 10.1016/S0958-1669(97)80098-5

Cooper, 1984, Metabolism of methylglyoxal in microorganisms, Annu. Rev. Microbiol., 38, 49, 10.1146/annurev.mi.38.100184.000405

Ferguson, 1998, Methylglyoxal production in bacteria: Suicide or survival?, Arch. Microbiol., 170, 209, 10.1007/s002030050635

Foster, 1990, Regulation of NAD metabolism in Salmonella typhimurium: Molecular sequence analysis of the bifunctional nadR regulator and the nadA–pnuC operon, J. Bacteriol., 172, 4187, 10.1128/jb.172.8.4187-4196.1990

Izui, 1981, Regulation of Escherichia coli phosphoenolpyruvate carboxylase by multiple effectors in vivo. II. Kinetic studies with a reaction system containing physiological concentrations of ligands, J. Biochem., 90, 1321, 10.1093/oxfordjournals.jbchem.a133597

Lee, 1999

Leonardo, 1996, Role of NAD in regulating the adhE gene of Escherichia coli, J. Bacteriol., 178, 6013, 10.1128/jb.178.20.6013-6018.1996

Lopez, 1998, Cofactor engineering: A novel approach to metabolic engineering in Lactococcus lactis by controlled expression of NADH oxidase, J. Bacteriol., 180, 3804, 10.1128/JB.180.15.3804-3808.1998

Park, 1999, Utilization of electrically reduced neutral red by Actinobacillus succinogenes: Physiological function of neutral red in membrane-driven fumarate reduction and energy conservation, J. Bacteriol., 181, 2403, 10.1128/JB.181.8.2403-2410.1999

Riondet, 2000, Extracellular oxidoreduction potential modifies carbon and electron flow in Escherichia coli, J. Bacteriol., 182, 620, 10.1128/JB.182.3.620-626.2000

Rock, 2000, Pantothenate kinase regulation of the intracellular concentration of coenzyme A, J. Biol. Chem., 275, 1377, 10.1074/jbc.275.2.1377

Stephanopoulos, 1998

Stephanopoulos, 1990, Network rigidity and metabolic engineering in metabolite overproduction, Science, 252, 675

Terada, 1991, Site-directed mutagenesis of phosphoenolpyruvate carboxylase from E. coli: The role of His579 in the catalytic and regulatory functions, J. Biochem., 109, 49

Tolentino, 1992, A pH-regulated promoter for the expression of recombinant proteins in Escherichia coli, Biotechnol. Lett., 14, 157, 10.1007/BF01023351

Vallari, 1987, Isolation and characterization of temperature-sensitive pantothenate kinase (coaA) mutants of Escherichia coli, J. Bacteriol., 169, 5795, 10.1128/jb.169.12.5795-5800.1987

Wubbolts, 1990, Variation of cofactor levels in Escherichia coli, J. Biol. Chem., 265, 17665, 10.1016/S0021-9258(18)38215-2

Yang, 1999, The interactions of nuo and ack/pta mutations on metabolic flux redistribution in Escherichia coli, Biotechnol. Bioeng., 65, 291, 10.1002/(SICI)1097-0290(19991105)65:3<291::AID-BIT6>3.0.CO;2-F

Yoshimoto, 1999, Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus, Yeast, 15, 409, 10.1002/(SICI)1097-0061(19990330)15:5<409::AID-YEA366>3.0.CO;2-Q