Mechanisms of bacterial resistance to macrolide antibiotics

Yoshinori Nakajima1
1Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan

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Chabbert, 1956, In vitro antagonism between erythromycin and spiramycin, Ann Inst Pasteur, 90, 787

Woodward, 1957, Structure and biogenesis of the macrolides, Angew Chem, 69, 50, 10.1002/ange.19570690109

Taubman, 1966, Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol, Biochem Biophys Acta, 123, 438

Bryskier, 1995, Chantot J-F. New insights into the structure-activity relationship of macrolides and azalides, 3

McGuire, 1952, “Ilotycin”, a new antibiotic, Antibiot Chemother, 2, 281

Haight, 1952, Resistance of bacteria to erythromycin, Proc Soc Exp Biol Med, 81, 183, 10.3181/00379727-81-19816

Westh, 1995, Prevalence of erm gene classes in erythromycin-resistant Staphylococcus aureus strains isolated between 1959 and 1988, Antimicrob Agents Chemother, 39, 369, 10.1128/AAC.39.2.369

Garrod, 1957, The erythromycin group of antibiotics, BMdJ, 2, 57

Jones, 1966, Development of resistance and cross-resistance in vitro to erythromycin, carbomycin, oleandomycin and streptogramin, Proc Soc Exp Biol Med, 93, 388, 10.3181/00379727-93-22766

Lampson, 1986, Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolidelincosamide-streptogramin B resistance contains a deleted attenuator, J Bacteriol, 166, 479, 10.1128/jb.166.2.479-483.1986

Thakker-Varia, 1987, Molecular epidemiology of macrolidelincosamide- streptogramin B resistance in Staphylococcus aureus and coagulase-negative staphylococci, Antimicrob Agents Chemother, 31, 735, 10.1128/AAC.31.5.735

Horinouchi, 1983, A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis, J Bacteriol, 154, 1252, 10.1128/JB.154.3.1252-1262.1983

Shaw, 1985, Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis, J Bacteriol, 164, 782, 10.1128/JB.164.2.782-796.1985

Serwold-Davis, 1988, Identification of a methylase gene for erythromycin resistance within the sequence of a spontaneously deleting fragment of Corynebacterium diphtheriae plasmid pNG2, FEMS Microbiol Lett, 46, 7, 10.1111/j.1574-6968.1988.tb03142.x

Berryman, 1989, Cloning and hybridization analysis of ermP, a macrolide-lincosamide-streptogramin B resistance determinant from Clostridium perfringens, Antimicrob Agents Chemother, 33, 1346, 10.1128/AAC.33.8.1346

Berryman, 1994, Cloning and sequence analysis of ermQ, the predominant macrolide-lincosamide-streptogramin B resistance gene in Clostridium perfringens, Antimicrob Agents Chemother, 38, 1041, 10.1128/AAC.38.5.1041

Hächler, 1987, Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferrable to Staphylococcus aureus, Antimicrob Agents Chemother, 31, 1039, 10.1128/AAC.31.7.1039

Monod, 1986, Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis, J Bacteriol, 167, 138, 10.1128/jb.167.1.138-147.1986

Monod, 1987, Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B reisistance element from Bacillus sphaericus, J Bacteriol, 169, 340, 10.1128/jb.169.1.340-350.1987

Gryczen, 1984, DNA sequence and regulation of ermD, a macrolide-lincosamidestreptogramin B resistance element from Bacillus licheniformis, Mol Gen Gent, 194, 349, 10.1007/BF00425543

Kim, 1993, A macrolide-lincosamidestreptogramin B resistance determinant from Bacillus anthracis 590: cloning and expression of ermJ, J Gen Microbiol, 139, 601, 10.1099/00221287-139-3-601

Kwak, 1991, Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis, J Bacteriol, 173, 4725, 10.1128/jb.173.15.4725-4735.1991

Tannock, 1994, Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63, Plasmid, 31, 60, 10.1006/plas.1994.1007

Eady, 1989, Macrolide-lincosamide–streptogramin B (MLS) resistance in cutaneous propionibacteria: definition of phenotype, J Antimicrob Chemother, 23, 493, 10.1093/jac/23.4.493

Rasmussen, 1986, Complete nucleotide sequence and transcription of ermF, a macrolide-lincosamidestreptogramin B resistance determinant from Bacteroides fragilis, J Bacteriol, 168, 523, 10.1128/jb.168.2.523-533.1986

Smith, 1987, Nucleotide sequence analysis of Tn4551: use of ermFS operon fusions to detect promoter activity in Bacteroides fragilis, J Bacteriol, 169, 4589, 10.1128/jb.169.10.4589-4596.1987

Halula, 1991, Nucleotide sequence of ermFU, a macrolide-lincosamide-streptogramin (MLS) resistance gene encoding an RNA methylase from the conjugal element of Bacteroides fragilis V503, Nucleic Acids Res, 19, 3453, 10.1093/nar/19.12.3453

Brisson-Noël, 1988, Evidence for natural gene transfer from Gram-positive cocci to Escherichia coli, J Bacteriol, 170, 1739, 10.1128/jb.170.4.1739-1745.1988

Arthur, 1987, Distribution of erythromycin esterase and RNA methylase gene in members of the family Enterobacteriaceae highly resistant to erythromycin, Antimicrob Agents Chemother, 31, 404, 10.1128/AAC.31.3.404

Kamimiya, 1988, Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae, J Bacteriol, 170, 1800, 10.1128/jb.170.4.1800-1811.1988

Zalacain, 1989, Methylation of 23S rRNA by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae, J Bacteriol, 171, 4254, 10.1128/jb.171.8.4254-4260.1989

Zalacain, 1991, Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae, Gene, 97, 137, 10.1016/0378-1119(91)90021-3

Epp, 1987, Cloning and nucleotide sequence of carbomycin-resistance gene from Streptomyces thermotolerans, Gene, 53, 73, 10.1016/0378-1119(87)90094-1

Caleutt, 1990, Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin and characterization of the resistance mechanism, J Bacteriol, 172, 4710, 10.1128/jb.172.8.4710-4714.1990

Zhang, 1992, Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11, Mol Microbiol, 6, 2147, 10.1111/j.1365-2958.1992.tb01388.x

Jenkins, 1991, Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics, Gene, 108, 55, 10.1016/0378-1119(91)90487-V

Hara, 1990, Cloning of midecamycin (MLS)-resistance genes from Streptomyces mycarofaciens, Streptomyces lividans and Streptomyces coelicolor A3(2), J Antibiot, 43, 977, 10.7164/antibiotics.43.977

Inouye, 1994, Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida, Gene, 141, 39, 10.1016/0378-1119(94)90125-2

Uchiyama, 1985, N-Methyl transferase of Streptomyces erythreus that confers resistance to the macrolide-lincosamidestreptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci, Gene, 38, 103, 10.1016/0378-1119(85)90208-2

Roberts, 1985, An erythromycin-resistance gene from an erythromycin-producing strain of Arthrobacter sp, Gene, 35, 259, 10.1016/0378-1119(85)90004-6

Weisblum, 1995, Erythromycin resistance by ribosome modification, Antimicrob Agents Chemother, 39, 577, 10.1128/AAC.39.3.577

Ross, 1990, Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family, Mol Microbiol, 4, 1207, 10.1111/j.1365-2958.1990.tb00696.x

Lampson, 1986, Novel mechanism for plasmid-mediated erythromycin resistance by pNE24 from Staphylococcus epidermidis, Antimicrob Agents Chemother, 30, 653, 10.1128/AAC.30.5.653

Wondrack, 1996, Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides, Antimicrob Agents Chemother, 40, 992, 10.1128/AAC.40.4.992

Monro, 1967, Ribosome-catalyzed peptidyl transfer: effect of some inhibitors of protein synthesis, J Mol Biol, 28, 161, 10.1016/S0022-2836(67)80085-8

Vazquez, 1967, Inhibitors of protein synthesis at the ribosome level, Site of action. Life Sci, 6, 381, 10.1016/0024-3205(67)90007-0

Cerná, 1971, Effects of macrolide antibiotics on the ribosomal peptidyl transferase in cell-free systems derived from Escherichia coli B and erythromycin-resistant mutant of Escherichia coli B, Biochim Biophys Acta, 240, 109, 10.1016/0005-2787(71)90517-X

Mao, 1972, Erythromycin, a peptidyltransferase effector, Biochemistry, 11, 4864, 10.1021/bi00775a035

Vogel, 1971, Effect of erythromycin on peptide bond formation and the termination reaction, FEBS Lett, 15, 249, 10.1016/0014-5793(71)80323-X

Nakajima, 1990, Greatly improved activity of staphylococcal ribosomes in polyadenylate directed polylysine synthesis: as an assay system for investigating their sensitivity to macrolide antibiotics, J Pharmacobiodyn, 13, 378, 10.1248/bpb1978.13.378

Davis, 1990, What are antibiotics? Archaic functions for modern activities, Mol Microbiol, 4, 1227, 10.1111/j.1365-2958.1990.tb00701.x

Crick, 1968, The origin of the genetic code, J Mol Biol, 38, 367, 10.1016/0022-2836(68)90392-6

Wittman, 1973, Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins, Mol Gen Gent, 127, 175, 10.1007/BF00333665

Noller, 1981, Secondary structure model for 23S ribosomal RNA, Nucleic Acids Res, 9, 6167, 10.1093/nar/9.22.6167

Douthwaite, 1985, Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin mutant, Proc Natl Acad Sci USA, 82, 8330, 10.1073/pnas.82.24.8330

Douthwaite, 1992, Functional interactions within 23S rRNA involving peptidyltransferase center, J Bacteriol, 174, 1333, 10.1128/jb.174.4.1333-1338.1992

Noller, 1992, Unusual resistance of peptidyl transferase to protein extraction procedures, Science, 256, 1416, 10.1126/science.1604315

Nitta, 1998, Possible involvement of Escherichia coli 23S ribosomal RNA in peptide bond formation, RNA, 4, 257

Nitta, 1998, Reconstitution of peptide bond formation with Escherichia coli 23S rRNA ribosomal RNA domains, Science, 281, 666, 10.1126/science.281.5377.666

Versalovic, 1996, Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori, Antimicrob Agents Chemother, 40, 477, 10.1128/AAC.40.2.477

Lai, 1971, Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus, Proc Natl Acad Sci USA, 68, 856, 10.1073/pnas.68.4.856

Egebjerg, 1990, Structural map of 23S rRNA, 168

Shivakumar, 1980, Posttranscriptional regulation of an erythromycin resistance protein specified by plasmid pE194, Proc Natl Acad Sci USA, 7, 3903, 10.1073/pnas.77.7.3903

Horinouchi, 1980, Posttranscriptional modification of mRNA conformation: mechanism that regulates erythromycininduced resistance, Proc Natl Acad Sci USA, 77, 7079, 10.1073/pnas.77.12.7079

Choi, 1997, Role of mRNA termination in regulation of ermK, J Bacteriol, 179, 2065, 10.1128/jb.179.6.2065-2067.1997

Meier, 1994, Identification of mutations in the 23S ribosomal RNA gene of clarithromycin resistant Mycobacterium intracellulare, Antimicrob Agents Chemother, 38, 381, 10.1128/AAC.38.2.381

Moazed, 1987, Chloramphenicol, erythromycin and vernamycin B protect overlapping site in the peptidyl transferase region of 23S ribosomal RNA, Biochemie, 69, 879, 10.1016/0300-9084(87)90215-X

Douthwaite, 1993, Erythromycin binding is reduced in ribosomes with conformational alterations in the 23S rRNA peptidyl transferase loop, J Mol Biol, 232, 725, 10.1006/jmbi.1993.1426

Fernandez-Muñoz, 1971, Substrate and antibiotic-binding sites at the peptidyltransferase center of Escherichia coli ribosomes. Studies on the chloramphenicol, lincomycin and erythromycin sites, Eur J Biochem, 23, 185, 10.1111/j.1432-1033.1971.tb01607.x

Nakajima, 1968, A mode of resistance to macrolide antibiotics in Staphylococcus aureus, Jpn J Microbiol, 12, 248, 10.1111/j.1348-0421.1968.tb00390.x

Yamagishi, 1971, Decrease in accumulation of macrolide antibiotics as a mechanism of resistance in Staphylococcus aureus, Jpn J Microbiol, 15, 39, 10.1111/j.1348-0421.1971.tb00549.x

Weisblum, 1985, Inducible resistance to macrolides, lincosamides and streptogramin type B antibiotics: the resistance phenotype, its biological diversity, and structural elements that regulate expression— a review, J Antimicrob Chemother, 16, 63, 10.1093/jac/16.suppl_A.63

Weisblum, 1995, Insights into erythromycin action from studies of its activity as inducer of resistance, Antimicrob Agents Chemother, 39, 797, 10.1128/AAC.39.4.797

Leclercq, 1991, Bacterial resistance to macrolide, lincosamides, and streptogramin antibiotics by target modification, Antimicrob Agents Chemother, 35, 1267, 10.1128/AAC.35.7.1267

Nakajima, 1995, Macrolides, the attractive antibiotics—from a structural and functional aspect. (in Japanese), Jpn J Bacterol, 50, 717, 10.3412/jsb.50.717

Weisblum, 1998, Macrolide resistance, Drug Resistance Updates, 1, 29, 10.1016/S1368-7646(98)80212-4

Wang, 1998, Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics, Antimicrob Agents Chemother, 42, 1952, 10.1128/AAC.42.8.1952

Ross, 1997, Clinical resistance to erythromycin and clindamycin in cutaneous Propionibacteria isolated from acne patients is associated with mutations in 23S rRNA, Antimicrob Agents Chemother, 41, 1162, 10.1128/AAC.41.5.1162

Dam, 1996, Mutation in domain II of 23S rRNA facilitates translation of a 23S rRNA-encoded pentateptide conferring erythromycin resistance, J Mol Biol, 259, 1, 10.1006/jmbi.1996.0296

Tenson, 1997, A functional peptide encoded in the Escherichia coli 23S rRNA, Proc Natl Acad Sci USA, 93, 5641, 10.1073/pnas.93.11.5641

Douthwaite, 1989, Defining the structural requirements for a helix in 23S ribosomal RNA that confers erythromycin resistance, J Mol Biol, 209, 655, 10.1016/0022-2836(89)93000-3

Tenson, 1997, Erythromycin resistance peptides selected from random peptide libraries, J Biol Chem, 272, 17425, 10.1074/jbc.272.28.17425

Ross, 1989, Characterization and molecular cloning of the novel macrolidestreptogramin B resistance determinant from Staphylococcus epidermidis, J Antimicrob Chemother, 24, 851, 10.1093/jac/24.6.851

Ross, 1996, Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220, Gene, 183, 143, 10.1016/S0378-1119(96)00541-0

Goldman, 1990, Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15- membered macrolides in Staphylococcus epidermidis, Antimicrob Agents Chemother, 34, 1973, 10.1128/AAC.34.10.1973

Paulsen, 1996, Proton-dependent multidrug efflux systems, Microbiol Rev, 60, 575, 10.1128/MR.60.4.575-608.1996

Lewis, 1994, Multidrug resistance pumps in bacteria: variations on a theme, Trends Biochem Sci, 19, 119, 10.1016/0968-0004(94)90204-6

Clancy, 1996, Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, Streptococcus pyogenes, Mol Microbiol, 22, 867, 10.1046/j.1365-2958.1996.01521.x

Tait-Kamaradt, 1997, mefE is necessary for erythromycin-resistant M phenotype in Streptococcus pneumoniae, Antimicrob Agents Chemother, 41, 2251, 10.1128/AAC.41.10.2251

Clancy, 1997, Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae, Antimicrob Agents Chemother, 41, 2719, 10.1128/AAC.41.12.2719

Jánosi, 1990, Characterization of plasmids that confer inducible resistance to 14-membered macrolide and streptogramin type B antibiotics in Staphylococcus aureus, Microbiol Immunol, 34, 723, 10.1111/j.1348-0421.1990.tb01050.x

Matsuoka, 1995, A mechanism of resistance to partial macrolide and streptogramin B antibiotics in Staphylococcus aureus clinically isolated in Hungary, Biol Pharm Bull, 18, 1482, 10.1248/bpb.18.1482

Matsuoka, 1996, A distinctive effect of CCCP on the transfer of erythromycin to 1-octanol: as a possible model for playing a role in promoting the intracellular antibioticaccumulation through lipid in a staphylococcal cytoplasmic membrane, Res Commun Mol Pathol Pharmacol, 92, 85

Mao, 1968, Mode of action of macrolides, Biochim Biophys Acta, 157, 404, 10.1016/0005-2787(68)90094-4

Gryczan, 1980, Confomational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance, Nucleic Acids Res, 8, 6081, 10.1093/nar/8.24.6081

Matsuoka, 1997, A dyadic plasmid that shows MLS and PMS resistance in Staphylococcus aureus, FEMS Microbiol Lett, 148, 91, 10.1111/j.1574-6968.1997.tb10272.x

Matsuoka, 1998, A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus, FEMS Microbiol Lett, 167, 221, 10.1111/j.1574-6968.1998.tb13232.x

Endou, 1990, Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes, FEMS Microbiol Lett, 72, 93, 10.1111/j.1574-6968.1990.tb03868.x

Agouridas, 1998, HMR3647: antibacterial activity and resistance, (abstract 1.24), 25

Jones, 1997, Antimicrobial activity of RU66647, a new ketolide, Diagn Microbiol Infect Dis, 27, 7, 10.1016/S0732-8893(96)00181-2

Mao, 1969, The intermolecular complex of erythromycin and ribosome, J Mol Biol, 44, 347, 10.1016/0022-2836(69)90180-6

Wilhelm, 1968, Interaction of antibiotics with ribosomes: structure-function relationships and a possible common mechanism for the antibacterial action of the macrolides and lincomycin, Antimicrob Agents Chemother, 1967, 236

Igarashi, 1969, Comparative studies on the mechanism of action of lincomycin, streptogramin, and erythromycin, Biochem Biophys Res Comm, 37, 499, 10.1016/0006-291X(69)90943-7

Igarashi, 1969, Evidence for one functional phenylalanyltRNA binding site on the 30S ribosomal subunit, Proc Natl Acad Sci USA, 62, 498, 10.1073/pnas.62.2.498

Mao, 1971, Effects of macrolides on peptidebond formation and translocation, Biochemistry, 10, 2054, 10.1021/bi00787a014

Ennis, 1972, Polysome metabolism in Escherichia coli. Effect of antibiotics on polysome stability, Antimicrob Agents Chemother, 1, 197, 10.1128/AAC.1.3.197

Cundliffe, 1967, Bacterial protein synthesis: the effect of antibiotics, J Mol Biol, 30, 137, 10.1016/0022-2836(67)90249-5

Cundliffe, 1969, Antibiotics and polyribosomes. II. Some effects of lincomycin, spiramycin, and streptogramin A in vivo, Biochemistry, 8, 2063, 10.1021/bi00833a042

Menninger, 1982, Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes, Antimicrob Agents Chemother, 21, 811, 10.1128/AAC.21.5.811

Murphy, 1985, Nucleotide sequence of ermA, a macrolidelincosamide- streptogramin B determinant in Staphylococcus aureus, J Bacteriol, 162, 633, 10.1128/JB.162.2.633-640.1985

Matsuoka, 1998, A new class of erm genes mediating MLS-coresistance in Staphylococcus aureus: it resides on plasmid pMS97 together with msrSA9 gene coding for an active efflux pump

Lampson, 1986, Nucleotide sequence of the constitutive macrolide-lincosamide-streptogramin B resistance plasmid pNE131 from Staphylococcus epidermidis and homologies with Staphylococcus aureus plasmid pE194 and pSN2, J Bacteriol, 167, 888, 10.1128/jb.167.3.888-892.1986

Oh, 1998, Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics, J Bacteriol, 180, 5788, 10.1128/JB.180.21.5788-5791.1998

Serwold-Davis, 1986, Mapping and cloning of Corynebacterium diphtheriae plasmid pNG2 and characterization of its relatedness to plasmid from skin coryneforms, Antimicrob Agents Chemother, 30, 69, 10.1128/AAC.30.1.69

Hodgson, 1990, Nucleotide sequence of the erythromycin resistance gene Corynebacterium plasmid pNG2, Nucleic Acids Res, 18, 1891, 10.1093/nar/18.7.1891

Occhialini, 1997, Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes, Antimicrob Agents Chemother, 41, 2724, 10.1128/AAC.41.12.2724

Sutcliffe, 1996, Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system, Antimicrob Agents Chemother, 40, 1817, 10.1128/AAC.40.8.1817

Ounissi, 1985, Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli, Gene, 35, 271, 10.1016/0378-1119(85)90005-8

Authur, 1986, Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II, Nucleic Acids Res, 14, 4987, 10.1093/nar/14.12.4987

Allignet, 1988, Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginamycin-like antibiotics, Plasmid, 20, 271, 10.1016/0147-619X(88)90034-0

O’hara, 1989, Purification and characterization of macrolide 2'-phosphotransferase from a strain of E. coli that is highly resistant to erythromycin, Antimicrob Agents Chemother, 33, 1354, 10.1128/AAC.33.8.1354

Noguchi, 1996, Cloning and nucleotide sequence of the mphB gene for macrolide 2’-phosphotransferase II in Escherichia coli, FEMS Microbiol Lett, 144, 197

Kim, 1996, Nucleotide sequence, expression and transcriptional analysis of the Escherichia coli mphK gene encoding macrolide phosphotransferase, Mol Cells, 6, 153

Brisson-Noël, 1988, Inactivation of lincosamide antibiotics in Staphylococcus, J Biol Chem, 263, 15880, 10.1016/S0021-9258(18)37532-X

Dubnau, 1984, Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics, CRC Crit Rev Biochem, 16, 103, 10.3109/10409238409102300