Metabolic Damage Presents Differently in Young and Early-Aged C57BL/6 Mice Fed a High-Fat Diet

Fabbrini, 2010, Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications, Hepatology, 51, 679, 10.1002/hep.23280 Heal, 2009, Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders, Br J Clin Pharmacol, 68, 861, 10.1111/j.1365-2125.2009.03549.x Mathus-Vliegen, 2012, Obesity and the elderly, J Clin Gastroenterol, 46, 533, 10.1097/MCG.0b013e31825692ce Tsou, 2014, Prevalence of metabolic syndrome and risk factor analysis among urban elderly in one medical center in northern Taiwan, Int J Gerontol, 8, 127, 10.1016/j.ijge.2013.10.006 Panchal, 2011, Rodent models for metabolic syndrome research, J Biomed Biotechnol, 2011, 351982 Vickers, 2011, The utility of animal models to evaluate novel anti-obesity agents, Br J Pharmacol, 164, 1248, 10.1111/j.1476-5381.2011.01245.x Sung, 2011, Increased cd36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction, J Mol Med (Berl), 89, 459, 10.1007/s00109-010-0720-4 Rabasa-Lhoret, 2003, Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states, J Clin Endocrinol Metab, 88, 4917, 10.1210/jc.2002-030316 Tchoukalova, 2008, Subcutaneous adipocyte size and body fat distribution, Am J Clin Nutr, 87, 56, 10.1093/ajcn/87.1.56 Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, 41, 1313, 10.1002/hep.20701 Novik, 2010, A microfluidic hepatic coculture platform for cell-based drug metabolism studies, Biochem Pharmacol, 79, 1036, 10.1016/j.bcp.2009.11.010 Guo, 2008, Development of a real-time PCR method for Firmicutes and Bacteroidetes in faeces and its application to quantify intestinal population of obese and lean pigs, Lett Appl Microbiol, 47, 367, 10.1111/j.1472-765X.2008.02408.x Mathus-Vliegen, 2012, World Gastroenterology Organisation global guidelines on obesity, J Clin Gastroenterol, 46, 555, 10.1097/MCG.0b013e318259bd04 Flier, 2004, Obesity wars: Molecular progress confronts an expanding epidemic, Cell, 116, 337, 10.1016/S0092-8674(03)01081-X Mittendorfer, 2011, Origins of metabolic complications in obesity: Adipose tissue and free fatty acid trafficking, Curr Opin Clin Nutr Metab Care, 14, 535, 10.1097/MCO.0b013e32834ad8b6 Lee, 2010, Adipose tissue remodeling in pathophysiology of obesity, Curr Opin Clin Nutr Metab Care, 13, 371, 10.1097/MCO.0b013e32833aabef Reaven, 1988, Banting lecture 1988. Role of insulin resistance in human disease, Diabetes, 37, 1595, 10.2337/diab.37.12.1595 Gregor, 2011, Inflammatory mechanisms in obesity, Annu Rev Immunol, 29, 415, 10.1146/annurev-immunol-031210-101322 Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337/db06-1491 Backhed, 2004, The gut microbiota as an environmental factor that regulates fat storage, Proc Natl Acad Sci U S A, 101, 15718, 10.1073/pnas.0407076101 Ley, 2005, Obesity alters gut microbial ecology, Proc Natl Acad Sci U S A, 102, 11070, 10.1073/pnas.0504978102 Ley, 2006, Microbial ecology: Human gut microbes associated with obesity, Nature, 444, 1022, 10.1038/4441022a Nascimento, 2010, Adipose tissue, liver and pancreas structural alterations in c57bl/6 mice fed high-fat-high-sucrose diet supplemented with fish oil (n-3 fatty acid rich oil), Exp Toxicol Pathol, 62, 17, 10.1016/j.etp.2008.12.008 Gallou-Kabani, 2007, C57bl/6j and a/j mice fed a high-fat diet delineate components of metabolic syndrome, Obesity (Silver Spring), 15, 1996, 10.1038/oby.2007.238