Mechanisms of Disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis

Springer Science and Business Media LLC - Tập 1 Số 2 - Trang 102-110 - 2005
Ulf Müller‐Ladner1, Thomas Pap1, Renate E. Gay2, Michel Neidhart2, Steffen Gay2
1Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Kerckhoff-Clinic, Bad Nauheim, Germany
2Department of Rheumatology, at the University Hospital and Center for Integrative Human Physiology (CIHP), Zürich, Switzerland

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Neumann E et al. (2002) Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction. Arthritis Rheum 46: 52–63

Faour WH et al. (2005) Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-α gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts. J Biol Chem 280: 9536–9546

Garcia-Vicuna R et al. (2004) CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum 50: 3866–3877

Kasperkovitz PV et al. (2005) Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum 52: 430–441

Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423: 356–361

Ferrari-Lacraz S et al. (2004) Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 173: 5818–5826

Miranda-Carus ME et al. (2004) IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol 173: 1463–1476

Neumann E et al. (2005) The RANK/RANKL/OPG system in rheumatoid arthritis: new insights from animal models. Arthritis Rheum 52: 2960–2967

Schmutz C et al. (2005) Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5. Arthritis Res Ther 7: R217–R229

Takemura S et al. (2001) Lymphoid neogenesis in rheumatoid synovitis. J Immunol 167: 1072–1080

Zheng B et al. (2005) CXCL13 neutralization reduces the severity of collagen-induced arthritis. Arthritis Rheum 52: 620–626

Van der Voort R et al. (2005) Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints. Arthritis Rheum 52: 1381–1391

Franz JK et al. (1998) Interleukin-16 produced by synovial fibroblasts mediates chemoattraction to CD4+ T-cells in rheumatoid arthritis. Eur J Immunol 28: 2661–2671

Sawai H et al. (2005) T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum 52: 1392–1401

Ohata J et al. (2005) Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol 174: 864–870

Tarner IH et al. (2005) The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive. Best Pract Res Clin Rheumatol 19: 19–35

Bijlsma JW et al. (2005) Clinical aspects of immune neuroendocrine mechanism in rheumatic diseases. Rheum Dis Clin North Am 31: xiii–xvi

Zeisel MB et al. (2005) MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin α5β1. Arthritis Res Ther 7: R118–R126

Seibl R et al. (2004) Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am J Pathol 162: 1221–1227

Pierer M et al. (2004) Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 172: 1256–1265

Roelofs MF et al. (2005) The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 52: 2313–2322

Neidhart M et al. (2000) Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 43: 2634–2447

Ospelt C et al. (2004) Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways. Ann Rheum Dis 63 (Suppl II): ii90–ii91

Kurowska M et al. (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. J Immunol 169: 1760–1767

Schedel J et al. (2002) FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum 46: 1512–1518

Amano T et al. (2003) Synoviolin/Hrd1, an ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 17: 2436–2449

Franz JK et al. (2000) Expressions of sentrin, a novel anti-apoptopic molecule at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 43: 544–607

Miyashita T et al. (2004) Osteoprotegerin (OPG) acts as an endogenous decoy receptor in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells. Clin Exp Immunol 137: 430–436

Schedel J et al. (2004) Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis. Ann Rheum Dis 63: 1205–1211

Pap T et al. (2000) Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Res 2: 59–64

Distler JH et al. (2005) The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cells microparticles. Proc Natl Acad Sci USA 102: 2892–2897

Smolen JS et al. (2003) Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2: 473–488

Müller-Ladner U et al. (1997) Expression of alternatively spliced CS-1 fibronectin isoform and its counter-receptor VLA-4 in rheumatoid arthritis synovium. J Rheumatol 24: 1873–1880

Johnston A et al. (2005) The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 114: 154–163

Valencia X et al. (2004) Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med 200: 1673–1679

Neidhart M et al. (1999) Synovial fluid CD146 (MUC18) a marker for synovial membrane angiogenesis in rheumatoid arthritis. Arthritis Rheum 42: 622–630

Giatromanolaki A et al. (2001) The angiogenic pathway 'vascular endothelial growth factor/flk-1(KDR)-receptor' in rheumatoid arthritis and osteoarthritis. J Pathol 194: 101–108

Afuwape AO et al. (2003) Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis. Gene Ther 10: 1950–1960

Nakahara H et al. (2003) Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 48: 1521–1529

Park YW et al. (2004) Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol 165: 2087–2098

Takahara K et al. (2004) Autocrine/paracrine role of the angiopoietin-1 and -2 /Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis. Hum Pathol 35: 150–158

Pap T et al. (2000) Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum 43: 1226–1232

Judex MO and Mueller BM (2005) Plasminogen activation/plasmin in rheumatoid arthritis: matrix degradation and more. Am J Pathol 166: 645–647

Yang YH et al. (2005) Reduction of arthritis severity in protease-activated receptor-deficient mice. Arthritis Rheum 52: 1325–1332

Schäffler A et al. (2003) Adipocytokines in synovial fluid. JAMA 290: 1709–1710

Bokarewa M et al. (2005) Resistin, an adipokine with potent proinflammatory properties. J Immunol 174: 5789–5795

Van Lent P et al. (2005) Expression of the novel metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed membranes of rheumatoid arthritis patients. Ann Rheum Dis 64: 368–374

Fassbender HG et al. (1980) Transformation of synovial cells in rheumatoid arthritis. Verh Dtsch Ges Pathol 64: 193–212

Gay S et al. (1993) Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis 52 (Suppl 1): S39–S47

Neidhart M et al. (2005). Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Ann Rheum Dis 64: 419–424