Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure

PLoS ONE - Tập 2 Số 9 - Trang e941
Biju Parekkadan1,2, Daan van Poll1,3, Kazuhiro Suganuma1, Edward A. Carter1, François Berthiaume1, Arno W. Tilles1, Martin L. Yarmush1,2
1Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America
2Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
3Department of Surgery, University Medical Center, University of Utrecht, Utrecht, The Netherlands

Tóm tắt

Từ khóa


Tài liệu tham khảo

AJ Strain, 2002, A bioartificial liver–state of the art., Science, 295, 1005, 10.1126/science.1068660

M Shinoda, 2007, A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats., J Surg Res, 137, 130, 10.1016/j.jss.2006.08.009

M Shinoda, 2006, Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist., Tissue Eng, 12, 1313, 10.1089/ten.2006.12.1313

F Dazzi, 2006, The role of mesenchymal stem cells in haemopoiesis., Blood Rev, 20, 161, 10.1016/j.blre.2005.11.002

KW Liechty, 2000, Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep., Nat Med, 6, 1282, 10.1038/81395

K Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells., Lancet, 363, 1439, 10.1016/S0140-6736(04)16104-7

S Aggarwal, 2005, Human mesenchymal stem cells modulate allogeneic immune cell responses., Blood, 105, 1815, 10.1182/blood-2004-04-1559

Y Zhang, 2004, Simultaneous injection of bone marrow cells and stromal cells into bone marrow accelerates hematopoiesis in vivo., Stem Cells, 22, 1256, 10.1634/stemcells.2004-0173

R Meisel, 2004, Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation., Blood, 103, 4619, 10.1182/blood-2003-11-3909

S Beyth, 2005, Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness., Blood, 105, 2214, 10.1182/blood-2004-07-2921

B Maitra, 2004, Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation., Bone Marrow Transplant, 33, 597, 10.1038/sj.bmt.1704400

M Gnecchi, 2005, Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells., Nat Med, 11, 367, 10.1038/nm0405-367

M Gnecchi, 2006, Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement., Faseb J, 20, 661, 10.1096/fj.05-5211com

M Shito, 2001, A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha., Dig Dis Sci, 46, 1700, 10.1023/A:1010653504568

B Parekkadan, 2007, Immunomodulation of Activated Hepatic Stellate Cells by Mesenchymal Stem Cells., Biochem Biophys Res Commun.