Mesenchymal stem cells as anti-inflammatories: Implications for treatment of Duchenne muscular dystrophy

Muntoni, 2003, Dystrophin and mutations: one gene, several proteins, multiple phenotypes, Lancet Neurol., 2, 731, 10.1016/S1474-4422(03)00585-4 Lapidos, 2004, The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma, Circ. Res., 94, 1023, 10.1161/01.RES.0000126574.61061.25 Miller, 1999, Seeking muscle stem cells, Curr. Top. Dev. Biol., 43, 191, 10.1016/S0070-2153(08)60382-8 Lund, 2007, Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice, Muscle Nerve, 36, 387, 10.1002/mus.20824 Merrick, 2009, Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation, Dis. Model Mech., 2, 374, 10.1242/dmm.001008 Cossu, 2000, Myogenic stem cells for the therapy of primary myopathies: wishful thinking or therapeutic perspective?, J. Clin. Invest., 105, 1669, 10.1172/JCI10376 Spuler, 1998, Unexpected sarcolemmal complement membrane attack complex deposits on nonnecrotic muscle fibers in muscular dystrophies, Neurology, 50, 41, 10.1212/WNL.50.1.41 Eagle, 2002, Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation, Neuromuscul. Disord., 12, 926, 10.1016/S0960-8966(02)00140-2 Fenichel, 1991, Long-term benefit from prednisone therapy in Duchenne muscular dystrophy, Neurology, 41, 1874, 10.1212/WNL.41.12.1874 Romero, 2004, Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy, Hum. Gene Ther., 15, 1065, 10.1089/hum.2004.15.1065 van Deutekom, 2007, Local dystrophin restoration with antisense oligonucleotide PRO051, N. Engl. J. Med., 357, 2677, 10.1056/NEJMoa073108 Torrente, 2007, Autologous transplantation of muscle-derived CD133+ stem cells in Duchenne muscle patients, Cell Transplant., 16, 563, 10.3727/000000007783465064 Law, 1992, Feasibility, safety, and efficacy of myoblast transfer therapy on Duchenne muscular dystrophy boys, Cell Transplant., 1, 235, 10.1177/0963689792001002-305 Mendell, 1995, Myoblast transfer in the treatment of Duchenne’s muscular dystrophy, N. Engl. J. Med., 333, 832, 10.1056/NEJM199509283331303 Skuk, 2007, First test of a “high-density injection” protocol for myogenic cell transplantation throughout large volumes of muscles in a Duchenne muscular dystrophy patient: eighteen months follow-up, Neuromuscul. Disord., 17, 38, 10.1016/j.nmd.2006.10.003 Skuk, 2006, Dystrophin expression in muscles of Duchenne muscular dystrophy patients after high-density injections of normal myogenic cells, J. Neuropathol. Exp. Neurol., 65, 371, 10.1097/01.jnen.0000218443.45782.81 Skuk, 2004, Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells, Mol. Ther., 9, 475, 10.1016/j.ymthe.2003.11.023 Ispirlidis, 2008, Time-course of changes in inflammatory and performance responses following a soccer game, Clin. J. Sport Med., 18, 423, 10.1097/JSM.0b013e3181818e0b Gosselin, 2004, Targeting the immune system to improve ventilatory function in muscular dystrophy, Med. Sci. Sports Exer., 36, 44, 10.1249/01.MSS.0000106185.22349.2C Chen, 2000, Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology, J. Cell Biol., 151, 1321, 10.1083/jcb.151.6.1321 Evans, 2009, Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy, Am. J. Phys. Med. Rehabil., 88, 502, 10.1097/PHM.0b013e3181a5a24f Marotta, 2009, Muscle genome-wide expression profiling during disease evolution in mdx mice, Physiol. Genomics, 37, 119, 10.1152/physiolgenomics.90370.2008 Acharyya, 2007, Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy, J. Clin. Invest., 117, 889, 10.1172/JCI30556 Porreca, 1999, Haemostatic abnormalities, cardiac involvement and serum tumor necrosis factor levels in X-linked dystrophic patients, Thromb. Haemost., 81, 543, 10.1055/s-0037-1614521 Pierno, 2007, Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice. a pharmacological approach, Neuropathol. Appl. Neurobiol., 33, 344, 10.1111/j.1365-2990.2007.00798.x Grounds, 2004, Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis, FASEB J., 18, 676, 10.1096/fj.03-1024com Grounds, 2008, Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle, Clin. Exp. Pharmacol. Physiol., 35, 846, 10.1111/j.1440-1681.2007.04868.x Porter, 2003, Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle, Neuromuscul. Disord., 13, 223, 10.1016/s0960-8966(02)00242-0 Parrish, 1996, Targeting widespread sites of damage in dystrophic muscle: engrafted macrophages as potential shuttles, Gene Ther., 3, 13 Villalta, 2009, Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy, Hum. Mol. Genet., 18, 482, 10.1093/hmg/ddn376 Demoule, 2005, Expression and regulation of CC class chemokines in the dystrophic (mdx) diaphragm, Am. J. Respir. Cell Mol. Biol., 33, 178, 10.1165/rcmb.2004-0347OC Gavina, 2006, VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation, Blood, 108, 2857 Sun, 2009, Intramuscular renin–angiotensin system is activated in human muscular dystrophy, J. Neurol. Sci., 10.1016/j.jns.2009.01.020 Radley, 2008, Reduced muscle necrosis and long-term benefits in dystrophic mdx mice after cV1q (blockade of TNF) treatment, Neuromuscul. Disord., 18, 227, 10.1016/j.nmd.2007.11.002 Hodgetts, 2006, Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFalpha function with Etanercept in mdx mice, Neuromuscul. Disord., 16, 591, 10.1016/j.nmd.2006.06.011 von Moers, 2005, Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy, Acta Neuropathol., 109, 285, 10.1007/s00401-004-0941-0 Gargioli, 2008, PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle, Nat. Med., 14, 973, 10.1038/nm.1852 Musch, 1975, A comparison of the structure of small blood vessels in normal, denervated and dystrophic human muscle, J. Neurol. Sci., 26, 221, 10.1016/0022-510X(75)90034-9 A.Y. Manzur et al., Glucocorticoid corticosteroids for Duchenne muscular dystrophy, Cochrane Database Syst. Rev. (1) (2008) CD003725. Connolly, 2002, High dose weekly oral prednisone improves strength in boys with Duchenne muscular dystrophy, Neuromuscul. Disord., 12, 917, 10.1016/S0960-8966(02)00180-3 Pollard, 2009, Trophic macrophages in development and disease, Nat. Rev. Immunol., 9, 259, 10.1038/nri2528 Martinez, 2008, Macrophage activation and polarization, Front. Biosci., 13, 453, 10.2741/2692 Sica, 2008, Macrophage polarization in tumour progression, Semin. Cancer Biol., 18, 349, 10.1016/j.semcancer.2008.03.004 Eriksson, 2009, Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages, J. Immunol., 182, 3105, 10.4049/jimmunol.0800224 Wang, 2007, Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease, Kidney Int., 72, 290, 10.1038/sj.ki.5002275 Malerba, 2008, Macrophage-secreted factors enhance the in vitro expansion of DMD muscle precursor cells while preserving their myogenic potential, Neurol. Res. Vetrone, 2009, Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta, J. Clin. Invest., 119, 1583, 10.1172/JCI37662 H.G. Radley, M.D. Grounds, Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice, Neurobiol. Dis. 23 (2) (2006) 387–397. J.T. Kissel et al., Mononuclear cell analysis of muscle biopsies in prednisone-treated and untreated Duchenne muscular dystrophy. CIDD Study Group, Neurology 41 (5) (1991) 667–672. De Luca, 2005, A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice, Am. J. Pathol., 166, 477, 10.1016/S0002-9440(10)62270-5 Farini, 2007, T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse, J. Pathol., 213, 229, 10.1002/path.2213 Morrison, 2000, T-cell-dependent fibrosis in the mdx dystrophic mouse, Lab. Invest., 80, 881, 10.1038/labinvest.3780092 Confalonieri, 2003, Muscle inflammation and MHC class I up-regulation in muscular dystrophy with lack of dysferlin: an immunopathological study, J. Neuroimmunol., 142, 130, 10.1016/S0165-5728(03)00255-8 McDouall, 1989, Expression of class I and class II MHC antigens in neuromuscular diseases, J. Neurol. Sci., 89, 213, 10.1016/0022-510X(89)90023-3 Laszlo, 1983, Antinuclear factor, smooth and striated muscle antibodies in Duchenne-type muscular dystrophy, Acta Paediatr. Hung., 24, 331 Spencer, 2001, Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle, Clin. Immunol., 98, 235, 10.1006/clim.2000.4966 Spencer, 1997, Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity, J. Clin. Invest., 99, 2745, 10.1172/JCI119464 Law, 1991, Myoblast transfer therapy for Duchenne muscular dystrophy, Acta Paediatr. Jpn, 33, 206, 10.1111/j.1442-200X.1991.tb01545.x Tremblay, 1993, Results of a triple blind clinical study of myoblast transplantations without immunosuppressive treatment in young boys with Duchenne muscular dystrophy, Cell Transplant., 2, 99, 10.1177/096368979300200203 Karpati, 1993, Myoblast transfer in Duchenne muscular dystrophy, Ann. Neurol., 34, 8, 10.1002/ana.410340105 Law, 1993, Cell transplantation as an experimental treatment for Duchenne muscular dystrophy, Cell Transplant., 2, 485, 10.1177/096368979300200607 Miller, 1997, Myoblast implantation in Duchenne muscular dystrophy: the San Francisco study, Muscle Nerve, 20, 469, 10.1002/(SICI)1097-4598(199704)20:4<469::AID-MUS10>3.0.CO;2-U A.J. Friedenstein et al., Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues, Transplantation 6 (2) (1968) 230–247. Zannettino, 2008, Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo, J. Cell Physiol., 214, 413, 10.1002/jcp.21210 Hoogduijn, 2007, Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities, Stem Cells Dev., 16, 597, 10.1089/scd.2006.0110 Chao, 2008, Islet-like clusters derived from mesenchymal stem cells in Wharton’s Jelly of the human umbilical cord for transplantation to control type 1 diabetes, PLoS ONE, 3, e1451, 10.1371/journal.pone.0001451 Jo, 2007, Isolation and characterization of postnatal stem cells from human dental tissues, Tissue Eng., 13, 767, 10.1089/ten.2006.0192 He, 2007, Concise review: multipotent mesenchymal stromal cells in blood, Stem Cells, 25, 69, 10.1634/stemcells.2006-0335 Oh, 2008, Immunological properties of umbilical cord blood-derived mesenchymal stromal cells, Cell. Immunol., 10.1016/j.cellimm.2008.04.003 Meng, 2007, Endometrial regenerative cells: a novel stem cell population, J. Transl. Med., 5, 57, 10.1186/1479-5876-5-57 Hida, 2008, Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells, Stem Cells, 26, 1695, 10.1634/stemcells.2007-0826 Patel, 2008, Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation, Cell Transplant., 17, 303, 10.3727/096368908784153922 Jazedje, 2009, Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures, J. Transl. Med., 7, 46, 10.1186/1479-5876-7-46 Prockop, 1997, Marrow stromal cells as stem cells for nonhematopoietic tissues, Science, 276, 71, 10.1126/science.276.5309.71 Lepski, 2009, Limited Ca(2+) and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells, Exp. Cell Res. Trzaska, 2009, Brain-derived neurotrophic factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons, J. Neurochem., 110, 1058, 10.1111/j.1471-4159.2009.06201.x Liu, 2007, Flk-1+ adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in mdx mice, Stem Cells Dev., 16, 695, 10.1089/scd.2006.0118 Chivu, 2009, In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors, Transl. Res., 154, 122, 10.1016/j.trsl.2009.05.007 Xie, 2009, Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro, Differentiation, 77, 483, 10.1016/j.diff.2009.01.001 Tao, 2009, Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice, J. Cell Biochem., 108, 693, 10.1002/jcb.22306 Kim, 2009, TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium, Front. Biosci., 14, 2845, 10.2741/3417 Qi, 2009, Identification and differentiation of magnetically labeled mesenchymal stem cells in vivo in swines with myocardial infarction, Int. J. Cardiol., 131, 417, 10.1016/j.ijcard.2007.07.164 Chung, 2009, Intraarterially delivered human umbilical cord blood-derived mesenchymal stem cells in canine cerebral ischemia, J. Neurosci. Res., 10.1002/jnr.22162 Qian, 2008, Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells, Int. J. Mol. Med., 22, 325 Rojas, 2005, Bone marrow-derived mesenchymal stem cells in repair of the injured lung, Am. J. Respir. Cell Mol. Biol., 33, 145, 10.1165/rcmb.2004-0330OC Bruder, 1994, Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy, J. Cell Biochem., 56, 283, 10.1002/jcb.240560303 Tan, 2008, Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity, J. Comp. Neurol., 509, 167, 10.1002/cne.21729 Avniel, 2006, Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns, J. Invest. Dermatol., 126, 468, 10.1038/sj.jid.5700069 Fox, 2008, Mobilization of endothelial progenitor cells into the circulation in burned patients, Br. J. Surg., 95, 244, 10.1002/bjs.5913 Kitaori, 2009, Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model, Arthritis Rheum., 60, 813, 10.1002/art.24330 Penn, 2009, Importance of the SDF-1:CXCR4 axis in myocardial repair, Circ. Res., 104, 1133, 10.1161/CIRCRESAHA.109.198929 Schonemeier, 2008, Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain, J. Neuroimmunol., 198, 39, 10.1016/j.jneuroim.2008.04.010 Goncalves, 2006, Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion, Hum. Mol. Genet., 15, 213, 10.1093/hmg/ddi438 N.H. Riordan et al., Cord blood in regenerative medicine: do we need immune suppression? J. Transl. Med. 5 (2007) 8. Nemeth, 2009, Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production, Nat. Med., 15, 42, 10.1038/nm.1905 Gonzalez, 2009, Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells, Arthritis Rheum., 60, 1006, 10.1002/art.24405 Zheng, 2008, Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis, Rheumatology (Oxford), 47, 22, 10.1093/rheumatology/kem284 Fiorina, 2009, Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes, J. Immunol., 183, 993, 10.4049/jimmunol.0900803 Madec, 2009, Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells, Diabetologia, 52, 1391, 10.1007/s00125-009-1374-z Constantin, 2009, Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis, Stem Cells, 10.1002/stem.194 Rafei, 2009, Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis, Mol. Ther., 17, 1799, 10.1038/mt.2009.157 Zhou, 2008, Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice, Cell. Mol. Immunol., 5, 417, 10.1038/cmi.2008.52 Song, 2009, Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis, Biochim. Biophys. Acta Rafei, 2009, Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner, J. Immunol., 182, 5994, 10.4049/jimmunol.0803962 Spaggiari, 2009, MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2, Blood, 113, 6576, 10.1182/blood-2009-02-203943 Yang, 2008, Experimental study on influence of bone marrow mesenchymal stem cells on activation and function of mouse peritoneal macrophages, Zhonghua Xue Ye Xue Za Zhi, 29, 540 Batten, 2006, Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves, Tissue Eng., 12, 2263, 10.1089/ten.2006.12.2263 Selmani, 2008, Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells, Stem Cells, 26, 212, 10.1634/stemcells.2007-0554 Bai, 2009, Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis, Glia, 57, 1192, 10.1002/glia.20841 Casiraghi, 2008, Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells, J. Immunol., 181, 3933, 10.4049/jimmunol.181.6.3933 Chen, 2007, Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34+ cells, Stem Cells Dev., 16, 719, 10.1089/scd.2007.0065 Campioni, 2009, A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs, Cytometry B Clin. Cytom., 76, 225, 10.1002/cyto.b.20461 Bishopric, 2008, Mesenchymal stem cell-derived IL-10 and recovery from infarction: a third pitch for the chord, Circ. Res., 103, 125, 10.1161/CIRCRESAHA.108.180596 Puissant, 2005, Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells, Br. J. Haematol., 129, 118, 10.1111/j.1365-2141.2005.05409.x Nasef, 2008, Leukemia inhibitory factor: role in human mesenchymal stem cells mediated immunosuppression, Cell. Immunol., 253, 16, 10.1016/j.cellimm.2008.06.002 Jones, 2007, Immunosuppression by placental indoleamine 2,3-dioxygenase: a role for mesenchymal stem cells, Placenta, 28, 1174, 10.1016/j.placenta.2007.07.001 Rizzo, 2008, A functional role for soluble HLA-G antigens in immune modulation mediated by mesenchymal stromal cells, Cytotherapy, 10, 364, 10.1080/14653240802105299 Renner, 2009, Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function, Transplant. Proc., 41, 2607, 10.1016/j.transproceed.2009.06.119 Ryan, 2007, Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells, Clin. Exp. Immunol., 149, 353, 10.1111/j.1365-2249.2007.03422.x Opitz, 2009, Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R, Stem Cells, 27, 909, 10.1002/stem.7 <http://www.osiristx.com/pdf/PR%20123%2008Sep09%20Phase%20III%20GvHD%20Topline%20Results.pdf>. Le Blanc, 2008, Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study, Lancet, 371, 1579, 10.1016/S0140-6736(08)60690-X Ning, 2008, The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study, Leukemia, 22, 593, 10.1038/sj.leu.2405090 Ball, 2008, Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia, Leukemia, 22, 1256, 10.1038/sj.leu.2405013 Ringden, 2006, Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease, Transplantation, 81, 1390, 10.1097/01.tp.0000214462.63943.14 Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439, 10.1016/S0140-6736(04)16104-7 Muller, 2008, Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation, Blood Cells Mol. Dis., 40, 25, 10.1016/j.bcmd.2007.06.021 Horwitz, 2002, Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone, Proc. Natl. Acad. Sci. USA, 99, 8932, 10.1073/pnas.132252399 Koc, 2002, Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH), Bone Marrow Transplant., 30, 215, 10.1038/sj.bmt.1703650 Mazzini, 2009, Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a Phase I clinical trial, Exp. Neurol. Sun, 2009, Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans, Stem Cells, 27, 1421, 10.1002/stem.68 Kharaziha, 2009, Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial, Eur. J. Gastroenterol. Hepatol., 21, 1199, 10.1097/MEG.0b013e32832a1f6c Garcia-Olmo, 2009, Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial, Dis. Colon. Rectum., 52, 79, 10.1007/DCR.0b013e3181973487 Le Blanc, 2007, Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells, Leukemia, 21, 1733, 10.1038/sj.leu.2404777 Lazarus, 2005, Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients, Biol. Blood Marrow Transplant., 11, 389, 10.1016/j.bbmt.2005.02.001 Ball, 2007, Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation, Blood, 110, 2764, 10.1182/blood-2007-04-087056 Imberti, 2007, Insulin-like growth factor-1 sustains stem cell mediated renal repair, J. Am. Soc. Nephrol., 18, 2921, 10.1681/ASN.2006121318 Sadat, 2007, The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF, Biochem. Biophys. Res. Commun., 363, 674, 10.1016/j.bbrc.2007.09.058 Lee, 2009, Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung, Proc. Natl. Acad. Sci. USA, 106, 16357, 10.1073/pnas.0907996106 Mackenzie, 2002, Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice, J. Pediatr. Surg., 37, 1058, 10.1053/jpsu.2002.33844 Chan, 2007, Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse, Stem Cells, 25, 875, 10.1634/stemcells.2006-0694 Feng, 2008, Dynamic distribution of bone marrow-derived mesenchymal stromal cells and change of pathology after infusing into mdx mice, Cytotherapy, 10, 254, 10.1080/14653240802020381 Shabbir, 2009, Muscular dystrophy therapy by nonautologous mesenchymal stem cells: muscle regeneration without immunosuppression and inflammation, Transplantation, 87, 1275, 10.1097/TP.0b013e3181a1719b Gang, 2009, Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery, Exp. Cell Res., 315, 2624, 10.1016/j.yexcr.2009.05.009 M.P. Murphy et al., Allogeneic endometrial regenerative cells: an “Off the shelf solution” for critical limb ischemia? J. Transl. Med. 6 (2008) 45. Hida, 2008, Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells, Stem Cells, 26, 1695, 10.1634/stemcells.2007-0826 Cui, 2007, Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation, Mol. Biol. Cell, 18, 1586, 10.1091/mbc.E06-09-0872 Zhong, 2009, Feasibility investigation of allogeneic endometrial regenerative cells, J. Transl. Med., 7, 15, 10.1186/1479-5876-7-15 Ichim, 2008, Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy, Reprod. Biomed. Online, 16, 898, 10.1016/S1472-6483(10)60159-9 Urban, 2008, Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes, Stem Cells, 26, 244, 10.1634/stemcells.2007-0267 Otto, 2009, The origin, molecular regulation and therapeutic potential of myogenic stem cell populations, J. Anat., 215, 477, 10.1111/j.1469-7580.2009.01138.x Nunes, 2007, Stem cells from umbilical cord blood differentiate into myotubes and express dystrophin in vitro only after exposure to in vivo muscle environment, Biol. Cell, 99, 185, 10.1042/BC20060075 Jazedje, 2009, Stem cells from umbilical cord blood do have myogenic potential, with, without differentiation induction in vitro, J. Transl. Med., 7, 6, 10.1186/1479-5876-7-6