Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

Genes and Diseases - Tập 9 - Trang 494-509 - 2022
Ruigong Zhu1, Xian Ji1, Xuan Wu1, Jiajing Chen1, Xuesong Li1, Hong Jiang1, Haiping Fu1, Hui Wang1, Zhe Lin1, Xin Tang1, Shixiu Sun1, Qingguo Li2, Bingjian Wang3, Hongshan Chen1,2,4,3
1Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, PR China
2Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210003, PR China
3Department of Cardiology, Huai'an First People's Hospital Affiliated with Nanjing Medical University, Huai'an, Jiangsu 223399, PR China
4Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, PR China

Tài liệu tham khảo

He, 2017, Senescence in health and disease, Cell, 169, 1000, 10.1016/j.cell.2017.05.015 Childs, 2017, Senescent cells: an emerging target for diseases of ageing, Nat Rev Drug Discov, 16, 718, 10.1038/nrd.2017.116 Sharpless, 2015, Forging a signature of in vivo senescence, Nat Rev Cancer, 15, 397, 10.1038/nrc3960 Tamura, 2017, Long-term melatonin treatment delays ovarian aging, J Pineal Res, 62, e12381, 10.1111/jpi.12381 Zhang, 2019, Melatonin regulates the activities of ovary and delays the fertility decline in female animals via MT1/AMPK pathway, J Pineal Res, 66, e12550, 10.1111/jpi.12550 Sunkara, 2012, Should androgen supplementation be used for poor ovarian response in IVF?, Hum Reprod, 27, 637, 10.1093/humrep/der464 Dou, 2017, Short-term rapamycin treatment increases ovarian lifespan in young and middle-aged female mice, Aging Cell, 16, 825, 10.1111/acel.12617 Yang, 2019, Moxibustion improves ovary function by suppressing apoptosis events and upregulating antioxidant defenses in natural aging ovary, Life Sci, 229, 166, 10.1016/j.lfs.2019.05.040 Acosta, 2013, A complex secretory program orchestrated by the inflammasome controls paracrine senescence, Nat Cell Biol, 15, 978, 10.1038/ncb2784 Papatheodoridi, 2020, The role of senescence in the development of nonalcoholic fatty liver disease and progression to nonalcoholic steatohepatitis, Hepatology, 71, 363, 10.1002/hep.30834 Wiggins, 2019, IL-1alpha cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype, Aging Cell, 18, e12946, 10.1111/acel.12946 Coppe, 2010, The senescence-associated secretory phenotype: the dark side of tumor suppression, Annu Rev Pathol, 5, 99, 10.1146/annurev-pathol-121808-102144 Roundtree, 2017, Dynamic RNA modifications in gene expression regulation, Cell, 169, 1187, 10.1016/j.cell.2017.05.045 Meyer, 2012, Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons, Cell, 149, 1635, 10.1016/j.cell.2012.05.003 Yu, 2019, m6A reader YTHDF2 regulates LPS-induced inflammatory response, Int J Mol Sci, 20, 1323, 10.3390/ijms20061323 Nilsen, 2014, Molecular biology. Internal mRNA methylation finally finds functions, Science, 343, 1207, 10.1126/science.1249340 Rauch, 2018, Targeted m(6)A reader proteins to study epitranscriptomic regulation of single RNAs, J Am Chem Soc, 140, 11974, 10.1021/jacs.8b05012 Lee, 2020, Molecular mechanisms driving mRNA degradation by m(6)A modification, Trends Genet, 36, 177, 10.1016/j.tig.2019.12.007 Li, 2017, NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation, J Cell Biochem, 118, 2587, 10.1002/jcb.25957 Huang, 2019, Cyclophosphamide regulates N6-methyladenosine and m6A RNA enzyme levels in human granulosa cells and in ovaries of a premature ovarian aging mouse model, Front Endocrinol (Lausanne), 10, 415, 10.3389/fendo.2019.00415 Jahanban-Esfahlan, 2018, Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes, Br J Pharmacol, 175, 3230, 10.1111/bph.13898 Majidinia, 2018, The role of melatonin, a multitasking molecule, in retarding the processes of ageing, Ageing Res Rev, 47, 198, 10.1016/j.arr.2018.07.010 Suofu, 2017, Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release, Proc Natl Acad Sci U S A, 114, E7997, 10.1073/pnas.1705768114 He, 2016, Mitochondria synthesize melatonin to ameliorate its function and improve mice oocyte's quality under in vitro conditions, Int J Mol Sci, 17, 939, 10.3390/ijms17060939 Bizzarri, 2013, Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review, Expert Opin Ther Targets, 17, 1483, 10.1517/14728222.2013.834890 Rong, 2019, Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice, J Pineal Res, 66, e12561, 10.1111/jpi.12561 Nicke, 2005, Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells, Mol Cell, 20, 673, 10.1016/j.molcel.2005.10.038 Chen, 2015, MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype, Mol Cell, 59, 719, 10.1016/j.molcel.2015.07.011 Samsonraj, 2013, Telomere length analysis of human mesenchymal stem cells by quantitative PCR, Gene, 519, 348, 10.1016/j.gene.2013.01.039 Lin, 2019, RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail, Nat Commun, 10, 2065, 10.1038/s41467-019-09865-9 Salles, 1999, Analysis of poly(A) tail lengths by PCR: the PAT assay, Methods Mol Biol, 118, 441 Lichinchi, 2016, Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells, Nat Microbiol, 1, 16011, 10.1038/nmicrobiol.2016.11 Chen, 2014, MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation, Nat Struct Mol Biol, 21, 981, 10.1038/nsmb.2903 Herranz, 2015, mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype, Nat Cell Biol, 17, 1205, 10.1038/ncb3225 Oubaha, 2016, Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy, Sci Transl Med, 8, 362ra144, 10.1126/scitranslmed.aaf9440 Zhang, 2019, Can ovarian aging be delayed by pharmacological strategies?, Aging (Albany NY), 11, 817, 10.18632/aging.101784 Agarwal, 2005, Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity, Cancer Res, 65, 7378, 10.1158/0008-5472.CAN-05-1036 Ismail, 2000, Differential gene expression between normal and tumor-derived ovarian epithelial cells, Cancer Res, 60, 6744 Liu, 2018, Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway, Aging (Albany NY), 10, 2016, 10.18632/aging.101526 Lord, 2013, Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro, Biol Reprod, 88, 67, 10.1095/biolreprod.112.106450 Chuffa, 2011, Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat, Braz J Med Biol Res, 44, 217, 10.1590/S0100-879X2011007500018 Desrosiers, 1974, Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells, Proc Natl Acad Sci U S A, 71, 3971, 10.1073/pnas.71.10.3971 Chen, 2019, Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival, Am J Cancer Res, 9, 752 Wang, 2018, Novel insights on m(6)A RNA methylation in tumorigenesis: a double-edged sword, Mol Cancer, 17, 101, 10.1186/s12943-018-0847-4 Fu, 2014, Gene expression regulation mediated through reversible m(6)A RNA methylation, Nat Rev Genet, 15, 293, 10.1038/nrg3724 Shen, 2015, Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5, J Clin Endocrinol Metab, 100, E148, 10.1210/jc.2014-1893 Daoud, 2016, Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay, J Med Genet, 53, 200, 10.1136/jmedgenet-2015-103399 Yang, 2016, Increased N6-methyladenosine in human sperm RNA as a risk factor for asthenozoospermia, Sci Rep, 6, 24345, 10.1038/srep24345 Xiang, 2017, RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response, Nature, 543, 573, 10.1038/nature21671 Li, 2017, FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase, Cancer Cell, 31, 127, 10.1016/j.ccell.2016.11.017 Barbieri, 2017, Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control, Nature, 552, 126, 10.1038/nature24678 Vu, 2017, The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells, Nat Med, 23, 1369, 10.1038/nm.4416 Weng, 2018, METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification, Cell Stem Cell, 22, 191, 10.1016/j.stem.2017.11.016 Liu, 2019, CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1alpha-mediated glycolysis, Immunity, 50, 600, 10.1016/j.immuni.2019.01.021 Vizioli, 2020, Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence, Genes Dev, 34, 428, 10.1101/gad.331272.119 Wang, 2014, Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation, Proc Natl Acad Sci U S A, 111, 7683, 10.1073/pnas.1310972111 Jin, 2016, Senescence-associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells, Antioxid Redox Signal, 24, 471, 10.1089/ars.2015.6359 Yu, 2017, Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells, J Pineal Res, 63, e12405, 10.1111/jpi.12405 Fang, 2018, Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress, Aging (Albany NY), 10, 2954, 10.18632/aging.101602 Bae, 2018, Effects of melatonin and its underlying mechanism on ethanol-stimulated senescence and osteoclastic differentiation in human periodontal ligament cells and cementoblasts, Int J Mol Sci, 19, 1742, 10.3390/ijms19061742 Zhong, 2018, Circadian clock regulation of hepatic lipid metabolism by modulation of m(6)A mRNA methylation, Cell Rep, 25, 1816, 10.1016/j.celrep.2018.10.068 Zhang, 2019, Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction, Exp Mol Med, 51, 1, 10.1038/s12276-019-0273-8 Song, 2012, Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction, J Pineal Res, 53, 335, 10.1111/j.1600-079X.2012.01003.x Wang, 2017, Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig, Aging (Albany NY), 9, 1552, 10.18632/aging.101252 Hou, 2019, YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma, Mol Cancer, 18, 163, 10.1186/s12943-019-1082-3