Mechanobiology of portal hypertension
Tài liệu tham khảo
Dupont, 2022, Mechanical regulation of chromatin and transcription, Nat Rev Genet, 23, 624, 10.1038/s41576-022-00493-6
Wynn, 2012, Mechanisms of fibrosis: therapeutic translation for fibrotic disease, Nat Med, 18, 1028, 10.1038/nm.2807
Gracia-Sancho, 2021, Role of liver sinusoidal endothelial cells in liver diseases, Nat Rev Gastroenterol Hepatol, 18, 411, 10.1038/s41575-020-00411-3
Kang, 2020, Mechanotransduction in liver diseases, Semin Liver Dis, 40, 84, 10.1055/s-0039-3399502
Baffy, 2018, Origins of portal hypertension in nonalcoholic fatty liver disease, Dig Dis Sci, 63, 563, 10.1007/s10620-017-4903-5
Wells, 2008, The role of matrix stiffness in regulating cell behavior, Hepatology, 47, 1394, 10.1002/hep.22193
Loneker, 2021, Perspective: the mechanobiology of hepatocellular carcinoma, Cancers (Basel), 13, 10.3390/cancers13174275
Maurer, 2019, The driving force: nuclear mechanotransduction in cellular function, fate, and disease, Annu Rev Biomed Eng, 21, 443, 10.1146/annurev-bioeng-060418-052139
Maniotis, 1997, Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure, Proc Natl Acad Sci U S A, 94, 849, 10.1073/pnas.94.3.849
Kechagia, 2019, Integrins as biomechanical sensors of the microenvironment, Nat Rev Mol Cell Biol, 20, 457, 10.1038/s41580-019-0134-2
Elosegui-Artola, 2016, Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity, Nat Cell Biol, 18, 540, 10.1038/ncb3336
Buscemi, 2011, The single-molecule mechanics of the latent TGF-beta1 complex, Curr Biol, 21, 2046, 10.1016/j.cub.2011.11.037
Le Roux, 2019, The plasma membrane as a mechanochemical transducer, Philos Trans R Soc Lond B Biol Sci, 374, 10.1098/rstb.2018.0221
Coste, 2010, Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels, Science, 330, 55, 10.1126/science.1193270
Li, 2014, Piezo1 integration of vascular architecture with physiological force, Nature, 515, 279, 10.1038/nature13701
Hilscher, 2019, Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension, Gastroenterology, 157, 193, 10.1053/j.gastro.2019.03.013
Solis, 2019, Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity, Nature, 573, 69, 10.1038/s41586-019-1485-8
Yin, 2010, Mechanotransduction by TRP channels: general concepts and specific role in the vasculature, Cell Biochem Biophys, 56, 1, 10.1007/s12013-009-9067-2
Swain, 2021, Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress, J Biol Chem, 296, 10.1074/jbc.RA120.015059
Shihata, 2016, Caveolae: a role in endothelial inflammation and mechanotransduction?, Front Physiol, 7, 628, 10.3389/fphys.2016.00628
Huveneers, 2009, Adhesion signaling - crosstalk between integrins, Src and Rho, J Cell Sci, 122, 1059, 10.1242/jcs.039446
Versaevel, 2014, Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites, Sci Rep, 4, 7362, 10.1038/srep07362
Lammerding, 2016, Nuclear envelope rupture: actin fibers are putting the squeeze on the nucleus, J Cell Biol, 215, 5, 10.1083/jcb.201609102
Gupta, 2015, Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing, Nat Commun, 6, 7525, 10.1038/ncomms8525
Killaars, 2019, Extended exposure to stiff microenvironments leads to persistent chromatin remodeling in human mesenchymal stem cells, Adv Sci (Weinh), 6
Walker, 2021, Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts, Nat Biomed Eng, 5, 1485, 10.1038/s41551-021-00709-w
Tajik, 2016, Transcription upregulation via force-induced direct stretching of chromatin, Nat Mater, 15, 1287, 10.1038/nmat4729
Elosegui-Artola, 2017, Force triggers YAP nuclear entry by regulating transport across nuclear pores, Cell, 171, 1397, 10.1016/j.cell.2017.10.008
Panciera, 2017, Mechanobiology of YAP and TAZ in physiology and disease, Nat Rev Mol Cell Biol, 18, 758, 10.1038/nrm.2017.87
Mannaerts, 2015, The Hippo pathway effector YAP controls mouse hepatic stellate cell activation, J Hepatol, 63, 679, 10.1016/j.jhep.2015.04.011
Caliari, 2016, Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation, Sci Rep, 6, 10.1038/srep21387
Miralles, 2003, Actin dynamics control SRF activity by regulation of its coactivator MAL, Cell, 113, 329, 10.1016/S0092-8674(03)00278-2
Wojtowicz, 2010, Zyxin mediation of stretch-induced gene expression in human endothelial cells, Circ Res, 107, 898, 10.1161/CIRCRESAHA.110.227850
Dupont, 2011, Role of YAP/TAZ in mechanotransduction, Nature, 474, 179, 10.1038/nature10137
Min, 2019, Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease, Exp Cell Res, 376, 92, 10.1016/j.yexcr.2019.01.005
Gracia-Sancho, 2019, Hepatic microcirculation and mechanisms of portal hypertension, Nat Rev Gastroenterol Hepatol, 16, 221, 10.1038/s41575-018-0097-3
Wanless, 2020, The role of vascular injury and congestion in the pathogenesis of cirrhosis: the congestive escalator and the parenchymal extinction sequence, Curr Hepatol Rep, 19, 40, 10.1007/s11901-020-00508-y
Garcia-Pagan, 2012, Functional aspects on the pathophysiology of portal hypertension in cirrhosis, J Hepatol, 57, 458, 10.1016/j.jhep.2012.03.007
Pinzani, 1996, Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells, Gastroenterology, 110, 534, 10.1053/gast.1996.v110.pm8566602
Failli, 2000, Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells, Gastroenterology, 119, 479, 10.1053/gast.2000.9354
Rockey, 1996, Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance, Hepatology, 24, 233, 10.1002/hep.510240137
Xie, 2012, Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats, Gastroenterology, 142, 918, 10.1053/j.gastro.2011.12.017
Deleve, 2008, Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence, Hepatology, 48, 920, 10.1002/hep.22351
Lee, 2005, Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts, Am J Pathol, 166, 1861, 10.1016/S0002-9440(10)62495-9
Routray, 2011, Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes, Am J Physiol Cell Physiol, 301, C66, 10.1152/ajpcell.00038.2011
Selicean, 2021, Regression of portal hypertension: underlying mechanisms and therapeutic strategies, Hepatol Int, 15, 36, 10.1007/s12072-021-10135-4
Lorenz, 2018, Mechanosensing by beta1 integrin induces angiocrine signals for liver growth and survival, Nature, 562, 128, 10.1038/s41586-018-0522-3
Tzima, 2005, A mechanosensory complex that mediates the endothelial cell response to fluid shear stress, Nature, 437, 426, 10.1038/nature03952
Conway, 2013, Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1, Curr Biol, 23, 1024, 10.1016/j.cub.2013.04.049
Dekker, 2002, Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2), Blood, 100, 1689, 10.1182/blood-2002-01-0046
Gracia-Sancho, 2011, Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver, Gut, 60, 517, 10.1136/gut.2010.220913
Jiang, 2017, Methylation of kruppel-like factor 2 (KLF2) associates with its expression and non-small cell lung cancer progression, Am J Transl Res, 9, 2024
Gracia-Sancho, 2008, Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability, Hepatology, 47, 1248, 10.1002/hep.22166
Guixe-Muntet, 2017, Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury, J Hepatol, 66, 86, 10.1016/j.jhep.2016.07.051
Hilscher, 2016, Congestive hepatopathy, Clin Liver Dis (Hoboken), 8, 68, 10.1002/cld.573
Jufri, 2015, Mechanical stretch: physiological and pathological implications for human vascular endothelial cells, Vasc Cell, 7, 8, 10.1186/s13221-015-0033-z
Ortega-Ribera, 2023, Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension, JHEP Rep, 10.1016/j.jhepr.2023.100722
Cerini, 2016, Enoxaparin reduces hepatic vascular resistance and portal pressure in cirrhotic rats, J Hepatol, 64, 834, 10.1016/j.jhep.2015.12.003
Vilaseca, 2017, The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells, Hepatology, 65, 2031, 10.1002/hep.29084
Ryou, 2020, Nonalcoholic fatty liver disease and portal hypertension, Explor Med, 1, 149, 10.37349/emed.2020.00011
Scorletti, 2022, A new perspective on NAFLD: focusing on lipid droplets, J Hepatol, 76, 934, 10.1016/j.jhep.2021.11.009
Francque, 2019, Portal hypertension in NASH: is it different from other aetiologies?, Curr Hepatol Rep, 18, 134, 10.1007/s11901-019-00459-z
Berzigotti, 2013, Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis, Gastroenterology, 144, 102, 10.1053/j.gastro.2012.10.001
Berzigotti, 2017, Non-invasive evaluation of portal hypertension using ultrasound elastography, J Hepatol, 67, 399, 10.1016/j.jhep.2017.02.003
Trebicka, 2022, Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease, Gut, 71, 402, 10.1136/gutjnl-2020-323419
Georges, 2007, Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis, Am J Physiol Gastrointest Liver Physiol, 293, G1147, 10.1152/ajpgi.00032.2007
Guixe-Muntet, 2020, Nuclear deformation mediates liver cell mechanosensing in cirrhosis, JHEP Rep, 2
Desai, 2016, Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha, Hepatology, 64, 261, 10.1002/hep.28450
Natarajan, 2015, Substrate stiffness regulates primary hepatocyte functions, RSC Adv, 5, 80956, 10.1039/C5RA15208A
Olsen, 2011, Hepatic stellate cells require a stiff environment for myofibroblastic differentiation, Am J Physiol Gastrointest Liver Physiol, 301, G110, 10.1152/ajpgi.00412.2010
Gortzen, 2015, Interplay of matrix stiffness and c-SRC in hepatic fibrosis, Front Physiol, 6, 359, 10.3389/fphys.2015.00359
Lachowski, 2019, Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis, Sci Rep, 9, 7299, 10.1038/s41598-019-43759-6
Patsenker, 2011, Role of integrins in fibrosing liver diseases, Am J Physiol Gastrointest Liver Physiol, 301, G425, 10.1152/ajpgi.00050.2011
Loneker, 2023, Lipid droplets are intracellular mechanical stressors that impair hepatocyte function, Proc Natl Acad Sci U S A, 120, 10.1073/pnas.2216811120
Chin, 2020, Lipid droplets disrupt mechanosensing in human hepatocytes, Am J Physiol Gastrointest Liver Physiol, 319, G11, 10.1152/ajpgi.00098.2020
Martin, 2016, PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis, Nat Commun, 7, 10.1038/ncomms12502
Bertero, 2016, Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension, J Clin Invest, 126, 3313, 10.1172/JCI86387
Bertero, 2015, Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit, Cell Rep, 13, 1016, 10.1016/j.celrep.2015.09.049
Zheng, 2017, Intrahepatic upregulation of MRTF-A signaling contributes to increased hepatic vascular resistance in cirrhotic rats with portal hypertension, Clin Res Hepatol Gastroenterol, 41, 303, 10.1016/j.clinre.2016.11.010
Shi, 2020, Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis, Am J Physiol Gastrointest Liver Physiol, 318, G504, 10.1152/ajpgi.00302.2019
Dou, 2018, P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts, Gastroenterology, 154, 2209, 10.1053/j.gastro.2018.02.015
Wang, 2019, p300 acetyltransferase is a cytoplasm-to-nucleus shuttle for SMAD2/3 and TAZ nuclear transport in transforming growth factor beta-stimulated hepatic stellate cells, Hepatology, 70, 1409, 10.1002/hep.30668
Stowers, 2019, Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility, Nat Biomed Eng, 3, 1009, 10.1038/s41551-019-0420-5
Moran-Salvador, 2017, Epigenetics and liver fibrosis, Cell Mol Gastroenterol Hepatol, 4, 125, 10.1016/j.jcmgh.2017.04.007
Kweon, 2016, Wnt pathway stabilizes MeCP2 protein to repress PPAR-gamma in activation of hepatic stellate cells, PLoS One, 11, 10.1371/journal.pone.0156111
Stroka, 2011, Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction, Blood, 118, 1632, 10.1182/blood-2010-11-321125
Mambetsariev, 2014, Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation, PLoS One, 9, 10.1371/journal.pone.0092670
Liu, 2017, Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis, Nat Mater, 16, 1252, 10.1038/nmat5024
Caliari, 2016, Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression, Integr Biol (Camb), 8, 720, 10.1039/C6IB00027D
Yang, 2014, Mechanical memory and dosing influence stem cell fate, Nat Mater, 13, 645, 10.1038/nmat3889
Tada, 2021, Association of liver stiffness and steatosis with hepatocellular carcinoma development in patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response, Hepatol Res, 51, 860, 10.1111/hepr.13677
Nakagomi, 2019, Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment, J Gastroenterol Hepatol, 34, 921, 10.1111/jgh.14530
Zhao, 2010, Mechanical stiffness of liver tissues in relation to integrin beta1 expression may influence the development of hepatic cirrhosis and hepatocellular carcinoma, J Surg Oncol, 102, 482, 10.1002/jso.21613
Kornek, 2008, Accelerated orthotopic hepatocellular carcinomas growth is linked to increased expression of pro-angiogenic and prometastatic factors in murine liver fibrosis, Liver Int, 28, 509, 10.1111/j.1478-3231.2008.01670.x
Schrader, 2011, Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells, Hepatology, 53, 1192, 10.1002/hep.24108
Perra, 2014, YAP activation is an early event and a potential therapeutic target in liver cancer development, J Hepatol, 61, 1088, 10.1016/j.jhep.2014.06.033
Yang, 2020, CXCR4 mediates matrix stiffness-induced downregulation of UBTD1 driving hepatocellular carcinoma progression via YAP signaling pathway, Theranostics, 10, 5790, 10.7150/thno.44789
Harrison, 2018, Simtuzumab is ineffective for patients with bridging fibrosis or compensated cirrhosis caused by nonalcoholic steatohepatitis, Gastroenterology, 155, 1140, 10.1053/j.gastro.2018.07.006
Meissner, 2016, Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial, Liver Int, 36, 1783, 10.1111/liv.13177
Muir, 2019, Simtuzumab for primary sclerosing cholangitis: phase 2 study results with insights on the natural history of the disease, Hepatology, 69, 684, 10.1002/hep.30237
Chalasani, 2020, Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension, Gastroenterology, 158, 1334, 10.1053/j.gastro.2019.11.296
Schuppan, 2018, Liver fibrosis: direct antifibrotic agents and targeted therapies, Matrix Biol, 68–69, 435, 10.1016/j.matbio.2018.04.006
Henderson, 2013, Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs, Nat Med, 19, 1617, 10.1038/nm.3282
Turaga, 2021, Targeting integrin alphavbeta3 by a rationally designed protein for chronic liver disease treatment, Commun Biol, 4, 1087, 10.1038/s42003-021-02611-2
Patsenker, 2008, Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression, Gastroenterology, 135, 660, 10.1053/j.gastro.2008.04.009
Patsenker, 2009, Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis, Hepatology, 50, 1501, 10.1002/hep.23144
Rikitake, 2005, Rho GTPases, statins, and nitric oxide, Circ Res, 97, 1232, 10.1161/01.RES.0000196564.18314.23
Abraldes, 2007, Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats, J Hepatol, 46, 1040, 10.1016/j.jhep.2007.01.020
Abraldes, 2009, Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial, Gastroenterology, 136, 1651, 10.1053/j.gastro.2009.01.043
Abraldes, 2016, Addition of simvastatin to standard therapy for the prevention of variceal rebleeding does not reduce rebleeding but increases survival in patients with cirrhosis, Gastroenterology, 150, 1160, 10.1053/j.gastro.2016.01.004
Lampi, 2016, Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption, PLoS One, 11, 10.1371/journal.pone.0147033
Klein, 2012, Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats, Lab Invest, 92, 1440, 10.1038/labinvest.2012.106
Trebicka, 2007, Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase, Hepatology, 46, 242, 10.1002/hep.21673
Marrone, 2015, KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins, Gut, 64, 1434, 10.1136/gutjnl-2014-308338
Fukuda, 2014, Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis, J Gastroenterol Hepatol, 29, 325, 10.1111/jgh.12360
Klein, 2019, Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats, Sci Rep, 9, 2256, 10.1038/s41598-019-38678-5
Nalkurthi, 2022, ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis, JHEP Rep, 4
Guimarães, 2020, The stiffness of living tissues and its implications for tissue engineering, Nat Rev Mater, 5, 351, 10.1038/s41578-019-0169-1
Bazerbachi, 2019, Range of normal liver stiffness and factors associated with increased stiffness measurements in apparently healthy individuals, Clin Gastroenterol Hepatol, 17, 54, 10.1016/j.cgh.2018.08.069
Obrzut, 2021, Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers, Sci Rep, 11, 10.1038/s41598-021-99243-7
Caliari, 2016, A practical guide to hydrogels for cell culture, Nat Methods, 13, 405, 10.1038/nmeth.3839
Tibbitt, 2009, Hydrogels as extracellular matrix mimics for 3D cell culture, Biotechnol Bioeng, 103, 655, 10.1002/bit.22361
Guvendiren, 2012, Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics, Nat Commun, 3, 792, 10.1038/ncomms1792
Kloxin, 2010, Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms, Nat Protoc, 5, 1867, 10.1038/nprot.2010.139
Krieg, 2019, Atomic force microscopy-based mechanobiology, Nat Rev Phys, 1, 41, 10.1038/s42254-018-0001-7
Killian, 2018, Optical tweezers: a force to Be reckoned with, Cell, 175, 1445, 10.1016/j.cell.2018.11.019
Sarkar, 2016, A guide to magnetic tweezers and their applications, Front Phys, 4, 10.3389/fphy.2016.00048
Mohammed, 2019, Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction, Front Bioeng Biotechnol, 7, 162, 10.3389/fbioe.2019.00162
Illa, 2014, A novel modular bioreactor to in vitro study the hepatic sinusoid, PLoS One, 9, 10.1371/journal.pone.0111864
Ortega-Ribera, 2018, Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications, Biotechnol Bioeng, 115, 2585, 10.1002/bit.26776
Du, 2017, Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip, Lab Chip, 17, 782, 10.1039/C6LC01374K
Shroff, 2022, Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics, Open Biol, 12, 10.1098/rsob.210333
Kaur, 2023, In Vitro models for the study of liver biology and diseases: advances and limitations, Cell Mol Gastroenterol Hepatol, 15, 559, 10.1016/j.jcmgh.2022.11.008
Peterson, 2002, Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton, Chem Biol, 9, 1275, 10.1016/S1074-5521(02)00284-3
Lampi, 2018, Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials, Sci Transl Med, 10, 10.1126/scitranslmed.aao0475
Wen, 2014, Interplay of matrix stiffness and protein tethering in stem cell differentiation, Nat Mater, 13, 979, 10.1038/nmat4051
Trappmann, 2012, Extracellular-matrix tethering regulates stem-cell fate, Nat Mater, 11, 642, 10.1038/nmat3339
Marrone, 2013, The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins, J Hepatol, 58, 98, 10.1016/j.jhep.2012.08.026
Leite, 2016, Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro, Biomaterials, 78, 1, 10.1016/j.biomaterials.2015.11.026
Al-Akkad, 2019, PS-209-Whole Human liver decellularisation-recellularisation for future liver transplantation and extracorporeal device application, J Hepatol, 70, e139, 10.1016/S0618-8278(19)30243-9
Uygun, 2010, Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix, Nat Med, 16, 814, 10.1038/nm.2170
Baptista, 2013, Human liver bioengineering using a whole liver decellularized bioscaffold, Methods Mol Biol, 1001, 289, 10.1007/978-1-62703-363-3_24
Baptista, 2011, The use of whole organ decellularization for the generation of a vascularized liver organoid, Hepatology, 53, 604, 10.1002/hep.24067
Mazza, 2017, Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization, Sci Rep, 7, 5534, 10.1038/s41598-017-05134-1
Kojima, 2018, Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells, Am J Transpl, 18, 1351, 10.1111/ajt.14666
Banaeiyan, 2017, Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform, Biofabrication, 9, 10.1088/1758-5090/9/1/015014