Melancholic Symptoms During Concurrent Olanzapine and Fluoxetine

Annals of Clinical Psychiatry - Tập 12 - Trang 167-170 - 2000
Leigh Anne Nelson1, Conrad M. Swartz2
1Department of Psychiatry, St. Louis University School of Medicine, St. Louis
2Department of Psychiatry, Southern Illinois University School of Medicine, USA

Tóm tắt

The concomitant use of olanzapine and fluoxetine has been advocated for the treatment of various psychiatric disease states. We describe a case in which the combination of olanzapine and fluoxetine appears to have caused the psychopathology of melancholic depression requiring hospitalization in a 40-year-old female. Postulated mechanisms for this drug interaction, particularly CYP450 isoenzyme inhibition by fluoxetine, is discussed.

Tài liệu tham khảo

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