Mechanisms of estrogen signaling and gene expression via GPR30

Ahola, 2002, Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells, Endocrinology, 143, 4620, 10.1210/en.2002-220492

Ahola, 2002, G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells, Endocrinology, 143, 3376, 10.1210/en.2001-211445

Ahola, 2002, Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells, Eur. J. Biochem., 269, 2485, 10.1046/j.1432-1033.2002.02912.x

Albanito, 2008, G protein-coupled receptor 30 and estrogen receptor alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells, Environ. Health Perspect., 116, 1648, 10.1289/ehp.11297

Albanito, 2007, G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells, Cancer Res., 67, 1859, 10.1158/0008-5472.CAN-06-2909

Albanito, 2008, Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells, Endocrinology, 149, 3799, 10.1210/en.2008-0117

Alyea, 2008, The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells, J. Neurochem., 106, 1525, 10.1111/j.1471-4159.2008.05491.x

Baquedano, 2007, Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues, J. Clin. Endocrinol. Metab., 92, 2215, 10.1210/jc.2006-2329

Beatson, 1896, On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases, Lancet ii, 104, 10.1016/S0140-6736(01)72307-0

Bhola, 2008, Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer, Front. Biosci., 13, 1857, 10.2741/2805

Boivin, 2008, G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?, J. Recept. Signal Transduct. Res., 28, 15, 10.1080/10799890801941889

Bologa, 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30, Nat. Chem. Biol., 2, 207, 10.1038/nchembio775

Bouskine, 2008, Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A, Endocrinology, 149, 565, 10.1210/en.2007-1318

Carmeci, 1997, Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer, Genomics, 45, 607, 10.1006/geno.1997.4972

Das, 2000, Estrogen targets genes involved in protein processing, calcium homeostasis, and Wnt signaling in the mouse uterus independent of estrogen receptor-alpha and -beta, J. Biol. Chem., 275, 28834, 10.1074/jbc.M003827200

Dennis, 2009, In vivo effects of a GPR30 antagonist, Nat. Chem. Biol., 5, 421, 10.1038/nchembio.168

DeWire, 2007, Beta-arrestins and cell signaling, Annu. Rev. Physiol., 69, 483, 10.1146/annurev.physiol.69.022405.154749

Eddy, 1996, Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility, Endocrinology, 137, 4796, 10.1210/en.137.11.4796

Edwards, 2005, Regulation of signal transduction pathways by estrogen and progesterone, Annu. Rev. Physiol., 67, 335, 10.1146/annurev.physiol.67.040403.120151

Fan, 2007, Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II, Biochem. Biophys. Res. Commun., 355, 1012, 10.1016/j.bbrc.2007.02.062

Fan, 2007, Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans, Environ. Health Perspect., 115, 720, 10.1289/ehp.9758

Filardo, 2002, Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer, J. Steroid Biochem. Mol. Biol., 80, 231, 10.1016/S0960-0760(01)00190-X

Filardo, 2006, Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression, Clin. Cancer Res., 12, 6359, 10.1158/1078-0432.CCR-06-0860

Filardo, 2000, Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF, Mol. Endocrinol., 14, 1649, 10.1210/me.14.10.1649

Filardo, 2002, Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis, Mol. Endocrinol., 16, 70, 10.1210/me.16.1.70

Filardo, 2005, GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release, Trends Endocrinol. Metab., 16, 362, 10.1016/j.tem.2005.08.005

Freeman, 2000, Feedback control of intercellular signalling in development, Nature, 408, 313, 10.1038/35042500

Fu, 2008, Extra-nuclear signaling of estrogen receptors, IUBMB Life, 60, 502, 10.1002/iub.80

Haas, 2009, Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity, Circ. Res., 104, 288, 10.1161/CIRCRESAHA.108.190892

Harrington, 2006, Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action, Mol. Endocrinol., 20, 491, 10.1210/me.2005-0186

Henderson, 1982, Endogenous hormones as a major factor in human cancer, Cancer Res., 42, 3232

Heneweer, 2004, A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase, Toxicol. Lett., 146, 183, 10.1016/j.toxlet.2003.10.002

Hsieh, 2007, G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage, Am. J. Pathol., 170, 1210, 10.2353/ajpath.2007.060883

Jacobs, 2002, Steroid hormone receptors and dietary ligands: a selected review, Proc. Nutr. Soc., 61, 105, 10.1079/PNS2001140

Jensen, 1967, Estrogen-receptor interactions in target tissues, Arch. Anat. Microsc. Morphol. Exp., 56, 547

Kamanga-Sollo, 2008, Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures, Domest. Anim. Endocrinol., 35, 254, 10.1016/j.domaniend.2008.06.001

Kanda, 2003, 17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages, J. Invest. Dermatol., 121, 771, 10.1046/j.1523-1747.2003.12487.x

Kanda, 2003, 17Beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression, J. Invest. Dermatol., 121, 1500, 10.1111/j.1523-1747.2003.12617.x

Kanda, 2004, 17Beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression, J. Invest. Dermatol., 123, 319, 10.1111/j.0022-202X.2004.12645.x

Kuhn, 2008, GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat, Eur. J. Neurosci., 27, 1700, 10.1111/j.1460-9568.2008.06131.x

Lange, 2007, Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer, Annu. Rev. Physiol., 69, 171, 10.1146/annurev.physiol.69.031905.160319

Lefkowitz, 2004, Historical review: a brief history and personal retrospective of seven-transmembrane receptors, Trends Pharmacol. Sci., 25, 413, 10.1016/j.tips.2004.06.006

Levin, 2003, Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor, Mol. Endocrinol., 17, 309, 10.1210/me.2002-0368

Ma, 2007, Beta-arrestin signaling and regulation of transcription, J. Cell Sci., 120, 213, 10.1242/jcs.03338

MacGregor, 1998, Basic guide to the mechanisms of antiestrogen action, Pharmacol. Rev., 50, 151

Madak-Erdogan, 2008, Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors, Mol. Endocrinol., 22, 2116, 10.1210/me.2008-0059

Maggiolini, 2004, The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells, J. Biol. Chem., 279, 27008, 10.1074/jbc.M403588200

Mårtensson, 2009, Deletion of the G protein-coupled receptor GPR30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice, Endocrinology, 150, 687, 10.1210/en.2008-0623

Moore, 1967, Carcinoma of the breast. A decade of new results with old concepts, N. Engl. J. Med., 277, 411, 10.1056/NEJM196708242770807

Moriarty, 2006, Minireview: estrogen receptor-mediated rapid signaling, Endocrinology, 147, 5557, 10.1210/en.2006-0729

Muller, 1979, Studies on the mechanism of estradiol uptake by rat uterine cells and on estradiol binding to uterine plasma membranes, Adv. Exp. Med. Biol., 117, 401, 10.1007/978-1-4757-6589-2_22

O’Dowd, 1998, Discovery of three novel G-protein-coupled receptor genes, Genomics, 47, 310, 10.1006/geno.1998.5095

Otto, 2008, GPR30 localizes to the endoplasmic reticulum and is not activated by estradiol, Endocrinology, 149, 4846, 10.1210/en.2008-0269

Otto, 2009, GPR30 does not mediate estrogenic responses in reproductive organs in mice, Biol. Reprod., 80, 34, 10.1095/biolreprod.108.071175

Owman, 1996, Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues, Biochem. Biophys. Res. Commun., 228, 285, 10.1006/bbrc.1996.1654

Pandey, 2009, Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF, EMBO J., 28, 523, 10.1038/emboj.2008.304

Pang, 2008, Estrogen signaling characteristics of Atlantic croaker G protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest, Endocrinology, 149, 3410, 10.1210/en.2007-1663

Pasqualini, 1989, Importance of estrogen sulfates in breast cancer, J. Steroid Biochem., 34, 155, 10.1016/0022-4731(89)90077-0

Persson, 1996, Cancer incidence and mortality in women receiving estrogen and estrogen–progestin replacement therapy—long-term follow-up of a Swedish cohort, Int. J. Cancer, 67, 327, 10.1002/(SICI)1097-0215(19960729)67:3<327::AID-IJC4>3.0.CO;2-T

Prossnitz, 2008, Estrogen signaling through the transmembrane G protein-coupled receptor GPR30, Annu. Rev. Physiol., 70, 165, 10.1146/annurev.physiol.70.113006.100518

Prossnitz, 2008, GPR30: a novel therapeutic target in estrogen-related disease, Trends Pharmacol. Sci., 29, 116, 10.1016/j.tips.2008.01.001

Razandi, 2003, Proximal events in signaling by plasma membrane estrogen receptors, J. Biol. Chem., 278, 2701, 10.1074/jbc.M205692200

Revankar, 2005, A transmembrane intracellular estrogen receptor mediates rapid cell signaling, Science, 307, 1625, 10.1126/science.1106943

Roberge, 2004, Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor, Toxicol. Lett., 154, 61, 10.1016/j.toxlet.2004.07.005

Romano, 2008, Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons, Endocrinology, 149, 5335, 10.1210/en.2008-0424

Rozengurt, 2007, Mitogenic signaling pathways induced by G protein-coupled receptors, J. Cell. Physiol., 213, 589, 10.1002/jcp.21246

Sanderson, 2001, Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes, Environ. Health Perspect., 109, 1027, 10.1289/ehp.011091027

Sirianni, 2008, The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line, Endocrinology, 149, 5043, 10.1210/en.2007-1593

Smith, 2007, GPR30: a novel indicator of poor survival for endometrial carcinoma, Am. J. Obstet. Gynecol., 196, 386.e1, 10.1016/j.ajog.2007.01.004

Starek, 2003, Estrogens and organochlorine xenoestrogens and breast cancer risk, Int. J. Occup. Med. Environ. Health, 16, 113

Sukocheva, 2006, Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1, J. Cell Biol., 173, 301, 10.1083/jcb.200506033

Takada, 1997, Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress, Biochem. Biophys. Res. Commun., 240, 737, 10.1006/bbrc.1997.7734

Teng, 2008, The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation, Endocrinology, 149, 4024, 10.1210/en.2007-1669

Tennant, 1994, Chloro-s-triazine antagonism of estrogen action: limited interaction with estrogen receptor binding, J. Toxicol. Environ. Health, 43, 197, 10.1080/15287399409531915

Thomas, 2005, Identity of an estrogen membrane receptor coupled to a G-protein in human breast cancer cells, Endocrinology, 146, 624, 10.1210/en.2004-1064

van Leeuwen, 1994, Risk of endometrial cancer after tamoxifen treatment of breast cancer, Lancet, 343, 448, 10.1016/S0140-6736(94)92692-1

Vivacqua, 2006, 17b-Estradiol, genistein and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the G protein-coupled receptor GPR30, Mol. Pharmacol., 70, 1414, 10.1124/mol.106.026344

Vivacqua, 2006, The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17b-estradiol and hydroxytamoxifen in endometrial cancer cells, Mol. Endocrinol., 20, 631, 10.1210/me.2005-0280

Wang, 2009, Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1, J. Immunol., 182, 3294, 10.4049/jimmunol.0803205

Wang, 2008, GPR30 contributes to estrogen-induced thymic atrophy, Mol. Endocrinol., 22, 636, 10.1210/me.2007-0359

Wang, 2007, Expression of GPR30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones, Endocrinology, 148, 4853, 10.1210/en.2007-0727

Wang, 2008, G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary, Endocrinology, 149, 4452, 10.1210/en.2008-0441

Waterhouse, 1982