Metabolic Adaptation of the Hypertrophied Heart: Role of the Malate/Aspartate and α -Glycerophosphate Shuttles

Journal of Molecular and Cellular Cardiology - Tập 32 - Trang 2287-2297 - 2000
Brian E Rupert1, Jeffrey L Segar1, Brian C Schutte1, Thomas D Scholz1
1Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA

Tài liệu tham khảo

Anversa, 1986, Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review, J Am Coll Cardiol, 7, 1140, 10.1016/S0735-1097(86)80236-4 Chien, 1991, Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response, FASEB J, 5, 3037, 10.1096/fasebj.5.15.1835945 Hefti, 1997, Signaling pathways in cardiac myocyte hypertrophy, J Mol Cell Cardiol, 29, 2873, 10.1006/jmcc.1997.0523 Bishop, 1970, Increased glycolytic metabolism in cardiac hypertrophy and congestive failure, Am J Physiol, 218, 153, 10.1152/ajplegacy.1970.218.1.153 Allard, 1994, Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts, Am J Physiol, 267, H742 Christe, 1994, Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat, J Mol Cell Cardiol, 26, 1371, 10.1006/jmcc.1994.1155 Barger, 1999, Fatty acid utilization in the hypertrophied and failing heart: molecular regulatory mechanisms, Am J Med Sci, 318, 36, 10.1097/00000441-199907000-00006 Sack, 1996, Fatty acid oxidation enzyme gene expression is downregulated in the failing heart, Circulation, 94, 2837, 10.1161/01.CIR.94.11.2837 Montessuit, 1999, Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists, J Biol Chem, 274, 9006, 10.1074/jbc.274.13.9006 Vatner, 1984, Effects of moderate pressure overload cardiac hypertrophy on the distribution of creatine kinase isozymes, Proc Soc Exp Biol Med, 175, 5, 10.3181/00379727-175-1-RC2 Koehler, 1985, Left ventricular enzyme activities of the energy-supplying metabolism in Goldblatt-II rats, Res Exp Med, 185, 299, 10.1007/BF01851955 Taegtmeyer, 1988, Effects of moderate hypertension on cardiac function and metabolism in the rabbit, Hypertension, 11, 416, 10.1161/01.HYP.11.5.416 Smith, 1990, Regional changes in creatine kinase and myocyte size in hypertensive and nonhypertensive cardiac hypertrophy, Circ Res, 67, 1334, 10.1161/01.RES.67.6.1334 Do, 1997, Energy metabolism in normal and hypertrophied right ventricle of the ferret heart, J Mol Cell Cardiol, 29:, 1903, 10.1006/jmcc.1997.0429 Dawson, 1979, Oxidation of cytosolic NADH formed during aerobic metabolism in mammalian cells, Trends Biochem Sci, 4, 171, 10.1016/0968-0004(79)90417-1 Scholz, 1995, Reducing equivalent shuttles in developing myocardium: enhanced capaÍcity in the newborn heart, Pediatr Res, 38, 221, 10.1203/00006450-199508000-00015 Scholz, 2000, Thyroid hormone regulation of the NADH shuttles in liver and cardiac mitochondria, J Mol Cell Cardiol, 32, 1, 10.1006/jmcc.1999.1047 Scholz, 1997, Developmental regulation of the α-glycerophosphate shuttle in porcine myocardium, J Mol Cell Cardiol, 29, 1605, 10.1006/jmcc.1997.0394 Scholz, 1998, Ontogeny of malate/aspartate shuttle capacity and gene expression in cardiac mitochondria, Am J Physiol, 274, C780, 10.1152/ajpcell.1998.274.3.C780 McKee, 1990, Isolation and incubation conditions to study heart mitochondrial protein synthesis, Am J Physiol, 258, E492 Mattingly, 1987, Molecular cloning and in vivo expression of a precursor to rat mitochondrial aspartate aminotransferase, Biochem Biophys Res Commun, 149, 859, 10.1016/0006-291X(87)90487-6 Grant, 1986, Isolation and nucleotide sequence of a cDNA clone encoding rat mitochondrial malate dehydrogenase, Nucleic Acids Res, 14, 6053, 10.1093/nar/14.15.6053 Brown, 1994, Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains, J Biol Chem, 269, 14363, 10.1016/S0021-9258(17)36629-2 Muller, 1994, Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones, Proc Natl Acad Sci USA, 91, 10581, 10.1073/pnas.91.22.10581 Bonham, 1996, Improved purification and yields of RNA by RNeasy, BioTechniques, 21, 57, 10.2144/96211bm12 Runswick, 1990, Sequence of the bovine 2-oxoÍglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins, Biochemistry, 29, 11033, 10.1021/bi00502a004 Iacobazzi, 1992, Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier, DNA Sequence, 3, 79, 10.3109/10425179209034000 Feldman, 1993, Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding, Circ Res, 73, 184, 10.1161/01.RES.73.1.184 Bauer, 1998, Upregulated and downregulated transcription of myocardial genes after pulmonary artery banding in pigs, Ann Thorac Surg, 66, 527, 10.1016/S0003-4975(98)00445-7 Swynghedauw, 1999, Molecular mechanisms of myocardial remodeling, Physiol Rev, 79, 215, 10.1152/physrev.1999.79.1.215 Massie, 1995, Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy, Circulation, 91, 1814, 10.1161/01.CIR.91.6.1814 Kelly, 1989, The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. Medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase, J Biol Chem, 264, 18921, 10.1016/S0021-9258(19)47245-1 Zhu, 1996, Substrate metabolism, hormone interaction, and angiotensin-converting enzyme inhibitors in left ventricular hypertrophy, Diabetes, 45, S59, 10.2337/diab.45.1.S59 Rolph, 1983, Regulation of glycolytic flux in the heart of the fetal guinea pig, J Dev Physiol, 5, 31 Ren, 1993, Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle, J Biol Chem, 268, 16113, 10.1016/S0021-9258(19)85395-4 Anversa, 1976, Morphometry and autoradiography of early hypertrophic changes in the ventricular myocardium of adult rat: an electron microscopic study, Lab Invest, 35, 475 Rabinowitz, 1975, Mitochondria and cardiac hypertrophy, Circ Res, 36, 367, 10.1161/01.RES.36.3.367 Wittels, 1968, Defective lipid metabolism in the failing heart, J Clin Invest, 47, 1787, 10.1172/JCI105868 Sack, 1996, Fatty acid oxidation enzyme gene expression is downregulated in the failing heart, Circulation, 94, 2837, 10.1161/01.CIR.94.11.2837