Arriagada P V, Growdon J H, Hedley-Whyte E T, Hyman B T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology, 1992, 42(3Pt1): 631–639
Alonso A C, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K. Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci USA, 2001, 98(12): 6923–6928.
Tian Q, Wang J Z. Role of serine/theonine protein phosphatase in Alzheimer’s disease. Neurosignals, 2002, 11(5): 262–269
Gong C X, Singh T J, Grundke-Iqbal I, Iqbal K. Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem, 1993, 61(3): 921–927
Gong C X, Shaikh S, Wang J Z, Zaidi T, Grundke-Iqbal I, Iqbal K. Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J Neurochem, 1995, 65(2): 732–738.
Vogelsberg-Ragaglia V, Schuck T, Trojanowski J Q, Lee V M. PP2A mRNA expression is quantitatively decreased in Alzheimer’s disease hippocampus. Exp Neurol, 2001, 168(2): 402–412
Sontag E, Nunbhakdi-Craig V, Lee G, Bloom G S, Mumby M C. Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron, 1996, 17(6): 1201–1207
Kim D, Su J, Cotman C W. Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment. Brain Res, 1999, 839(2): 253–262
Gong C X, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer’s disease. J Biol Chem, 2000, 275(8): 5535–5544.
Sun L, Liu S Y, Wang J Z. Inhibition of PP2A and PP1 induced tau hyperphosphorylation and impairment of spatial memory retention in rats. Neuroscience, 2003, 118(4): 1175–1182
Whitehouse P J, Price D L, Struble R G, Clark A W, Coyle J T, DeLong M R. Alzheimer’s disease and senile dementia: loss of neurons in the basal forebrain. Science, 1982, 215(4537): 1237–1239
Coyle J T, Price D L, DeLong M R. Alzheimer’s disease: a disorder of cortical cholinergic innervation. Science, 1983, 219(4589): 1184–1190
Rasool C G, Svendsen C N, Selkoe D J. Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer’s disease. Ann Neurol, 1986, 20(4): 482–488
Samuel W, Terry R D, DeTeresa R, Butters N, Masliah E. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch Neurol, 1994, 51(8): 772–778
Tian Q, Lin Z Q, Wang X C, Chen J, Wang Q, Gong C X, Wang J Z. Injection of okadaic acid into the Meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience, 2004, 126(2): 277–284
Brandeis R, Brandys Y, Yehuda S. The use of the Morris water maze in the study of memory and learning. Int J Neurosci, 1989, 48(1–2): 29–69
Paxinos G, Watson C J. The Rat Brain in Stereotaxic Coordinates, 1996, 2nd Edition, Academic Press, New York
Gong C X, Singh T J, Grundke-Iqbal I, Iqbal K. Alzheimer’s disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin). J Neurochem, 1994, 62(2): 803–806
Zhang C E, Tian Q, Wei W, Pen J H, Liu G P, Zhou X W, Wang Q, Wang D W, Wang J Z. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 2007 [Epub ahead of print]
Bialojan C, Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases, Specificity and kinetics. Biochem J, 1988, 256(1): 283–290
Sarter M, Bruno J P. Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents. Neuroscience, 2000, 95(4): 933–952
Semba K. Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance. Behav Brain Res, 2000, 115(2): 117–141
Szymusiak R, Alam N, McGinty D. Discharge patterns of neurons in cholinergic regions of the basal forebrain during waking and sleep. Behav Brain Res, 2000, 115(2): 171–182
Mesulam M M. The systems-level organization of cholinergic innervation in the human cerebral cortex and its alterations in Alzheimer’s disease. Prog Brain Res, 1996, 109: 285–297
Imperato A, Dazzi L, Obinu M C, Gessa G L, Biggio G. Inhibition of hippocampal acetylcholine release by benzodiazepines: antagonism by flumazenil. Eur J Pharmacol. 1993, 238(1): 135–137
Issa A M, Gauthier S, Collier B. Effects of the phosphatase inhibitors calyculin A and okadaic acid on acetylcholine synthesis and content of rat hippocampal formation. J Neurochem, 1996, 66(5): 1924–1932
Gong C X, Wang J Z, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett, 2003, 340(2): 107–110
Wang J Z, Tung Y C, Wang Y, Li X T, Iqbal K, Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells. FEBS Lett, 2001, 507(1): 81–87
Wang L Y, Diao L M, Tian Q, Wang J Z, Gong C X. Protein phosphatase 2A regulatesphosphorylation of microtubule-associated protein 1b. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan, 2004, 31(11): 986–990 (in Chinese)