Medication adherence to disease-modifying anti-rheumatic drugs among patients with rheumatoid arthritis at Assiut University Hospital, Egypt
Tóm tắt
Rheumatoid arthritis is a chronic disabling autoimmune disease with predilection to synovial joints and many extraarticular manifestations. Disease-modifying anti-rheumatic drugs are the cornerstone and initial therapy in rheumatoid arthritis. Although medication adherence is crucial for successful therapy, non-adherence is a substantial problem in some. This study aimed to determine the adherence rate of treatment with disease-modifying anti-rheumatic drugs among patients with rheumatoid arthritis in an Egyptian university hospital. In this study, seventy-three adult rheumatoid arthritis patients who are on disease-modifying anti-rheumatic drugs treatment for at least 6 months were included in this study. After full history and clinical examination, assessment of the adherence rate to disease-modifying anti-rheumatic drugs was done using the Clinician Rating Scale. Measuring the quality of life using the Health Assessment Questionnaire Disability Index and screening for depression and anxiety using the Hospital Anxiety and Depression Scale were done. The socio-economic level of the patients was assessed by socio-economic status scale. In the current study, 65.1% of the patients were highly adherent to their disease-modifying anti-rheumatic drug (DMARD) medications, while 26% showed middle level of adherence. There was a significant difference between medication adherence and anxiety, but not with other demographic data, clinical data, disease activity, or socio-economic level. In this study, no significant difference was found between medication adherence and demographic, clinical, or socio-economic data. However, anxiety was significantly related to DMARD adherence in the studied group. Age and HAQ-DI were found to be strong predictors to medication adherence in our RA patients. Further studies should be conducted on a large number of patients with rheumatoid arthritis to become generalizable to a broader population.
Tài liệu tham khảo
Matcham F, Scott I, Rayner L, Hotopf M, Kingsley G, Norton S, et al., editors (2014) King’s research portal. Semin Arthritis Rheum
Waimann CA, Marengo MF, de Achaval S, Cox VL, Garcia-Gonzalez A, Reveille JD et al (2013) Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence. Arthritis Rheum 65(6):1421–1429
Nell V, Machold K, Eberl G, Stamm T, Uffmann M, Smolen J (2004) Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology 43(7):906–914
Harrold LR, Andrade SE (eds) (2009) Medication adherence of patients with selected rheumatic conditions: a systematic review of the literature. Seminars in arthritis and rheumatism. Elsevier
Sabaté E (2017) Adherence to long-term therapies: evidence for action. World Health Organization 2003 WHO/MNC/03.01, Geneva
Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T et al (2012) A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 73(5):691–705
Tanwar VS, Singh H, Saini A, Sukhija G, Arora S, Kalra A (2019) Rheumatoid Arthritis Disease Activity Index-5: an easy and effective way of monitoring patients with rheumatoid arthritis. Egypt Rheumatol Rehabil 46(4):269
Contreras-Yáñez I, Cabiedes J, Rull-Gabayet M, Pascual-Ramos V, De León SP (2010) Inadequate therapy behavior is associated to disease flares in patients with rheumatoid arthritis who have achieved remission with disease-modifying antirheumatic drugs. Am J Med Sci 340(4):282–290
Van den Bemt B (2009) Optimizing pharmacotherapy in patients with rheumatoid arthritis. An Individualized Approac https://repository.ubn.ru.nl/bitstream/handle/2066/81554/81554.pdf?sequence=1 Accessed 21 Mar 2020.
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569–2581
Prevoo M, Van'T Hof MA, Kuper H, Van Leeuwen M, Van De Putte L, Van Riel P (1995) Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthr Rheum 38(1):44–48
Wells G, Becker J, Teng J, Dougados M, Schiff M, Smolen J et al (2009) Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 68(6):954–960
Kemp R, Hayward P, Applewhaite G, Everitt B, David A (1996) Compliance therapy in psychotic patients: randomised controlled trial. BMJ 312(7027):345–349
Kemp R, Kirov G, Everitt B, Hayward P, David A (1998) Randomised controlled trial of compliance therapy. 18-month follow-up. Br J Psychiatry 172:413–419
Bruce B, Fries JF (2003) The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation. J Rheumatol 30(1):167–178
Zigmond AS, Snaith RP (1983) The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 67(6):361–370
Olssøn I, Mykletun A, Dahl AA (2005) The Hospital Anxiety and Depression Rating Scale: a cross-sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry 5(1):46
Terkawi AS, Tsang S, AlKahtani GJ, Al-Mousa SH, Al Musaed S, AlZoraigi US et al (2017) Development and validation of Arabic version of the Hospital Anxiety and Depression Scale. Saudi J Anaesth 11(Suppl 1):S11–S18. https://doi.org/10.4103/sja.SJA_43_17
Tawab A (2004)Socioeconomic Scale to Assess Socioeconomic Status of the Family. Faculty of Education, Assiut University.
Darweesh AEDM, Mohamed NAEM, Marzouk HK (2013) Psychological assessment of patients with myocardial infarction. Life Sci J 10(1):651–662
Smolen J, Aletaha D, McInnes I (2016) Rheumatoid arthritis 388, pg 2023. Lancet.
Bondt A, Hafkenscheid L, Falck D, Kuijper TM, Rombouts Y, Hazes JM et al (2018) ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis. Ann Rheum Dis 77(8):1130–1136
Park DC, Hertzog C, Leventhal H, Morrell RW, Leventhal E, Birchmore D et al (1999) Medication adherence in rheumatoid arthritis patients: older is wiser. J Am Geriatr Soc 47(2):172–183
DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW (2002) Patient adherence and medical treatment outcomes a meta-analysis. Med Care 40(9):794–811
McDonnell PJ, Jacobs MR (2002) Hospital admissions resulting from preventable adverse drug reactions. Ann Pharmacother 36(9):1331–1336
Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS (2005) Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 43(6):521–530
Schiff GD, Fung S, Speroff T, McNutt RA (2003) Decompensated heart failure: symptoms, patterns of onset, and contributing factors. Am J Med 114(8):625–630
Jha AK, Aubert RE, Yao J, Teagarden JR, Epstein RS (2012) Greater adherence to diabetes drugs is linked to less hospital use and could save nearly $5 billion annually. Health Aff 31(8):1836–1846
Pasma A, vant Spijker A, Hazes JMW, Busschbach JJV, Luime JJ (2013) Factors associated with adherence to pharmaceutical treatment for rheumatoid arthritis patients: a systematic review. Semin Arthritis Rheum 43:18–28
Ragab OM, Zayed HS, Abdelaleem EA, Girgis AE (2017) Effect of early treatment with disease-modifying anti-rheumatic drugs and treatment adherence on disease outcome in rheumatoid arthritis patients. Egypt Rheumatol 39(2):69–74
Prudente LR, de Souza DJ, Ferreira TXAM, Lima DM, Silva NA, Saraiva G et al (2016) Medication adherence in patients in treatment for rheumatoid arthritis and systemic lupus erythematosus in a university hospital in Brazil. Patient Pref Adher 10:863–870
Müller R, Kallikorm R, Põlluste K, Lember M (2012) Compliance with treatment of rheumatoid arthritis. Rheumatol Int 32(10):3131–3135
Tuncay R, Eksioglu E, Cakir B, Gurcay E, Cakci A (2007) Factors affecting drug treatment compliance in patients with rheumatoid arthritis. Rheumatol Int 27(8):743–746
Xia Y, Yin R, Fu T, Zhang L, Zhang Q, Guo G et al (2016) Treatment adherence to disease-modifying antirheumatic drugs in Chinese patients with rheumatoid arthritis. Patient Pref Adher 10:735–742
Sharma S, Roshi VRT, Mahajan A (2015) A study evaluating adherence and compliance of anti-rheumatic drugs in women suffering from rheumatoid arthritis. J Clin Diagn Res 9(11):OC01
Curkendall S, Patel V, Gleeson M, Campbell R, Zagari M, Dubois R (2008) Compliance with biologic therapies for rheumatoid arthritis: do patient out-of-pocket payments matter? Arthritis Care Res 59(10):1519–1526
Garcia-Gonzalez A, Richardson M, Popa-Lisseanu MG, Cox V, Kallen MA, Janssen N et al (2008) Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol 27(7):883–889
Rauscher V, Englbrecht M, van der Heijde D, Schett G, Hueber AJ (2015) High degree of nonadherence to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. J Rheumatol 42(3):386–390
Bliddal H, Eriksen SA, Christensen R, Lorenzen T, Hansen MS, Østergaard M et al (2015) Adherence to methotrexate in rheumatoid arthritis: a Danish nationwide cohort study. Arthritis. 2015 https://doi.org/10.1155/2015/915142
Li L, Cui Y, Yin R, Chen S, Zhao Q, Chen H, et al (2017) Medication adherence has an impact on disease activity in rheumatoid arthritis: a systematic review and meta-analysis. Patient Prefer Adherence 11:1343
Lorish CD, Richards B, Brown S (1989) Missed medication doses in rheumatic arthritis patients: intentional and unintentional reasons. Arthritis Rheum 2(1):3–9
Zhang L, Xia Y, Zhang Q, Fu T, Yin R, Guo G et al (2017) The correlations of socioeconomic status, disease activity, quality of life, and depression/anxiety in Chinese patients with rheumatoid arthritis. Psychol Health Med 22(1):28–36
Julian LJ, Yelin E, Yazdany J, Panopalis P, Trupin L, Criswell LA et al (2009) Depression, medication adherence, and service utilization in systemic lupus erythematosus. Arthritis Care Res 61(2):240–246
JWG J, Silva J (2015) Psychological factors associated with response to treatment in rheumatoid arthritis. Curr Pharm Des 21(2):257–269
Cabrera-Marroquin R, Contreras-Yáñez I, Alcocer-Castillejos N, Pascual-Ramos V (2014) Major depressive episodes are associated with poor concordance with therapy in rheumatoid arthritis patients: the impact on disease outcomes. Clin Exp Rheumatol 32(6):904–913
Hope HF, Hyrich KL, Anderson J, Bluett J, Sergeant JC, Barton A et al (2020) The predictors of and reasons for non-adherence in an observational cohort of patients with rheumatoid arthritis commencing methotrexate. Rheumatology 59(1):213–223
Salt E, Frazier SK (2011) Predictors of medication adherence in patients with rheumatoid arthritis. Drug Dev Res 72(8):756–763
Smolen JS, Gladman D, McNeil HP, Mease PJ, Sieper J, Hojnik M et al (2019) Predicting adherence to therapy in rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis: a large cross-sectional study. RMD Open 5:e000585. https://doi.org/10.1136/rmdopen-2017-000585
Van Den Bemt BJ, Zwikker HE, Van Den Ende CH, Horne O, Haynes et al (2012) Medication adherence in patients with rheumatoid arthritis: a critical appraisal of the existing literature. Expert Rev Clin Immunol 8(4):337–351
Cohen MJ, Shaykevich S, Cawthon C, Kripalani S, Paasche-Orlow MK, Schnipper JL (2012) Predictors of medication adherence postdischarge: the impact of patient age, insurance status, and prior adherence. J Hosp Med 7(6):470–475
Hromadkova L, Soukup T, Vlcek J (2015) Quality of life and drug compliance: their interrelationship in rheumatic patients. J Eval Clin Pract 21(5):919–924