Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes

Journal of Controlled Release - Tập 112 - Trang 240-248 - 2006
Sabine Boeckle1, Julia Fahrmeir1, Wolfgang Roedl1, Manfred Ogris1, Ernst Wagner1
1Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, D-81377 Munich, Germany

Tài liệu tham khảo

Zuber, 2001, Towards synthetic viruses, Adv. Drug Deliv. Rev., 52, 245, 10.1016/S0169-409X(01)00213-7 Wagner, 2004, Strategies to improve DNA polyplexes for in vivo gene transfer: will “artificial viruses” be the answer?, Pharm. Res., 21, 8, 10.1023/B:PHAM.0000012146.04068.56 Kursa, 2003, Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer, Bioconjug. Chem., 14, 222, 10.1021/bc0256087 Wolschek, 2002, Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice, Hepatology, 36, 1106, 10.1053/jhep.2002.36372 Baker, 1997, Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier, Nucleic Acids Res., 25, 1950, 10.1093/nar/25.10.1950 Uherek, 1998, A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery, J. Biol. Chem., 273, 8835, 10.1074/jbc.273.15.8835 Plank, 1992, Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand, Bioconjug. Chem., 3, 533, 10.1021/bc00018a012 Sparrow, 1998, Synthetic peptide-based DNA complexes for nonviral gene delivery, Adv. Drug Deliv. Rev., 30, 115, 10.1016/S0169-409X(97)00111-7 Ogris, 2001, Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors, J. Biol. Chem., 276, 47550, 10.1074/jbc.M108331200 Bettinger, 2001, Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells, Nucleic Acids Res., 29, 3882, 10.1093/nar/29.18.3882 Boeckle, 2005, C- versus N-terminally linked melittinpolyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes, J. Gene Med., 7, 1335, 10.1002/jgm.783 Plank, 1994, The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems, J. Biol. Chem., 269, 12918, 10.1016/S0021-9258(18)99963-1 Mechtler, 1997, Gene transfer mediated by influenza virus peptides: the role of peptide sequence, New J. Chem., 21, 105 Werkmeister, 2002, Sequence requirements for the activity of membrane-active peptides, J. Pept. Res., 60, 232, 10.1034/j.1399-3011.2002.21011.x Boeckle, 2004, Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer, J. Gene Med., 6, 1102, 10.1002/jgm.598 Snyder, 1975, An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines, Anal. Biochem., 64, 284, 10.1016/0003-2697(75)90431-5 Walker, 2005, Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo, Molec. Ther., 11, 418, 10.1016/j.ymthe.2004.11.006 Shir, 2006, EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice, PLoS Med., 3, e6, 10.1371/journal.pmed.0030006 Blondelle, 1991, Hemolytic and antimicrobial activities of the twentyfour individual omission analogues of melittin, Biochemistry, 30, 4671, 10.1021/bi00233a006