Megasatellites: một lớp mới của các lặp lại lớn được phát hiện trong nấm men gây bệnh Candida glabrata

Cellular and Molecular Life Sciences - Tập 67 - Trang 671-676 - 2009
Agnès Thierry1, Bernard Dujon1, Guy-Franck Richard1
1Unité de Génétique Moléculaire des Levures, Institut Pasteur, CNRS URA2171, Université Pierre et Marie Curie UFR 927, Paris, France

Tóm tắt

Megasatellite là các chuỗi DNA lặp lại theo kiểu dãy tandem được tạo thành từ các motif lớn; chúng được phát hiện ở nấm men Candida glabrata. Chúng phổ biến trong loài này (40 bản sao) nhưng chưa được tìm thấy ở bất kỳ hemiascomycete nào khác cho đến nay, đặt ra câu hỏi thú vị về nguồn gốc của chúng. Chúng chủ yếu được tìm thấy trong các gen mã hóa sản phẩm của màng tế bào, cho thấy rằng megasatellite có thể đã được chọn lọc vì một chức năng liên quan đến sự gắn kết tế bào hoặc khả năng gây bệnh. Vai trò giả thuyết của chúng trong việc thúc đẩy sự sắp xếp lại hệ gen bằng cách can thiệp vào sự sao chép DNA cũng sẽ được thảo luận.

Từ khóa

#Megasatellite #nấm men #Candida glabrata #lặp lại lớn #tái sắp xếp gen #khả năng gây bệnh

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