Medikamentöse Therapie bei Frauen – Was gilt es zu beachten?

citation_journal_title=N Engl J Med; citation_title=Enrollment of women in cardiovascular clinical trials funded by the national heart, lung, and blood institute; citation_author=DJ Harris, PS Douglas; citation_volume=343; citation_publication_date=2000; citation_pages=475-480; citation_doi=10.1056/NEJM200008173430706; citation_id=CR1 citation_journal_title=Clin Pharmacol Ther; citation_title=Underrepresentation of women in clinical drug trials; citation_author=DL Schmucker, ES Vesell; citation_volume=54; citation_publication_date=1993; citation_pages=11-15; citation_doi=10.1038/clpt.1993.102; citation_id=CR2 citation_journal_title=Nature; citation_title=Sex bias in trials and treatment must end; citation_author=AM Kim, CM Tingen, TK Woodruff; citation_volume=465; citation_publication_date=2010; citation_pages=688-689; citation_doi=10.1038/465688a; citation_id=CR3 citation_journal_title=JAMA; citation_title=Vitamin E in the primary prevention of cardiovascular disease and cancer: the women’s health study: a randomized controlled trial; citation_author=IM Lee, NR Cook, JM Gaziano, D Gordon, PM Ridker, JE Manson, CH Hennekens, JE Buring; citation_volume=294; citation_publication_date=2005; citation_pages=56-65; citation_doi=10.1001/jama.294.1.56; citation_id=CR4 citation_journal_title=JAMA; citation_title=Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial; citation_author=JE Rossouw, GL Anderson, RL Prentice, AZ LaCroix, C Kooperberg, ML Stefanick, RD Jackson, SA Beresford, BV Howard, KC Johnson, JM Kotchen, J Ockene; citation_volume=288; citation_publication_date=2002; citation_pages=321-333; citation_doi=10.1001/jama.288.3.321; citation_id=CR5 citation_journal_title=Ann Pharmacother; citation_title=Risk factors for adverse drug events: a 10-year analysis; citation_author=RS Evans, JF Lloyd, GJ Stoddard, JR Nebeker, MH Samore; citation_volume=39; citation_publication_date=2005; citation_pages=1161-1168; citation_doi=10.1345/aph.1E642; citation_id=CR6 citation_journal_title=Am J Clin Dermatol; citation_title=Do women have more adverse drug reactions?; citation_author=M Rademaker; citation_volume=2; citation_publication_date=2001; citation_pages=349-351; citation_doi=10.2165/00128071-200102060-00001; citation_id=CR7 citation_journal_title=J Womens Health (Larchmt); citation_title=Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics; citation_author=GD Anderson; citation_volume=14; citation_publication_date=2005; citation_pages=19-29; citation_doi=10.1089/jwh.2005.14.19; citation_id=CR8 citation_journal_title=Clin Pharmacokinet; citation_title=The influence of sex on pharmacokinetics; citation_author=JB Schwartz; citation_volume=42; citation_publication_date=2003; citation_pages=107-121; citation_doi=10.2165/00003088-200342020-00001; citation_id=CR9 citation_journal_title=Clin Pharmacokinet; citation_title=Sex differences in pharmacokinetics and pharmacodynamics; citation_author=OP Soldin, DR Mattison; citation_volume=48; citation_publication_date=2009; citation_pages=143-157; citation_doi=10.2165/00003088-200948030-00001; citation_id=CR10 citation_journal_title=Int Rev Neurobiol; citation_title=Gender differences in pharmacological response; citation_author=GD Anderson; citation_volume=83; citation_publication_date=2008; citation_pages=1-10; citation_doi=10.1016/S0074-7742(08)00001-9; citation_id=CR11 citation_journal_title=Clin Pharmacol Ther; citation_title=Pharmacokinetic analysis of bioequivalence trials: implications for sex-related issues in clinical pharmacology and biopharmaceutics; citation_author=ML Chen, SC Lee, MJ Ng, DJ Schuirmann, LJ Lesko, RL Williams; citation_volume=68; citation_publication_date=2000; citation_pages=510-521; citation_doi=10.1067/mcp.2000.111184; citation_id=CR12 citation_journal_title=Hepatology; citation_title=Sex is a major determinant of CYP3A4 expression in human liver; citation_author=R Wolbold, K Klein, O Burk, AK Nussler, P Neuhaus, M Eichelbaum, M Schwab, UM Zanger; citation_volume=38; citation_publication_date=2003; citation_pages=978-988; citation_id=CR13 citation_journal_title=J Clin Pharmacol; citation_title=Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans; citation_author=ME Krecic-Shepard, CR Barnas, J Slimko, MP Jones, JB Schwartz; citation_volume=40; citation_publication_date=2000; citation_pages=219-230; citation_doi=10.1177/00912700022008883; citation_id=CR14 citation_journal_title=Clin Pharmacol Ther; citation_title=Race and sex influence clearance of nifedipine: results of a population study; citation_author=ME Krecic-Shepard, K Park, C Barnas, J Slimko, DR Kerwin, JB Schwartz; citation_volume=68; citation_publication_date=2000; citation_pages=130-142; citation_doi=10.1067/mcp.2000.108678; citation_id=CR15 citation_journal_title=Clin Pharmacol Ther; citation_title=Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers; citation_author=AB Luzier, A Killian, JH Wilton, MF Wilson, A Forrest, DJ Kazierad; citation_volume=66; citation_publication_date=1999; citation_pages=594-601; citation_id=CR16 citation_journal_title=Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz; citation_title=Gender-related differences in pharmacokinetics and pharmacodynamics; citation_author=PA Thurmann; citation_volume=48; citation_publication_date=2005; citation_pages=536-540; citation_doi=10.1007/s00103-005-1039-0; citation_id=CR17 citation_journal_title=Clin Pharmacol Ther; citation_title=Biologic determinants of propranolol disposition: results from 1308 patients in the beta-blocker heart attack trial; citation_author=T Walle, RP Byington, CD Furberg, KM McIntyre, PS Vokonas; citation_volume=38; citation_publication_date=1985; citation_pages=509-518; citation_doi=10.1038/clpt.1985.216; citation_id=CR18 citation_journal_title=Clin Pharmacokinet; citation_title=How important are gender differences in pharmacokinetics?; citation_author=B Meibohm, I Beierle, H Derendorf; citation_volume=41; citation_publication_date=2002; citation_pages=329-342; citation_doi=10.2165/00003088-200241050-00002; citation_id=CR19 citation_journal_title=Clin Pharmacol Ther; citation_title=The current state of knowledge on age, sex, and their interactions on clinical pharmacology; citation_author=JB Schwartz; citation_volume=82; citation_publication_date=2007; citation_pages=87-96; citation_doi=10.1038/sj.clpt.6100226; citation_id=CR20 citation_journal_title=JAMA; citation_title=Association of serum digoxin concentration and outcomes in patients with heart failure; citation_author=SS Rathore, JP Curtis, Y Wang, MR Bristow, HM Krumholz; citation_volume=289; citation_publication_date=2003; citation_pages=871-878; citation_doi=10.1001/jama.289.7.871; citation_id=CR21 citation_journal_title=Clin Pharmacokinet; citation_title=Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs; citation_author=AD Kashuba, AN Nafziger; citation_volume=34; citation_publication_date=1998; citation_pages=203-218; citation_doi=10.2165/00003088-199834030-00003; citation_id=CR22 citation_journal_title=Clin J Pain; citation_title=Sex differences in opioid analgesia: „from mouse to man“; citation_author=RM Craft; citation_volume=19; citation_publication_date=2003; citation_pages=175-186; citation_doi=10.1097/00002508-200305000-00005; citation_id=CR23 citation_journal_title=Acta Anaesthesiol Scand; citation_title=Gender differences in drug effects: implications for anesthesiologists; citation_author=H Pleym, O Spigset, ED Kharasch, O Dale; citation_volume=47; citation_publication_date=2003; citation_pages=241-259; citation_doi=10.1034/j.1399-6576.2003.00036.x; citation_id=CR24 citation_journal_title=J Neurosci; citation_title=mu-opioid receptor-mediated antinociceptive responses differ in men and women; citation_author=JK Zubieta, YR Smith, JA Bueller, Y Xu, MR Kilbourn, DM Jewett, CR Meyer, RA Koeppe, CS Stohler; citation_volume=22; citation_publication_date=2002; citation_pages=5100-5107; citation_id=CR25 citation_journal_title=Am J Psychiatry; citation_title=Gender differences in treatment response to sertraline versus imipramine in chronic depression; citation_author=SG Kornstein, AF Schatzberg, ME Thase, KA Yonkers, JP McCullough, GI Keitner, AJ Gelenberg, SM Davis, WM Harrison, MB Keller; citation_volume=157; citation_publication_date=2000; citation_pages=1445-1452; citation_doi=10.1176/appi.ajp.157.9.1445; citation_id=CR26 citation_journal_title=N Engl J Med; citation_title=Sex-based differences in the effect of digoxin for the treatment of heart failure; citation_author=SS Rathore, Y Wang, HM Krumholz; citation_volume=347; citation_publication_date=2002; citation_pages=1403-1411; citation_doi=10.1056/NEJMoa021266; citation_id=CR27 citation_journal_title=Mol Interv; citation_title=Sex, digitalis, and the sodium pump; citation_author=MP Blaustein, SW Robinson, SS Gottlieb, CW Balke, JM Hamlyn; citation_volume=3; citation_publication_date=2003; citation_pages=68-72; citation_doi=10.1124/mi.3.2.68; citation_id=CR28 citation_journal_title=N Engl J Med; citation_title=The puzzle of aspirin and sex; citation_author=RI Levin; citation_volume=352; citation_publication_date=2005; citation_pages=1366-1368; citation_doi=10.1056/NEJMe058051; citation_id=CR29 citation_journal_title=N Engl J Med; citation_author=; citation_volume=321; citation_publication_date=1989; citation_pages=129-135; citation_id=CR30 citation_journal_title=N Engl J Med; citation_title=A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women; citation_author=PM Ridker, NR Cook, IM Lee, D Gordon, JM Gaziano, JE Manson, CH Hennekens, JE Buring; citation_volume=352; citation_publication_date=2005; citation_pages=1293-1304; citation_doi=10.1056/NEJMoa050613; citation_id=CR31 citation_journal_title=Trends Pharmacol Sci; citation_title=Gender differences in drug toxicity; citation_author=TJ Nicolson, HR Mellor, RR Roberts; citation_volume=31; citation_publication_date=2010; citation_pages=108-114; citation_doi=10.1016/j.tips.2009.12.001; citation_id=CR32 citation_journal_title=Int J Toxicol; citation_title=Gender-based differences in the toxicity of pharmaceuticals – the food and drug administration’s perspective; citation_author=MA Miller; citation_volume=20; citation_publication_date=2001; citation_pages=149-152; citation_doi=10.1080/109158101317097728; citation_id=CR33 citation_journal_title=Eur J Clin Pharmacol; citation_title=Women encounter ADRs more often than do men; citation_author=Y Zopf, C Rabe, A Neubert, KG Gassmann, W Rascher, EG Hahn, K Brune, H Dormann; citation_volume=64; citation_publication_date=2008; citation_pages=999-1004; citation_doi=10.1007/s00228-008-0494-6; citation_id=CR34 citation_journal_title=Br J Clin Pharmacol; citation_title=Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies; citation_author=RM Martin, PN Biswas, SN Freemantle, GL Pearce, RD Mann; citation_volume=46; citation_publication_date=1998; citation_pages=505-511; citation_doi=10.1046/j.1365-2125.1998.00817.x; citation_id=CR35 citation_journal_title=Drug Saf; citation_title=Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome; citation_author=MD Drici, N Clement; citation_volume=24; citation_publication_date=2001; citation_pages=575-585; citation_doi=10.2165/00002018-200124080-00002; citation_id=CR36 citation_journal_title=JAMA; citation_title=Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs; citation_author=RR Makkar, BS Fromm, RT Steinman, MD Meissner, MH Lehmann; citation_volume=270; citation_publication_date=1993; citation_pages=2590-2597; citation_doi=10.1001/jama.1993.03510210076031; citation_id=CR37 citation_journal_title=Pharmacol Ther; citation_title=Drugs for men and women – how important is gender as a risk factor for TdP?; citation_author=SJ Coker; citation_volume=119; citation_publication_date=2008; citation_pages=186-194; citation_doi=10.1016/j.pharmthera.2008.03.005; citation_id=CR38 citation_journal_title=Pharmacol Ther; citation_title=Gender disparity in cardiac electrophysiology: implications for cardiac safety pharmacology; citation_author=MK Jonsson, MA Vos, G Duker, S Demolombe, TA van Veen; citation_volume=127; citation_publication_date=2010; citation_pages=9-18; citation_doi=10.1016/j.pharmthera.2010.04.002; citation_id=CR39 citation_journal_title=Circulation; citation_title=Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative; citation_author=KP Alexander, AY Chen, LK Newby, JB Schwartz, RF Redberg, JS Hochman, MT Roe, WB Gibler, EM Ohman, ED Peterson; citation_volume=114; citation_publication_date=2006; citation_pages=1380-1387; citation_doi=10.1161/CIRCULATIONAHA.106.620815; citation_id=CR40 citation_journal_title=Pharm World Sci; citation_title=Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies; citation_author=HJ Beijer, CJ de Blaey; citation_volume=24; citation_publication_date=2002; citation_pages=46-54; citation_doi=10.1023/A:1015570104121; citation_id=CR41 citation_journal_title=JAMA; citation_title=Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies; citation_author=J Lazarou, BH Pomeranz, PN Corey; citation_volume=279; citation_publication_date=1998; citation_pages=1200-1205; citation_doi=10.1001/jama.279.15.1200; citation_id=CR42 citation_journal_title=BMJ; citation_title=Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients; citation_author=M Pirmohamed, S James, S Meakin, C Green, AK Scott, TJ Walley, K Farrar, BK Park, AM Breckenridge; citation_volume=329; citation_publication_date=2004; citation_pages=15-19; citation_doi=10.1136/bmj.329.7456.15; citation_id=CR43 citation_journal_title=Br J Clin Pharmacol; citation_title=Incidence of fatal adverse drug reactions: a population based study; citation_author=K Wester, AK Jonsson, O Spigset, H Druid, S Hagg; citation_volume=65; citation_publication_date=2008; citation_pages=573-579; citation_doi=10.1111/j.1365-2125.2007.03064.x; citation_id=CR44 citation_journal_title=Br J Clin Pharmacol; citation_title=Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands; citation_author=EM Rodenburg, BH Stricker, LE Visser; citation_volume=71; citation_publication_date=2011; citation_pages=95-104; citation_doi=10.1111/j.1365-2125.2010.03811.x; citation_id=CR45 citation_journal_title=Z Evid Fortbild Qual Gesundhwes; citation_title=Gender: new methodological approaches in guideline development; citation_author=S Weinbrenner, S Lonnfors, B Babitsch; citation_volume=104; citation_publication_date=2010; citation_pages=547-553; citation_doi=10.1016/j.zefq.2010.08.001; citation_id=CR46