Mechanisms of cooperativity and allosteric regulation in proteins

Quarterly Reviews of Biophysics - Tập 22 Số 2 - Trang 139-237 - 1989
M. F. Perutz1
1Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

Tóm tắt

AUosteric proteins control and coordinate chemical events in the living cell. When Monod conceived that idea he said that he had discovered the second secret of life. The first was the structure of DNA. The theory as published by Monodet al.(1963) was concerned chiefly with cooperativity and feedback inhibition of enzymes, such as the inhibition of threonine deaminase, the first enzyme in the pathway of the synthesis of isoleucine, by isoleucine, and its activation by valine. Two years later the theory was formalized by Monodet al.(1965).

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