Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

Barrachina, 2006, Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease, Neuropathol. Appl. Neurobiol., 32, 505, 10.1111/j.1365-2990.2006.00756.x Blennow, 2006, Alzheimer's disease, Lancet, 368, 387, 10.1016/S0140-6736(06)69113-7 Block, 2007, Microglia-mediated neurotoxicity: uncovering the molecular mechanisms, Nat. Rev. Neurosci., 8, 57, 10.1038/nrn2038 Brown, 2006, Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation, Biophys. J., 90, 4651, 10.1529/biophysj.106.081372 Chou, 2005, Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution, Biophys. J., 88, 455, 10.1529/biophysj.104.046813 Chromy, 2003, Self-assembly of Abeta(1-42) into globular neurotoxins, Biochemistry, 42, 12749, 10.1021/bi030029q Chung, 1999, Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells, J. Biol. Chem., 274, 32301, 10.1074/jbc.274.45.32301 Cooper, 2006, Clathrin-mediated endocytosis and lysosomal cleavage of hepatitis B virus capsid-like core particles, J. Biol. Chem., 281, 16563, 10.1074/jbc.M601418200 Coraci, 2002, CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils, Am. J. Pathol., 160, 101, 10.1016/S0002-9440(10)64354-4 Dahlgren, 2002, Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability, J. Biol. Chem., 277, 32046, 10.1074/jbc.M201750200 El Khoury, 1996, Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils, Nature, 382, 716, 10.1038/382716a0 Feng, 2007, Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity, Oncogene, 26, 3431, 10.1038/sj.onc.1210129 Graves, 2008, The Cl-/H+antiporter ClC-7 is the primary chloride permeation pathway in lysosomes, Nature, 453, 788, 10.1038/nature06907 Haass, 2007, Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide, Nat. Rev. Mol. Cell Biol., 8, 101, 10.1038/nrm2101 Hu, 2009, Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide, Proc. Natl Acad. Sci. USA, 106, 20324, 10.1073/pnas.0911281106 Huang, 2009, Enlargement of Abeta aggregates through chemokine-dependent microglial clustering, Neurosci. Res., 63, 280, 10.1016/j.neures.2009.01.001 Husemann, 2002, Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system, Glia, 40, 195, 10.1002/glia.10148 Jiang, 2008, ApoE promotes the proteolytic degradation of Abeta, Neuron, 58, 681, 10.1016/j.neuron.2008.04.010 Klyubin, 2005, Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo, Nat. Med., 11, 556, 10.1038/nm1234 Lee, 2008, Clearance and deposition of extracellular alpha-synuclein aggregates in microglia, Biochem. Biophys. Res. Commun., 372, 423, 10.1016/j.bbrc.2008.05.045 Lesne, 2006, A specific amyloid-beta protein assembly in the brain impairs memory, Nature, 440, 352, 10.1038/nature04533 Longva, 2002, Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies, J. Cell Biol., 156, 843, 10.1083/jcb.200106056 Majumdar, 2007, Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils, Mol. Biol. Cell, 18, 1490, 10.1091/mbc.e06-10-0975 Mandrekar, 2009, Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis, J. Neurosci., 29, 4252, 10.1523/JNEUROSCI.5572-08.2009 Marques, 2004, Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells, FASEB J., 18, 1424, 10.1096/fj.04-1743fje Meilandt, 2009, Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice, J. Neurosci., 29, 1977, 10.1523/JNEUROSCI.2984-08.2009 Moore, 2006, Scavenger receptors in atherosclerosis: beyond lipid uptake, Arterioscler. Thromb. Vasc. Biol., 26, 1702, 10.1161/01.ATV.0000229218.97976.43 Mueller-Steiner, 2006, Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease, Neuron, 51, 703, 10.1016/j.neuron.2006.07.027 Nakamura, 1989, Lysosome instability in aged rat brain, Neurosci. Lett., 97, 215, 10.1016/0304-3940(89)90166-3 Nakanishi, 2009, Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging, Behav. Brain Res., 201, 1, 10.1016/j.bbr.2009.02.001 Nishi, 2002, The vacuolar (H+)-ATPases—nature's most versatile proton pumps, Nat. Rev. Mol. Cell Biol., 3, 94, 10.1038/nrm729 Ono, 2009, Structure–neurotoxicity relationships of amyloid beta-protein oligomers, Proc. Natl Acad. Sci. USA, 106, 14745, 10.1073/pnas.0905127106 Paresce, 1996, Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor, Neuron, 17, 553, 10.1016/S0896-6273(00)80187-7 Parvathy, 2008 Roychaudhuri, 2009, Amyloid beta-protein assembly and Alzheimer disease, J. Biol. Chem., 284, 4749, 10.1074/jbc.R800036200 Schuck, 2000, Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling, Biophys. J., 78, 1606, 10.1016/S0006-3495(00)76713-0 Selkoe, 2001, Clearing the brain's amyloid cobwebs, Neuron, 32, 177, 10.1016/S0896-6273(01)00475-5 Shankar, 2008, Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory, Nat. Med., 14, 837, 10.1038/nm1782 Shie, 2005, Microglia lacking E prostanoid receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity, Am. J. Pathol., 166, 1163, 10.1016/S0002-9440(10)62336-X Shimizu, 2008, IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1–42) by rat primary type 2 microglia, J. Immunol., 181, 6503, 10.4049/jimmunol.181.9.6503 Sondag, 2009, Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia, J. Neuroinflammation, 6, 1, 10.1186/1742-2094-6-1 Stine, 2003, In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis, J. Biol. Chem., 278, 11612, 10.1074/jbc.M210207200 Streit, 2006, Microglial senescence: does the brain's immune system have an expiration date?, Trends Neurosci., 29, 506, 10.1016/j.tins.2006.07.001 Streit, 2009, Life and death of microglia, J. Neuroimmune Pharmacol., 4, 371, 10.1007/s11481-009-9163-5 Sun, 2008, Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease, Neuron, 60, 247, 10.1016/j.neuron.2008.10.001 Tahara, 2006, Role of toll-like receptor signalling in Abeta uptake and clearance, Brain, 129, 3006, 10.1093/brain/awl249 Townsend, 2006, Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers, J. Physiol., 572, 477, 10.1113/jphysiol.2005.103754 Walsh, 2007, A beta oligomers—a decade of discovery, J. Neurochem., 101, 1172, 10.1111/j.1471-4159.2006.04426.x Wang, 1995, Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment, J. Biol. Chem., 270, 24924, 10.1074/jbc.270.42.24924 Wang, 2006, Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives, Drug Discov. Today, 11, 931, 10.1016/j.drudis.2006.08.004 Yamasaki, 2007, Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice, Mol. Cell. Neurosci., 35, 573, 10.1016/j.mcn.2007.05.002 Yang, 1998, Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1–42 pathogenesis, J. Neurosci. Res., 52, 691, 10.1002/(SICI)1097-4547(19980615)52:6<691::AID-JNR8>3.0.CO;2-3