Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry

Journal of Pineal Research - Tập 18 Số 1 - Trang 28-31 - 1995
R. Dubbels1, Rüssel J. Reiter2, E. Klenke3, Anna Goebel4, E. Schnakenberg3, Chr Ehlers3, HANS WALTER SCHIWARA4, W. Schloot3
1Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
2Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antionio, Texas USA
3Center of Human Genetics and Genetic Counselling, University of Bremen, Bremen, Germany
4Gemeinschaftslabor Dr. Schiwara et al., Bremen, Germany

Tóm tắt

Abstract: Melatonin, the chief hormone of the pineal gland in vertebrates, is widely distributed in the animal kingdom. Among many functions, melatonin synchronizes circadian and circannual rhythms, stimulates immune function, may increase life span, inhibits growth of cancer cells in vitro and cancer progression and promotion in vivo, and was recently shown to be a potent hydroxyl radical scavenger and antioxidant. Hydroxyl radicals are highly toxic by‐products of oxygen metabolism that damage cellular DNA and other macromolecules. Herein we report that melatonin, in varying concentrations, is also found in a variety of plants. Melatonin concentrations, measured in nine different plants by radioimmunoassay, ranged from 0 to 862 pg melatonin/mg protein. The presence of melatonin was verified by gas chromatography/mass spectrometry. Our findings suggest that the consumption of plant materials that contain high levels of melatonin could alter blood melatonin levels of the indole as well as provide protection of macromolecules against oxidative damage.

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Tài liệu tham khảo

10.1111/j.1600-079X.1994.tb00119.x

Blask D.E., 1993, Melatonin, 447

10.1016/0003-2697(76)90527-3

Gentile A.G., 1971, Susceptibility of Lycopersion ssp. to ozone injury, J. Am. Soc. Hortic. Sci., 96, 94, 10.21273/JASHS.96.1.94

10.4141/cjps91-037

10.1016/0016-6480(81)90106-4

10.1016/0269-7491(91)90076-9

Hill S.M., 1988, Effects of the pineal hormone melatonin on proliferation and morphological characteristics of human breast cancer cells (MCF‐7) in culture, Cancer Res., 48, 6121

10.1007/BF01451037

10.1016/0024-3205(94)00928-7

10.1016/0304-4238(92)90139-4

Namboodiri M.A.A., 1983, Methods in Biogenic Amine Research, 549

10.1007/BF01134354

10.1111/j.1600-079X.1993.tb00498.x

10.1016/1043-2760(91)90055-R

Reiter R.J., 1991, Melatonin: That ubiqiutously acting pineal hormone, News Physiol. Sci., 6, 223

Reiter R.J., 1993, Antioxidant capacity of melatonin: A novel action not requiring a receptor, Neu-roendocrinol. Lett., 15, 103

Reiter R.J., 1994, Advances in Pineal Research, 211

10.1111/j.1749-6632.1994.tb56817.x

10.1210/endo-102-2-582

10.1126/science.7423204

10.1111/j.1600-079X.1994.tb00102.x

10.1002/bms.1200101207

Tan D.X., 1993, Melatonin: A potent, endogenous hydroxyl radical scavenger, Endocrine J., 1, 57

10.1016/0304-3835(93)90076-L

Tenga A.Z., 1990, Recovery of tomato plants from ozone injury, Hortiscience, 25, 1230, 10.21273/HORTSCI.25.10.1230

10.1016/0003-9861(59)90516-8

10.1016/0024-3205(85)90412-6

10.1111/j.2042-7158.1958.tb10345.x

10.1159/000123170

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Journal of Pineal Research

Tập 18 Số 1

28-31

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