Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders

Journal of Neuroimmunology - Tập 117 Số 1-2 - Trang 1-8 - 2001
Ralf Gold1, Frank Buttgereit2, Klaus V. Toyka1
1Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Julius Maximilians Universität Würzburg, Germany.
2Department of Medicine (Rheumatology), Charité University Hospital, Humboldt Universität Berlin, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bachmann, 1999, Impairment of TNF-receptor-1 signaling but not Fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice, Am. J. Pathol., 154, 1417, 10.1016/S0002-9440(10)65395-3

Barnes, 1997, Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis, Lancet, 349, 902, 10.1016/S0140-6736(96)06453-7

Beck, 1992, A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis, N. Engl. J. Med., 326, 581, 10.1056/NEJM199202273260901

Behrens, 1997, Cytotoxic mechanisms in inflammatory myopathies: co-expression of Fas and protective Bcl-2 in muscle fibers anid inflammatory cells, Brain, 120, 929, 10.1093/brain/120.6.929

Bracken, 1990, A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: results of the Second National Acute Spinal Cord Injury Study [see comments], N. Engl. J. Med., 322, 1405, 10.1056/NEJM199005173222001

Brusaferri, 2000, Steroids for multiple sclerosis and optic neuritis: a meta-analysis of randomized controlled clinical trials, J. Neurol., 247, 435, 10.1007/s004150070172

Bursch, 1990, Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats, Carcinogenesis, 11, 847, 10.1093/carcin/11.5.847

Buttgereit, 1993, Effects of methylprednisolone on the energy metabolism of quiescent and ConA-stimulated thymocytes of the rat, Biosci. Rep., 13, 41, 10.1007/BF01138177

Buttgereit, 1994, The effects of methylprednisolone on oxidative phosphorylation in Concanavalin-A-stimulated thymocytes: top-down elasticity analysis and control analysis, Eur. J. Biochem., 223, 513, 10.1111/j.1432-1033.1994.tb19020.x

Buttgereit, 1997, Methylprednisolone inhibits uptake of Ca2+ and Na+ ions into concanavalin A-stimulated thymocytes, Biochem. J., 326, 329, 10.1042/bj3260329

Buttgereit, 1998, A new hypothesis of modular glucocorticoid actions: steroid treatment of rheumatic diseases revisited, Arthritis Rheum., 41, 761, 10.1002/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M

Buttgereit, 1999, Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy, Biochem. Pharmacol., 58, 363, 10.1016/S0006-2952(99)00090-8

Buttgereit, 2000, Bioenergetics of immune functions: fundamental and therapeutic aspects, Immunol. Today, 21, 192, 10.1016/S0167-5699(00)01593-0

Chan, 2001, Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system, Glia, 33, 87, 10.1002/1098-1136(20010101)33:1<87::AID-GLIA1008>3.0.CO;2-S

Cohen, 1992, Apoptosis and programmed cell death in immunity, Annu. Rev. Immunol., 10, 267, 10.1146/annurev.iy.10.040192.001411

Dalakas, 1991, Polymyositis, dermatomyositis and inclusion-body myositis [see comments], N. Engl. J. Med., 325, 1487, 10.1056/NEJM199111213252107

Diba, 2001, 5′UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor, J. Cell. Biochem., 81, 149, 10.1002/1097-4644(20010401)81:1<149::AID-JCB1031>3.0.CO;2-W

Falkenstein, 2000, Multiple actions of steroid hormones-A focus on rapid, nongenomic effects, Pharmacol. Rev., 52, 513

Falkenstein, 2000, Mannheim classification of nongenomically initiated (rapid) steroid action(s), J. Clin. Endocrinol. Metab., 85, 2072, 10.1210/jc.85.5.2072

Gametchu, 1987, Glucocorticoid receptor-like antigen in lymphoma cell membranes: correlation to cell lysis, Science, 236, 456, 10.1126/science.3563523

Gametchu, 1993, Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients, FASEB J., 7, 1283, 10.1096/fasebj.7.13.8405814

Gold, 1994, Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques, Lab. Invest., 71, 219

Gold, 1996, Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death: a model for T cell apoptosis in vivo, Brain, 119, 651, 10.1093/brain/119.2.651

Gold, 1996, Secretion of nitrite by Schwann cells and its effect on T-cell activation in vitro, Cell. Immunol., 168, 69, 10.1006/cimm.1996.0050

Gold, 1997, T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms, Trends Neurosci., 20, 399, 10.1016/S0166-2236(97)01079-5

Gold, 2000, Animal models for autoimmune demyelinating disorders of the nervous system, Mol. Med. Today, 6, 88, 10.1016/S1357-4310(99)01639-1

Hartung, 1988, The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis, Brain, 111, 1039, 10.1093/brain/111.5.1039

Hench, 1949, The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone, compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis, Proc. Staff Meet. Mayo Clin., 24, 181

Kaufman, 2000, Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis—report of the Quality Standards Subcommittee of the American Academy of Neurology, Neurology, 54, 2039, 10.1212/WNL.54.11.2039

Kerr, 1972, Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics, Br. J. Cancer, 26, 239, 10.1038/bjc.1972.33

Kojima, 1997, Myosin-induced autoimmune polymyositis in the rat, J. Neurol. Sci., 151, 141, 10.1016/S0022-510X(97)00148-2

Leussink, 2001, High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes, Arch. Neurol., 58, 91, 10.1001/archneur.58.1.91

Lucchinetti, 2000, Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination, Ann. Neurol., 47, 707, 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q

McCombe, 1996, Corticosteroid treatment of experimental autoimmune encephalomyelitis in the Lewis rat results in loss of Vβ8.2+ and myelin basic protein-reactive cells from the spinal cord, with increased total T-cell apoptosis but reduced apoptosis of Vβ8.2+ cells, J. Neuroimmunol., 70, 93, 10.1016/S0165-5728(96)00043-4

Nguyen, 1997, Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone, J. Neuropathol. Exp. Neurol., 56, 58, 10.1097/00005072-199701000-00006

Nicholson, 1999, Caspase structure, proteolytic substrates, and function during apoptotic cell death, Cell Death Differ., 6, 1028, 10.1038/sj.cdd.4400598

Noseworthy, 1999, Treatment of multiple sclerosis: recent trials and future perspectives, Curr. Opin. Neurol., 12, 279, 10.1097/00019052-199906000-00007

Orchinik, 1991, A corticosteroid receptor in neuronal membranes, Science, 252, 1848, 10.1126/science.2063198

Pender, 1991, Apoptosis in the nervous system in experimental allergic encephalomyelitis, J. Neurol. Sci., 104, 81, 10.1016/0022-510X(91)90219-W

Savill, 1993, Phagocyte recognition of cells undergoing apoptosis, Immunol. Today, 14, 131, 10.1016/0167-5699(93)90215-7

Schmid, 2000, Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states, Biosci. Rep., 20, 289, 10.1023/A:1026445108136

Schmidt, 2000, T-cell apoptosis in situ in experimental autoimmune encephalomyelitis following methylprednisolone pulse therapy, Brain, 123, 1431, 10.1093/brain/123.7.1431

Schneider, 1996, MHC class I mediated cytotoxicity does not induce apoptosis in muscle fibers nor in inflammatory T cells: studies in patients with polymyositis, dermatomyositis, and inclusion body myositis, J. Neuropathol. Exp. Neurol., 55, 1205, 10.1097/00005072-199612000-00003

Sellebjerg, 1999, A randomized, controlled trial of oral high-dose methylprednisolone in acute optic neuritis, Neurology, 52, 1479, 10.1212/WNL.52.7.1479

Smith, 1996, Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis, J. Autoimmun., 9, 167, 10.1006/jaut.1996.0020

Vermes, 1995, A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V, J. Immunol. Methods, 184, 39, 10.1016/0022-1759(95)00072-I

Weber, 1994, Human astrocytes are only partially competent antigen presenting cells: possible implications for lesion development in multiple sclerosis, Brain, 117, 59, 10.1093/brain/117.1.59

Weishaupt, 2001, Glucocorticosteroids modulate antigen-induced T cell apoptosis in experimental autoimmune neuritis and cause T cell proliferation in situ, Acta Neuropathol. (Berl.), 10.1007/s004010000356

Wyllie, 1980, Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation, Nature, 284, 555, 10.1038/284555a0

Zacharchuk, 1990, Programmed T lymphocyte cell death: cell activation- and steroid-induced pathways are mutually antagonistic, J. Immunol., 145, 4037, 10.4049/jimmunol.145.12.4037

Zettl, 1995, Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat, J. Neuropathol. Exp. Neurol., 54, 540, 10.1097/00005072-199507000-00008

Zettl, 1996, In situ demonstration of T cell activation and elimination in the peripheral nervous system during experimental autoimmune neuritis in the Lewis rat, Acta Neuropathol. (Berl.), 91, 360, 10.1007/s004010050437

Zipp, 2000, Dual effect of glucocorticoids on apoptosis of human autoreactive and foreign antigen-specific T cells, J. Neuroimmunol., 110, 214, 10.1016/S0165-5728(00)00337-4