Melatonin: therapeutic and clinical utilization

International Journal of Clinical Practice - Tập 61 Số 5 - Trang 835-845
Armağan Altun1, Betül Uğur-Altun2
1Departments of Cardiology
2Endocrinology & Metabolism, Medical School, Trakya University, Edirne, Turkey

Tóm tắt

Từ khóa


Tài liệu tham khảo

Witt-Enderby, 2003, Melatonin receptors and their regulation: biochemical and structural mechanisms, Life Sci, 72, 2183, 10.1016/S0024-3205(03)00098-5

Scheer, 2005, Melatonin, sleep and circadian rhythms, Sleep Med Rev, 9, 5, 10.1016/j.smrv.2004.11.004

Cardinali, 2002, Melatonin in sleep disorders and jet lag, Neuro Endocrinol Lett, 23, 9

Buscemi, 2004, Melatonin for treatment of sleep disorders, Evid Rep Technol Assess (Summ), 108, 1

Herxheimer, 2004, Jet lag, Clinical Evid, 12, 2394

Beaumont, 2004, Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel, J Appl Physiol, 96, 50, 10.1152/japplphysiol.00940.2002

Zhdanova, 2005, Melatonin as a hypnotic: pro, Sleep Med Rev, 9, 51, 10.1016/j.smrv.2004.04.003

Brzezinski, 2005, Effects of exogenous melatonin on sleep: a meta-analysis, Sleep Med Rev, 9, 41, 10.1016/j.smrv.2004.06.004

Santhi, 2005, Scheduling of sleep/darkness affects the circadian phase of night shift workers, Neurosci Lett, 384, 316, 10.1016/j.neulet.2005.04.094

Van Den Heuvel, 2005, Melatonin as a hypnotic: con, Sleep Med Rev, 9, 71, 10.1016/j.smrv.2004.07.001

Arendt, 2005, Melatonin as a chronobiotic, Sleep Med Rev, 9, 25, 10.1016/j.smrv.2004.05.002

Claustrat, 2005, The basic physiology and pathophysiology of melatonin, Sleep Med Rev, 9, 11, 10.1016/j.smrv.2004.08.001

Jonas, 2003, Impaired nocturnal melatonin secretion in non-dipper hypertensive patients, Blood Press, 12, 19

Zeman, 2005, Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile, Life Sci, 76, 1795, 10.1016/j.lfs.2004.08.034

Esquifino, 2004, Circadian organization of the immune response: a role for melatonin, Clin Appl Immunol Rev, 4, 423, 10.1016/j.cair.2004.08.002

Guerrero, 2002, Melatonin-immune system relationships, Curr Top Med Chem, 2, 167, 10.2174/1568026023394335

Maestroni, 1993, The immunoneuroendocrine role of melatonin, J Pineal Res, 14, 1, 10.1111/j.1600-079X.1993.tb00478.x

Liu, 2001, Pineal indoles stimulate the gene expression of immunomodulating cytokines, J Neural Transm, 108, 397, 10.1007/s007020170061

Garcia-Maurino, 2000, Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines, J Pineal Res, 29, 129, 10.1034/j.1600-079X.2000.290301.x

Molinero, 2000, Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin and a1 and thymulin concentrations: observations in rats and humans, J Neuroimmunol, 103, 108, 10.1016/S0165-5728(99)00237-4

Sainz, 1999, Melatonin regulates glucocorticoid receptor: an answer to its antiapoptic action in thymus, FASEB J, 13, 1547, 10.1096/fasebj.13.12.1547

Withyachumnarnkul, 1990, Interferon-gamma modulates melatonin production in rat pineal glands in organ culture, J Interferon Res, 10, 403, 10.1089/jir.1990.10.403

Sutherland, 2002, Immunomodulatory effects of melatonin in asthma, Am J Respir Crit Care Med, 166, 1055, 10.1164/rccm.200204-356OC

Sulli, 2002, Melatonin serum levels in rheumatoid arthritis, Ann N Y Acad Sci, 966, 276, 10.1111/j.1749-6632.2002.tb04227.x

Cutolo, 2005, The melatonin-cytokine connection in rheumatoid arthritis, Ann Rheum Dis, 64, 1109, 10.1136/ard.2005.038588

Cutolo, 2005, Circadian rhythms and arthritis, Rheum Dis Clin North Am, 31, 115, 10.1016/j.rdc.2004.09.005

Maestroni, 2005, Does melatonin play a disease-promoting role in rheumatoid arthritis, J Neuroimmunol, 158, 106, 10.1016/j.jneuroim.2004.08.015

Sutherland, 2003, Elevated serum melatonin is associated with the nocturnal worsening of asthma, J Allergy Clin Immunol, 112, 513, 10.1016/S0091-6749(03)01717-2

Campos, 2004, Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study, Am J Respir Crit Care Med, 170, 947, 10.1164/rccm.200404-488OC

Cagnoni, 1995, Melatonin for treatment of chronic refractory sarcoidosis, Lancet, 34, 1229, 10.1016/S0140-6736(95)92935-5

Calvo, 2002, Melatonin triggers Crohn's disease symptoms, J Pineal Res, 32, 277, 10.1034/k.1600-079X.2002.01881.x

Blask, 2002, Melatonin as a chronobiotic/anti-cancer agent: cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy, Curr Top Med Chem, 2, 113, 10.2174/1568026023394407

Sauer, 2001, Polyunsaturated fatty acids, melatonin and cancer progression, Biochem Pharmacol, 61, 1455, 10.1016/S0006-2952(01)00634-7

Lissoni, 2002, Is there a role for melatonin in supportive care, Support Care Cancer, 10, 110, 10.1007/s005200100281

Lissoni, 2003, Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study, Neuro Endocrinol Lett, 24, 259

Lissoni, 2003, Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial, J Pineal Res, 35, 12, 10.1034/j.1600-079X.2003.00032.x

Ugur-Altun, 2006, Melatonin: From Molecules to Therapy

Sanchez-Barcelo, 2005, Melatonin-estrogen interactions in breast cancer, J Pineal Res, 38, 217, 10.1111/j.1600-079X.2004.00207.x

Vijayalaxmi, 2002, Melatonin: from basic research to cancer treatment clinics, J Clin Oncol, 20, 2575, 10.1200/JCO.2002.11.004

Reiter, 2004, Mechanisms of cancer inhibition by melatonin, J Pineal Res, 3, 213, 10.1111/j.1600-079X.2004.00165.x

Reiter, 2002, Melatonin: reducing the toxicity and increasing the efficacy of drugs, J Pharm Pharmacol, 54, 1299, 10.1211/002235702760345374

Lissoni, 1996, Is there a rold for melatonin in the treatment of neoplastic cachexia, Eur J Cancer, 32A, 1340, 10.1016/0959-8049(96)00136-0

Persson, 2005, Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study, Nutrition, 21, 170, 10.1016/j.nut.2004.05.026

Lercher, 2000, Melatonin in patients with coronary artery disease, hypertensive heart disease and dilated cardiomyopathy, Atherosclerosis, 151, 203, 10.1016/S0021-9150(00)80926-0

Rapoport, 2000, Melatonin production in hypertensive patients, Klin Med (Mosk), 78, 21

Lusardi, 2000, Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study, Br J Clin Pharmacol, 49, 423, 10.1046/j.1365-2125.2000.00195.x

Escames, 2004, Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine, J Hypertens, 22, 629, 10.1097/00004872-200403000-00027

Scheer, 2004, Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension, Hypertension, 43, 192, 10.1161/01.HYP.0000113293.15186.3b

Yaprak, 2003, Decreased nocturnal synthesis of melatonin in patients with coronary artery disease, Int J Cardiol, 89, 103, 10.1016/S0167-5273(02)00461-8

Girotti, 2000, Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease, J Pineal Res, 29, 138, 10.1034/j.1600-079X.2000.290302.x

Sakotnik, 1999, Decreased melatonin synthesis in patients with coronary artery disease, Eur Heart J, 20, 1314, 10.1053/euhj.1999.1527

Marktl, 1997, Melatonin and coronary heart disease, Wiener Klin Wochenschr, 109, 747

Brugger, 1995, Impaired nocturnal secretion of melatonin in coronary heart disease, Lancet, 345, 1408, 10.1016/S0140-6736(95)92600-3

Dominguez-Rodriguez, 2005, Elevated levels of oxidized low-density lipoprotein and impaired nocturnal synthesis of melatonin in patients with myocardial infarction, Atherosclerosis, 180, 101, 10.1016/j.atherosclerosis.2004.11.003

Dominguez-Rodriguez, 2002, Decreased nocturnal melatonin levels during acute myocardial infarction, J Pineal Res, 33, 248, 10.1034/j.1600-079X.2002.02938.x

Tutuncu, 2005, Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy, J Pineal Res, 39, 43, 10.1111/j.1600-079X.2005.00213.x

Cavallo, 2004, Blood pressure-lowering effect of melatonin in type 1 diabetes, J Pineal Res, 36, 262, 10.1111/j.1600-079X.2004.00126.x

Cavallo, 2004, Blood pressure response to melatonin in type 1 diabetes, Pediatr Diabetes, 5, 26, 10.1111/j.1399-543X.2004.00031.x

O'Brien, 1986, Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy, Clin Endocrinol (Oxf), 24, 359, 10.1111/j.1365-2265.1986.tb01639.x

Girotti, 2003, Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure, Endocrine, 22, 245, 10.1385/ENDO:22:3:245

Sandyk, 1994, The relationship between melatonin secretion and serum cholesterol in patients with multiple sclerosis, Int J Neurosci, 76, 81, 10.3109/00207459408985994

Rindone, 1997, Effect of melatonin on serum lipids in patients with hypercholesterolemia: a pilot study, Am J Ther, 4, 409, 10.1097/00045391-199711000-00012

Pittalis, 1997, Effect of a chronic therapy with the pineal hormone melatonin on cholesterol levels in idiopathic hypercholesterolemic patients, Recenti Prog Med, 88, 401

Altun, 2002, Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X, Neurosci Lett, 327, 143, 10.1016/S0304-3940(02)00368-3

Altun, 2006, Melatonin: From Molecules to Therapy

Zanoboni, 1978, Effect of pinealectomy on arterial blood pressure and food and water intake in the rat, J Endocrinol Invest, 1, 125, 10.1007/BF03350359

Holmes, 1976, The effect of melatonin on pinealectomy-induced hypertension in the rat, Br J Pharmacol, 56, 360

Nishiyama, 2001, Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men, Am Heart J, 141, E9, 10.1067/mhj.2001.114368

Cagnacci, 1998, Influences of melatonin administration on the circulation of women, Am J Physiol, 274, R335

Arangino, 1999, Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men, Am J Cardiol, 83, 1417, 10.1016/S0002-9149(99)00112-5

Lusardi, 1997, Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects, Blood Press Monit, 2, 99

Birau, 1981, Hypotensive effect of melatonin in essential hypertension, IRCS Med Sci, 9, 906

Zaslavskaya, 2003, Individualized time series-based assessment of melatonin effects on blood pressure: model for pediatricians, Neuroendocrinol Lett, 24, 238

Arendt, 1985, Some effects of melatonin and the control of its secretion in humans, Ciba Found Symp, 117, 266

Mishima, 2000, Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons, Chronobiol Int, 17, 419, 10.1081/CBI-100101055

Sharkey, 2002, Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study, Am J Physiol, 282, R454

Santana, 1989, Role of postsynaptic alpha-adrenergic receptors in the beta-adrenergic stimulation of melatonin production in the Syrian hamster pineal gland in organ culture, J Pineal Res, 7, 13, 10.1111/j.1600-079X.1989.tb00437.x

McLeod, 1995, Preliminary evidence of a synergistic alpha1- and beta1-adrenoceptor regulation of rat pineal hydroxyindole-O-methyltranferase, Gen Comp Endocrinol, 97, 283, 10.1006/gcen.1995.1028

Arendt, 1985, Immunoassasy of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol, J Clin Endocrinol Metab, 60, 1166, 10.1210/jcem-60-6-1166

Cowen, 1985, Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration, Br J Clin Pharmacol, 19, 258, 10.1111/j.1365-2125.1985.tb02640.x

Brismar, 1987, Depressed melatonin secretion in patients with nightmares due to beta-adrenoceptor blocking drugs, Acta Med Scand, 221, 155, 10.1111/j.0954-6820.1987.tb01260.x

Rommel, 1994, Influence of chronic beta-adrenoceptor blocker treatment on melatonin secretion and sleep quality in patients with essential hypertension, J Neural Transm Gen Sect, 95, 39, 10.1007/BF01283029

Stoschitzky, 1999, Influence of beta-blockers on melatonin release, Eur J Clin Pharmacol, 55, 111, 10.1007/s002280050604

Zaslavskaia, 1998, Comparative study of the effectiveness of Cozaar monotherapy and Cozaar and melatonin combined therapy in aged patients with hypertension, Klin Med (Mosk), 76, 49

Zaslavskaia, 2000, Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension, Klin Med (Mosk), 78, 41

Cagnacci, 1992, Melatonin: a major regulator of the circadian rhythm of core temperature in humans, J Clin Endocrinol Metab, 75, 447

Ahmed, 2005, Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity, Bioorg Med Chem, 13, 1847, 10.1016/j.bmc.2004.10.066

Sahna, 2003, Melatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrations, J Pineal Res, 35, 257, 10.1034/j.1600-079X.2003.00084.x

Kim, 2005, Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin, J Cardiovasc Pharmacol, 46, 200, 10.1097/01.fjc.0000171750.97822.a2

Dziegiel, 2003, Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication, J Pineal Res, 35, 183, 10.1034/j.1600-079X.2003.00079.x

Paskaloglu, 2004, Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum, Eur J Pharmacol, 499, 345, 10.1016/j.ejphar.2004.08.002

Zaslavskaya, 2004, Melatonin, refractory hypertension, myocardial ischemia and other challenges in nightly blood pressure lowering, Biomed Pharmacother, 58, S129, 10.1016/S0753-3322(04)80021-0

O'Rourke, 2003, Melatonin inhibits nitrate tolerance in isolated coronary arteries, Br J Pharmacol, 139, 1326, 10.1038/sj.bjp.0705383

Gazi, 2006, Contrast-induced nephropathy: preventive and protective effects of melatonin, J Pineal Res, 41, 53, 10.1111/j.1600-079X.2006.00336.x

Szarszoi, 2001, Effects of melatonin on ischemia and reperfusion injury of the rat heart, Cardiovasc Drugs Ther, 15, 251, 10.1023/A:1011920407691

Lee, 2002, Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo, J Pineal Res, 33, 72, 10.1034/j.1600-079X.2002.01869.x

Sahna, 2002, Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin, J Pineal Res, 33, 234, 10.1034/j.1600-079X.2002.02924.x

Sahna, 2002, Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced, J Pineal Res, 32, 194, 10.1034/j.1600-079x.2002.1o853.x

Sahna, 2005, Protective effects of melatonin on myocardial ischemia reperfusion induced infarct size and oxidative changes, Physiol Res, 55, 491, 10.33549/physiolres.930664

Acikel, 2003, Protective effects of melatonin against myocardial injury induced by isoproterenol in rats, J Pineal Res, 35, 75, 10.1034/j.1600-079X.2003.00056.x

Claustrat, 2003, Melatonin: Biological Basis of its Function in Health and Disease, 218

Claustrat, 2004, Melatonin secretion is supersensitive to light in migraine, Cephalalgia, 24, 128, 10.1111/j.1468-2982.2004.00645.x

Pringsheim, 2002, Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function, Can J Neurol Sci, 29, 33, 10.1017/S0317167100001694

Peres, 2005, Melatonin, the pineal gland and their implications for headache disorders, Cephalalgia, 25, 403, 10.1111/j.1468-2982.2005.00889.x

Beloosesky, 2002, Melatonin rhythms in stroke patients, Neurosci Lett, 319, 103, 10.1016/S0304-3940(01)02568-X

Fiorina, 1999, Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients, Scand J Immunol, 50, 228, 10.1046/j.1365-3083.1999.00579.x

Pang, 1990, Acute cerebral hemorrhage changes the nocturnal surge of plasma melatonin in humans, J Pineal Res, 9, 193, 10.1111/j.1600-079X.1990.tb00708.x

Reiter, 2005, When melatonin gets on your nerves: its beneficial actions in experimental models of stroke, Exp Biol Med (Maywood), 230, 104, 10.1177/153537020523000205

Macleod, 2005, Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke, J Pineal Res, 38, 35, 10.1111/j.1600-079X.2004.00172.x

Srinivasan, 2005, Role of melatonin in neurodegenerative diseases, Neurotox Res, 7, 293, 10.1007/BF03033887

Mayo, 2005, Melatonin and Parkinson's disease, Endocrine, 27, 169, 10.1385/ENDO:27:2:169

Wu, 2005, The human pineal gland and melatonin in aging and Alzheimer's disease, J Pineal Res, 38, 145, 10.1111/j.1600-079X.2004.00196.x

Gupta, 2004, Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial, Epilepsy Behav, 5, 316, 10.1016/j.yebeh.2004.01.012

Molina-Carballo, 1997, Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years experience, J Pineal Res, 23, 97, 10.1111/j.1600-079X.1997.tb00341.x

Gordon, 2000, The therapeutics of melatonin: a paediatric perspective, Brain Dev, 22, 213, 10.1016/S0387-7604(00)00120-0

Sheldon, 1998, Pro-convulsant effects of oral melatonin in neurologically disabled children, Lancet, 351, 1254, 10.1016/S0140-6736(05)79321-1

Pacchierotti, 2001, Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry, Front Neuroendocrinol, 22, 18, 10.1006/frne.2000.0202

Claustrat, 1984, A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression, Biol Psychiatry, 19, 1215

Voderholzer, 1997, Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep, Psychiatry Res, 71, 151, 10.1016/S0165-1781(97)00048-6

Crasson, 2004, Serum melatonin and urinary 6-sulfatoxymelatonin in major depression, Psychoneuroendocrinology, 29, 1, 10.1016/S0306-4530(02)00123-3

Rabe-Jablonska, 2001, Diurnal profile of melatonin secretion in the acute phase of major depression and in remission, Med Sci Monit, 7, 946

Magnusson, 2003, Seasonal affective disorder: an overview, Chronobiol Int, 20, 189, 10.1081/CBI-120019310

Karadottir, 2001, Melatonin secretion in SAD patients and healthy subjects matched with respect to age and sex, Int J Circumpolar Health, 60, 548, 10.1080/25761900.2022.12220631

Arendt, 1992, Plasma melatonin levels in anorexia nervosa, Br J Psychiatry, 161, 361, 10.1192/bjp.161.3.361

Balan, 2003, The relation between the clinical subtypes of delirium and the urinary level of 6-SMT, J Neuropsychiatry Clin Neurosci, 15, 363, 10.1176/appi.neuropsych.15.3.363

Vijayalaxmi, 2004, Int J Radiat Oncol Biol Phys, 59, 639

Sebra, 2000, Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment, J Pineal Res, 29, 193, 10.1034/j.1600-0633.2002.290401.x

Jahnke, 1999, Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats, Toxicol Sci, 50, 271, 10.1093/toxsci/50.2.271