Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 75 Số 1 - Trang 139-146 - 2020
Thomas Yates1,2, Charlotte L. Edwardson1,2, Carlos Celis‐Morales3, Stuart Biddle4, Danielle H. Bodicoat1, Melanie J. Davies1,2, Dale Esliger5,6, Joseph Henson1,2, Aadil Kazi7, Kamlesh Khunti1,8, Naveed Sattar3, Alan J. Sinclair9, Alex V. Rowlands1,2, Latha Velayudhan10,11, Francesco Zaccardi1, Jason M. R. Gill3
1Diabetes Research Centre, College of Life Sciences, University of Leicester, Australia
2NIHR Leicester Biomedical Research Centre, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Australia
3Institute of Cardiovascular and Medical Sciences, University of Glasgow, Australia
4Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Australia
5National Centre for Sport and Exercise Medicine, University of Loughborough, Diabetes Frail Ltd and University of Aston, Birmingham
6School of Sport, Exercise, and Health Sciences, Loughborough University, Birmingham
7Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Diabetes Frail Ltd and University of Aston, Birmingham
8NIHR Collaborations for Leadership in Applied Health Research and Care (CLAHRC) East Midlands, Diabetes Frail Ltd and University of Aston, Birmingham
9Foundation for Diabetes Research in Older People, Diabetes Frail Ltd and University of Aston, Birmingham
10Department of Health Sciences, University of Leicester
11Institute of Psychiatry, Psychology and Neurosciences, King's College London

Tóm tắt

Abstract Background Prolonged sitting is common in older adults and is associated with insulin resistance and poor cardiometabolic health. We investigate whether breaking prolonged sitting with regular short bouts of standing or light walking improves postprandial metabolism in older white European and South Asian adults and whether effects are modified by ethnic group. Methods Thirty South Asian (15 women) and 30 white European (14 women) older adults (aged 65–79 years) undertook three experimental conditions in random order. (a) Prolonged sitting: continuous sitting during an observation period if 7.5 hours consuming two standardized mixed meals. (b) Standing breaks: sitting interrupted with 5 minutes of standing every 30 minutes (accumulating 60 minutes of standing over the observation period). (c) Walking breaks: sitting interrupted with 5 minutes of self-paced light walking every 30 minutes (accumulating 60 minutes of walking). Blood samples (glucose, insulin, triglycerides) and blood pressure were sampled regularly throughout each condition. Results Compared with prolonged sitting, walking breaks lowered postprandial insulin by 16.3 mU/L, (95% CI: 19.7, 22.0) with greater reductions (p = .029) seen in South Asians (22.4 mU/L; 12.4, 32.4) than white Europeans (10.3 mU/L; 5.9, 14.7). Glucose (0.3 mmol/L; 0.1, 0.5) and blood pressure (4 mm Hg; 2, 6), but not triglycerides, were lower with walking breaks, with no ethnic differences. Standing breaks did not improve any outcome. Conclusions Breaking prolonged sitting with short bouts of light walking, but not standing, resulted in clinically meaningful improvements in markers of metabolic health in older adults, with South Asians gaining a greater reduction in postprandial insulin. Trial Registration NCT02453204

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Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Tập 75 Số 1

139-146

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