Menin/PRMT5/Hedgehog Signaling: A Potential Target for the Treatment of Multiple Endocrine Neoplasia Type 1 Tumors
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A study of GDC-0449 (hedgehog pathway inhibitor) in patients treated with GDC-0449 in a previous Genentech-sponsored Phase I or II cancer study. http://clinicaltrials.gov/ct2/show/NCT00959647?term=NCT00959647&rank=1
GDC-0449 and erlotinib hydrochloride with or without gemcitabine hydrochloride in treating patients with metastatic pancreatic cancer or solid tumors that cannot be removed by surgery. http://clinicaltrials.gov/ct2/show/NCT00878163?term=NCT00878163&rank=1