Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA

Cabili, 2015, Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution, Genome Biol., 16, 20, 10.1186/s13059-015-0586-4 Iyer, 2015, The landscape of long noncoding RNAs in the human transcriptome, Nat. Genet., 47, 199, 10.1038/ng.3192 Guttman, 2009, Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals, Nature, 458, 223, 10.1038/nature07672 Chiu, 2018, Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes in each tumor context, Cell Rep., 23, 297, 10.1016/j.celrep.2018.03.064 Balas, 2018, Exploring the mechanisms behind long noncoding RNAs and cancer, Noncoding RNA Res, 3, 108, 10.1016/j.ncrna.2018.03.001 Chen, 2020, The physiological function of long-noncoding RNAs, Noncoding RNA Res, 5, 178, 10.1016/j.ncrna.2020.09.003 Ghafouri-Fard, 2020, TINCR: an lncRNA with dual functions in the carcinogenesis process, Noncoding RNA Res, 5, 109, 10.1016/j.ncrna.2020.06.003 Grixti, 2020, Long noncoding RNAs and their link to cancer, Noncoding RNA Res, 5, 77, 10.1016/j.ncrna.2020.04.003 Nagase, 1995, Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1, DNA Res., 2, 37, 10.1093/dnares/2.1.37 Kretz, 2012, Suppression of progenitor differentiation requires the long noncoding RNA ANCR, Genes Dev., 26, 338, 10.1101/gad.182121.111 Brooks, 2014, Mechanism of activation of protein kinase JAK2 by the growth hormone receptor, Science, 344, 1249783, 10.1126/science.1249783 Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455 Chen, 2019, DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing IL-11-STAT3 signaling and CCND1 expression, Mol. Ther., 27, 326, 10.1016/j.ymthe.2018.12.015 Zhang, 2019, Long noncoding RNA DANCR promotes nasopharyngeal carcinoma progression by interacting with STAT3, enhancing IL-6/JAK1/STAT3 signaling, Biomed. Pharmacother., 113, 108713, 10.1016/j.biopha.2019.108713 Liu, 2020, LncRNA DANCR promotes sorafenib resistance via activation of IL-6/STAT3 signaling in hepatocellular carcinoma cells, OncoTargets Ther., 13, 1145, 10.2147/OTT.S229957 Behrens, 1998, Functional interaction of an axin homolog, conducting, with beta-catenin, APC, and GSK3beta, Science, 280, 596, 10.1126/science.280.5363.596 Korinek, 1997, Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma, Science, 275, 1784, 10.1126/science.275.5307.1784 Morin, 1997, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, 275, 1787, 10.1126/science.275.5307.1787 Suzuki, 2004, Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer, Nat. Genet., 36, 417, 10.1038/ng1330 Pan, 2017, Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells, Oncotarget, 9, 1915, 10.18632/oncotarget.23019 Yuan, 2016, Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1, Hepatology, 63, 499, 10.1002/hep.27893 Tian, 2020, Long non-coding RNA DANCR promotes cervical cancer growth via activation of the Wnt/β-catenin signaling pathway, Canc. Cell Int., 20, 61, 10.1186/s12935-020-1139-9 Fan, 2016, Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells, Oncol. Rep., 36, 2999, 10.3892/or.2016.5130 Wang, 2008, FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma, Int. J. Canc., 123, 561, 10.1002/ijc.23600 Yu, 2020, Long noncoding RNA DANCR activates Wnt/β-catenin signaling through MiR-216a inhibition in non-small cell lung cancer, Biomolecules, 10, 1646, 10.3390/biom10121646 Margueron, 2011, The Polycomb complex PRC2 and its mark in life, Nature, 469, 343, 10.1038/nature09784 Zhang, 2020, The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription, Mol Oncol, 14, 309, 10.1002/1878-0261.12622 Wang, 2019, Long noncoding RNA DANCR regulates proliferation and migration by epigenetically silencing FBP1 in tumorigenesis of cholangiocarcinoma, Cell Death Dis., 10, 585, 10.1038/s41419-019-1810-z Jia, 2016, Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3, Oncotarget, 7, 37868, 10.18632/oncotarget.9350 Guo, 2018, Long non-coding RNA DANCR promotes the progression of non-small-cell lung cancer by inhibiting p21 expression, OncoTargets Ther., 12, 135, 10.2147/OTT.S186607 Zhang, 2020, Resveratrol suppresses human nasopharyngeal carcinoma cell growth via inhibiting differentiation antagonizing non-protein coding RNA (DANCR) expression, Med Sci Monit, 26 Hu, 2020, IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader, Cell Death Differ., 27, 1782, 10.1038/s41418-019-0461-z Xie, 2020, Tripartite motif containing 24 regulates cell proliferation in colorectal cancer through YAP signaling, Cancer Med, 9, 6367, 10.1002/cam4.3310 Wen, 2018, Long non-coding RNA DANCR stabilizes HIF-1α and promotes metastasis by interacting with NF90/NF45 complex in nasopharyngeal carcinoma, Theranostics, 8, 5676, 10.7150/thno.28538 Tang, 2018, LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA, Cell Death Dis., 9, 1167, 10.1038/s41419-018-1220-7 Cui, 2020, SP1-induced lncRNA DANCR contributes to proliferation and invasion of ovarian cancer, Kaohsiung J. Med. Sci. Luo, 2020, LncRNA DANCR promotes proliferation and metastasis in pancreatic cancer by regulating miRNA-33b, FEBS Open Bio, 10, 18, 10.1002/2211-5463.12732 Zheng, 2019, LncRNA DANCR promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells through miR-135a-5p/KLF8 axis, Canc. Cell Int., 19, 302, 10.1186/s12935-019-1016-6 Wang, 2018, Long noncoding RNA DANCR aggravates retinoblastoma through miR-34c and miR-613 by targeting MMP-9, J. Cell. Physiol., 233, 6986, 10.1002/jcp.26621 Ma, 2019, Long noncoding RNA DANCR contributes to docetaxel resistance in prostate cancer through targeting the miR-34a-5p/JAG1 pathway, OncoTargets Ther., 12, 5485, 10.2147/OTT.S197009 Ma, 2018, Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway, Neurochem. Int., 118, 233, 10.1016/j.neuint.2018.03.011 Zhan, 2018, Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA, J. Exp. Clin. Canc. Res., 37, 273, 10.1186/s13046-018-0921-1 Lu, 2018, LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression, J. Cell Mol. Med., 22, 1527, 10.1111/jcmm.13420 Lin, 2019, LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145, Mol. Carcinog., 58, 2286, 10.1002/mc.23117 Liang, 2019, LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335-5p, J. Cell. Physiol., 234, 7266, 10.1002/jcp.27484 Wang, 2018, Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma, Mol. Canc., 17, 89, 10.1186/s12943-018-0837-6 Bi, 2020, Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma, Cell Death Dis., 11, 296, 10.1038/s41419-020-2492-2 Wang, 2019, DANCR contributed to hepatocellular carcinoma malignancy via sponging miR-216a-5p and modulating KLF12, J. Cell. Physiol., 234, 9408, 10.1002/jcp.27625 Guo, 2019, DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway, Cell Prolif, 52, 10.1111/cpr.12628 Wu, 2020, LncRNA DANCR upregulation induced by TUFT1 promotes malignant progression in triple negative breast cancer via miR-874-3p-SOX2 axis, Exp. Cell Res., 396, 112331, 10.1016/j.yexcr.2020.112331 Pan, 2020, LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p, Biomed. Pharmacother., 122, 109707, 10.1016/j.biopha.2019.109707 Tang, 2020, LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer, Invest. N. Drugs, 38, 714, 10.1007/s10637-019-00798-0