Mechanostimulation-induced integrin αvβ6 and latency associated peptide coupling activates TGF-β and regulates cancer metastasis and stemness

Nano Today - Tập 50 - Trang 101882 - 2023
Udesh Dhawan1,2, Wei-Li Wang2, Yuh-Charn Lin3, Ruey-Bing Yang4,5,6, Matthew J. Dalby7, Manuel Salmeron-Sanchez1, Hsiao-hua Yu2
1Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow G116EW, UK
2Smart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Academia Road, Nankang, Taipei 115201, Taiwan (R.O.C.)
3Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan (R.O.C.)
4Institute of Biomedical Sciences, Academia Sinica, Taipei 115201, Taiwan (R.O.C.)
5Biomedical Translation Research Center, Academia Sinica, Taipei 115202, Taiwan (R.O.C.)
6Ph.D. program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan (R.O.C.)
7Centre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland G12 8QQ, UK

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