Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity
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Porter, 1945, A study of tissue culture cells by electron microscopy: methods and preliminary observations, J Exp Med, 81, 233, 10.1084/jem.81.3.233
Palade, 1954, Studies on the endoplasmic reticulum. I. Its identification in cells in situ, J Exp Med, 100, 641, 10.1084/jem.100.6.641
Palade, 1975, Intracellular aspects of the process of protein synthesis, Science, 189, 347, 10.1126/science.1096303
Palade, 1956, Liver microsomes; an integrated morphological and biochemical study, J Biophys Biochem Cytol, 2, 171, 10.1083/jcb.2.6.671
Mazzarello, 2003, The sarcoplasmic reticulum: its discovery and rediscovery, Nat Rev Mol Cell Biol, 4, 69, 10.1038/nrm1003
Krieg, 1989, Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel, J Cell Biol, 109, 2033, 10.1083/jcb.109.5.2033
Deshaies, 1987, A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum, J Cell Biol, 105, 633, 10.1083/jcb.105.2.633
Caro, 1964, Protein synthesis, storage, and discharge in the pancreatic exocrine cell. An autoradiographic study, J Cell Biol, 20, 473, 10.1083/jcb.20.3.473
Schwanhausser, 2011, Global quantification of mammalian gene expression control, Nature, 473, 337, 10.1038/nature10098
Freedman, 1989, Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteins, Cell, 57, 1069, 10.1016/0092-8674(89)90043-3
Schachter, 1974, The subcellular sites of glycosylation, 57
Gidalevitz, 2013, Orchestration of secretory protein folding by ER chaperones, Biochim Biophys Acta, 1833, 2410, 10.1016/j.bbamcr.2013.03.007
Montero, 1995, Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells, EMBO J, 14, 5467, 10.1002/j.1460-2075.1995.tb00233.x
Hirai, 2006, Immunohistochemical distribution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach, Anticancer Res, 26, 71
Yokota, 2003, Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease, Biochem Biophys Res Commun, 303, 413, 10.1016/S0006-291X(03)00352-8
Yamamoto, 2013, Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma, Int J Oncol, 43, 1855, 10.3892/ijo.2013.2145
Zhang, 2010, Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP, J Biol Chem, 285, 15065, 10.1074/jbc.M109.087445
Li, 2006, Stress induction of GRP78/BiP and its role in cancer, Curr Mol Med, 6, 45, 10.2174/156652406775574523
Panayi, 2006, BiP regulates autoimmune inflammation and tissue damage, Autoimmun Rev, 5, 140, 10.1016/j.autrev.2005.08.006
Kosakowska-Cholody, 2014, HKH40A downregulates GRP78/BiP expression in cancer cells, Cell Death Dis, 5, e1240, 10.1038/cddis.2014.203
Panaretakis, 2008, The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death, Cell Death Differ, 15, 1499, 10.1038/cdd.2008.67
Dihazi, 2013, Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset, J Cell Sci, 126, 3649, 10.1242/jcs.125088
Gaucci, 2013, The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells, J Cell Biochem, 114, 2461, 10.1002/jcb.24590
Leys, 2007, Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer, Surgery, 141, 41, 10.1016/j.surg.2006.05.009
Xu, 2014, Protein disulfide isomerase: a promising target for cancer therapy, Drug Discov Today, 19, 222, 10.1016/j.drudis.2013.10.017
Xu, 2012, Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment, Proc Natl Acad Sci U S A, 109, 16348, 10.1073/pnas.1205226109
Dejeans, 2012, Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence, Free Radic Biol Med, 52, 993, 10.1016/j.freeradbiomed.2011.12.019
Zhang, 2009, Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1, Cancer Invest, 27, 453, 10.1080/07357900802527239
Pan, 2009, Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells, Int J Oncol, 35, 823, 10.3892/ijo_00000395
Zhang, 2008, Increased expression of GRP94 protein is associated with decreased sensitivity to adriamycin in ovarian carcinoma cell lines, Clin Exp Obstet Gynecol, 35, 257
Garg, 2012, Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin, Cancer Immunol Immunother, 61, 215, 10.1007/s00262-011-1184-2
Korbelik, 2011, Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release, Cancer Immunol Immunother, 60, 1431, 10.1007/s00262-011-1047-x
Gold, 2010, Calreticulin: non-endoplasmic reticulum functions in physiology and disease, FASEB J, 24, 665, 10.1096/fj.09-145482
Scaffidi, 2002, Release of chromatin protein HMGB1 by necrotic cells triggers inflammation, Nature, 418, 191, 10.1038/nature00858
Dumitriu, 2005, Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products, J Immunol, 174, 7506, 10.4049/jimmunol.174.12.7506
Wang, 1999, HMG-1 as a late mediator of endotoxin lethality in mice, Science, 285, 248, 10.1126/science.285.5425.248
Tamura, 2011, Tumor-produced secreted form of binding of immunoglobulin protein elicits antigen-specific tumor immunity, J Immunol, 186, 4325, 10.4049/jimmunol.1004048
Udono, 1994, Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo, Proc Natl Acad Sci U S A, 91, 3077, 10.1073/pnas.91.8.3077
Bodman-Smith, 2004, Anti-BiP antibody levels in juvenile idiopathic arthritis (JIA), Rheumatology, 43, 1305, 10.1093/rheumatology/keh186
Eggleton, 1997, Clinical relevance of calreticulin in systemic lupus erythematosus, Lupus, 6, 564, 10.1177/096120339700600703
Kishore, 1997, The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes, Clin Exp Immunol, 108, 181, 10.1046/j.1365-2249.1997.3761273.x
Tarr, 2010, Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells, Arthritis Rheum, 62, 2919, 10.1002/art.27602
Weber, 2010, Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus, Rheumatology, 49, 2255, 10.1093/rheumatology/keq272
Ling, 2013, Citrullinated calreticulin potentiates rheumatoid arthritis shared epitope signaling, Arthritis Rheum, 65, 618, 10.1002/art.37814
Ling, 2006, Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope, Arthritis Rheum, 54, 3423, 10.1002/art.22178
Basu, 2001, CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin, Immunity, 14, 303, 10.1016/S1074-7613(01)00111-X
Srivastava, 2002, Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses, Annu Rev Immunol, 20, 395, 10.1146/annurev.immunol.20.100301.064801
Berwin, 2001, Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96, J Biol Chem, 276, 21083, 10.1074/jbc.M101836200
Garg, 2012, A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death, EMBO J, 31, 1062, 10.1038/emboj.2011.497
Clark, 2001, The inducible Hsp70 as a marker of tumor immunogenicity, Cell Stress Chaperones, 6, 121, 10.1379/1466-1268(2001)0060121:TIHAAM2.0.CO;2
Feng, 2001, Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity, Blood, 97, 3505, 10.1182/blood.V97.11.3505
Feng, 2002, Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells, Blood, 100, 4108, 10.1182/blood-2002-05-1389
Feng, 2003, Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity, Blood, 101, 245, 10.1182/blood-2002-05-1580
Obeid, 2007, Calreticulin exposure dictates the immunogenicity of cancer cell death, Nat Med, 13, 54, 10.1038/nm1523
Vandivier, 2002, Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex, J Immunol, 169, 3978, 10.4049/jimmunol.169.7.3978
Donnelly, 2006, Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus, Arthritis Rheum, 54, 1543, 10.1002/art.21783
Chao, 2010, Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47, Sci Transl Med, 2, 63ra94, 10.1126/scitranslmed.3001375
Chao, 2010, Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma, Cell, 142, 699, 10.1016/j.cell.2010.07.044
Gardai, 2005, Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte, Cell, 123, 321, 10.1016/j.cell.2005.08.032
Kepp, 2010, Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death, Cell Cycle, 9, 3072, 10.4161/cc.9.15.12459
Obeid, 2008, ERP57 membrane translocation dictates the immunogenicity of tumor cell death by controlling the membrane translocation of calreticulin, J Immunol, 181, 2533, 10.4049/jimmunol.181.4.2533
Ni, 2013, Serum levels of calreticulin in correlation with disease activity in patients with rheumatoid arthritis, J Clin Immunol, 33, 947, 10.1007/s10875-013-9885-2
Kinoshita, 1999, Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice, Clin Exp Immunol, 115, 268, 10.1046/j.1365-2249.1999.00794.x
Casciola-Rosen, 1994, Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes, J Exp Med, 179, 1317, 10.1084/jem.179.4.1317
Matzinger, 1994, Tolerance, danger, and the extended family, Annu Rev Immunol, 12, 991, 10.1146/annurev.immunol.12.1.991
Komurasaki, 2010, LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6, Drug Metab Pharmacokinet, 25, 84, 10.2133/dmpk.25.84
Watanabe, 2006, Anti-calreticulin antibodies in patients with inflammatory bowel disease, Fukushima J Med Sci, 52, 1, 10.5387/fms.52.1
Suzuki, 2011, Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis, J Neuroimmunol, 237, 87, 10.1016/j.jneuroim.2011.06.011
Kreisel, 1999, High prevalence of antibodies to calreticulin of the IgA class in primary biliary cirrhosis: a possible role of gut-derived bacterial antigens in its aetiology?, Scand J Gastroenterol, 34, 623, 10.1080/003655299750026100
Goeb, 2009, Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes, Arthritis Res Ther, 11, R38, 10.1186/ar2644
Eggleton, 2000, Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization, Clin Exp Immunol, 120, 384, 10.1046/j.1365-2249.2000.01214.x
Nagayama, 1994, Occurrence of autoantibody to protein disulfide isomerase in patients with hepatic disorder, J Toxicol Sci, 19, 163, 10.2131/jts.19.3_155
Raiter, 2014, The presence of anti-GRP78 antibodies in the serum of patients with colorectal carcinoma: a potential biomarker for early cancer detection, Int J Biol Markers, 29, e431, 10.5301/jbm.5000086
Sanchez, 2008, Anti-calreticulin immunoglobulin A (IgA) antibodies in refractory coeliac disease, Clin Exp Immunol, 153, 351, 10.1111/j.1365-2249.2008.03701.x
Hong, 2004, An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer, Cancer Res, 64, 5504, 10.1158/0008-5472.CAN-04-0077
Liu, 2010, Serum autoantibody profiling using a natural glycoprotein microarray for the prognosis of early melanoma, J Proteome Res, 9, 6044, 10.1021/pr100856k
Platet, 2000, Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms, Mol Endocrinol, 14, 999, 10.1210/mend.14.7.0492
Arnaudeau, 2002, Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria, J Biol Chem, 277, 46696, 10.1074/jbc.M202395200
Chen, 2009, Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer, Ann Surg Oncol, 16, 524, 10.1245/s10434-008-0243-1
Lu, 2011, Changes in tumor growth and metastatic capacities of J82 human bladder cancer cells suppressed by down-regulation of calreticulin expression, Am J Pathol, 179, 1425, 10.1016/j.ajpath.2011.05.015
Kageyama, 2004, Identification by proteomic analysis of calreticulin as a marker for bladder cancer and evaluation of the diagnostic accuracy of its detection in urine, Clin Chem, 50, 857, 10.1373/clinchem.2003.027425
Liu, 2012, Calreticulin as a potential diagnostic biomarker for lung cancer, Cancer Immunol Immunother, 61, 855, 10.1007/s00262-011-1146-8
Song, 2012, Proteomic analysis of breast cancer tissues to identify biomarker candidates by gel-assisted digestion and label-free quantification methods using LC-MS/MS, Arch Pharm Res, 35, 1839, 10.1007/s12272-012-1018-6
Galazis, 2012, Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration, Fertil Steril, 98, 1590.e, 10.1016/j.fertnstert.2012.08.002
Morelli, 2014, DJ-1 in endometrial cancer: a possible biomarker to improve differential diagnosis between subtypes, Int J Gynecol Cancer, 24, 649, 10.1097/IGC.0000000000000102
Yoon, 2000, Nuclear matrix of calreticulin in hepatocellular carcinoma, Cancer Res, 60, 1117
Alaiya, 2000, Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma, Anal Cell Pathol, 21, 1, 10.1155/2000/351963
Alur, 2009, Suppressive roles of calreticulin in prostate cancer growth and metastasis, Am J Pathol, 175, 882, 10.2353/ajpath.2009.080417
Liu, 2013, Autoimmune disease and subsequent urological cancer, J Urol, 189, 2262, 10.1016/j.juro.2012.12.014
Hemminki, 2013, Subsequent leukaemia in autoimmune disease patients, Br J Haematol, 161, 677, 10.1111/bjh.12330
Hemminki, 2013, Subsequent brain tumors in patients with autoimmune disease, Neuro Oncol, 15, 1142, 10.1093/neuonc/not070
Castro, 2014, Increased risk of hepatobiliary cancers after hospitalization for autoimmune disease, Clin Gastroenterol Hepatol, 12, 1038, 10.1016/j.cgh.2013.11.007
Aguilar-Guzman, 2014, Human survivin and Trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo, PLoS One, 9, e95457, 10.1371/journal.pone.0095457
Ramirez, 2012, Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth, Mol Immunol, 52, 133, 10.1016/j.molimm.2012.05.006
Lopez, 2010, Antiangiogenic and antitumor effects of Trypanosoma cruzi calreticulin, PLoS Negl Trop Dis, 4, e730, 10.1371/journal.pntd.0000730
Munro, 1987, A C-terminal signal prevents secretion of luminal ER proteins, Cell, 48, 899, 10.1016/0092-8674(87)90086-9
Altmeyer, 1996, Tumor-specific cell surface expression of the-KDEL containing, endoplasmic reticular heat shock protein gp96, Int J Cancer, 69, 340, 10.1002/(SICI)1097-0215(19960822)69:4340::AID-IJC183.0.CO;2-9
Robert, 1999, Cell surface expression of the endoplasmic reticular heat shock protein gp96 is phylogenetically conserved, J Immunol, 163, 4133, 10.4049/jimmunol.163.8.4133
Wiest, 1997, Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident†molecular chaperones, Proc Natl Acad Sci U S A, 94, 1884, 10.1073/pnas.94.5.1884
Sauk, 1998, Hsp47 binds to the KDEL receptor and cell surface expression is modulated by cytoplasmic and endosomal pH, Connect Tissue Res, 37, 105, 10.3109/03008209809028904
Nangalia, 2013, Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2, N Engl J Med, 369, 2391, 10.1056/NEJMoa1312542
Vannucchi, 2014, Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value, Leukemia, 28, 1811, 10.1038/leu.2014.100
Capitani, 2009, The KDEL receptor: new functions for an old protein, FEBS Lett, 583, 3863, 10.1016/j.febslet.2009.10.053
Cancino, 2013, Regulation of Golgi signaling and trafficking by the KDEL receptor, Histochem Cell Biol, 140, 395, 10.1007/s00418-013-1130-9
Han, 2007, Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases, Am J Pathol, 170, 2042, 10.2353/ajpath.2007.061266
Townsley, 1993, Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport, EMBO J, 12, 2821, 10.1002/j.1460-2075.1993.tb05943.x
Pulvirenti, 2008, A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway, Nat Cell Biol, 10, 912, 10.1038/ncb1751
Giannotta, 2012, The KDEL receptor couples to Galphaq/11 to activate Src kinases and regulate transport through the Golgi, EMBO J, 31, 2869, 10.1038/emboj.2012.134
Panaretakis, 2009, Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death, EMBO J, 28, 578, 10.1038/emboj.2009.1
Denning, 1997, Calreticulin biosynthesis and processing in human myeloid cells: demonstration of signal peptide cleavage and N-glycosylation, Blood, 90, 372, 10.1182/blood.V90.1.372
Tarr, 2010, A mechanism of release of calreticulin from cells during apoptosis, J Mol Biol, 401, 799, 10.1016/j.jmb.2010.06.064
Tsai, 2002, Retro-translocation of proteins from the endoplasmic reticulum into the cytosol, Nat Rev Mol Cell Biol, 3, 246, 10.1038/nrm780
Afshar, 2005, Retrotranslocation of the chaperone calreticulin from the endoplasmic reticulum lumen to the cytosol, Mol Cell Biol, 25, 8844, 10.1128/MCB.25.20.8844-8853.2005
Holaska, 2001, Calreticulin is a receptor for nuclear export, J Cell Biol, 152, 127, 10.1083/jcb.152.1.127
Lopez Sambrooks, 2012, Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis, J Biol Chem, 287, 22043, 10.1074/jbc.M111.338335
Saha, 2011, Posttranslational arginylation as a global biological regulator, Dev Biol, 358, 1, 10.1016/j.ydbio.2011.06.043
Wang, 2014, Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo, Chem Biol, 21, 331, 10.1016/j.chembiol.2013.12.017
Decca, 2007, Post-translational arginylation of calreticulin: a new isospecies of calreticulin component of stress granules, J Biol Chem, 282, 8237, 10.1074/jbc.M608559200
Ling, 2010, Identification of the rheumatoid arthritis shared epitope binding site on calreticulin, PLoS One, 5, e11703, 10.1371/journal.pone.0011703
Ling, 2007, The rheumatoid arthritis shared epitope triggers innate immune signaling via cell surface calreticulin, J Immunol, 179, 6359, 10.4049/jimmunol.179.9.6359
Multhoff, 1996, Cell surface expression of heat shock proteins and the immune response, Cell Stress Chaperones, 1, 167, 10.1379/1466-1268(1996)0010167:CSEOHS2.3.CO;2
Arispe, 2000, ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes, J Biol Chem, 275, 30839, 10.1074/jbc.M005226200
Paidassi, 2011, Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition, J Mol Biol, 408, 277, 10.1016/j.jmb.2011.02.029
Oyadomari, 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway, Proc Natl Acad Sci U S A, 98, 10845, 10.1073/pnas.191207498
Patel, 1999, Increased expression of calreticulin is linked to ANG IV-mediated activation of lung endothelial NOS, Am J Physiol, 277, L794
Apetoh, 2007, Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy, Nat Med, 13, 1050, 10.1038/nm1622
Ghiringhelli, 2009, Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors, Nat Med, 15, 1170, 10.1038/nm.2028
D’Eliseo, 2013, Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells, Cell Stress Chaperones, 18, 801, 10.1007/s12192-013-0422-2
Peters, 2011, Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells, J Immunol, 187, 919, 10.4049/jimmunol.1100690
Wemeau, 2010, Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia, Cell Death Dis, 1, e104, 10.1038/cddis.2010.82
Kepp, 2009, Disruption of the PP1/GADD34 complex induces calreticulin exposure, Cell Cycle, 8, 3971, 10.4161/cc.8.23.10191
Martins, 2011, Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress, Oncogene, 30, 1147, 10.1038/onc.2010.500
Tufi, 2008, Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin, Cell Death Differ, 15, 274, 10.1038/sj.cdd.4402275
Zappasodi, 2010, Improved clinical outcome in indolent B-cell lymphoma patients vaccinated with autologous tumor cells experiencing immunogenic death, Cancer Res, 70, 9062, 10.1158/0008-5472.CAN-10-1825
Fucikova, 2011, Human tumor cells killed by anthracyclines induce a tumor-specific immune response, Cancer Res, 71, 4821, 10.1158/0008-5472.CAN-11-0950
Menger, 2012, Cardiac glycosides exert anticancer effects by inducing immunogenic cell death, Sci Transl Med, 4, 143ra99, 10.1126/scitranslmed.3003807
Fredly, 2011, Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis, Oncol Rep, 25, 1549, 10.3892/or.2011.1229