Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbers

Allen, 1975, Evidence for firm linkages between microtubules and membrane-bounded vesicles, J. Cell Biol., 64, 497, 10.1083/jcb.64.2.497 Allison, 1968, Effects of general anaesthetics on microtubules: a possible mechanism of anaesthesia, Lancet, 2, 1326, 10.1016/S0140-6736(68)91821-7 Amer, 1965, Cytological effects of pesticides, I. Mitotic effects of N-methyl-1-naphthyl carbamate “Sevin”, Cytologia, 30, 175, 10.1508/cytologia.30.175 Amoore, 1963, Non-identical mechanisms of mitotic arrest by respiratory inhibitors in pea root tips and sea urchin eggs, J. Cell. Biol., 18, 555, 10.1083/jcb.18.3.555 Amy, 1979, Involvement of glutathione in the inhibition of sea urchin egg mitosis by phenyl glyoxal, J. Cell Physiol., 100, 187, 10.1002/jcp.1041000119 Andersen, 1978, Specific visualization of the distribution of the calcium dependent regulatory protein of cyclic nucleotide phosphodiesterase (modulator protein) in tissue culture cells by immunofluorescence microscopy; mitosis and intercellular bridge, Cytobiologie, 17, 354 Asakawa, 1979, Coloring conditions of thiobarbituric acid test for detecting lipid hydroperoxides, Lipids, 15, 137, 10.1007/BF02540959 Aszolos, 1985, Depolymerization of microtubules increases the motional freedom of molecular probes in cellular plasma membranes, J. Cell Biol., 100, 1351 Aubin, 1980, Intermediate filaments of the vimentin-type and the cytokeratin-type are distributed differently during mitosis, Exp. Cell Res., 129, 149, 10.1016/0014-4827(80)90340-7 Banerjee, 1979, Colcemid and colchicine binding to tubulin, FEBS Lett., 99, 333, 10.1016/0014-5793(79)80985-0 Barak, 1981, Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: Is actin involved in chromosomal movement?, 78, 3034 Baret, 1983, Variation of superoxide dismutase levels in fetal calf serum, Mutation Res., 121, 293, 10.1016/0165-7992(83)90217-8 Becker, 1980, Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum, J. Biol. Chem., 255, 9009, 10.1016/S0021-9258(19)70515-8 Bensch, 1969, Microtubule crystals: A new biophysical phenomenon induced by Vinca alkaloids, Nature (London), 218, 1176, 10.1038/2181176a0 Benz, 1983, The molecular mechanism of action of the proton ionophore FCCP (carbonylcyamide p-trifluoromethoxyphenylhydrazone), Biophys. J., 41, 381, 10.1016/S0006-3495(83)84449-X Berns, 1977, Continuation of mitosis after selective laser microbeam destruction of the centriolar region, J. Cell Biol., 75, 977, 10.1083/jcb.75.3.977 Berridge, 1984, Inositol triphosphate, a novel second messenger in cellular signal transduction, Nature (London), 312, 315, 10.1038/312315a0 Berridge, 1984, Inositol triphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor, Biochem. J., 222, 195, 10.1042/bj2220195 Bershadsky, 1981, ATP-dependent regulation of cytoplasmic microtubule diassembly, 78, 3610 Bershadsky, 1980, Destruction of microfilament bundles in mouse embryo fibroblasts treated with inhibitors of energy metabolism, Exp. Cell Res., 127, 421, 10.1016/0014-4827(80)90446-2 Bilzer, 1984, Interaction of a glutathione S-conjugate with glutathione reductase, Kinetic and X-ray crystallographic studies, Eur. J. Biochem., 138, 373, 10.1111/j.1432-1033.1984.tb07925.x Bloom, 1984, Wide spread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules, J. Cell Biol., 98, 331, 10.1083/jcb.98.1.331 Blose, 1982, Observations on the vimentin-10-nm filaments during mitosis in BHK21 cells, Exp. Cell Res., 142, 57, 10.1016/0014-4827(82)90408-6 Blose, 1981, Visualization of the 10-nm filament vimentin rings in vascular endothelial cells in situ, Exp. Cell Res., 135, 299, 10.1016/0014-4827(81)90166-X Blose, 1979, Ten-nanometer filaments and mitosis: Maintenance of structural continuity in dividing endothelial cells, 76, 3372 Bond, 1984, Systems for detecting meiotic aneuploidy in Sordaria and Neurospora, 721 Borisy, 1967, The mechanism of action of colchicine: binding of colchicine-3H to cellular protein, J. Cell. Biol., 34, 525, 10.1083/jcb.34.2.525 Boveris, 1977, Mitochondrial production of superoxide radical and hydrogen peroxide, Adv. Exp. Med. Biol., 20, 67, 10.1007/978-1-4615-9035-4_5 Bowman, 1977, Fusion of chromocenters in premeiotic interphase of Secale cereale and its possible relationship to chromosome pairing, Can. J. Genet. Cytol., 19, 313, 10.1139/g77-034 Boyland, 1983, Surface active agents as tumor promoters, Environ. Health Perspect., 50, 347 De Brabander, 1975, Oncodazole (R 17934): A new anti-cancer drug interfering with microtubules, Effects on neoplastic cells cultured in vitro and in vivo, 509 Brinkley, 1975, Studies of microtubules in dividing and non-dividing mammalian cells using antibody to 6-s bovine brain tubulin, 297 Browne, 1980, Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells, J. Cell Biol., 87, 336, 10.1083/jcb.87.2.336 Burchill, 1978, Microtubule dynamics and glutathione metabolism in phagocytizing human polymorphonuclear leukocytes, J. Cell Biol., 76, 439, 10.1083/jcb.76.2.439 Burk, 1980, Rat hepatic cytosolic glutathione-dependent enzyme protection against lipid peroxidation in the NADPH-microsomal lipid peroxidation system, Biochim. Biophys. Acta, 618, 35, 10.1016/0005-2760(80)90051-X Burk, 1983, Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation, Biochim. Biophys. Acta, 757, 21, 10.1016/0304-4165(83)90148-4 Bus, 1979, Lipid peroxidation and its role in toxicology, Rev. Biochem. Toxicol., 1, 125 Böhm, 1981, Excessive reversible phenobarbital induced nuclear DNA-polyploidization in the growing mouse liver, Histochemistry, 72, 63, 10.1007/BF00496780 Cabral, 1983, Isolation of Chinese hamster ovary cell mutants requiring the continuous presence of taxol for cell division, J. Cell Biol., 97, 22, 10.1083/jcb.97.1.22 Cabral, 1982, Revertants of a Chinese hamster ovary cell mutant with an altered β-tubulin: Evidence that the altered tubulin confers both colcemid resistance and temperature sensitivity on the cell, Mol. Cell. Biol., 2, 720, 10.1128/MCB.2.6.720 Cabral, 1981, Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in α-tubulin, 78, 4388 Cabral, 1983, Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly, J. Cell Biol., 97, 30, 10.1083/jcb.97.1.30 Cabral, 1980, CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered β-tubulin, Cell, 20, 29, 10.1016/0092-8674(80)90231-7 Cachelin, 1983, Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells, Nature (London), 304, 462, 10.1038/304462a0 Cande, 1982, Nucleotide requirements for anaphase chromosome movements in permeabilized mitotic cells: Anaphase B but not anaphase A requires ATP, Cell, 28, 15, 10.1016/0092-8674(82)90370-1 Cande, 1983, Creatine kinase role in anaphase chromosome movement, Nature (London), 304, 557, 10.1038/304557a0 Cande, 1981, A permeabilized cell model for studying cell division: A comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells, J. Cell Biol., 88, 618, 10.1083/jcb.88.3.618 Capco, 1983, Mitotic architecture of the cell: The filament networks of the nucleus and cytoplasm, J. Cell Biol., 96, 896, 10.1083/jcb.96.3.896 Carafoli, 1971, A survey of the interaction of calcium ions with mitochondria from different tissues and species, Biochem. J., 122, 681, 10.1042/bj1220681 Carlberg, 1981, Effects of inducers of drug metabolizing enzymes on glutathione reductase and glutathione peroxidase in rat liver, Biochim. Biophys. Acta, 677, 140, 10.1016/0304-4165(81)90155-0 Carlsson, 1981, Colchicine treatment of HeLa cells alters the G/F actin ratio, FEBS Lett., 124, 282, 10.1016/0014-5793(81)80156-1 Cavanee, 1983, Expression of recessive alleles by chromosomal mechanisms in retinoblastoma, Nature (London), 305, 779, 10.1038/305779a0 Chafouleas, 1983, Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes, Methods Enzymol., 102, 104, 10.1016/S0076-6879(83)02011-X Chafouleas, 1981, Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells, 78, 996 Chasseaud, 1974, Glutathione S-transferases, 90 Chasseaud, 1979, The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents, Vol. 29, 175 Cheung, 1980, Calmodulin plays a pivotal role in cellular regulation, Science, 207, 19, 10.1126/science.6243188 Clearkin, 1937, The effect of colchicine on normal and neoplastic tissues in mice, J. Pathol. Bacteriol., 44, 469, 10.1002/path.1700440220 Clowes, 1950, Action of nitro- and halophenols upon oxygen consumption and phosphorylation by a cell-free particulate system from Arbacia eggs, J. Gen. Physiol., 33, 555, 10.1085/jgp.33.5.555 Cohen, 1982, The role of protein phosphorylation in neural and hormonal control of cellular activity, Nature (London), 296, 613, 10.1038/296613a0 Coluccio, 1984, Phalloidin enhances actin assembly by preventing monomer dissociation, J. Cell Biol., 99, 529, 10.1083/jcb.99.2.529 Comings, 1970, Association of nuclear membrane fragments with metaphase and anaphase chromosomes as observed by whole mount electron microscopy, Exp. Cell Res., 63, 62, 10.1016/0014-4827(70)90331-9 Connolly, 1977, Immunofluorescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to τ protein, 74, 2437 Connolly, 1981, Microtubules in colcemid-resistant mutants of CHO cells, Exp. Cell Res., 132, 147, 10.1016/0014-4827(81)90091-4 Coss, 1974, The effects of isopropyl-N-phenylcarbamate on the green alga Oedogonium cardiacum, I. Cell division, J. Cell Biol., 63, 84, 10.1083/jcb.63.1.84 Coss, 1975, Studies on the mechanism of action of isopropyl-N-phenylcarbamate, Exp. Cell Res., 92, 394, 10.1016/0014-4827(75)90393-6 Cox, 1973, A quantitative analysis of colcemid-induced chromosomal non-disjunction in Chinese hamster cells in vitro, Cytogenet. Cell Genet., 12, 165, 10.1159/000130452 Crossin, 1981, Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis, Cell, 23, 61, 10.1016/0092-8674(81)90270-1 Danford, 1984, Measurements of level of aneuploidy in mammalian cells using a modified hypotonic treatment, Mutation Res., 139, 127, 10.1016/0165-7992(84)90007-1 Davidse, 1975, Antimitotic activity of methyl benzimidazol-2-yl carbamate in fungi and its binding to cellular protein, 483 Dawson, 1985, Monoclonal antibody to intermediate filament antigen cross-reacts with higher plant cells, J. Cell Biol., 100, 1793, 10.1083/jcb.100.5.1793 Debetto, 1984, Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes, J. Biol. Chem., 259, 13824, 10.1016/S0021-9258(18)89820-9 Dedman, 1977, Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase, J. Biol. Chem., 252, 8415, 10.1016/S0021-9258(19)75234-X Deery, 1984, Calmodulin-microtubule association in cultured mammalian cells, J. Cell Biol., 98, 904, 10.1083/jcb.98.3.904 Deysson, 1975, Microtubules and antimitotic substances, 427 Dikstein, 1971, Stimulability, adenosine triphosphatases and their control by cellular redox processes, Naturwissenschaften, 58, 439, 10.1007/BF00624617 Dover, 1973, The effect of spindle inhibitors applied before meiosis on meiotic chromosome pairing, J. Cell Sci., 12, 143, 10.1242/jcs.12.1.143 Durham, 1982, Calcium ions and the control of proliferation in normal and cancer cells, Biosci. Rep., 2, 15, 10.1007/BF01142195 Dyrssen, 1980, Major and minor elements, chemical speciation in estuarine waters, 71 Eggleston, 1974, Regulation of the pentose phosphate cycle, Biochem. J., 138, 425, 10.1042/bj1380425 Egrie, 1980, Are the sea urchin mitotic Ca2+-ATPase and Ca2+-sequestering activities affected by calmodulin?, Ann. N.Y. Acad. Sci., 356, 376, 10.1111/j.1749-6632.1980.tb29634.x Ehrenberg, 1983, Mutation Res., 123, 121, 10.1016/0165-1110(83)90024-6 Eisen, 1985, Source and sinks for the calcium released during fertilization of single sea urchin eggs, J. Cell Biol., 100, 1522, 10.1083/jcb.100.5.1522 Emerit, 1983, Suppression of tumor promoter phorbol myristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism, Mutation Res., 110, 327, 10.1016/0027-5107(83)90149-5 Endo, 1977, Calcium release from the sarcoplasmic reticulum, Physiol. Rev., 57, 71, 10.1152/physrev.1977.57.1.71 Epel, 1963, The effects of carbon monoxide inhibition on ATP level and the rate of mitosis in the sea urching egg, J. Cell Biol., 17, 315, 10.1083/jcb.17.2.315 Epstein, 1971, Introduction to discussion of lens and red cell sulfhydryl membrane groups, Exp. Eye Res., 11, 351, 10.1016/S0014-4835(71)80046-5 Euteneuer, 1983, Polarity of kinetochore microtubules in Chinese hamster ovary cells after recovery from a colcemid block, J. Cell Biol., 97, 202, 10.1083/jcb.97.1.202 Euteneuer, 1981, Structural polarity of kinetochore microtubules in PtK cells, J. Cell Biol., 89, 338, 10.1083/jcb.89.2.338 Fahey, 1976, The glutathione thiol-disulfide status in the sea urchin egg during fertilization and the first cell division cycle, Biochim. Biophys. Acta, 437, 445, 10.1016/0304-4165(76)90013-1 Fiskesjö, 1969, Some results from Allium tests with organic mercury halogenides, Hereditas, 62, 314, 10.1111/j.1601-5223.1969.tb02241.x Fiskum, 1979, Regulated release of calcium from respiring mitochondria by calcium-proton antiport, J. Biol. Chem., 254, 6236, 10.1016/S0021-9258(18)50352-5 Flohé, 1976, Glutathione peroxidase, 115 Flohé, 1979, The glutathione peroxidase reaction: A key to understand the selenium requirement of mammals, 263 Forer, 1978, Chromosome movements during cell-division: Possible involvement of actin filaments, 21 Forer, 1981, Light microscopic studies of chromosome movements in living cells, 135 Franke, 1978, Antibody to prekeratin, Decoration of tonofilament-like arrays in various cells of epithelial character, Exp. Cell Res., 116, 429, 10.1016/0014-4827(78)90466-4 Franks, 1984, Do general anaesthetics act by competitive binding to specific receptors?, Nature (London), 310, 599, 10.1038/310599a0 Franks, 1982, Molecular mechanisms of general anaesthesia, Nature (London), 300, 487, 10.1038/300487a0 Franks, 1978, Where do general anaesthetics act?, Nature (London), 274, 339, 10.1038/274339a0 Frank, 1982, Localization of vimentin and desmin in BHK21/C13 cells and in baby hamster kidney, Exp. Cell Res., 139, 235, 10.1016/0014-4827(82)90248-8 Fredborg, 1970, Decreased glutathione-reductase activity in the mitotic Ehrlich ascites-tumour cell, Exp. Cell Res., 59, 452, 10.1016/0014-4827(70)90653-1 Friedkin, 1979, Anti-tubulin agents enhance the stimulation of DNA synthesis by polypeptide growth factors in 3T3 mouse fibroblasts, 76, 3909 Fujiwara, 1976, Fluorescent antibody localization of myosin in the cytoplasm, cleavage furrow and mitotic spindle of human cells, J. Cell. Biol., 71, 848, 10.1083/jcb.71.3.848 Füchtenbauer, 1983, Disruption of microfilament organization after injection of F-actin capping proteins into living tissue culture cells, Nature (London), 304, 361, 10.1038/304361a0 Fühner, 1921, Die Wirkungsstärke der Narcotica, I. Versuche am isolierten Froschherzen, Biochem. Z., 120, 143 Ganther, 1978, Modification of methyl mercury toxicity and metabolism by selenium and vitamin E: Possible mechanisms, Environ. Health Perspect., 25, 71, 10.1289/ehp.782571 Geiger, 1984, Microfilament-organizing centers in areas of cell contact: cytoskeletal interactions during cell attachment and locomotion, J. Cell Biol., 99, 83s, 10.1083/jcb.99.1.83s Gibson, 1980, Glutathione-dependent inhibition of lipid peroxidation by a soluble, heat-labile factor in animal tissues, Biochim. Biophys. Acta, 620, 572, 10.1016/0005-2760(80)90149-6 Gill, 1976, Purification and characterization of 3′:5′-cyclic GMP-dependent protein kinase, 73, 3918 Gould, 1977, The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation, J. Cell Biol., 73, 601, 10.1083/jcb.73.3.601 Greengard, 1978, Phosphorylated proteins as physiological effectors, Science, 199, 146, 10.1126/science.22932 Grell, 1979, Origin of meiotic non disjunction in Drosophila females, Environ. Health Perspect., 31, 33, 10.1289/ehp.793133 Griffiths, 1979, Neurospora prototroph selection system for studying aneuploid production, Environ. Health Perspect., 31, 75, 10.1289/ehp.793175 Griffith, 1982, The interaction of actin filaments with microtubules and microtubule-associated proteins, J. Biol. Chem., 257, 9143, 10.1016/S0021-9258(18)34254-6 Gualandi, 1984, Genotoxicity of the free-radical producers CCl4 and lipoperoxide in Aspergillus nidulans, Mutation Res., 136, 109, 10.1016/0165-1218(84)90151-4 Guerriero, 1981, Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme, Cell, 27, 449, 10.1016/0092-8674(81)90386-X Gull, 1973, Griseofulvin inhibits fungal mitosis, Nature (London), 244, 292, 10.1038/244292a0 Haga, 1975, Microtubule formation from two components separated by gel filtration, Biochim. Biophys. Acta, 392, 335, 10.1016/0304-4165(75)90015-X Hahn, 1976, Effect of phenobarbital on lipid peroxidation in the liver, Biochem. Pharmacol., 25, 769, 10.1016/0006-2952(76)90144-1 Hansch, 1979 Hansch, 1972, Linear relationships between lipophilic character and biological activity of drugs, J. Pharm. Sci., 61, 1, 10.1002/jps.2600610102 Harris, 1972, Non-specific reactions of the glutathione oxidant “diamide” with mammalian cells, Biochem. Biophys. Res. Commun., 46, 1743, 10.1016/0006-291X(72)90045-9 Harris, 1975, The role of membranes in the organization of the mitotic apparatus, Exp. Cell. Res., 94, 409, 10.1016/0014-4827(75)90507-8 Harris, 1983, Caffeine-induced monaster cycling in fertilized eggs of the sea urchin Strongylocentrotus purpuratus, Dev. Biol., 96, 277, 10.1016/0012-1606(83)90164-1 Harris, 1978, Triggers, trigger waves and mitosis: A new model, 75 Harris, 1981, Calcium regulation of cell cycle events, 29 Hartwig, 1979, Cytochalasin B and the structure of actin gels, J. Mol. Biol., 134, 539, 10.1016/0022-2836(79)90366-8 Hatzfeld, 1975, Temperature-sensitive cell cycle mutants: a Chinese hamster cell line with a reversible block in cytokinesis, Cell, 5, 123, 10.1016/0092-8674(75)90020-3 Hauser, 1980, Caffeine and Ca2+ accelerate chromosome movement in Locusta meiosis, Eur. J. Cell Biol., 22, 313 Held, 1982, Polyploidy and aneuploidy induced by colcemid in Drosophila melanogaster, Mutation Res., 94, 87, 10.1016/0027-5107(82)90171-3 Hepler, 1969, Isopropyl-N-phenylcarbamate affects spindle microtubule orientation in dividing endosperm cells of Haemanthus katherinae Baker, J. Cell Sci., 5, 727, 10.1242/jcs.5.3.727 Hepler, 1980, Membranes in the mitotic apparatus of barley cells, J. Cell. Biol., 86, 490, 10.1083/jcb.86.2.490 Hepler, 1985, Calcium restriction prolongs metaphase in dividing Tradescantia stamen hair cells, J. Cell Biol., 100, 1363, 10.1083/jcb.100.5.1363 Herman, 1978, Actin localization in fixed dividing cells stained with fluorescent heavy meromyosin, Exp. Cell. Res., 114, 15, 10.1016/0014-4827(78)90030-7 Hinderer, 1976, Comparative enzyme activities and cytochrome P-450 levels of some rat tissues with respect to their metabolism of several pesticides, Pest. Biochem. Physiol., 6, 148, 10.1016/0048-3575(76)90034-1 Hiramoto, 1981, Quantitative studies on the polarization optical properties of living cells, II. The role of microtubules in birefringence of the spindle of the sea urchin egg, J. Cell Biol., 89, 121, 10.1083/jcb.89.1.121 Hirata, 1983, Ca2+ release in the endoplasmic reticulum of guinea pig peritoneal macrophages, J. Biochem., 94, 1155, 10.1093/oxfordjournals.jbchem.a134460 Hoebeke, 1976, Interaction of oncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin, Bichem. Biophys. Res. Commun., 69, 319, 10.1016/0006-291X(76)90524-6 Holmgren, 1979, Reduction of disulfides by thioredoxin, Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action, J. Biol. Chem., 254, 9113, 10.1016/S0021-9258(19)86818-7 Hotta, 1973, Biochemical aspects of colchicine action on meiotic cells, Mol. Gen. Genet., 122, 243, 10.1007/BF00278600 IARC, 1976 IARC, 1977 Ii, 1974, Glutathione reductase in the sea urchin egg, II. Cleavage-associating fluctuation of the activity and its possible regulatory mechanism, Biochim. Biophys. Acta, 350, 151, 10.1016/0005-2744(74)90213-7 Isaacs, 1977, Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissue, Biochim. Biophys. Acta, 497, 192, 10.1016/0304-4165(77)90152-0 Isaacs, 1977, Cyclic AMP-dependent control of the rat hepatic glutathione disulfide-sulfhydryl ratio, Biochim. Biophys. Acta, 498, 29, 10.1016/0304-4165(77)90084-8 Izant, 1983, The role of calcium ions during mitosis, Calcium participates in the anaphase trigger, Chromosoma, 88, 1, 10.1007/BF00329497 Jackson, 1982, Membrane distribution in dividing endosperm cells of Haemanthus, J. Cell. Biol., 94, 637, 10.1083/jcb.94.3.637 Jackson, 1969, Regulation of mitosis, II. Interaction of isopropyl-N-phenylcarbamate and melatonin, J. Cell Sci., 5, 745, 10.1242/jcs.5.3.745 Jakoby, 1978, The glutathione S-transferases: A group of multifunctional detoxification proteins, Adv. Enzymol., 46, 383 Jameson, 1981, Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins, 78, 3413 Jawaid, 1978, Solvent extraction studies on the complex formation between methylmercury and bromide, chloride and nitrate ions, Acta Chem. Scand., A32, 7, 10.3891/acta.chem.scand.32a-0007 Jensen, 1969, Biological methylation of mercury in aquatic organisms, Nature (London), 223, 753, 10.1038/223753a0 Jenssen, 1980, The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested, Mutation Res., 75, 191, 10.1016/0165-1110(80)90014-7 Johnson, 1984, Mechanism of force production for microtubule-dependent movements, J. Cell Biol., 99, 132s, 10.1083/jcb.99.1.132s Johnson, 1973, The opposing effects of pressure and general anaesthetics on the cation permeability of liposomes of varying lipid composition, Biochim. Biophys. Acta, 307, 42, 10.1016/0005-2736(73)90023-0 Karsenti, 1984, Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase, J. Cell Biol., 99, 47s, 10.1083/jcb.99.1.47s Katz, 1980, Mechanism of stimulation of calcium transport in cardiac sarcoplasmic reticulum preparations by calmodulin, Ann. N.Y. Acad. Sci., 356, 267, 10.1111/j.1749-6632.1980.tb29617.x Keith, 1983, Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules, J. Cell Biol., 97, 1918, 10.1083/jcb.97.6.1918 Keller, 1982, Strongylocentrotus purpuratus spindle tubulin, II. Characteristics of its sensitivity to Ca++ and the effects of calmodulin from bovine brain and S. purpuratus eggs, J. Cell Biol., 93, 797, 10.1083/jcb.93.3.797 Kemphues, 1979, Mutation in a structural gene for a β-tubulin specific to testis in Drosophila melanogaster, 76, 3991 Kershaw, 1980, The relationship between blood levels and dose of methyl mercury in man, Arch. Environ. Health, 35, 28, 10.1080/00039896.1980.10667458 Kiehart, 1981, Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system, J. Cell Biol., 88, 604, 10.1083/jcb.88.3.604 Kiehart, 1977, Evidence that force production in chromosome movement does not involve myosin, J. Cell Biol., 75, 258a Kilmartin, 1981, Purification of yeast tubulin by self assembly in vitro, Biochemistry, 20, 3629, 10.1021/bi00515a050 Klein, 1981, The role of gene dosage and genetic transpositions in carcinogenesis, Nature (London), 294, 313, 10.1038/294313a0 Klein, 1980, Cell kinetic alterations in normal and neoplastic cell populations in vitro and in vivo following vincristine, Cell Tissue Kinet, 13, 425 Klein, 1970, An ultrasensitive assay for soluble sulfhydryl and its application to the study of glutathione levels during the HeLa life cycle, J. Cell Biol., 46, 165, 10.1083/jcb.46.1.165 Koons, 1982, Immunofluorescence and inhibitor studies on creatine kinase and mitosis, Exp. Cell Res., 140, 401, 10.1016/0014-4827(82)90130-6 Kosower, 1976, Chemical basis of the perturbation of glutathione-glutathione disulfide status of biological systems by diazenes, 139 Kosower, 1978, The glutathione status of cells, Int. Rev. Cytol., 54, 109, 10.1016/S0074-7696(08)60166-7 Kosower, 1976, Functional aspects of glutathione disulfide and hidden forms of glutathione, 159 Kostoff, 1940, Atypical growth, abnormal mitosis and polyploidy induced by ethyl-mercury-chloride, Cytopathol. Z., 13, 91 Krebs, 1979, Phosphorylation-dephosphorylation of enzymes, Annu. Rev. Biochem., 48, 923, 10.1146/annurev.bi.48.070179.004423 Kunz, 1983, Quantitative aspects of chemical carcinogenesis and tumor promotion in liver, Environ. Health Perspect., 50, 113, 10.1289/ehp.8350113 Kuriyama, 1974, Role of tubulin-SH groups in polymerization to microtubules, J. Biochem., 76, 651, 10.1093/oxfordjournals.jbchem.a130609 Laduron, 1983, Chemotherapeutic efficacy of nocodazole encapsulated in liposomes on L1210 murine leukemia, Res. Commun. Chem. Pathol. Pharmacol., 39, 419 Lakowicz, 1980, Permeability of lipid bilayers to methyl mercury chloride: Quantification by fluorescence quenching of a carbazole-labeled phospholipid, Chem.-Biol. Interact., 30, 309, 10.1016/0009-2797(80)90054-X Lawrence, 1975, Synthesis of microtubule protein in HeLa cells approaching division, Cytobios, 13, 167 Lee, 1973, The chemical characterization of calf brain microtubule protein subunits, J. Biol. Chem., 20, 7253, 10.1016/S0021-9258(19)43386-3 Lee, 1982, Two opposing effects of calmodulin on microtubule assembly dependent on the presence of microtubule-associated proteins, J. Biol. Chem., 257, 6306, 10.1016/S0021-9258(20)65140-7 Lehninger, 1978, Regulation of Ca2+-release from mitochondria by the oxidation-reduction state of pyridine nucleotides, 75, 1690 Lenaz, 1978, A conformational model for the action of general anesthetics at the membrane level, I. Theoretical considerations, Ital. J. Biochem., 27, 378 Lenaz, 1978, A conformational model for the action of general anesthetics at the membrane level, II. Experimental observations on the effects of anesthetics on lipid fluidity and lipid protein interactions, Ital. J. Biochem., 27, 401 Leo, 1971, Partition coefficients and their uses, Chem. Rev., 71, 525, 10.1021/cr60274a001 Levan, 1943, The mechanism of c-mitotic action, Hereditas, 29, 381, 10.1111/j.1601-5223.1943.tb03297.x Levan, 1938, The effect of colchicine on root mitoses in Allium, Hereditas, 24, 471, 10.1111/j.1601-5223.1938.tb03221.x Levan, 1949, The influence on chromosomes and mitosis of chemicals as studied by the Allium test, Hereditas, 325 Levan, 1971, Cytogenetic effects of hexyl mercury bromide in the Allium test, J. Indian Bot. Soc., Golden Jubilee, Vol., 50A, 340 Liang, 1985, Induction of aneuploidy by mitotic arrestants in mouse bone marrow, Mutation Res., 155, 61, 10.1016/0165-1218(85)90026-6 Lockwood, 1979, Molecules in mammalian brain that interact with the colchicine site of tubulin, 76, 1184 Luduena, 1975, Cross-linked tubulin, 47 Mabuchi, 1973, ATPase in the cortical layer of sea urchin egg, its properties and interaction with cortex protein, Biochim. Biophys. Acta, 297, 317, 10.1016/0304-4165(73)90079-2 Manfredi, 1982, Taxol binds to cellular microtubules, J. Cell Biol., 94, 688, 10.1083/jcb.94.3.688 Mangenot, 1941, Substances mitoclasiques et cellules végétales, Rev. Cytol. Cytophysiol. Végét., 5, 196 Mannervik, 1980, Role of cytoplasmic thioltransferase in cellular regulation by thiol-disulphide interchange, Biochem. J., 190, 125, 10.1042/bj1900125 Mannervik, 1980, Mercaptans, 185 Marcum, 1978, Control of microtubule assembly-disassembly by calcium-dependent regulator protein, 75, 3771 Margolis, 1977, Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning, 74, 3466 Margolis, 1981, Role of GTP hydrolysis in microtubule treadmilling and assembly, 78, 1586 Maro, 1982, Reorganization of HeLa cell cytoskeleton induced by an uncoupler of oxidative phosphorylation, Nature (London), 295, 334, 10.1038/295334a0 Mazia, 1958, SH compounds in mitosis, I. The action of mercaptoethanol on the eggs of the sand dollar Dendrasteo excentricus, Exp. Cell Res., 14, 486, 10.1016/0014-4827(58)90156-3 Mazia, 1972, A Ca2+-activated ATPase in the mitotic apparatus of the sea urchin egg (isolated by a new method), Exp. Cell Res., 70, 325, 10.1016/0014-4827(72)90143-7 McIntosh, 1981, Microtubule polarity and interaction in mitotic spindle function, 359 McNiven, 1984, Chromatophores — models for studying cytomatrix translocations, J. Cell Biol., 99, 152s, 10.1083/jcb.99.1.152s Means, 1980, Calmodulin — an intracellular calcium receptor, Nature (London), 285, 73, 10.1038/285073a0 Means, 1984, Post-receptor signal transduction by cyclic adenosine monophosphate and the Ca2+ calmodulin complex, J. Cell Biol., 99, 226s, 10.1083/jcb.99.1.226s Means, 1982, Regulation of the cytoskeleton by Ca2+-calmodulin and c-AMP, Ann. N.Y. Acad. Sci., 383, 63, 10.1111/j.1749-6632.1982.tb23162.x Meredith, 1982, Status of the mitochondrial pool of glutathione in the isolated hepatocyte, J. Biol. Chem., 257, 3747, 10.1016/S0021-9258(18)34844-0 Metcalf, 1968, The proton relaxation of benzyl alcohol in erythrocyte membranes (human blood), Mol. Pharmacol., 4, 87 Meyer, 1935, Beiträge zur Theorie der Narkose, III. Biochem. Z., 277, 39 Miller, 1979, Covalent binding of carbaryl(1-naphthyl-N-methyl-carbamate) to rat liver microsomes in vitro, Chem.-Biol. Interact., 24, 1, 10.1016/0009-2797(79)90099-1 Mitchinson, 1984, Microtubule assembly nucleated by isolated centrosomes, Nature (London), 312, 232, 10.1038/312232a0 Mitchinson, 1984, Dynamic instability of microtubule growth, Nature (London), 312, 237, 10.1038/312237a0 Modig, 1968, Cellular mixed disulphides between thiols and proteins, and their possible implication for radiation protection, Biochem. Pharmacol., 17, 177, 10.1016/0006-2952(68)90321-3 Moll, 1980, Membranes of the mitotic apparatus of mammalian cells, Eur. J. Cell. Biol., 21, 280 Moolenar, 1984, Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH, Nature (London), 312, 371, 10.1038/312371a0 Moore, 1983, On the relationship between Ca2+ efflux and membrane damage during t-butylhydroperoxide metabolism by liver mitochondria, FEBS Lett., 153, 289, 10.1016/0014-5793(83)80626-7 Moore, 1977, Energy-dependent calcium uptake activity in cultured mouse fibroblast microsomes, J. Biol. Chem., 252, 6304, 10.1016/S0021-9258(17)39956-8 Moore, 1980, Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride), Biochem. Pharmacol., 29, 2505, 10.1016/0006-2952(80)90356-1 Moore, 1976, Calcium uptake of rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride, J. Biol. Chem., 251, 1197, 10.1016/S0021-9258(17)33820-6 Morris, 1979, Identification of a gene for α-tubulin in Aspergillus nidulans, Cell, 16, 437, 10.1016/0092-8674(79)90019-9 Mukhtar, 1976, Effects of phenobarbital and 3-methylcholanthrene administration on glutathione S-epoxide transferase activity in rat liver, Biochem. Pharmacol., 25, 1081, 10.1016/0006-2952(76)90501-3 Mullins, 1979, Effects of griseofulvin on mitosis in PtK1 cells, Chromosoma, 72, 105, 10.1007/BF00286432 Nath, 1976, Effect of caffeine and other methylxanthines on the development and metabolism of sea urchin eggs, J. Cell Biol., 68, 440, 10.1083/jcb.68.3.440 Nath, 1973, Studies on cyclic AMP levels and phosphodiesterase activity in developing sea urchin eggs, Effects of puromycin, 6-dimethylaminopurine and aminophylline, Exp. Cell Res., 77, 319, 10.1016/0014-4827(73)90583-1 Nunez, 1979, Competitive inhibition of colchicine binding to tubulin by microtubule associated proteins, 76, 86 Oakley, 1980, β-Tubulin mutants of Aspergillus nidulans defective for microtubule assembly and function, J. Cell Biol., 87, 237a Oakley, 1981, A β-tubulin mutation in Aspergillus nidulans that blocks microtubule function without blocking assembly, Cell, 24, 837, 10.1016/0092-8674(81)90109-4 Ohnishi, 1984, Ethanol increases calcium permeability of heavy sarcoplasmic reticulum of skeletal muscle, Arch. Biochem. Biophys., 233, 588, 10.1016/0003-9861(84)90483-1 Oliver, 1976, Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils, J. Cell Biol., 71, 921, 10.1083/jcb.71.3.921 Oliver, 1978, A carbamate herbicide causes microtubule and microfilament disruption and nuclear fragmentation in fibroblasts, Exp. Cell Res., 116, 229, 10.1016/0014-4827(78)90079-4 Oliver, 1978, Microtubule assembly and function in normal and glutathione synthetase deficient polymorphonuclear leukocytes, J. Immunol., 120, 1181 Olmsted, 1984, Cellular regulation of microtubule organization, J. Cell Biol., 99, 285s, 10.1083/jcb.99.1.28s Önfelt, A., Spindle disturbances in mammalian cells, IV. The action of some glutathione specific agents in V79 Chinese hamster cells; changes in levels of free sulfhydryls and ATP, c-mitosis and effects on DNA-metabolism, submitted. Önfelt, A., Spindle disturbances in mammalian cells, III. Toxicity, c-mitosis and aneuploidy with 22 different compounds, Specific and unspecific mechanisms, submitted. Önfelt, 1983, Spindle disturbances in mammalian cells, II. Induction of viable aneuploid/polyploid cells and multiple chromatid exchanges after treatment of V79 Chinese hamster cells with carbaryl, Modifying effects of glutathione and S9, Mutation Res., 119, 319, 10.1016/0165-7992(83)90180-X Önfelt, 1984, Sister-chromatid ex-changes and thioguanine resistance in V79 Chinese hamster cells after treatment with the aneuploidy-inducing agent carbaryl±S9 mix, Mutation Res., 125, 269, 10.1016/0027-5107(84)90076-9 Önfelt, 1983, Spindle disturbances in mammalian cells, I. Changes in the quantity of free sulfhydryl groups in relation to survival and c-mitosis in V79 Chinese hamster cells after treatment with colcemid, diamide, carbaryl and methyl mercury, Chem.-Biol. Interact., 46, 201, 10.1016/0009-2797(83)90029-7 Önfelt, 1986, Relationships between induction of anesthesia and mitotic spindle disturbances studied by use of principal component analysis, Mutation Res., 174, 109, 10.1016/0165-7992(86)90099-0 Östergren, 1943, The connection between c-mitotic activity and water solubility in some monocyclic compounds, Hereditas, 29, 496 Östergren, 1944, Colchicine mitosis, chromosome contraction, narcosis and protein chain folding, Hereditas, 30, 429, 10.1111/j.1601-5223.1944.tb02739.x Östergren, 1950, Cytological standards for the quantitative estimation of spindle disturbances, Hereditas, 36, 371, 10.1111/j.1601-5223.1950.tb03383.x Östergren, 1951, Narcotized mitosis and the precipitation hypothesis of narcosis, Mécanisme de la Narcose, Colloques Internationaux du Centre National de la Recherche Scientifique, Vol. XXVI, 77 Otto, 1979, Cytoskeleton-disrupting drugs enhance effect of growth factors and hormones on initiation of DNA synthesis, 76, 6435 Otto, 1981, Microtubule-disrupting agents affect two different events regulating the initiation of DNA synthesis in Swiss 3T3 cells, 78, 3063 Overton, 1901 Pang, 1979, On the coupling between anesthetic induced membrane fluidization and cation permeability in lipid vesicles, Mol. Pharmacol., 15, 729 Parke, 1982, Mechanisms of chemical toxicity — a unifying hypothesis, Reg. Toxicol. Pharmacol., 2, 267, 10.1016/0273-2300(82)90001-0 Parry, 1981, Tumour promotors induce mitotic aneuploidy in yeast, Nature (London), 294, 263, 10.1038/294263a0 Parry, 1979, Detection of mitotic and meiotic aneuploidy in the yeast, Saccharomyces cerevisiae, Environ. Health Perspect., 31, 97, 10.1289/ehp.793197 Paweletz, 1981, Membranes and microtubules of the mitotic apparatus of mammalian cells, J. Ultrastruct. Res., 76, 127, 10.1016/S0022-5320(81)80011-1 Paweletz, 1981, Mini-review, Membranes in the mitotic apparatus, Cell. Biol. Int. Rep., 5, 323, 10.1016/0309-1651(81)90001-1 Pepper, 1984, Studies of a microtubule-associated protein using a monoclonal antibody elicited against mammalian mitotic spindles, J. Cell Biol., 99, 503, 10.1083/jcb.99.2.503 Periano, 1971, Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in rat by 2-acetylaminofluorene, Cancer Res., 31, 1506 Petzelt, 1981, The mitotic Ca2+-ATPase is an essential part of the intracellular Ca2+-regulating system, J. Cell. Biol., 91, 318a Petzelt, 1972, Ca2+-activated ATPase during the cell cycle of the sea urchin Strongylocentrotus purpuratus, Exp. Cell Res., 70, 333, 10.1016/0014-4827(72)90144-9 Petzelt, 1979, Biochemistry of the mitotic spindle, Int. Rev. Cytol., 60, 53, 10.1016/S0074-7696(08)61259-0 Petzelt, 1980, Immunocytochemical localization of the mitotic Ca2+ ATPase in mitotic apparatus isolated with different methods, Eur. J. Cell Biol., 22, 314 Le Peuch, 1979, Concerted regulation of cardiac sarcoplasmic reticulum, Calcium transport by cyclic adenosine monophosphate-dependent and calcium-calmodulin-dependent phosphorylations, Biochemistry, 18, 5150, 10.1021/bi00590a019 Picket-Heaps, 1984, Chromosome motion and the spindle matrix, J. Cell Biol., 99, 137s, 10.1083/jcb.99.1.137s Picket-Heaps, 1967, The effects of colchicine on the ultrastructure of dividing plant cells, xylem wall differentiation and distribution of cytoplasmic microtubules, Dev. Biol., 15, 206, 10.1016/0012-1606(67)90041-3 Picket-Heaps, 1982, Rethinking mitosis, Cell, 29, 729, 10.1016/0092-8674(82)90435-4 Pollack, 1975, Patterns of organization of actin and myosin in normal and transformed cultured cells, 72, 994 Pollard, 1984, Interaction of actin filaments with microtubules, J. Cell Biol., 99, 33s, 10.1083/jcb.99.1.33s Pomerat, 1939, Studies on the growth of tissues in vitro, VII. Carbohydrate metabolism and mitosis, J. Exp. Biol., 16, 232, 10.1242/jeb.16.2.232 Porter, 1960, Studies on the endoplasmic reticulum, IV. Its form and distribution during mitosis in cells of onion root tip, J. Biophys. Biochem. Cytol., 7, 167, 10.1083/jcb.7.1.167 Porter, 1976, Motility in cells, 1 Porter, 1983, The cytoplasmic matrix, Mod. Cell Biol., 2, 259 Pratt, 1980, Dynein-like Mg2+ATPase in mitotic spindles isolated from sea urchin embryos (Strongylocentrotus dröbachiensis), J. Cell Biol., 86, 738, 10.1083/jcb.86.3.738 Prohaska, 1977, Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver, Biochem. Biophys. Res. Commun., 76, 437, 10.1016/0006-291X(77)90744-6 Pryor, 1982, Free radical biology: Xenobiotics, cancer, and aging, Ann. N.Y. Acad. Sci., 393, 1, 10.1111/j.1749-6632.1982.tb31228.x Rabenstein, 1978, The aqueous solution chemistry of methyl mercury and its complexes, Acc. Chem. Res., 11, 100, 10.1021/ar50123a004 Raes, 1984, Polyploid cells in ageing hamster fibroblasts in vitro: possible implication of the centrosome, Eur. J. Cell Biol., 35, 70 Raff, 1984, Genetics of microtubule systems, J. Cell Biol., 99, 1, 10.1083/jcb.99.1.1 Ramel, 1979, Chemical production of non-disjunction in Drosophila, Environ. Health Perspect, 31, 59, 10.1289/ehp.793159 Ramel, 1969, Genetic effects of organic mercury compounds, II. Chromosome segregation in Drosophila melanogaster, Hereditas, 61, 231, 10.1111/j.1601-5223.1969.tb01839.x Ramel, 1969, Genetic effects of organic mercury compounds, I. Cytological investigations on Allium roots, Hereditas, 61, 208, 10.1111/j.1601-5223.1969.tb01838.x Ramel, 1972, Genetic effects, 169 Rebhun, 1973, Cleavage inhibition in marine eggs by puromycin and 6-dimethylaminopurine, Exp. Cell Res., 77, 312, 10.1016/0014-4827(73)90582-X Rebhun, 1976, Calcium, sulfhydryls and the mitotic apparatus, Am. Zool., 16, 469, 10.1093/icb/16.3.469 Rebhun, 1977, Cyclic nucleotides, calcium, and cell division, Int. Rev. Cytol., 49, 1, 10.1016/S0074-7696(08)61946-4 Rebhun, 1974, Regulation of the in vivo mitotic apparatus by glycols and metabolic inhibitors, Ann. N.Y. Acad. Sci., 253, 362, 10.1111/j.1749-6632.1975.tb19214.x Reddy, 1982, Vitamin E dependent reduced glutathione inhibition of rat liver microsomal lipid peroxidation, Life Sci., 31, 571, 10.1016/0024-3205(82)90486-6 Regula, 1981, Microtubule assembly and disassembly at alkaline pH, J. Cell Biol., 89, 45, 10.1083/jcb.89.1.45 Reiter, 1982, Chemically-induced glutathione depletion and lipid peroxidation, Chem.-Biol. Interact., 40, 365, 10.1016/0009-2797(82)90159-4 Robbins, 1964, Histochemical and ultrastructural studies on HeLa cell cultures exposed to spindle inhibitors with special reference to the interphase cell, J. Histochem. Cytochem., 12, 704, 10.1177/12.9.704 Roobol, 1976, Inhibition by griseofulvin of microtubule assembly in vitro, FEBS Lett., 67, 248, 10.1016/0014-5793(76)80539-X Sakai, 1959, Studies on sulfhydryl groups during cell division of sea urchin eggs, Exp. Cell Res., 16, 24, 10.1016/0014-4827(59)90192-2 Salmon, 1982, The rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo, J. Cell Biol., 95, 309a Salmon, 1984, Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine, J. Cell Biol., 99, 1066, 10.1083/jcb.99.3.1066 Salonen, 1982, A colcemid-sensitive mechanism involved in regulation of chromosome movements during meiotic pairing, Chromosoma, 85, 611, 10.1007/BF00330775 Sandoval, 1976, Protein kinase associated with tubulin: Affinity chromatography and properties, Biochemistry, 15, 3424, 10.1021/bi00661a005 Sandoval, 1976, Opposing effects of cyclic AMP and cyclic GMP on protein phosphorylation in tubulin preparations, Nature (London), 262, 511, 10.1038/262511a0 Sandoval, 1978, Calcium-induced inactivation of microtubule formation in brain extracts, Eur. J. Biochem., 92, 463, 10.1111/j.1432-1033.1978.tb12768.x Sankaranarayanan, 1979, The role of non-disjunction in aneuploidy in man, an overview, Mutation Res., 61, 1, 10.1016/0027-5107(79)90003-4 Sass, 1937, Histological and cytological studies of ethyl mercury phosphate poisoning in corn seedlings, Cytopathology, 27, 95 1978 Saunders, 1982, Calcium ionophore A23187 stimulates cytokinin-like mitosis in Funaria, Science, 217, 943, 10.1126/science.217.4563.943 Sawada, 1969, The effect of dinitrophenol and other phosphorylation uncouplers on the birefringence of the mitotic apparatus of marine eggs, Exp. Cell. Res., 55, 33, 10.1016/0014-4827(69)90450-9 Schatten, 1982, Effects of griseofulvin on fertilization and early development of sea urchins, Independence of DNA synthesis, chromosome condensation, and cytokinesis cycles from microtubule-mediated events, J. Cell Biol., 27, 74 Schatten, 1982, Detection of sequestered calcium during mitosis in mammalian cell cultures and in mitotic apparatus isolated from sea urchin zygotes, Cell Biol. Int. Rep., 6, 717, 10.1016/0309-1651(82)90163-1 Schiff, 1979, Promotion of microtubule assembly in vitro by taxol, Nature (London), 277, 665, 10.1038/277665a0 Schliwa, 1981, Stabilization of the cytoplasmic ground substance in detergent opened cells and a structural and biochemical analysis of its composition, 78, 4329 Schliwa, 1981, Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins, 78, 1037 Schmitt, 1978, Binding of antimitotic drugs around cysteine residues of tubulin, Exp. Cell Res., 115, 408, 10.1016/0014-4827(78)90295-1 Schönharting, 1973, Der biologische Abbau von Colchicin in vivo und in vitro, Hoppe-Seyler's Z. Physiol. Chemie, 354, 1242 Seiler, 1976, The mutagenicity of benzimidazole and benzimidazole derivatives, VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster, Mutation Res., 40, 339, 10.1016/0165-1218(76)90032-X Selden, 1983, Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments, J. Biol. Chem., 258, 7064, 10.1016/S0021-9258(18)32333-0 Sevanian, 1983, The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides, Arch. Biochem. Biophys., 223, 441, 10.1016/0003-9861(83)90608-2 Shepard, 1974, The effect of colchicine on synapsis and chiasma formation in microsporocytes of Lilium, Chromosoma, 44, 423, 10.1007/BF00284902 Sherline, 1982, Epidermal growth factor-induced centrosomal separation: Mechanism and relationship to mitogenesis, J. Cell Biol., 95, 316, 10.1083/jcb.95.1.316 Sherline, 1979, Endogenous inhibitor of colchicine tubulin binding in rat brain, Science, 205, 593, 10.1126/science.451622 Sherr-Neiss, 1978, Identification of a gene for β-tubulin in Aspergillus nidulans, Cell, 15, 639, 10.1016/0092-8674(78)90032-6 Shiomo, 1976, A temperature-sensitive mutant defective in mitosis and cytokinesis, Exp. Cell Res., 100, 297, 10.1016/0014-4827(76)90151-8 Sies, 1981, Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver, 78, 3358 Siliprandi, 1974, Action of “diamide” on some energy linked processes of rat liver mitochondria, FEBS Lett., 42, 197, 10.1016/0014-5793(74)80784-2 Silver, 1980, Isolation of mitotic apparatus containing vesicles with calcium sequestration activity, Cell, 19, 505, 10.1016/0092-8674(80)90525-5 Skerfving, 1974, Methylmercury-induced chromosome damage in man, Environ. Res., 7, 83, 10.1016/0013-9351(74)90078-4 Slaga, 1983, Overview of tumor promotion in animals, Environ. Health Perspect., 50, 3, 10.1289/ehp.83503 Sloboda, 1979, Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins, Biochemistry, 18, 48, 10.1021/bi00568a008 Sloboda, 1976, Griseofulvin: Association with tubulin and inhibition of in vitro microtubule assembly, J. Cell Biol., 70, 290a Smith, 1972, A cell line which is temperature-sensitive for cytokinesis, J. Cell Physiol., 80, 253, 10.1002/jcp.1040800212 Soltys, 1985, Polymerization of tubulin in vivo: Direct evidence for assembly onto microtubule ends and from centrosomes, J. Cell Biol., 100, 1682, 10.1083/jcb.100.5.1682 Sora, 1982, Meiotic diploid progeny and meiotic non-disjunction in Saccharomyces cerevisiae, Genetics, 101, 17, 10.1093/genetics/101.1.17 Sora, 1984, Drug synergism or antagonism in the induction of diploid meiotic products in Saccharomyces cerevisiae, Mutation Res., 141, 161, 10.1016/0165-7992(84)90090-3 Spiegelman, 1979, Multiple sites for the initiation of microtubule assembly in mammalian cells, Cell, 16, 239, 10.1016/0092-8674(79)90002-3 Stadler, 1972, Colchicine-binding proteins in chromatin and membranes, Nature (London), 237, 237 Stadler, 1974, Characterization of the colchicine binding of membrane fractions from rat and mouse liver, J. Cell Biol., 60, 297, 10.1083/jcb.60.1.297 Stearns, 1984, Cytomatrix in chromatophores, J. Cell Biol., 99, 144s, 10.1083/jcb.99.1.144s Steinert, 1984, Intermediate filaments, J. Cell Biol., 99, 22s, 10.1083/jcb.99.1.22s Stephens, 1966, Sulfhydryl balance in mitosis: The effect of mercaptoethanol on spindle birefringence, Biol. Bull., 131, 409 Stossel, 1984, Contribution of actin to the structure of the cytoplasmic matrix, J. Cell Biol., 99, 15s, 10.1083/jcb.99.1.15s Sugawara, 1980, An experimental approach to the analysis of mechanisms of meiotic non-disjunction and anaphase lagging in primary oocytes, Cytogenet. Cell Genet., 28, 251, 10.1159/000131538 Summer, 1980, 1-Chloro-2,4-dinitrobenzene depletes glutathione in rat skin and is mutagenic in Salmonella typhimurium, Mutation Res., 77, 91, 10.1016/0165-1218(80)90124-X Sutou, 1981, The mechanisms of endoreduplication, Cancer Genet. Cytogenet., 3, 317, 10.1016/0165-4608(81)90040-6 Tanaka, 1980, Hydrophobic regions function in calmodulin-enzyme(s) interactions, J. Biol. Chem., 255, 11078, 10.1016/S0021-9258(19)70253-1 Taylor, 1965, The mechanism of colchicine inhibition of mitosis, I. Kinetics of inhibition and the binding of H3-colchicine, J. Cell Biol., 25, 145, 10.1083/jcb.25.1.145 Telzer, 1981, Decoration of spindle microtubules with dynein: evidence for uniform polarity, J. Cell Biol., 89, 373, 10.1083/jcb.89.2.373 Telzer, 1975, Assembly of microtubules onto kinetochores of isolated mitotic chromosomes of HeLa cells, 72, 4023 Tenchini, 1983, Double Y as an indicator in a test of mitotic non-disjunction in cultured human lymphocytes, Mutation Res., 121, 139, 10.1016/0165-7992(83)90112-4 Teng, 1977, Synergism between anti-microtubule agents and growth stimulants in enhancement of cell cycle traverse, Nature (London), 268, 739, 10.1038/268739a0 Thompson, 1976, A CHO-cell mutant with a defect in cytokinesis, Somat. Cell Genet., 2, 387, 10.1007/BF01542720 Timson, 1977, Caffeine, Mutation Res., 47, 1, 10.1016/0165-1110(77)90016-1 Tiwari, 1984, Cytoskeleton and integration of cellular function in cells of higher plants, J. Cell Biol., 99, 63s, 10.1083/jcb.99.1.63s Traut, 1974, The induction of aneuploidy by colcemid fed to Drosophila melanogaster females, Mutation Res., 23, 179, 10.1016/0027-5107(74)90138-9 Trotta, 1982, Lipid peroxidation and haemoglobin degradation in red blood cells exposed to t-butyl hydroperoxide, Effects of the hexose monophosphate shunt as mediated by glutathione and ascorbate, Biochem. J., 204, 405, 10.1042/bj2040405 Tsien, 1982, T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes, Nature (London), 295, 68, 10.1038/295068a0 Tucker, 1984, Spatial organization of microtubule-organizing centers and microtubules, J. Cell Biol., 99, 55s, 10.1083/jcb.99.1.55s van Tuyl, 1977, Genetics of Fungal Resistance to Systemic Fungicides Vaughan, 1978, Role of biotransformation in the toxicity of inhalation anesthetics, Life Sci., 23, 2447, 10.1016/0024-3205(78)90168-6 Wang, 1974, Temperature-sensitive mammalian cell line blocked in mitosis, Nature (London), 248, 76, 10.1038/248076a0 Wang, 1984, A 45000-mol-wt protein from unfertilized sea urchin eggs severs actin filaments in a calcium-dependent manner and increases the steady-state concentration of non-filamentous actin, J. Cell Biol., 99, 844, 10.1083/jcb.99.3.844 Wang, 1980, Induction of heteroploidy in Gallus domesticus, Mutation Res., 69, 263, 10.1016/0027-5107(80)90091-3 Wang, 1976, A novel temperature-sensitive mammalian cell line exhibiting defective prophase progression, Cell, 8, 257, 10.1016/0092-8674(76)90009-X Wang, 1983, Studies on cell division in mammalian cells, VII. A temperature-sensitive cell line abnormal in centriole separation and chromosome movement, J. Cell Biol., 96, 301, 10.1083/jcb.96.1.301 Ward Orsini, 1952, The natural resistance of the golden hamster to colchicine, Science, 115, 88, 10.1126/science.115.2978.88 Watterson, 1976, Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts, 73, 2711 Weber, 1968, The mechanism of the action of caffeine on sarcoplasmic reticulum, J. Gen. Physiol., 52, 760, 10.1085/jgp.52.5.760 Weber, 1976, Griseofulvin interacts with microtubules both in vivo and in vitro, J. Mol. Biol., 102, 817, 10.1016/0022-2836(76)90293-X Weeds, 1982, Actin-binding proteins — regulators of cell architecture and motility, Nature (London), 296, 811, 10.1038/296811a0 Welsh, 1979, Tubulin and calmodulin, Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus, J. Cell Biol., 81, 624, 10.1083/jcb.81.3.624 Wendel, 1981, Drug-induced lipid peroxidation in mice, I. Modulation by monoxygenase activity, glutathione and selenium status, Biochem. Pharmacol., 30, 2513, 10.1016/0006-2952(81)90576-1 Westöö, 1966, Determination of methylmercury compounds in foodstuffs, I. Methyl mercury in fish, identification and determination, Acta Chem. Scand., 20, 2131, 10.3891/acta.chem.scand.20-2131 Whitaker, 1984, Inositol 1,4,5-triphosphate microinjection activates sea urchin eggs, Nature (London), 312, 636, 10.1038/312636a0 Whitfield, 1981, The roles of calcium and cyclic AMP in cell proliferation, Ann. N.Y. Acad. Sci., 339, 216, 10.1111/j.1749-6632.1980.tb15980.x Wiche, 1978, Preferential binding of hog brain microtubule-associated proteins to mouse satellite versus bulk DNA preparations, Nature (London), 273, 403, 10.1038/273403a0 Wiebel, 1980, Mutagen-metabolizing enzymes in mammalian cell cultures: Possibilities and limitations for mutagenicity screening, 209 Wilson, 1984, Colchicine-binding activity distinguishes sea urchin egg and outer doublet tubulins, J. Cell Biol., 99, 37, 10.1083/jcb.99.1.37 Wilson, 1975, Biochemical mechanisms of action of microtubule inhibitors, 103 Wissinger, 1978, Studies on cell division in mammalian cells, IV. A temperature-sensitive cell line defective in post-metaphase chromosome movement, Exp. Cell Res., 112, 89, 10.1016/0014-4827(78)90528-1 Wolniak, 1980, Detection of the membrane-calcium distribution during mitosis in Haemanthus endosperm with chlorotetracycline, J. Cell. Biol., 87, 23, 10.1083/jcb.87.1.23 Wolniak, 1983, Ionic changes in the mitotic apparatus at the metaphase/anaphase transition, J. Cell. Biol., 96, 598, 10.1083/jcb.96.3.598 Wolniak, 1980, Changes in the associations of endo membranes and spindle microtubules during mitosis, J. Cell Biol., 87, 236a Yerna, 1979, Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells, 76, 184 Younes, 1981, Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo, Chem.-Biol. Interact., 34, 257, 10.1016/0009-2797(81)90098-3 Zeilig, 1977, Cell-cycle-related changes of 3′:5′-cyclic GMP levels in Novikoff hepatoma cells, 74, 1052 Zeilig, 1976, Adenosine 3′:5′-monophosphate content and actions in the division cycle of synchronized HeLa cells, J. Cell Biol., 71, 515, 10.1083/jcb.71.2.515 Zieve, 1980, Isolation and partial characterization of a cage of filaments that surrounds the mammalian mitotic spindle, J. Cell Biol., 87, 160, 10.1083/jcb.87.1.160 Zimmermann, 1984, Induction of aneuploidy by oncodazole (nocodazole) and anti-tubulin agent, and acetone, Mutation Res., 141, 15, 10.1016/0165-7992(84)90030-7 Zotin, 1965, ATP level and cleavage of sea urchin eggs Strongylocentrotus dröbachiensis, Exp. Cell Res., 39, 567, 10.1016/0014-4827(65)90058-3