Mechanisms of induction and repair of DNA double-strand breaks by ionizing radiation: Some contradictions

Akpa TC, Weber KJ, Schneider E, Kiefer J, Frankenberg-Schwager M, Harbich R, Frankenberg D (1992) Heavy ion-induced DNA double-strand breaks in yeast. Int J Radiat Biol 62:279–287 Andrews J, Martin-Bertram H, Hagen U (1984) S1 nuclease-sensitive sites in yeast DNA: an assay for radiation-induced base damage. Int J Radiat Biol 45:497–504 Barendsen GW (1993) Sublethal damage and DNA double-strand breaks have similar RBE-LET relationships: evidence and implications. Int J Radiat Biol 63:325–330 Bases R, Franklin WA, Moy T, Mendez F (1992) Enhanced excision repair activity in mammalian cells after ionizing radiation. Int J Radiat Biol 62:427–441 Baumstark-Kahn C (1993) X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells. Int J Radiat Biol 63:305–311 Bessho T, Nitta N, Negish K, Hayatsu H (1992) Blockage of polymerase-catalyzed DNA chain elongation by chemically modified cytosine residues in templates and the release of blockage for readthrough. Nucleic Acids Res 20:4213–4220 Blöcher D (1990a) Dose response in neutral filter elution. Radiat Res 123:176–181 Blöcher D (1990b) In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. Int J Radiat Biol 57:7–12 Blöcher D, Kunhi M (1990) DNA double-strand analysis by CHEF electrophoresis. Int J Radiat Biol 58:23–34 Blöcher D, Sigut SD, Hannan MA (1991) Fibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate gamma-irradiation as assayed by pulsed field electrophoresis. Int J Radiat Biol 60:791–802 Bopp A, Hagen U (1970) End group determination in gamma-irradiated DNA. Biochim Biophys Acta 209:320–326 Bopp A, Carpy S, Burkart B, Hagen U (1973) Action of exonuclease III on gamma-irradiated DNA. Biochim Biophys Acta 294:47–56 Boreham DR, Mitchel EJ (1991) DNA lesions that signal the induction of radioresistance and DNA repair in yeast. Radiat Res 128:19–28 Brenner DJ, Ward JF (1992) Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int J Radiat Biol 61:737–748 Bryant PE (1985) Enzymatic restriction of mammalian cell DNA: evidence for double-strand breaks as potentially lethal lesions. Int J Radiat Biol 48:55–60 Buchko GW, Weinfeld M (1993) Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation. Biochemistry 32:2186–2193 Chen BX, Hubbard K, Ide H, Wallace SS, Erlanger BF (1990) Characterization of a monoclonal antibody to thymidine glycol monophosphate. Radiat Res 124:131–136 Chiu SM, Sokany NM, Friedman LR, Oleinick NL (1984) Differential processing of ultraviolet or ionizing radiation-induced DNA-protein crosslinks in Chinese hamster cell. Int J Radiat Biol 46:681–690 Chiu SM, Friedman LR, Sokany NM, Xue LY, Oleinick NL (1986) Nuclear matrix proteins are crosslinked to transcriptionally active gene sequences by ionizing radiation. Radiat Res 107:24–38 Chiu SM, Xue LY, Friedman LR, Oleinick NL (1992) Chromatin compaction and the efficiency of formation of DNA-protein crosslinks in gamma-irradiated mammalian cells. Radiat Res 129:184–191 Cooper PK, Hanawalt PC (1972) Heterogeneity of patch size in repair replicated DNA inEscherichia coli. J Mol Biol 67:1–14 Coquerelle T, Bopp A, Kessler B, Hagen U (1973) Strand breaks and 5′ end groups in DNA of irradiated thymocytes. Int J Radiat Biol 24:397–404 Cullis PM, Elsy D, Fan S, Symons MCR (1993) Marked effect of buffers on yield of single-and double-strand breaks in DNA irradiated at room temperature and at 77 K. Int J Radiat Biol 63:161–1165 Dahm-Daphi J, Dikomey E, Pyttlik C, Jeggo PA (1993) Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutantsxrs1 andxrs5. Int J Radiat Biol 64:19–26 Deeley JOT, Mitchell SM, Sanders A, Moore JL (1992) Heterogeneity of radiation-induced damage measured by microgel electrophoresis. (abstract) Int J Radiat Biol 62:372 Dertinger H, Jung H (1969) Molekulare Strahlenbiologie. Springer, Berlin Heidelberg New York Dizdaroglu M (1992) Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol 61:175–183 Evans HH, Ricanati M, Horng M-F, Jiang Q, Mencl J, Olive P (1993) DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines. Radiat Res 134:307–315 Fairman MP, Johnson AP, Thacker J (1992) Multiple components are involved in the efficient joining of double stranded DNA breaks in human cell extracts. Nucleic Acids Res 20:4145–4152 Feingold JM, Masch J, Maio J, Mendez F, Bases R (1988) Base sequence damage in DNA from X-irradiated monkey CV-1 cells. Int J Radiat Biol 53:217–235 Flentje M, Asadpour B, Latz D, Weber KJ (1993) Sensitivity of neutral filter elution but not PFGE can be modified by non-dsb chromatin damage. Int J Radiat Biol 63:715–724 Frankenberg-Schwager M (1990) Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiat Environ Biophys 29:273–292 Frankenberg-Schwager M, Frankenberg D, Blöcher D, Adamczyk C (1979) The influence of oxygen on the survival and yield of DNA double-strand breaks in irradiated yeast cells. Int J Radiat Biol 36:261–270 Frankenberg-Schwager M, Frankenberg D, Harbich R (1991) Different oxygen enhancement ratios for induced and unrejoined DNA double-strand breaks in eukaryotic cells. Radiat Res 128:243–250 Freifelder D, Trumbo B (1969) Matching of single-strand breaks to form double-strand breaks in DNA. Biopolymers 7:681–693 Friedberg EC (1985) DNA repair. Freeman, New York Friedl AA, Beisker W, Hahn K, Eckardt-Schupp F, Kellerer AM (1993) Application of pulsed field gel electrophoresis to determine gamma ray induced double-strand breaks in yeast chromosomal molecules. Int J Radiat Biol 63:1733–1181 Ganesh A, North P, Thacker J (1993) Repair and misrepair of site-specific DNA double-strand breaks by human cell extracts. Mutation Res 299:251–259 Geigl EM, Eckardt-Schupp F (1990) Chromosome-specific identification and quantification of S1 nuclease-sensitive sites in yeast chromatin by pulsed-field gel electrophoresis. Molec Microbiol 4:801–810 Geigl EM, Eckardt-Schupp F (1991a) The repair of double-strand breaks and S1 nuclease-sensitive sites can be monitored chromosome-specifically inSaccharomyces cereuisiae using pulsed-field electrophoresis. Molec Microbiol 5:1615–1620 Geigl EM, Eckardt-Schupp F (1991b) Repair of gamma ray-induced S1 nuclease hypersensitive sites in yeast depends on homologous mitotic recombination and a RAD18-dependent function. Curr Genet 20:33–37 Goodhead DT (1992) Track structure considerations in low dose and low dose rate effects of ionizing radiation. Adv Radiat Biol 16:7–44 Goodhead DT, Thacker J, Cox R (1993) Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int J Radiat Biol 63:543–556 Grimsley JK, Masters CI, Clark EP, Minton KW (1991) Analysis by pulse-field gel clectrophoresis of DNA double-strand breakage and repair inDeinococcus radiodurans and a radiosensitive mutant. Int J Radiat Biol 60:613–626 Hagen U (1967) Bestimmung von Einzel- und Doppelbrüchen in bestrahlter Desoxyribonukleinsäure durch die Molekulargewichtsverteilung. Biochim Biophys Acta 134:45–58 Heilmann J, Rink H, Taucher-Scholz G, Kraft G (1993) DNA strand break induction and rejoining and cellular recovery in mammalian cells after heavy-ion irradiation. Radiat Res 135:46–55 Iliakis G, Blöcher D, Metzger L, Pantelias G (1991) Comparison of DNA double-strand break rejoining as measured by pulsed field gel electrophoresis, neutral sucrose gradient centrifugation and non-unwinding filter elution in irradiated plateau-phase CHO cells. Int J Radiat Biol 59:927–939 Ito T, Saito M, Kobayashi K (1992) Dissociation of a model DNA compound dApdA by monochromatic soft X-rays in solids and comments on the high selectivity for 3′ breakage in the phosphoester bond. Int J Radiat Biol 62:129–136 Ito T, Baker SC, Stickley CD, Peak JG, Peak MJ (1993) Dependence of the yield of strand breaks induced by gamma-rays in DNA on the physical conditions of exposure: water content and temperature. Int J Radiat Biol 63:289–296 Janicek MF, Haseltine WA, Henner WD (1985) Malondialdehyde precursors in gamma-irradiated DNA, deoxynucleotides and deoxynucleosides. Nucleic Acids Res 13:9011–9017 Jenner TJ, Belli M, Goodhead DT, Ianzini F, Simones G, Tabocchini MA (1992) Direct comparison of biological effectiveness of protons and alpha-particles of the same LET. III. Initial yield of DNA double-strand breaks in V79 cells. Int J Radiat Biol 61:631–637 Junker B, Martin-Bertram H, Hagen U (1984) Distribution of S1-nuclease sensitive sites and double-strand breaks in gamma-irradiated lambda-DNA. Int J Radiat Biol 46:675–679 Kohfeldt E, Bertram H, Hagen U (1988) Action of gamma endonuclease on clustered lesions in irradiated DNA. Radiat Environ Biophys 27:123–132 Korystov YN (1992) Contributions of the direct and indirect effects of ionizing radiation to reproductive cell death. Radiat Res 129:228–234 Kraft G (1987) Radiobiological effects of very heavy ions: inactivation, induction of chromsome aberrations and strand breaks. Nucl Sci Appl 3:1–28 Kraft G, Krämer M, Scholz M (1992) LET, track structure and models. Radiat Environ Biophys 31:161–180 Krasin F, Hutchinson F (1977) Repair of DNA double-strand breaks inEscherichia coli which requires recA function and the presence of a duplicate genome. J Mol Biol 116:81–98 Kysela B, Michael BD, Arrand J (1982) The induction and rejoining of DNA double-strand breaks in repair-proficient and repair-deficient cell lines at biologically significant doses of ionizing radiation. (abstract) Int J Radiat Biol 62:371 Landbeck L, Hagen U (1973) Action of DNA polymerase I on gamma-irradiated DNA. Biochim Biophys Acta 331:318–327 Lennartz M, Coquerelle T, Hagen U (1973) Effect of oxygen on DNA strand breaks in irradiated thymocytes. Int J Radiat Biol 24:621–625 Lennartz M, Coquerelle T, Bopp A, Hagen U (1975a) Oxygen-effect on strand breaks and specific end-groups in DNA of irradiated thymocytes. Int J Radiat Biol 27:577–587 Lennartz M, Coquerelle T, Hagen U (1975b) Modification of end-groups in DNA strand breaks of irradiated thymocytes during early repair. Int J Radiat Biol 28:181–185 Lett JT (1990) Damage to DNA and chromatin structure from ionizing radiations, and the radiation sensitivities of mammalian cells. Prog Nucleic Acids Res 39:305–352 Lett JT (1992) Damage to cellular DNA from particulate radiations, the efficacy of its processing and the radiosensitivity of mammalian cells. Radiat Environ Biophys 31:257–277 Lopez BS, Bertrand-Mercat P, Corteggiani E, Coppey J (1992) Structural effect of donor DNA on the initation of recombination for double strand break repair in human nuclear extracts. Nucleic Acids Res 20:5167–5172 Maccubbin A, Evans M, Paul CR, Budzinski EE, Przybyzewski J, Box HC (1991) Enzymatic excision of radiation-induced lesions from DNA model compounds. Radiat Res 126:21–26 Martin-Bertram H, Hagen U (1979) Genomic integrity of T1 DNA after gamma- and ultraviolet irradiation. Biochim Biophys Acta 561:312–323 McGrath RA, Williams RW (1966) Reconstruction in vivo of irradiatedEscherichia coli deoxyribonucleic acid: the rejoining of broken pieces. Nature 212:534–535 Michalik V (1993a) Energy deposition clusters in nanometer regions of charged-particle tracks. Radiation Res 134:265–270 Michalik V (1993b) Estimation of double-strand break quality based on track-structure calculations. Radiat Environm Biophys 32:251–258 Mitzel-Landbeck L, Schütz G, Hagen U (1976) In vitro repair of radiation-induced strand breaks in DNA. Biochim Biophys Acta 432:145–153 Murcia G de, Huletsky A, Poirier GG (1988) Modulation of chromatin structure by poly(ADPribosyl)ation. Biochem Cell Biol 66:626–635 Nackerdien Z, Michie J, Böhm L (1989) Chromatin decondensed by acetylation shows an elevated radiation response. Radiat Res 117:234–244 Nevaldine B, Longo JA, King GA, Vilenchik M, Sagerman RH, Hahn PJ (1993) Induction and repair of DNA double-strand breaks. Radiat Res 133:370–374 North P, Ganesh A, Thacker J (1990) The rejoining of double-strand breaks in DNA by human cell extracts. Nucleic Acids Res 18:6205–6210 Olive PL (1992) DNA organisation affects cellular radiosensitivity and detection of initial DNA strand breaks. Int J Radiat Biol 62:389–396 Olive PL, Banáth JP, Durand RE (1990) Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the “comet” assay. Radiat Res 122:86–94 Painter RB, Cleaver JE (1967) Repair replication in HeLa cells after large doses of X-irradiation. Nature 216:369–370 Peak MJ, Wang L, Hill CK, Peak JG (1991) Comparison of repair of DNA double-strand breaks caused by neutron or gamma radiation in cultured human cells. Int J Radiat Biol 60:891–898 Powell S, McMillan TJ (1990) DNA damage and repair following treatment with ionizing radiation. Radiother Oncol 19:95–108 Resnick MA (1976) The repair of double-strand breaks in DNA: a model involving recombination. J Theor Biol 59:97–106 Resnick MA (1979) The induction of molecular and genetic recombination ineukaryotic cells. Adv Radiat Biol 8:175–217 Resnick MA, Nilsson-Tillgren T (1990) DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage. In: Mendelsohn ML, Albertini RJ (eds) Mutation and the environment, part B. Wiley-Liss, New York, pp 363–369 Resnick MA, Zgaga Z, Hieter P, Westmoreland J, Fogel S, Nilsson-Tillgren T (1992) Recombinational repair of diverged DNAs: a study of homoeologous chromosomes and mammalian YACs in yeast. Mol Gen Genet 234:65–73 Ritter MA, Cleaver JE, Tobias CA (1977) High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature 266:653–655 Roots R, Holley W, Chatterjee AA, Irizarry M, Kraft G (1990) The formation of strand breaks in DNA after high-LET irradiation: a comparison of data from in vitro and cellular systems. Int J Radiat Biol 58:55–69 Sandigursky M, Lalezari I, Franklin WA (1992) Excision of sugar-phosphate products at apurinic/apyrimidinic sites by DNA deoxyribosphosphodiesterase ofEscherichia coli. Radiat Res 131:332–337 Sapora O, Belli M, Maione B, Pazzaglia S, Tabocchini MA (1991) The influence of genome structural organization on DNA damage and repair in eukaryotic cells exposed to ionizing radiation. In: Fielden EM, O'Neill P (eds) The early effects of radiation on DNA. (NATO/ ASI series H, vol 54) Springer, Berlin Heidelberg New York, pp 85–101 Sato MS, Poirier GG, Lindahl T (1993) NAD+-dependent repair of damaged DNA by human cell extracts. J Biol Chem 268:5480–5487 Setlow RB, Carrier WL (1964) The disappearance of thymine dimers from DNA: an error correcting mechanisms. Proc Nat Acad Sci US 51:226–231 Silber JR, Loeb LA (1982) S1 nuclease does not cleave DNA at single-base mismatches. Biochim Biophys Acta 656:256–264 Smith CA, Hanawalt PC (1976) Repair replication in human cells. Simplified determination utilizing hydroxyurea. Biochim Biophys Acta 432:336–347 Sonntag C von (1987) The chemical basis of radiation biology. Taylor & Francis, London Sonntag C von, Hagen U, Schön-Bopp A, Schulte-Frohlinde D (1981) Radiation-induced strand breaks in DNA: chemical and enzymatic analysis of end groups and mechanistic aspects. Adv Radiat Biol 9:110–142 Stanton J, Taucher-Scholz G, Schneider M, Heilmann J, Kraft G (1993) Protection of DNA from high LET radiation by two OH radical scavengers, tris(hydroxymethyl)amino-methane and 2-mercaptoethanol. Radiat Environ Biophys 32:21–32 Swarts SG, Sevilla MD, Becker D, Tokar CJ, Wheeler KT (1992) Radiation-induced DNA damage as a function of hydration. I. Release of unaltered bases. Radiat Res 129:333–344 Téoule R (1987) Radiation-induced DNA damage and its repair. Int J Radiat Biol 51:573–589 Thacker J (1992) Mechanisms of radiation-induced mutation in human cells. (abstract) Int J Radiat Biol 62:373 Thacker J, Chalk J, Ganesh A, North PM (1992) A mechanism for deletion formation in DNA by human cell extracts: the involvement of short sequence repeats. Nucleic Acids Res 20:6138–6189 Ullrich M, Hagen U (1971) Base liberation and concomitant reactions in irradiated DNA solutions. Int J Radiat Biol 19:507–517 Ward JF (1981) Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiat Res 86:185–195 Ward JF (1985) Biochemistry of DNA lesions. Radiat Res 104:S103-Sl11 Ward JF (1990) The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int J Radiat Biol 57:1141–1150 Ward JF, Jones GDD, Milligan JR (1994) Biological consequences of non-homogeneous energy deposition by ionizing radiation. Radiat Prot Dosimetry 54:1–5 Warters RL, Lyons BW (1992) Variation in radiation-induced formation of DNA double-strand breaks as a function of chromatin structure. Radiat Res 130:309–318 West GJ, West IW-L, Ward JF (1982a) Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine). Int J Radiat Biol 42:481–490 West GJ, West IW-L, Ward JF (1982b) Radioimmunoassay of thymine glycol. Radiat Res 90:595–608 Whitaker SJ, McMillan TJ (1992) Oxyxgen effect for DNA double-strand break induction determined by pulsed-field gel electrophoresis. Int J Radiat Biol 61:29–41 Winters TA, Weinfeld M, Jorgensen TJ (1992) Human HeLa cell enzymes that remove phosphoglycolate 3′-end groups from DNA. Nucleic Acids Res 20:2573–2580 Wlodek S, Olive PL (1992) Neutral filter elution detects differences in chromatin organization which can influence cellular radiosensitivity. Radiat Res 132:242–247 Xue LY, Friedman LR, Oleinick NL (1988) Repair of chromatin damage in glutathione-depleted V-79 cells: comparison of oxic and hypoxic conditions. Radiat Res 116:89–99 Zaider M (1993) A mathematical formalism describing the yield of radiation-induced single-and double-strand DNA breaks, and its dependence on radiation quality. Radiat Res 134:1–8