Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review

World Health Organization. Leishmaniasis. [2017-08-08]. http://www.who.int/leishmaniasis/burden/en/. Bailey, 2007, Cutaneous leishmaniasis, Clin Dermatol, 25, 203, 10.1016/j.clindermatol.2006.05.008 Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, Arenas R. Leishmaniasis: a review. F1000Res 2017;6:750. Ashutosh, 2007, Molecular mechanisms of antimony resistance in Leishmania, J Med Microbiol, 56, 143, 10.1099/jmm.0.46841-0 Dias, 2007, Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance, Parasitol Res, 101, 667, 10.1007/s00436-007-0528-5 Mukherjee, 2006, Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani, Mol Biochem Parasitol, 145, 1, 10.1016/j.molbiopara.2005.08.016 Croft, 2006, Drug resistance in leishmaniasis, Clin Microbiol Rev, 19, 111, 10.1128/CMR.19.1.111-126.2006 Santos, 2008, Leishmaniasis treatment—a challenge that remains: a review, Parasitol Res, 103, 1, 10.1007/s00436-008-0943-2 Ameen, 2007, Cutaneous leishmaniasis: therapeutic strategies and future directions, Expert Opin Pharmacother, 8, 2689, 10.1517/14656566.8.16.2689 van Griensven, 2012, Visceral leishmaniasis, Infect Dis Clin North Am, 26, 309, 10.1016/j.idc.2012.03.005 Santa-Rita, 2004, Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis, J Antimicrob Chemother, 54, 704, 10.1093/jac/dkh380 Paris, 2004, Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes, Antimicrob Agents Chemother, 48, 852, 10.1128/AAC.48.3.852-859.2004 Ghorbani, 2018, Leishmaniasis in humans: drug or vaccine therapy?, Drug Des Devel Ther, 12, 25, 10.2147/DDDT.S146521 Veiga, 2017, Leishmania amazonensis and Leishmania chagasi: in vitro leishmanicide activity of Virola surinamensis (rol.) Warb, Exp Parasitol, 175, 68, 10.1016/j.exppara.2017.02.005 Delgado-Altamirano, 2017, In vitro antileishmanial activity of Mexican medicinal plants, Heliyon, 3, e00394, 10.1016/j.heliyon.2017.e00394 Nieto-Yañez, 2017, In vivo and in vitro antileishmanial effects of methanolic extract from bark of Bursera aptera, Afr J Tradit Complement Altern Med, 14, 188, 10.21010/ajtcam.v14i2.20 Valença, 2015, Headache research and medical practice in Brazil: an historical overview, Headache, 55, 4, 10.1111/head.12512 Oliveira, 2015, Ethnopharmacological evaluation of medicinal plants used against malaria by quilombola communities from Oriximiná, Brazil, J Ethnopharmacol, 173, 424, 10.1016/j.jep.2015.07.035 Odonne, 2017, Treating leishmaniasis in Amazonia: a review of ethnomedicinal concepts and pharmaco-chemical analysis of traditional treatments to inspire modern phytotherapies, J Ethnopharmacol, 199, 211, 10.1016/j.jep.2017.01.048 Bieski, 2015, Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil, J Ethnopharmacol, 173, 383, 10.1016/j.jep.2015.07.025 Itokawa, 2008, Recent advances in the investigation of curcuminoids, Chin Med, 3, 11, 10.1186/1749-8546-3-11 Fürst, 2014, Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress, Mediators Inflamm, 2014, 1, 10.1155/2014/146832 Gil, 2008, Produtos naturais com potencial leishmanicida, J Basic Appl Pharm Sci, 29, 223 Wang, 2009, New compounds of natural resources in 2008, J Biotechnol, 8, 4299 Stasi, 2002 Coelho-Ferreira, 2009, Medicinal knowledge and plant utilization in an Amazonian coastal community of Marudá, Pará State (Brazil), J Ethnopharmacol, 126, 159, 10.1016/j.jep.2009.07.016 Grenand, 2004 Ferreira, 2007, Estaquia e crescimento inicial de Crajiru (Arrabidaea chica (Humb. & Bonpl.) B.Verl.), Braz J Biosci, 5, 363 Leão, 2007, Levantamento de plantas de uso terapêutico no município de Santa Bárbara do Pará, Estado do Pará, Brasil. Rev Bras Farm, 88, 21 Behrens, 2012, Arrabidaea chica (Humb. & Bonpl.) B. Verlot (Bignoniaceae), Rev Fitos, 7, 236, 10.32712/2446-4775.2012.165 Veiga, 2002, O gênero Copaifera L, Quim Nova, 25, 273, 10.1590/S0100-40422002000200016 Bittencourt, 2014, Trade and use of plants and animals of importance magical/religious and medicinal in market of Guamá, city of Belém, state of Pará, Rev FSA, 11, 96 Agra, 2007, Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil, Braz J Pharmacogn, 17, 114, 10.1590/S0102-695X2007000100021 Costa Júnior, 2013, Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed, Basic Clin Pharmacol Toxicol, 112, 34, 10.1111/j.1742-7843.2012.00924.x Danelli, 2009, Leishmanicidal effect of LLD-3 (1), a nor-triterpene isolated from Lophanthera lactescens, Phytochemistry, 70, 608, 10.1016/j.phytochem.2009.03.009 Rodrigues, 2006, Plants and animals utilized as medicines in the Jaú National Park (JNP), Brazilian Amazon. Phyther Res, 20, 378 Romanik, 2007, Techniques of preparing plant material for chromatographic separation and analysis, J Biochem Biophys Methods, 70, 253, 10.1016/j.jbbm.2006.09.012 Gomes, 2010, Effectiveness of the immunomodulatory extract of Kalanchoe pinnata against murine visceral leishmaniasis, Parasitology, 137, 613, 10.1017/S0031182009991405 Nogueira, 2013, Genotoxicity and antileishmanial activity evaluation of Physalis angulata concentrated ethanolic extract, Environ Toxicol Pharmacol, 36, 1304, 10.1016/j.etap.2013.10.013 da Silva, 2015, In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis, BMC Complement Altern Med, 15, 249, 10.1186/s12906-015-0717-1 Da Silva, 2016, Physalis angulata induces death of promastigotes and amastigotes of Leishmania (Leishmania) amazonensis via the generation of reactive oxygen species, Micron, 82, 25, 10.1016/j.micron.2015.12.001 Ullah, 2016, Plants as antileishmanial agents: current scenario, Phyther Res, 30, 1905, 10.1002/ptr.5710 Tariq, 2016, Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodium and Leishmania parasites, Ann Clin Microbiol Antimicrob, 15, 52, 10.1186/s12941-016-0170-0 Oryan, 2015, Plant-derived compounds in treatment of leishmaniasis, Iran J Vet Res, 16, 1 Da Silva, 2012, Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species, Braz J Pharmacogn, 22, 1368, 10.1590/S0102-695X2012005000103 Costa, 2006, A pyrimidine-β-carboline and other alkaloids from Annona foetida with antileishmanial activity, J Nat Prod, 69, 292, 10.1021/np050422s Rodrigues, 2014, Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp, Biomed Res Int, 2014, 985171, 10.1155/2014/985171 Almeida, 2011, Constituintes químicos e atividade leishmanicida de Gustavia elliptica (Lecythidaceae), Quim Nova, 34, 1182, 10.1590/S0100-40422011000700015 Kuete, 2016, Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines, BMC Complement Altern Med, 16, 267, 10.1186/s12906-016-1253-3 Syed Najmuddin, 2016, Anti-cancer effect of Annona muricata Linn leaves crude extract (AMCE) on breast cancer cell line, BMC Complement Altern Med, 16, 311, 10.1186/s12906-016-1290-y Costa, 2011, Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of Annona foetida Mart. (Annonaceae), Molecules, 16, 9714, 10.3390/molecules16119714 Silveira, 2008, Revisão sobre a patogenia da Leishmaniose tegumentar Americana na Amazônia, com ênfase à doença causada por Leishmania (V.) braziliensis e Leishmania (L.) amazonensis, Rev Para Med, 22, 9 Walker, 2013, Mechanisms of cellular invasion by intracellular parasites, Cell Mol Life Sci, 71, 1245, 10.1007/s00018-013-1491-1 Von Stebut, 2015, Leishmaniasis, J Dtsch Dermatol Ges, 13, 191, 10.1111/ddg.12595_suppl De Lima, 2012, In vitro atileishmanial and cytotoxic activities of Annona mucosa (Annonaceae), Rev Virtual Quim, 4, 692 Cos, 2006, Anti-infective potential of natural products: how to develop a stronger in vitro “proof-of-concept”, J Ethnopharmacol, 106, 290, 10.1016/j.jep.2006.04.003 Da Silva, 2018, Selective effects of Euterpe oleracea (açai) on Leishmania (Leishmania) amazonensis and Leishmania infantum, Biomed Pharmacother, 97, 1613, 10.1016/j.biopha.2017.11.089 De Macedo-Silva, 2011, Antiproliferative, ultrastructural, and physiological effects of Amiodarone on promastigote and amastigote forms of Leishmania amazonensis, Mol Biol Int, 2011, 876021 Marín, 2016, Effective anti-leishmanial activity of minimalist squaramide-based compounds, Exp Parasitol, 170, 36, 10.1016/j.exppara.2016.07.013 Delorenzi, 2001, Antileishmanial activity of an indole alkaloid from Peschiera australis, Antimicrob Agents Chemother, 45, 1349, 10.1128/AAC.45.5.1349-1354.2001 Rosa, 2003, Antileishmanial activity of a linalool-rich essential oil from Croton cajucara, Antimicrob Agents Chemother, 47, 1895, 10.1128/AAC.47.6.1895-1901.2003 Pereira, 2005, Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection, J Infect, 51, 157, 10.1016/j.jinf.2004.09.009 Parvizi, 2017, Efficacy of cryotherapy plus topical Juniperus excelsa M. Bieb cream versus cryotherapy plus placebo in the treatment of Old World cutaneous leishmaniasis: a triple-blind randomized controlled clinical trial, PLoS Negl Trop Dis, 11, e0005957, 10.1371/journal.pntd.0005957 Tripathi, 2017, Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immune responses in Leishmania donovani infected hamsters, Phytomedicine, 24, 87, 10.1016/j.phymed.2016.11.012 Sasidharan, 2011, Extraction, isolation and characterization of biactive compounds from plants’ extracts, Afr J Tradit Complement Altern Med, 8, 1 Lima, 2015, Antileishmanial activity and trypanothione reductase effects of terpenes from the Amazonian species Croton cajucara Benth (Euphorbiaceae), Phytomedicine, 22, 1133, 10.1016/j.phymed.2015.08.012 Guimarães, 2010, Activity of the julocrotine, a glutarimide alkaloid from Croton pullei var. glabrior, on Leishmania (L.) amazonensis, Parasitol Res, 107, 1075, 10.1007/s00436-010-1973-0 Moraes, 2015, Leishmanicidal activity of (+)-phyllanthidine and the phytochemical profile of Margaritaria nobilis (Phyllanthaceae), Molecules, 20, 22157, 10.3390/molecules201219829 Guimarães, 2009, Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis, J Antimicrob Chemother, 64, 84, 10.1093/jac/dkp170 Guimarães, 2010, Effects of seco-steroids purified from Physalis angulata L., Solanaceae, on the viability of Leishmania sp, Braz J Pharmacogn, 20, 945, 10.1590/S0102-695X2010005000036 Costa Júnior, 2013, Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis, Nat Prod Res, 27, 470, 10.1080/14786419.2012.695363 Ferreira, 2010, Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits, Braz J Pharmacogn, 20, 1003, 10.1590/S0102-695X2010005000033 Maquiaveli, 2017, Antileishmanial activity of verbascoside: selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-γ, Biochem Pharmacol, 127, 28, 10.1016/j.bcp.2016.12.018 Mishra, 2009, Alkaloids: future prospective to combat leishmaniasis, Fitoterapia, 80, 81, 10.1016/j.fitote.2008.10.009 Plodek, 2016, New perspectives in the chemistry of marine pyridoacridine alkaloids, Mar Drugs, 14, 1, 10.3390/md14020026 Chan-Bacab, 2001, Plant natural products with leishmanicidal activity, Nat Prod Rep, 18, 674, 10.1039/b100455g Fournet, 2000, Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model, Int J Antimicrob Agents, 13, 189, 10.1016/S0924-8579(99)00117-X Da Costa, 2007, A review of the biologic activities of trans-dehydrocrotonin, a natural product obtained from Croton cajucara, Braz J Pharmacogn, 17, 275, 10.1590/S0102-695X2007000200024 Shabbir, 2014, Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (cobra) species, J Ethnopharmacol, 157, 222, 10.1016/j.jep.2014.09.039 Yin, 2014, α-Glucosidase inhibitors isolated from medicinal plants, Food Sci Hum Wellness, 3, 136, 10.1016/j.fshw.2014.11.003 Bizzo, 2009, Brazilian essential oils: general view, developments and perspectives, Quim Nova, 32, 588, 10.1590/S0100-40422009000300005 Monzote, 2012, Antiprotozoal activity of essential oils, Agric Conspec Sci, 77, 167 Costa, 2009, Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (Annonaceae), Quim Nova, 32, 78, 10.1590/S0100-40422009000100015 Santos, 2011, Leishmania amazonensis: effects of oral treatment with copaiba oil in mice, Exp Parasitol, 129, 145, 10.1016/j.exppara.2011.06.016 Santos, 2008, Effect of Brazilian copaiba oils on Leishmania amazonensis, J Ethnopharmacol, 120, 204, 10.1016/j.jep.2008.08.007 Rodrigues, 2013, In vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7-hydroxycalamenene against Leishmania chagasi, BMC Complement Altern Med, 13, 249, 10.1186/1472-6882-13-249 Calderon, 2009, Amazonian biodiversity: a view of drug development for leishmaniasis and malaria, J Braz Chem Soc, 20, 1011, 10.1590/S0103-50532009000600003 Leandro, 2012, Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins, Molecules, 17, 3866, 10.3390/molecules17043866 de Souza, 2017, In vitro and in vivo antimalarial potential of oleoresin obtained from Copaifera reticulata Ducke (Fabaceae) in the Brazilian Amazon rainforest, Phytomedicine, 24, 111, 10.1016/j.phymed.2016.11.021 Lima, 2003, In vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions, Phyther Res, 17, 1048, 10.1002/ptr.1295 de Mesquita, 2007, In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies, J Ethnopharmacol, 110, 165, 10.1016/j.jep.2006.09.015 Júnior, 2011, Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models, Epilepsy Behav, 22, 678, 10.1016/j.yebeh.2011.09.021 Boyom, 2003, Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants, Phytochemistry, 64, 1269, 10.1016/j.phytochem.2003.08.004 Maciel, 2000, Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara, J Ethnopharmacol, 70, 41, 10.1016/S0378-8741(99)00159-2 Bighetti, 1999, Anti-inflammatory and antinociceptive effects in rodents of the essential oil of Croton cajucara Benth, J Pharm Pharmacol, 51, 1447, 10.1211/0022357991777100 Hiruma-Lima, 2002, Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa, Phytomedicine, 9, 523, 10.1078/09447110260573155 Rozza, 2011, Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil, J Med Food, 14, 1011, 10.1089/jmf.2010.0173 Alviano, 2005, Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil on artificial biofilms and planktonic microorganisms, Oral Microbiol Immunol, 20, 101, 10.1111/j.1399-302X.2004.00201.x Veiga, 2001, Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil, Phyther Res, 15, 476, 10.1002/ptr.976 Briskin, 2000, Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health, Plant Physiol, 124, 507, 10.1104/pp.124.2.507 Gilbert, 2003, Synergy in plant medicines, Curr Med Chem, 10, 13, 10.2174/0929867033368583 Rasoanaivo, 2011, Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions, Malar J, 10, S4, 10.1186/1475-2875-10-S1-S4