Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor

Drug Metabolism and Disposition - Tập 44 Số 8 - Trang 1201-1212 - 2016
Paul A. Dickinson1, Mireille Cantarini1, Jo Collier1, Paul Frewer1, Scott Martin1, Kathryn Pickup1, Peter Ballard1
1AstraZeneca, Macclesfield (M.V.C., P.F., S.M., K.P., P.B.), Seda Pharmaceutical Development Services, Cheshire (P.A.D), and Quotient Clinical Ltd., Ruddington, United Kingdom (J.C.)

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